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Volumn 52, Issue 1, 1999, Pages 1-11

How BCG led to the discovery of immunostimulatory DNA

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; BACTERIAL DNA; BCG VACCINE; CYTOKINE; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; IMMUNOSTIMULATING AGENT; PLASMID VECTOR; VACCINE;

EID: 0032829670     PISSN: 13446304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (120)

References (91)
  • 1
    • 84964114580 scopus 로고
    • The cellular transfer of cutaneous hypersensitivity to tuberculin
    • Chase, M. W. (1945): The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exp. Biol. Med., 59, 134-135.
    • (1945) Proc. Soc. Exp. Biol. Med. , vol.59 , pp. 134-135
    • Chase, M.W.1
  • 2
    • 0343876835 scopus 로고
    • Antibody formation and sensitization with the aid of adjuvants
    • Freund, J., Thomson, K. T., Hough, H. B., Sommer, H. E. and Pisani, T. M. (1948): Antibody formation and sensitization with the aid of adjuvants. J. Immunol., 60, 383-398.
    • (1948) J. Immunol. , vol.60 , pp. 383-398
    • Freund, J.1    Thomson, K.T.2    Hough, H.B.3    Sommer, H.E.4    Pisani, T.M.5
  • 3
    • 0000642969 scopus 로고
    • The immunological basis of acquired cellular resistance
    • Mackaness, G. B. (1964): The immunological basis of acquired cellular resistance. J. Exp. Med., 120, 105-120.
    • (1964) J. Exp. Med. , vol.120 , pp. 105-120
    • Mackaness, G.B.1
  • 4
    • 0015815788 scopus 로고
    • Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response
    • Shevach, E. M., Rosenthal, A. S. (1973): Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response. J. Exp. Med., 138, 1213-1229.
    • (1973) J. Exp. Med. , vol.138 , pp. 1213-1229
    • Shevach, E.M.1    Rosenthal, A.S.2
  • 5
    • 84966150977 scopus 로고
    • Natural cytotoxic reactivity mediated by murine splenocytes
    • Herberman, R. B. (ed.). Academic Press, N.Y.
    • Herberman, R. B., Nunn, M. E. and Lavrin, D. H. (1975): Natural cytotoxic reactivity mediated by murine splenocytes. p.201-208. In Herberman, R. B. (ed.), NK cells and other natural effector cells. Academic Press, N.Y.
    • (1975) NK Cells and Other Natural Effector Cells , pp. 201-208
    • Herberman, R.B.1    Nunn, M.E.2    Lavrin, D.H.3
  • 6
    • 0013933261 scopus 로고
    • Mechanism of a reaction in vitro associated with delayed-type hypersensitivity
    • Bloom, B. R. and Bennett, B. (1966): Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science, 153, 80-82.
    • (1966) Science , vol.153 , pp. 80-82
    • Bloom, B.R.1    Bennett, B.2
  • 7
    • 0013923944 scopus 로고
    • Delayed hypersensitivity in vitro: Its mediation by cell-free substaneous formed by lymphoid cell antigen interaction
    • David, J. R. (1966): Delayed hypersensitivity in vitro: Its mediation by cell-free substaneous formed by lymphoid cell antigen interaction. Proc. Natl. Acad. Sci., USA, 56, 72-77.
    • (1966) Proc. Natl. Acad. Sci., USA , vol.56 , pp. 72-77
    • David, J.R.1
  • 10
    • 0022544031 scopus 로고
    • In vivo augmentation of natural killer cell activity with a deoxyribo-nucleic acid fraction of BCG
    • Shimada, S., Yano, O. and Tokunaga, T. (1986): In vivo augmentation of natural killer cell activity with a deoxyribo-nucleic acid fraction of BCG. Jpn. J. Cancer Res (Gann), 77, 808-816.
