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Volumn 3, Issue 8, 2005, Pages 1800-1814

Protease-activated receptors in hemostasis, thrombosis and vascular biology

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; TRYPTASE;

EID: 28344436780     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01377.x     Document Type: Conference Paper
Times cited : (874)

References (187)
  • 2
    • 0024386731 scopus 로고
    • Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
    • Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 1989; 134: 1087-97.
    • (1989) Am J Pathol , vol.134 , pp. 1087-1097
    • Drake, T.A.1    Morrissey, J.H.2    Edgington, T.S.3
  • 3
    • 0010460867 scopus 로고
    • Inducible endothelial functions in inflammation and coagulation
    • Bevilacqua MP, Gimbrone MA Jr. Inducible endothelial functions in inflammation and coagulation. Semin Thromb Hemost 1987; 13: 425-33.
    • (1987) Semin Thromb Hemost , vol.13 , pp. 425-433
    • Bevilacqua, M.P.1    Gimbrone Jr., M.A.2
  • 4
    • 0030070996 scopus 로고    scopus 로고
    • Cell biology of tissue factor, the principal initiator of blood coagulation
    • Camerer E, KolstØ AB, Prydz H. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 1996; 81: 1-41.
    • (1996) Thromb Res , vol.81 , pp. 1-41
    • Camerer, E.1    Kolstø, A.B.2    Prydz, H.3
  • 5
    • 0031756985 scopus 로고    scopus 로고
    • Tissue factor expression by monocytes: Regulation and pathophysiological roles
    • Osterud B. Tissue factor expression by monocytes: regulation and pathophysiological roles. Blood Coagul Fibrinolysis 1998;9(Suppl. 1(6 Pt 2)): S9-14.
    • (1998) Blood Coagul Fibrinolysis , vol.9 , Issue.9 SUPPL. 1 AND PART 2
    • Osterud, B.1
  • 7
    • 8644222225 scopus 로고    scopus 로고
    • Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation
    • Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood 2004; 104: 3190-7.
    • (2004) Blood , vol.104 , pp. 3190-3197
    • Chou, J.1    Mackman, N.2    Merrill-Skoloff, G.3    Pedersen, B.4    Furie, B.C.5    Furie, B.6
  • 9
    • 0031956683 scopus 로고    scopus 로고
    • Sol Sherry lecture in thrombosis: How thrombin 'talks' to cells: Molecular mechanisms and roles in vivo
    • Coughlin SR. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol 1998; 18: 514-8.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 514-518
    • Coughlin, S.R.1
  • 10
    • 0014191175 scopus 로고
    • Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets
    • Davey MG, Lüscher EF. Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets. Nature 1967; 216: 857-8.
    • (1967) Nature , vol.216 , pp. 857-858
    • Davey, M.G.1    Lüscher, E.F.2
  • 11
    • 0016748441 scopus 로고
    • Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
    • Hamberg M, Svensson J, Samuelsson B. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci U S A 1975; 72: 2994-8.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 2994-2998
    • Hamberg, M.1    Svensson, J.2    Samuelsson, B.3
  • 12
    • 0022221113 scopus 로고
    • A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
    • Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 1985; 101: 880-6.
    • (1985) J Cell Biol , vol.101 , pp. 880-886
    • Stenberg, P.E.1    McEver, R.P.2    Shuman, M.A.3    Jacques, Y.V.4    Bainton, D.F.5
  • 14
    • 0032168738 scopus 로고    scopus 로고
    • Integrin affinity modulation
    • Hughes PE, Pfaff M. Integrin affinity modulation. Trends Cell Biol 1998; 8: 359-64.
    • (1998) Trends Cell Biol , vol.8 , pp. 359-364
    • Hughes, P.E.1    Pfaff, M.2
  • 15
    • 0024325249 scopus 로고
    • Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane
    • Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. J Biol Chem 1989; 264: 17049-57.
    • (1989) J Biol Chem , vol.264 , pp. 17049-17057
    • Sims, P.J.1    Wiedmer, T.2    Esmon, C.T.3    Weiss, H.J.4    Shattil, S.J.5
  • 16
    • 0024391784 scopus 로고
    • Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140
    • Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 1989; 264: 7768-71.
    • (1989) J Biol Chem , vol.264 , pp. 7768-7771
    • Hattori, R.1    Hamilton, K.K.2    Fugate, R.D.3    McEver, R.P.4    Sims, P.J.5
  • 18
    • 0030030905 scopus 로고    scopus 로고
    • Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
    • Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 1996; 84: 563-74.