    • (1986) Jpn. J. Cancer Res (Gann) , vol.77 , pp. 808-816
    • Shimada, S.1    Yano, O.2    Tokunaga, T.3
  • 11
    • 0023689067 scopus 로고
    • In vitro augmentation of natural killer cell activity and production of interferon- α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG
    • Yamamoto, S., Kuramoto, E., Shimada, S. and Tokunaga, T. (1988): In vitro augmentation of natural killer cell activity and production of interferon- α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG. Jpn. J. Cancer Res (Gann), 79, 866-873.
    • (1988) Jpn. J. Cancer Res (Gann) , vol.79 , pp. 866-873
    • Yamamoto, S.1    Kuramoto, E.2    Shimada, S.3    Tokunaga, T.4
  • 12
    • 0026556987 scopus 로고
    • Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
    • Tokunaga, T., Yano, O., Kuramoto, E., Kimura, Y., Yamamoto, T., Kataoka, T. and Yamamoto, S. (1992): Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol., 36, 55-66.
    • (1992) Microbiol. Immunol. , vol.36 , pp. 55-66
    • Tokunaga, T.1    Yano, O.2    Kuramoto, E.3    Kimura, Y.4    Yamamoto, T.5    Kataoka, T.6    Yamamoto, S.7
  • 14
    • 0026464967 scopus 로고
    • DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
    • Yamamoto, S., Yamamoto, T., Shimada, S., Kuramoto, E., Yano, E., Yano, O., Kataoka, T. and Tokunaga, T. (1992): DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol., 36, 983-997.
    • (1992) Microbiol. Immunol. , vol.36 , pp. 983-997
    • Yamamoto, S.1    Yamamoto, T.2    Shimada, S.3    Kuramoto, E.4    Yano, E.5    Yano, O.6    Kataoka, T.7    Tokunaga, T.8
  • 15
    • 0028806487 scopus 로고
    • Does antisense exist ? It may, but only under very special circumstances
    • Stein, C. A. (1995): Does antisense exist ? It may, but only under very special circumstances. Nature Medicine, 1, 1119-1121.
    • (1995) Nature Medicine , vol.1 , pp. 1119-1121
    • Stein, C.A.1
  • 16
    • 0030273086 scopus 로고    scopus 로고
    • Immune activation by bacterial DNA: A new genetic code
    • Pisetsky, D. S. (1996): Immune activation by bacterial DNA: A new genetic code. Immunity, 5, 303-310.
    • (1996) Immunity , vol.5 , pp. 303-310
    • Pisetsky, D.S.1
  • 17
    • 0030205135 scopus 로고    scopus 로고
    • An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
    • Krieg, A. M. (1996): An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J. Lab. Clin. Med., 128, 128-133.
    • (1996) J. Lab. Clin. Med. , vol.128 , pp. 128-133
    • Krieg, A.M.1
  • 19
    • 0345267584 scopus 로고
    • Role of the "wax" of the tubercle bacillus in establishing delayed hypersensitivity II. Hypersensitivity to a protein antigen, egg albumin
    • Raffel, S., Arnaud, Le., Dukes, D. and Huang J. S. (1949): Role of the "wax" of the tubercle bacillus in establishing delayed hypersensitivity II. Hypersensitivity to a protein antigen, egg albumin. J. Exp. Med., 90, 53-72.
    • (1949) J. Exp. Med. , vol.90 , pp. 53-72
    • Raffel, S.1    Arnaud, Le.2    Dukes, D.3    Huang, J.S.4
  • 21
    • 0007312952 scopus 로고
    • Studies on the heterologous immunogenicity of a methanol-insoluble fraction of attenuated tubercle bacilli (BCG)
    • Weiss, D. W., Bonhag, R. S. and Parks, J. A. (1964): Studies on the heterologous immunogenicity of a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). J. Exp. Med., 119, 53-70.
    • (1964) J. Exp. Med. , vol.119 , pp. 53-70
    • Weiss, D.W.1    Bonhag, R.S.2    Parks, J.A.3
  • 22
    • 0015520841 scopus 로고
    • Water-soluble and lipid-free fracton from BCG with adjuvant and antitumor activity
    • Hiu, I. J. (1972): Water-soluble and lipid-free fracton from BCG with adjuvant and antitumor activity. Nature (New Biol), 238, 241-242.