    • (1996) Cell , vol.84 , pp. 563-574
    • Frenette, P.S.1    Mayadas, T.N.2    Rayburn, H.3    Hynes, R.O.4    Wagner, D.D.5
  • 19
    • 0028121374 scopus 로고
    • Regulation of vascular endothelial barrier function
    • Lum H, Malik AB. Regulation of vascular endothelial barrier function. Am J Physiol 1994; 267 (3 Pt 1): L223-41.
    • (1994) Am J Physiol , vol.267 , Issue.3 PART 1
    • Lum, H.1    Malik, A.B.2
  • 21
    • 0027368915 scopus 로고
    • Involvement of the 'tethered ligand' receptor in thrombin-induced endothelium-mediated relaxations
    • Tesfamariam B, Allen GT, Normandin D, Antonaccio MJ. Involvement of the 'tethered ligand' receptor in thrombin-induced endothelium-mediated relaxations. Am J Physiol 1993;H 1744-9.
    • (1993) Am J Physiol
    • Tesfamariam, B.1    Allen, G.T.2    Normandin, D.3    Antonaccio, M.J.4
  • 22
    • 0035816730 scopus 로고    scopus 로고
    • Increased expression of pro tease-activated receptor-2 (PA R2) and PA R4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
    • Hamilton JR, Frauman AG, Cocks TM. Increased expression of pro tease-activated receptor-2 (PA R2) and PA R4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists. Circ Res 2001; 89: 92-98.
    • (2001) Circ Res , vol.89 , pp. 92-98
    • Hamilton, J.R.1    Frauman, A.G.2    Cocks, T.M.3
  • 23
    • 0034936715 scopus 로고    scopus 로고
    • Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries
    • Hamilton JR, Moffatt JD, Frauman AG, Cocks TM. Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries. J Cardiovasc Pharmacol 2001 ; V38 (N1): 108-19.
    • (2001) J Cardiovasc Pharmacol , vol.V38 , Issue.N1 , pp. 108-119
    • Hamilton, J.R.1    Moffatt, J.D.2    Frauman, A.G.3    Cocks, T.M.4
  • 24
    • 0027374144 scopus 로고
    • Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs
    • Ku DD, Zaleski JK. Receptor mechanism of thrombin-induced endothelium-dependent and endothelium-independent coronary vascular effects in dogs. J Cardiovasc Pharmacol 1993; 22: 609-16.
    • (1993) J Cardiovasc Pharmacol , vol.22 , pp. 609-616
    • Ku, D.D.1    Zaleski, J.K.2
  • 25
    • 0017152878 scopus 로고
    • Mitogenicity of thrombin and surface alterations on mouse splenocytes
    • Chen EB, Teng NNH, Buchanan JM. Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp Cell Res 1976; 101: 41-46.
    • (1976) Exp Cell Res , vol.101 , pp. 41-46
    • Chen, E.B.1    Teng, N.N.H.2    Buchanan, J.M.3
  • 26
    • 0016432831 scopus 로고
    • Mitogenic activity of blood components. I. Thrombin and prothrombin
    • Chen EB, Buchanan JM. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 1975; 72: 131-5.
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 131-135
    • Chen, E.B.1    Buchanan, J.M.2
  • 27
    • 0027492461 scopus 로고
    • Thrombin stimulation of smooth muscle cell proliferation is mediated by a proteolytic, receptor-mediated mechanism
    • McNamara CA, Sarembok IJ, Gimple EW, Fenton JW II, Coughlin SR, Owens GK. Thrombin stimulation of smooth muscle cell proliferation is mediated by a proteolytic, receptor-mediated mechanism. J Clin Invest 1992; 91: 94-98.
    • (1992) J Clin Invest , vol.91 , pp. 94-98
    • McNamara, C.A.1    Sarembok, I.J.2    Gimple, E.W.3    Fenton II, J.W.4    Coughlin, S.R.5    Owens, G.K.6
  • 28
    • 0030036714 scopus 로고    scopus 로고
    • Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes
    • Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW II, Eibby P. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res 1996; 79: 286-94.
    • (1996) Circ Res , vol.79 , pp. 286-294
    • Kranzhöfer, R.1    Clinton, S.K.2    Ishii, K.3    Coughlin, S.R.4    Fenton II, J.W.5    Eibby, P.6
  • 30
    • 0028245263 scopus 로고
    • Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production
    • Mari B, Imbert V, Belhacene N, Far DF, Peyron JF, Pouyssegur J, Van O, Schilling E, Rossi B, Auberger P. Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. J Biol Chem 1994; 269: 8517-23.