    • (1972) Nature (New Biol) , vol.238 , pp. 241-242
    • Hiu, I.J.1
  • 23
    • 0016172627 scopus 로고
    • Shared antigens between Mycobacterium bovis (BCG) and neoplastic cells
    • Minden, P., McClatchy, J. K., Wainberg, M. and Weiss, D. W. (1974): Shared antigens between Mycobacterium bovis (BCG) and neoplastic cells. J. Natl. Cancer Inst., 53, 1325-1331.
    • (1974) J. Natl. Cancer Inst. , vol.53 , pp. 1325-1331
    • Minden, P.1    McClatchy, J.K.2    Wainberg, M.3    Weiss, D.W.4
  • 24
    • 0017072985 scopus 로고
    • Chemical and biological properties of hot-water extract from delipidated cells of Mycobacterium bovis strain BCG
    • Sato, H., Yokosawa, A., Arai, H., Nagai, H., Kurita, K., Kumano, N., Motomiya, M. and Konno, K. (1976): Chemical and biological properties of hot-water extract from delipidated cells of Mycobacterium bovis Strain BCG. Tohoku J. Exp. Med., 120, 75-81.
    • (1976) Tohoku J. Exp. Med. , vol.120 , pp. 75-81
    • Sato, H.1    Yokosawa, A.2    Arai, H.3    Nagai, H.4    Kurita, K.5    Kumano, N.6    Motomiya, M.7    Konno, K.8
  • 25
    • 0015326250 scopus 로고
    • Isolation and properties of a macromolecular, water-soluble, immunoadjuvant fraction from the cell wall of Mycobacterium smegmatis
    • Adam, A., Ciobaru, R., Petit, J-F. and Lederer, E. (1972): Isolation and properties of a macromolecular, water-soluble, immunoadjuvant fraction from the cell wall of Mycobacterium smegmatis. Proc. Natl. Acad. Sci. USA., 69, 851-854.
    • (1972) Proc. Natl. Acad. Sci. USA , vol.69 , pp. 851-854
    • Adam, A.1    Ciobaru, R.2    Petit, J.-F.3    Lederer, E.4
  • 26
    • 0021957292 scopus 로고
    • Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors
    • Shimada, S., Yano, O., Inoue, H., Kuramoto, E., Fukuda, T., Yamamoto, H., Kataoka, T. and Tokunaga, T. (1985): Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors. J. Natl. Cancer Inst., 74, 681-688.
    • (1985) J. Natl. Cancer Inst. , vol.74 , pp. 681-688
    • Shimada, S.1    Yano, O.2    Inoue, H.3    Kuramoto, E.4    Fukuda, T.5    Yamamoto, H.6    Kataoka, T.7    Tokunaga, T.8
  • 27
    • 0023683638 scopus 로고
    • A synthetic single-stranded DNA, poly (dG,dC), induces interferon-α/β and -γ, augments natural killer activity, and suppresses tumor growth
    • Tokunaga, T., Yamamoto, S. and Namba, K. (1988): A synthetic single-stranded DNA, poly (dG,dC), induces interferon-α/β and -γ, augments natural killer activity, and suppresses tumor growth. Jpn. J. Cancer Res. (Gann), 79, 682-686.
    • (1988) Jpn. J. Cancer Res. (Gann) , vol.79 , pp. 682-686
    • Tokunaga, T.1    Yamamoto, S.2    Namba, K.3
  • 28
    • 0024817466 scopus 로고
    • In situ infiltration of natural killer-like cells induced by intradermal injection of the nucleic acid fraction from BCG
    • Kuramoto, E., Toizumi, S., Shimada, S., and Tokunaga, T. (1989): In situ infiltration of natural killer-like cells induced by intradermal injection of the nucleic acid fraction from BCG. Microbiol. Immunol., 33, 929-940.
    • (1989) Microbiol. Immunol. , vol.33 , pp. 929-940
    • Kuramoto, E.1    Toizumi, S.2    Shimada, S.3    Tokunaga, T.4
  • 29
    • 0026751765 scopus 로고
    • Changes of host cell infiltration into meth A fibrosarcoma tumor during the course of regression induced by infections of a BCG nucleic acid fraction
    • Kuramoto, E., Watanabe, N., Iwata, D., Yano, O., Shimada, S. and Tokunaga, T. (1992): Changes of host cell infiltration into meth A fibrosarcoma tumor during the course of regression induced by infections of a BCG nucleic acid fraction. Int. J. Immunopharmac., 14, 773-782.
    • (1992) Int. J. Immunopharmac. , vol.14 , pp. 773-782
    • Kuramoto, E.1    Watanabe, N.2    Iwata, D.3    Yano, O.4    Shimada, S.5    Tokunaga, T.6
  • 30
    • 0024146124 scopus 로고
    • In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG
    • Mashiba, H., Matunaga, K., Tomoda, H., Furusawa, M., Jimi, S. and Tokunaga, T. (1988): In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG. Japan. J. Med Sci. Biol., 41, 197-202.
    • (1988) Japan. J. Med Sci. Biol. , vol.41 , pp. 197-202
    • Mashiba, H.1    Matunaga, K.2    Tomoda, H.3    Furusawa, M.4    Jimi, S.5    Tokunaga, T.6
  • 31
    • 0026599873 scopus 로고
    • Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG
    • Kataoka, T., Yamamoto, S., Yamamoto, T., Kuramoto, E., Kimura, Y. and Tokunaga, T. (1992): Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG. Jpn. J. Cancer Res., 83, 244-247.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 244-247
    • Kataoka, T.1    Yamamoto, S.2    Yamamoto, T.3    Kuramoto, E.4    Kimura, Y.5    Tokunaga, T.6
  • 32
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
    • Yamamoto, S., Yamamoto, T., Kataoka, T., Kuramoto, E., Yano, O. and Tokunaga, T. (1992): Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol., 148, 4072-4076.
    • (1992) J. Immunol. , vol.148 , pp. 4072-4076
    • Yamamoto, S.1    Yamamoto, T.2    Kataoka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 33
    • 0027978749 scopus 로고
    • Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
    • Yamamoto, T., Yamamoto, S., Kataoka, T., Komuro, K., Kohase, M. and Tokunaga, T. (1994): Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro. Jpn. J. Cancer Res., 85, 775-779.
    • (1994) Jpn. J. Cancer Res. , vol.85 , pp. 775-779
    • Yamamoto, T.1    Yamamoto, S.2    Kataoka, T.3    Komuro, K.4    Kohase, M.5    Tokunaga, T.6
  • 34
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas, Z. K., Rasmussen, W. L. and Krieg, A. M. (1996): Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol., 157, 1840-1845.
    • (1996) J. Immunol. , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 35
    • 0028087886 scopus 로고
    • Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length
    • Yamamoto, T., Yamamoto, S., Kataoka, T. and Tokunaga, T. (1994): Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length. Antisense Res. Develop, 4, 119-122.
    • (1994) Antisense Res. Develop , vol.4 , pp. 119-122
    • Yamamoto, T.1    Yamamoto, S.2    Kataoka, T.3    Tokunaga, T.4
  • 36
    • 0027945606 scopus 로고
    • Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN
    • Kimura, Y., Sonehara, K., Kuramoto, E., Makino, T., Yamamoto, S., Yamamoto, T., Kataoka, T. and Tokunaga, T. (1994): Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. J. Biochem., 116, 991-994.
    • (1994) J. Biochem. , vol.116 , pp. 991-994
    • Kimura, Y.1    Sonehara, K.2    Kuramoto, E.3    Makino, T.4    Yamamoto, S.5    Yamamoto, T.6    Kataoka, T.7    Tokunaga, T.8
  • 37
    • 0027946597 scopus 로고
    • Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity
    • Yamamoto, T., Yamamoto, S., Kataoka, T. and Tokunaga, T. (1994): Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity. Microbiol. Immunol., 38, 831-836.