    • (1994) J Biol Chem , vol.269 , pp. 8517-8523
    • Mari, B.1    Imbert, V.2    Belhacene, N.3    Far, D.F.4    Peyron, J.F.5    Pouyssegur, J.6    Van, O.7    Schilling, E.8    Rossi, B.9    Auberger, P.10
  • 31
    • 0033613183 scopus 로고    scopus 로고
    • How the protease thrombin talks to cells
    • Coughlin SR. How the protease thrombin talks to cells. Proc Natl Acad Sci USA 1999; 96: 11023-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11023-11027
    • Coughlin, S.R.1
  • 32
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • VuTK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-68.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 34
    • 0028364862 scopus 로고
    • Thrombin receptor activation: Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode
    • Chen J, Ishii M, Wang L, Ishii K, Coughlin SR. Thrombin receptor activation: Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem 1994; 269: 16041-5.
    • (1994) J Biol Chem , vol.269 , pp. 16041-16045
    • Chen, J.1    Ishii, M.2    Wang, L.3    Ishii, K.4    Coughlin, S.R.5
  • 35
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin Responses in Human Endothelial Cells. Contributions from receptors other than PARI include the transactivation of PAR2 by thrombin-cleaved PARI
    • O'Brien PJ, Prevost N, Molino M, Hollinger MK, Woolkalis MJ, Woulfe DS, Brass LF. Thrombin Responses in Human Endothelial Cells. Contributions from receptors other than PARI include the transactivation of PAR2 by thrombin-cleaved PARI. J Biol Chem 2000; 275: 13502-9.
    • (2000) J Biol Chem , vol.275 , pp. 13502-13509
    • O'Brien, P.J.1    Prevost, N.2    Molino, M.3    Hollinger, M.K.4    Woolkalis, M.J.5    Woulfe, D.S.6    Brass, L.F.7
  • 36
    • 0026775223 scopus 로고
    • Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides
    • Vassallo RR Jr, Kieber-Emmons T, Cichowski K, Brass LF. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 1992; 267: 6081-5.
    • (1992) J Biol Chem , vol.267 , pp. 6081-6085
    • Vassallo Jr., R.R.1    Kieber-Emmons, T.2    Cichowski, K.3    Brass, L.F.4
  • 37
    • 0026629249 scopus 로고
    • Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
    • Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem 1992; 267: 13146-9.
    • (1992) J Biol Chem , vol.267 , pp. 13146-13149
    • Scarborough, R.M.1    Naughton, M.A.2    Teng, W.3    Hung, D.T.4    Rose, J.5    Vu, T.K.6    Wheaton, V.I.7    Turck, C.W.8    Coughlin, S.R.9
  • 38
    • 0242332769 scopus 로고    scopus 로고
    • Proteinase-mediated signaling: Proteinase-activated receptors (PARs) and much more
    • Hollenberg MD. Proteinase-mediated signaling: proteinase-activated receptors (PARs) and much more. Life Sci 2003; 74: 237-46.
    • (2003) Life Sci , vol.74 , pp. 237-246
    • Hollenberg, M.D.1
  • 40
    • 0026003287 scopus 로고
    • The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity
    • Liu L, Vu T-KH, Esmon CT, Coughlin SR. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem 1991; 266: 16977-80.
    • (1991) J Biol Chem , vol.266 , pp. 16977-16980
    • Liu, L.1    Vu, T.-K.H.2    Esmon, C.T.3    Coughlin, S.R.4
  • 41
    • 0029026320 scopus 로고
    • Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate
    • Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. J Biol Chem 1995; 270: 16435-40.
    • (1995) J Biol Chem , vol.270 , pp. 16435-16440
    • Ishii, K.1    Gerszten, R.2    Zheng, Y.W.3    Welsh, J.B.4    Turck, C.W.5    Coughlin, S.R.6
  • 42
    • 0026690665 scopus 로고
    • Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
    • Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest 1992; 89: 1350-3.
    • (1992) J Clin Invest , vol.89 , pp. 1350-1353
    • Hung, D.T.1    Vu, T.K.2    Wheaton, V.I.3    Ishii, K.4    Coughlin, S.R.5
  • 44
    • 0033596749 scopus 로고    scopus 로고
    • Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: Evidence for a novel mechanism for preventing or terminating signaling by PARTs tethered ligand
    • Hammes SR. Coughlin SR. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PARTs tethered ligand. Biochemistry 1999; 38: 2486-93.