    • (1994) Microbiol. Immunol. , vol.38 , pp. 831-836
    • Yamamoto, T.1    Yamamoto, S.2    Kataoka, T.3    Tokunaga, T.4
  • 39
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird, A. P. (1986): CpG-rich islands and the function of DNA methylation. Nature, 321, 209-213.
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 40
    • 0344084905 scopus 로고
    • Basic studies of MY-1, a new biological response modifier
    • Special issue, in Japanese
    • Special issue (1990): Basic studies of MY-1, a new biological response modifier, Jpn. Pharmacology & Therapeutics, 18, Suppl., 6 1-347 (in Japanese).
    • (1990) Jpn. Pharmacology & Therapeutics , vol.18 , Issue.SUPPL. , pp. 61-347
  • 41
    • 0023039090 scopus 로고
    • Phase 1 clinical study of MY-1, a new biological response modifier
    • in Japanese
    • Majima, H. and Nomura, K. (1986): Phase 1 clinical study of MY-1, A new biological response modifier. Jpn. J. Cancer Chemother. 13, 109-115 (in Japanese).
    • (1986) Jpn. J. Cancer Chemother. , vol.13 , pp. 109-115
    • Majima, H.1    Nomura, K.2
  • 43
    • 0344516100 scopus 로고
    • Pilot study on local administration of a new BRM, MY-1, for the treatment of malignant skin tumors
    • in Japanese
    • Ishihara, K., Ikeda, S., Arao, T. and Matsunaka, M. (1988): Pilot study on local administration of a new BRM, MY-1, For the treatment of malignant skin tumors, Skin Cancer, 3, 273-281 (in Japanese).
    • (1988) Skin Cancer , vol.3 , pp. 273-281
    • Ishihara, K.1    Ikeda, S.2    Arao, T.3    Matsunaka, M.4
  • 44
    • 0344084902 scopus 로고
    • Late phase-II clinical study of MY-1 in the treatment of malignant skin tumors
    • in Japanese
    • Ishihara, K., Ikeda, S. and Furue, H. (1990): Late Phase-II clinical study of MY-1 in the treatment of malignant skin tumors, Skin Cancer, 5, 192-202 (in Japanese).
    • (1990) Skin Cancer , vol.5 , pp. 192-202
    • Ishihara, K.1    Ikeda, S.2    Furue, H.3
  • 45
    • 0026356335 scopus 로고
    • Adult T-cell leukemia/lymphoma and mycosis fungoides responding well to MY-1
    • in Japanese
    • Johno, M., Arao, T. and Ishihara, K. (1991): Adult T-cell leukemia/lymphoma and mycosis fungoides responding well to MY-1. West Jpn. Dermatol., 53, 1297-1306 (in Japanese).
    • (1991) West Jpn. Dermatol. , vol.53 , pp. 1297-1306
    • Johno, M.1    Arao, T.2    Ishihara, K.3
  • 48
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
    • Klinman, D. M., Yi, A-K., Beaucaga, S. L., Conover, J. and Krieg, A. M. (1996): CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc. Natl. Acad. Sci. USA, 93, 2879-2883.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.-K.2    Beaucaga, S.L.3    Conover, J.4    Krieg, A.M.5
  • 51
    • 0031908427 scopus 로고    scopus 로고
    • Gene vaccination: Plasmid DNA is more than just a blueprint
    • Tighe, H., Corr, M., Roman, M. and Raz, E. (1998): Gene vaccination: plasmid DNA is more than just a blueprint. Immunology Today, 19, 89-97.
    • (1998) Immunology Today , vol.19 , pp. 89-97
    • Tighe, H.1    Corr, M.2    Roman, M.3    Raz, E.4
  • 52
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi, Ae-K., Tuetken, R., Redford, T., Waldschmidt, M., Kirsch, J. and Krieg, A. M. (1998): CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol., 160, 4755-4761.
    • (1998) J. Immunol. , vol.160 , pp. 4755-4761
    • Yi, Ae.-K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6
  • 53
    • 0030028722 scopus 로고    scopus 로고
    • Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
    • Halpern, M. D., Kurlander, R. J. and Pisetsky, D. S. (1996): Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell. Immunol., 167, 72-78.