    • (1999) Biochemistry , vol.38 , pp. 2486-2493
    • Hammes, S.R.1    Coughlin, S.R.2
  • 45
    • 0026459474 scopus 로고
    • Thrombin receptor activating peptides: Importance of the N-terminal serine and its ionization state as judged by pH dependence, NMR spectroscopy, and cleavage by aminopeptidase M
    • Coller BS, Ward P, Ceruso M, Scudder LE, Springer K, Kutok J, Prestwich GD. Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, NMR spectroscopy, and cleavage by aminopeptidase M. Biochemistry 1992; 31: 11713-20.
    • (1992) Biochemistry , vol.31 , pp. 11713-11720
    • Coller, B.S.1    Ward, P.2    Ceruso, M.3    Scudder, L.E.4    Springer, K.5    Kutok, J.6    Prestwich, G.D.7
  • 46
    • 0017893796 scopus 로고
    • The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding
    • Bode W, Schwager P, Huber R. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. J Mol Biol 1978; 118:99-112.
    • (1978) J Mol Biol , vol.118 , pp. 99-112
    • Bode, W.1    Schwager, P.2    Huber, R.3
  • 47
    • 0029943079 scopus 로고    scopus 로고
    • Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function
    • Lerner DJ, Chen M, Tram T, Coughlin SR. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem 1996; 271: 13943-7.
    • (1996) J Biol Chem , vol.271 , pp. 13943-13947
    • Lerner, D.J.1    Chen, M.2    Tram, T.3    Coughlin, S.R.4
  • 50
    • 0029143923 scopus 로고
    • Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site
    • Nanevicz T, Ishii M, Wang L. Chen M, Chen J, Turck CW, Cohen FE. Coughlin SR. Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site. J Biol Chem 1995; 270: 21619-25.
    • (1995) J Biol Chem , vol.270 , pp. 21619-21625
    • Nanevicz, T.1    Ishii, M.2    Wang, L.3    Chen, M.4    Chen, J.5    Turck, C.W.6    Cohen, F.E.7    Coughlin, S.R.8
  • 51
    • 0030066317 scopus 로고    scopus 로고
    • Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling
    • Nanevicz T, Wang L, Chen M, Ishii M, Coughlin SR. Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. J Biol Chem 1996; 271: 702-6.
    • (1996) J Biol Chem , vol.271 , pp. 702-706
    • Nanevicz, T.1    Wang, L.2    Chen, M.3    Ishii, M.4    Coughlin, S.R.5
  • 52
    • 0027155450 scopus 로고
    • The thrombin receptor extracellular domain contains sites crucial for peptide-ligand induced activation
    • Bahou WF, Coller BS, Potter CL, Norton KJ, Kutok JL, Goligorsky MS. The thrombin receptor extracellular domain contains sites crucial for peptide-ligand induced activation. J Clin Invest 1993; 91: 1405-13.
    • (1993) J Clin Invest , vol.91 , pp. 1405-1413
    • Bahou, W.F.1    Coller, B.S.2    Potter, C.L.3    Norton, K.J.4    Kutok, J.L.5    Goligorsky, M.S.6
  • 53
    • 0037092952 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling
    • Kim S, Foster C, Lecchi A, Quinton TM, Presser DM, Jin J, Cattaneo M, Kunapuli SP. Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling. Blood 2002; 99: 3629-36.
    • (2002) Blood , vol.99 , pp. 3629-3636
    • Kim, S.1    Foster, C.2    Lecchi, A.3    Quinton, T.M.4    Presser, D.M.5    Jin, J.6    Cattaneo, M.7    Kunapuli, S.P.8
  • 54
    • 0030023688 scopus 로고    scopus 로고
    • Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: Receptor-stimulated GTPase and evaluation of agonists and partial agonists
    • Seiler SM. Peluso M, Tuttle JG, Pryor K, Klimas C, Matsueda GR, Bernatowicz MS. Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists. Mol Pharmacol 1996; 49: 190-7.
    • (1996) Mol Pharmacol , vol.49 , pp. 190-197
    • Seiler, S.M.1    Peluso, M.2    Tuttle, J.G.3    Pryor, K.4    Klimas, C.5    Matsueda, G.R.6    Bernatowicz, M.S.7
  • 55
    • 0031029553 scopus 로고    scopus 로고
    • Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor. G protein coupling
    • Barr AJ, Brass LF, Manning DR. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor. G protein coupling. J Biol Chem 1997; 272: 2223-9.
    • (1997) J Biol Chem , vol.272 , pp. 2223-2229
    • Barr, A.J.1    Brass, L.F.2    Manning, D.R.3
  • 56
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature 1997; 389: 183-6.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 59
    • 0344310763 scopus 로고    scopus 로고
    • Mechanisms of beta-adrenergic receptor desensitization and resensitization
    • Lefkowitz RJ, Pitcher J, Krueger K, Daaka Y. Mechanisms of beta-adrenergic receptor desensitization and resensitization. Adv Pharmacol 1998; 42: 416-20.
    • (1998) Adv Pharmacol , vol.42 , pp. 416-420
    • Lefkowitz, R.J.1    Pitcher, J.2    Krueger, K.3    Daaka, Y.4
  • 61
    • 0028009801 scopus 로고
    • Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G protein-coupled receptor kinases
    • Ishii K, Chen J, Ishii M. Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin SR. Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G protein-coupled receptor kinases. J Biol Chem 1994; 269: 1125-30.
    • (1994) J Biol Chem , vol.269 , pp. 1125-1130
    • Ishii, K.1    Chen, J.2    Ishii, M.3    Koch, W.J.4    Freedman, N.J.5    Lefkowitz, R.J.6    Coughlin, S.R.7
  • 62
    • 0037059795 scopus 로고    scopus 로고
    • Beta - Arrestins regulate pro tease-activated receptor-1 desensitization but not internalization or Down-regulation
    • Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J. beta - Arrestins regulate pro tease-activated receptor-1 desensitization but not internalization or Down-regulation. J Biol Chem 2002; 277: 1292-300.
    • (2002) J Biol Chem , vol.277 , pp. 1292-1300
    • Paing, M.M.1    Stutts, A.B.2    Kohout, T.A.3    Lefkowitz, R.J.4    Trejo, J.5
  • 63
    • 0028053488 scopus 로고
    • Intracellular targeting and trafficking of thrombin receptors: A novel mechanism for resensitization of a G protein-coupled receptor
    • Hein L, Ishii K, Coughlin SR, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors: a novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem 1994; 269: 27719-26.
    • (1994) J Biol Chem , vol.269 , pp. 27719-27726
    • Hein, L.1    Ishii, K.2    Coughlin, S.R.3    Kobilka, B.K.4
  • 64
    • 0032506111 scopus 로고    scopus 로고
    • Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting
    • Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A 1998; 95: 13698-702.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13698-13702
    • Trejo, J.1    Hammes, S.R.2    Coughlin, S.R.3
  • 65
    • 0033593210 scopus 로고    scopus 로고
    • The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
    • Trejo J. Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem 1999; 274: 2216-24.
    • (1999) J Biol Chem , vol.274 , pp. 2216-2224
    • Trejo, J.1    Coughlin, S.R.2
  • 66
    • 0027309290 scopus 로고
    • Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
    • Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J Biol Chem 1993; 268: 9780-6.
    • (1993) J Biol Chem , vol.268 , pp. 9780-9786
    • Ishii, K.1    Hein, L.2    Kobilka, B.3    Coughlin, S.R.4
  • 68
    • 2442592928 scopus 로고    scopus 로고
    • Regulated shedding of PARI N-terminal exodomain from endothelial cells
    • Epub 2004 Feb 24
    • Ludeman MJ. Zheng YW, Ishii K, Coughlin SR. Regulated shedding of PARI N-terminal exodomain from endothelial cells. J Biol Chem 2004: 279: 18592-9. Epub 2004 Feb 24.
    • (2004) J Biol Chem , vol.279 , pp. 18592-18599
    • Ludeman, M.J.1    Zheng, Y.W.2    Ishii, K.3    Coughlin, S.R.4
  • 69
    • 0026631543 scopus 로고
    • Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus
    • Brass LF, Vassallo RJ, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus. J Biol Chem 1992; 267: 13795-8.
    • (1992) J Biol Chem , vol.267 , pp. 13795-13798
    • Brass, L.F.1    Vassallo, R.J.2    Belmonte, E.3    Ahuja, M.4    Cichowski, K.5    Hoxie, J.A.6
  • 75
    • 0032879820 scopus 로고    scopus 로고
    • Ticlopidine and clopidogrel
    • Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation 1999; 100: 1667-72.
    • (1999) Circulation , vol.100 , pp. 1667-1672
    • Quinn, M.J.1    Fitzgerald, D.J.2
  • 80
    • 0141446361 scopus 로고    scopus 로고
    • Activated protein C signals through the thrombin receptor PARI in endothelial cells
    • Riewald M, Petrovan RJ, Donner A, Ruf W. Activated protein C signals through the thrombin receptor PARI in endothelial cells. J Endotoxin Res 2003; 9: 317-21.