    • (1996) Cell. Immunol. , vol.167 , pp. 72-78
    • Halpern, M.D.1    Kurlander, R.J.2    Pisetsky, D.S.3
  • 54
    • 0029670726 scopus 로고    scopus 로고
    • IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
    • Yi, A-K., Chace, J. H., Cowdery, J. S. and Krieg, A. M. (1996): IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol., 157, 558-564.
    • (1996) J. Immunol. , vol.157 , pp. 558-564
    • Yi, A.-K.1    Chace, J.H.2    Cowdery, J.S.3    Krieg, A.M.4
  • 55
    • 0031213914 scopus 로고    scopus 로고
    • Bacterial DNA-induces NK cell IFN-γ production is dependent on macrophage secretion of IL-12
    • Chace, J. H., Hooker, N. A., Mildenstein, K. L., Krieg, A. M. and Cowdery, J. S. (1997): Bacterial DNA-induces NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopath., 84, 185-193.
    • (1997) Clin. Immunol. Immunopath. , vol.84 , pp. 185-193
    • Chace, J.H.1    Hooker, N.A.2    Mildenstein, K.L.3    Krieg, A.M.4    Cowdery, J.S.5
  • 58
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser, T., Koch, E-S., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W. and Wagner, H. (1998): Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol., 28, 2045-2054.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1    Koch, E.-S.2    Vabulas, R.M.3    Heeg, K.4    Lipford, G.B.5    Ellwart, J.W.6    Wagner, H.7
  • 59
  • 61
  • 62
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey, K. J., Sweet, M. J. and Hume, D. A. (1996): Macrophages ingest and are activated by bacterial DNA. J. Immunol., 157, 2116-2122.
    • (1996) J. Immunol. , vol.157 , pp. 2116-2122
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 63
    • 0030812046 scopus 로고    scopus 로고
    • Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 b lymphocytes induced by several agents: Evidence for blockade of apoptosis at a distal signalling step
    • Macfarlane, D. E., Manzel, L. and Krieg, A. M. (1997): Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step. Immunology, 91, 586-593.
    • (1997) Immunology , vol.91 , pp. 586-593
    • Macfarlane, D.E.1    Manzel, L.2    Krieg, A.M.3
  • 64
    • 0032526607 scopus 로고    scopus 로고
    • CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
    • Yi, A-K., Chang, M., Peckham, D. W., Krieg, A. M. and Ashman, R. F. (1998): CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J. Immunol., 160, 5895-5906.
    • (1998) J. Immunol. , vol.160 , pp. 5895-5906
    • Yi, A.-K.1    Chang, M.2    Peckham, D.W.3    Krieg, A.M.4    Ashman, R.F.5
  • 65
    • 0031915373 scopus 로고    scopus 로고
    • CpG DNA rescue from anti-IgM-induced WEHI-231 b lymphoma apoptosis via modulation of I κ B α and I κ B β and sustained activation of nuclear factor-κ, B/cRel
    • Yi, A-K. and Krieg, A. M. (1998): CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I κ B α and I κ B β and sustained activation of nuclear factor-κ, B/cRel. J. Immunol., 160, 1240-1245.
    • (1998) J. Immunol. , vol.160 , pp. 1240-1245
    • Yi, A.-K.1    Krieg, A.M.2
  • 66
    • 0031802584 scopus 로고    scopus 로고
    • Genetic vaccines: Strategies for optimization
    • Gregoriadis, G. (1998): Genetic vaccines: Strategies for optimization. Pharmac. Res., 15, 661-670.
    • (1998) Pharmac. Res. , vol.15 , pp. 661-670
    • Gregoriadis, G.1
  • 67
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman, D. M., Yamshchikov, G. and Ishigatsubo, Y. (1997): Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol., 158, 3635-3639.