    • (2003) J Endotoxin Res , vol.9 , pp. 317-321
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Ruf, W.4
  • 83
    • 0029847188 scopus 로고    scopus 로고
    • Coagulation factors VII and X induce Ca2 + oscillations in Madin-Darby canine kidney cells only when proteolytically active
    • Camerer E, Røttingen JA, Iversen JG. Prydz H. Coagulation factors VII and X induce Ca2 + oscillations in Madin-Darby canine kidney cells only when proteolytically active. J Biol Chem 1996; 271: 29034-42.
    • (1996) J Biol Chem , vol.271 , pp. 29034-29042
    • Camerer, E.1    Røttingen, J.A.2    Iversen, J.G.3    Prydz, H.4
  • 84
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- And factor X-dependent activation of protease-activated receptor 2 by factor Vila
    • Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor Vila. Proc Natl Acad Sci U S A 2000; 97: 5255-60.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 85
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
    • Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci U S A 2001; 98: 7742-7.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 88
    • 0026003287 scopus 로고
    • The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity
    • Liu LW, Vu TK, Esmon CT, Coughlin SR. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem 1991; 266: 16977-80.
    • (1991) J Biol Chem , vol.266 , pp. 16977-16980
    • Liu, L.W.1    Vu, T.K.2    Esmon, C.T.3    Coughlin, S.R.4
  • 91
    • 0034733558 scopus 로고    scopus 로고
    • Struc-ture-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function
    • Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. Struc-ture-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. J Biol Chem 2000; 275: 19728-34.
    • (2000) J Biol Chem , vol.275 , pp. 19728-19734
    • Faruqi, T.R.1    Weiss, E.J.2    Shapiro, M.J.3    Huang, W.4    Coughlin, S.R.5
  • 92
    • 0023951925 scopus 로고
    • Cathepsin G is a strong platelet agonist released by neutrophils
    • Selak MA, Chignard M, Smith JB. Cathepsin G is a strong platelet agonist released by neutrophils. Biochem J 1988; 251: 293-9.
    • (1988) Biochem J , vol.251 , pp. 293-299
    • Selak, M.A.1    Chignard, M.2    Smith, J.B.3
  • 94
    • 0034682810 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
    • Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem 2000; 275: 25216-21.
    • (2000) J Biol Chem , vol.275 , pp. 25216-25221
    • Shapiro, M.J.1    Weiss, E.J.2    Faruqi, T.R.3    Coughlin, S.R.4
  • 95
    • 0034625055 scopus 로고    scopus 로고
    • Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
    • Covic L, Gresser AL, Kuliopulos A. Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets. Biochemistry 2000; 39: 5458-67.
    • (2000) Biochemistry , vol.39 , pp. 5458-5467
    • Covic, L.1    Gresser, A.L.2    Kuliopulos, A.3
  • 96
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns S, Laugwitz KL, Spicher K, Schultz G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci U S A 1994; 91: 504-8.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.L.2    Spicher, K.3    Schultz, G.4
  • 97
    • 0034733558 scopus 로고    scopus 로고
    • Structure-function analysis of protease-activated receptor-4 tethered tigand peptides: Determinants of specificity and utility in assays of receptor function
    • Faruqi TR, Weiss EJ, Shapiro MJ, Hung W, Coughlin SR. Structure-function analysis of protease-activated receptor-4 tethered tigand peptides: Determinants of specificity and utility in assays of receptor function. J Biol Chem 2000; 275: 19728-34.
    • (2000) J Biol Chem , vol.275 , pp. 19728-19734
    • Faruqi, T.R.1    Weiss, E.J.2    Shapiro, M.J.3    Hung, W.4    Coughlin, S.R.5
  • 98
    • 0018190052 scopus 로고
    • Platelet glycocalicin: Interaction with thrombin and role as thrombin receptor on the platelet surface
    • Okamura T, Hasitz M, Jamieson GA. Platelet glycocalicin: interaction with thrombin and role as thrombin receptor on the platelet surface. J Biol Chem 1978; 253: 3435-43.
    • (1978) J Biol Chem , vol.253 , pp. 3435-3443
    • Okamura, T.1    Hasitz, M.2    Jamieson, G.A.3
  • 101
    • 0025283519 scopus 로고
    • Variant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complex
    • De Marco L, Mazzucato M, Fabris F, De Roia D, Coser P, Girolami A, Vicente V, Ruggeri ZM. Variant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complex. J Clin Invest 1990; 86: 25-31.
    • (1990) J Clin Invest , vol.86 , pp. 25-31
    • De Marco, L.1    Mazzucato, M.2    Fabris, F.3    De Roia, D.4    Coser, P.5    Girolami, A.6    Vicente, V.7    Ruggeri, Z.M.8
  • 102
    • 0026317444 scopus 로고
    • Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin
    • De Marco L, Mazzucato M, Masotti A, Fenton JWd, Ruggeri ZM. Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. J Biol Chem 1991; 266: 23776-83.
    • (1991) J Biol Chem , vol.266 , pp. 23776-23783
    • De Marco, L.1    Mazzucato, M.2    Masotti, A.3    Jwd, F.4    Ruggeri, Z.M.5
  • 103
    • 0026041318 scopus 로고
    • The platelet glycoprotein Ib-IX complex
    • Ruggeri ZM. The platelet glycoprotein Ib-IX complex. Prog Hemost Thromb 1991; 10: 35-68.
    • (1991) Prog Hemost Thromb , vol.10 , pp. 35-68
    • Ruggeri, Z.M.1
  • 104
    • 0028181751 scopus 로고
    • Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha
    • De Marco L, Mazzucato M, Masotti A, Ruggeri ZM. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem 1994; 269: 6478-84.
    • (1994) J Biol Chem , vol.269 , pp. 6478-6484
    • De Marco, L.1    Mazzucato, M.2    Masotti, A.3    Ruggeri, Z.M.4
  • 105
    • 0035895962 scopus 로고    scopus 로고
    • Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
    • Epub 2000 Nov 17
    • De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets. J Biol Chem 2001; 276: 4692-8. Epub 2000 Nov 17.
    • (2001) J Biol Chem , vol.276 , pp. 4692-4698
    • De Candia, E.1    Hall, S.W.2    Rutella, S.3    Landolfi, R.4    Andrews, R.K.5    De Cristofaro, R.6
  • 107
    • 0030008312 scopus 로고    scopus 로고
    • Role of the thrombin receptor in development and evidence for a second receptor
    • Connolly AJ, Ishihara H, Kahn ML, Farese RV Jr, Coughlin SR. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996; 381: 516-9.
    • (1996) Nature , vol.381 , pp. 516-519
    • Connolly, A.J.1    Ishihara, H.2    Kahn, M.L.3    Farese Jr., R.V.4    Coughlin, S.R.5
  • 109
    • 0029016907 scopus 로고
    • Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases
    • Derian CK, Santulli RJ, Tomko KA, Haertlein BJ, Andrade-Gordon P. Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases. Thromb Res 1995; 6: 505-19.
    • (1995) Thromb Res , vol.6 , pp. 505-519
    • Derian, C.K.1    Santulli, R.J.2    Tomko, K.A.3    Haertlein, B.J.4    Andrade-Gordon, P.5
  • 110
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Comment In: Nature. 2001 Sep 6;413(6851):26-7 UI: 21429411
    • Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. [Comment In: Nature. 2001 Sep 6;413(6851):26-7 UI: 21429411]. Nature 2001; 413: 74-8.
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 113
    • 13244273430 scopus 로고    scopus 로고
    • Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets
    • Hamilton JR, Cornelissen I, Coughlin SR. Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets. J Thromb Haemost 2004; 2: 1429-35.
    • (2004) J Thromb Haemost , vol.2 , pp. 1429-1435
    • Hamilton, J.R.1    Cornelissen, I.2    Coughlin, S.R.3
  • 114
    • 0038494921 scopus 로고    scopus 로고
    • Platelet-collagen interaction: Is GPVI the central receptor?
    • Epub 2003 Mar 20
    • Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor? Blood 2003; 102: 449-61. Epub 2003 Mar 20.
    • (2003) Blood , vol.102 , pp. 449-461
    • Nieswandt, B.1    Watson, S.P.2
  • 119
    • 0347597765 scopus 로고    scopus 로고
    • Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency
    • Camerer E, Duong DN. Hamilton JR, Coughlin SR. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood 2004; 103: 1524.
    • (2004) Blood , vol.103 , pp. 1524
    • Camerer, E.1    Duong, D.N.2    Hamilton, J.R.3    Coughlin, S.R.4
  • 121
    • 0035979691 scopus 로고    scopus 로고
    • A role for thrombin receptor signaling in endothelial cells during embryonic development
    • Comment In: Science. 2001 Aug 31:293(5535): 1602 4 UI: 21425318
    • Griffin CT, Snnivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. [Comment In: Science. 2001 Aug 31:293(5535): 1602 4 UI: 21425318]. Science 2001; 293: 1666-70.