    • (1997) J. Immunol. , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 68
    • 0031948647 scopus 로고    scopus 로고
    • Therapeutic applications of CpG-containing oligodeoxynucleotides
    • Dennis, M. K. (1998): Therapeutic applications of CpG-containing oligodeoxynucleotides. Antisese Nucleic Acid Drug Develop., 8, 181-184.
    • (1998) Antisese Nucleic Acid Drug Develop. , vol.8 , pp. 181-184
    • Dennis, M.K.1
  • 69
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing systhetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford, G. B., Beaure, M., Blank, C., Reiter, R., Wagner, H. and Heeg, K. (1997): CpG-containing systhetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol., 27, 2340-2344.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Beaure, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 70
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu, R. A., Targori, O., Krieg, A. M., Lehmann, P. V. and Harding, C. V. (1997): CpG oligodeoxynucleotide act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med., 186, 1623-1631.
    • (1997) J. Exp. Med. , vol.186 , pp. 1623-1631
    • Chu, R.A.1    Targori, O.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 71
    • 0030716907 scopus 로고    scopus 로고
    • Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination
    • Carson, D. A. and Raz, E. (1997): Oligonucleotide adjuvants for T helper 1 (Th1)-specific vaccination. J. Exp. Med., 186, 1621-1622.
    • (1997) J. Exp. Med. , vol.186 , pp. 1621-1622
    • Carson, D.A.1    Raz, E.2
  • 73
    • 0031215046 scopus 로고    scopus 로고
    • The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA
    • Leclerc, C., Deriaud, E., Rojas, M. and Whalen, R. G. (1997): The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA. Cell. Immunol., 179, 97-106.
    • (1997) Cell. Immunol. , vol.179 , pp. 97-106
    • Leclerc, C.1    Deriaud, E.2    Rojas, M.3    Whalen, R.G.4
  • 74
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligonucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • Weiner, G. J., Liu, H. M., Wooldrodge, E. J., Dahle, C. E. and Krieg, A. M. (1997): Immunostimulatory oligonucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA, 94, 10833-10837.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10833-10837
    • Weiner, G.J.1    Liu, H.M.2    Wooldrodge, E.J.3    Dahle, C.E.4    Krieg, A.M.5
  • 75
    • 0031948647 scopus 로고    scopus 로고
    • Therapeutic applications of CpG-containing oligodeoxynucleotides
    • Klinman, D. M. (1998): Therapeutic applications of CpG-containing oligodeoxynucleotides, Antisense Nucleic Acid Drug Develop., 8, 181-184.
    • (1998) Antisense Nucleic Acid Drug Develop. , vol.8 , pp. 181-184
    • Klinman, D.M.1
  • 76
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu, Z., Love-Homan, L., Huang, W. Q. and Krieg, A. M. (1998): CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine, 16, 1216-1224.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 77
  • 78
    • 0025670612 scopus 로고
    • Immunotherapeutic potential in guinea-pig tumor model of DNA from BCG complexed with poly-L-lysine and carboxymethylcellulose
    • Kataoka, T., Yamamoto, S., Yamamoto, T. and Tokunaga, T. (1990): Immunotherapeutic potential in guinea-pig tumor model of DNA from BCG complexed with poly-L-lysine and carboxymethylcellulose. Jpn. J. Med. Sci. Biol., 43, 171-182.
    • (1990) Jpn. J. Med. Sci. Biol. , vol.43 , pp. 171-182
    • Kataoka, T.1    Yamamoto, S.2    Yamamoto, T.3    Tokunaga, T.4
  • 80
    • 0032521881 scopus 로고    scopus 로고
    • Cutting edge: CpG oligodeoxynucleotides tregger protective and curative Th1 response in lethal murine leishmaniasis
    • Zimmermann, S., Egeter, O., Hausmann, S., Lipford, G. B., Rocken, M., Wagner, H. and Heeg, K. (1998): Cutting edge: CpG oligodeoxynucleotides tregger protective and curative Th1 response in lethal murine leishmaniasis. J. Immunol., 160, 3627-3630.
    • (1998) J. Immunol. , vol.160 , pp. 3627-3630
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6    Heeg, K.7
  • 81
    • 0030900680 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
    • Wooldridge, J. E., Ballas, Z., Krieg, A. M. and Weiner, G. J. (1997): Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood, 89, 2994-2998.
    • (1997) Blood , vol.89 , pp. 2994-2998
    • Wooldridge, J.E.1    Ballas, Z.2    Krieg, A.M.3    Weiner, G.J.4
  • 82
    • 0029932729 scopus 로고    scopus 로고
    • Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA
    • Krieg, A. M. (1996): Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA. Trends Microbiol., 4, 73-77.
    • (1996) Trends Microbiol. , vol.4 , pp. 73-77
    • Krieg, A.M.1
  • 83
    • 0030844985 scopus 로고    scopus 로고
    • Immunostimulatory DNA: A clear and present danger ?
    • Pisetsky, D. S. (1997): Immunostimulatory DNA: A clear and present danger ?. Nature Med., 3, 829-831.
    • (1997) Nature Med. , vol.3 , pp. 829-831
    • Pisetsky, D.S.1
  • 85
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery, J. S., Chace, J. H., Yi, A-K. and Krieg, A. M. (1996): Bacterial DNA induces NK Cells to produce IFN-γ in vivo and increases the Toxicity of lipopolysaccharides. J. Immunol., 156, 4570-4575.
    • (1996) J. Immunol. , vol.156 , pp. 4570-4575
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.-K.3    Krieg, A.M.4
  • 86
    • 0030816325 scopus 로고    scopus 로고
    • Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-α -mediated shock
    • Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K. and Wagner, H. (1997): Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α -mediated shock. Eur. J. Immunol., 27, 1671-1679.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1671-1679
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3    Erdmann, A.4    Hacker, H.5    Heeg, K.6    Wagner, H.7
  • 88
    • 0028824955 scopus 로고
    • CpG DNA: A pathogenic factor in systemic lupus erythematosus ?
    • Krieg, A. M. (1995): CpG DNA: A pathogenic factor in systemic lupus erythematosus ?. J. Clin. Immunol., 15, 284-292.
    • (1995) J. Clin. Immunol. , vol.15 , pp. 284-292
    • Krieg, A.M.1
  • 89
    • 0030330133 scopus 로고    scopus 로고
    • CpG motif in DNA from immune complexes of SLE patients augments expression of intercellular adhesion molecule-1 on endothelial cells
    • Miyata, M., Kanno, T., Ishida, T., Kobayashi, H., Sato, Y., Sato, Y., Nishimaki, T. and Kasukawa, R. (1996): CpG motif in DNA from immune complexes of SLE patients augments expression of intercellular adhesion molecule-1 on endothelial cells. Clin. Pathol., (in Japanese), 44, 1125-1131.
    • (1996) Clin. Pathol., (in Japanese) , vol.44 , pp. 1125-1131
    • Miyata, M.1    Kanno, T.2    Ishida, T.3    Kobayashi, H.4    Sato, Y.5    Sato, Y.6    Nishimaki, T.7    Kasukawa, R.8
  • 90
    • 0031156982 scopus 로고    scopus 로고
    • Microbial products induce autoimmune disease by an IL-12-dependent pathway
    • Segal, B. M., Klinman, D. M. and Shevach, E. M. (1997): Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol., 158, 5087-5090.
    • (1997) J. Immunol. , vol.158 , pp. 5087-5090
    • Segal, B.M.1    Klinman, D.M.2    Shevach, E.M.3
  • 91
    • 0031135490 scopus 로고    scopus 로고
    • Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA
    • Wloch, M. K., Alexander, A. L., Pippen, A. M. M., Pisetsky, D. S. and Gilkeson, G. S. (1997): Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA. J. Immunol., 158, 4500-4506.
    • (1997) J. Immunol. , vol.158 , pp. 4500-4506
    • Wloch, M.K.1    Alexander, A.L.2    Pippen, A.M.M.3    Pisetsky, D.S.4    Gilkeson, G.S.5


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