    • (2001) Science , vol.293 , pp. 1666-1670
    • Griffin, C.T.1    Snnivasan, Y.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 122
    • 0036838525 scopus 로고    scopus 로고
    • Protection against thrombosis in mice lacking PA R3
    • Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PA R3. Blood 2002; 100: 3240-4.
    • (2002) Blood , vol.100 , pp. 3240-3244
    • Weiss, E.J.1    Hamilton, J.R.2    Lease, K.E.3    Coughlin, S.R.4
  • 123
    • 28344438473 scopus 로고    scopus 로고
    • Protease-activated receptor 4 is required for maximal thrombus growth but not for fibrin generation in thrombi after laser injury
    • Vandendries ER, Hamilton JA, Coughlin SR, Furie BC. Furie B. Protease-activated receptor 4 is required for maximal thrombus growth but not for fibrin generation in thrombi after laser injury. Blood 2004; 104: 181a.
    • (2004) Blood , vol.104
    • Vandendries, E.R.1    Hamilton, J.A.2    Coughlin, S.R.3    Furie, B.C.4    Furie, B.5
  • 124
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin MGDF in megakaryocyte development
    • Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin MGDF in megakaryocyte development. Cell 1995; 81: 695-704.
    • (1995) Cell , vol.81 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker-Franklin, D.3    Jackson, C.W.4    Hunt, P.5    Saris, C.J.6    Orkin, S.H.7
  • 125
    • 0032697618 scopus 로고    scopus 로고
    • Biochemistry and physiology of blood coagulation
    • Mann KG. Biochemistry and physiology of blood coagulation. Thromb Haemost 1999; 82: 165-74.
    • (1999) Thromb Haemost , vol.82 , pp. 165-174
    • Mann, K.G.1
  • 126
    • 0023805430 scopus 로고
    • Regulation of thrombin generation at cell surfaces
    • Tracy PB. Regulation of thrombin generation at cell surfaces. Semin Thromb Hemost 1988; 14: 227-33.
    • (1988) Semin Thromb Hemost , vol.14 , pp. 227-233
    • Tracy, P.B.1
  • 127
    • 0029914728 scopus 로고    scopus 로고
    • Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and 'clinical restenosis'
    • Reverter JC. Beguin S. Kessels H, Kumar R, Hemker HC, Coller BS. Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and 'clinical restenosis'. J Clin Invest 1996; 98: 863-74.
    • (1996) J Clin Invest , vol.98 , pp. 863-874
    • Reverter, J.C.1    Beguin, S.2    Kessels, H.3    Kumar, R.4    Hemker, H.C.5    Coller, B.S.6
  • 130
    • 0032525041 scopus 로고    scopus 로고
    • Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
    • Johnson K, Choi Y, DeGroot E. Samuels I, Creasey A, Aarden L. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J Immunol 1998; 160: 5130-5.
    • (1998) J Immunol , vol.160 , pp. 5130-5135
    • Johnson, K.1    Choi, Y.2    Degroot, E.3    Samuels, I.4    Creasey, A.5    Aarden, L.6
  • 132
    • 0018242325 scopus 로고
    • Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187
    • Weksler BB, Ley CW, Jaffe EA. Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187. J Clin Invest 1978; 62: 923-30.
    • (1978) J Clin Invest , vol.62 , pp. 923-930
    • Weksler, B.B.1    Ley, C.W.2    Jaffe, E.A.3
  • 134
    • 0037013268 scopus 로고    scopus 로고
    • Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
    • Camerer E. Kataoka H. Kahn M, Lease K, Coughlin SR. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem 2002; 277: 16081-7.
    • (2002) J Biol Chem , vol.277 , pp. 16081-16087
    • Camerer, E.1    Kataoka, H.2    Kahn, M.3    Lease, K.4    Coughlin, S.R.5
  • 135
    • 0029812590 scopus 로고    scopus 로고
    • The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice
    • Trejo J. Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem 1996; 271: 21536-41.
    • (1996) J Biol Chem , vol.271 , pp. 21536-21541
    • Trejo, J.1    Connolly, A.J.2    Coughlin, S.R.3
  • 136
    • 0027492461 scopus 로고
    • Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
    • McNamara CA. Sarembock IJ, Gimple LW, Fenton JW Jr, Coughlin SR, Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest 1993:91:94-8.
    • (1993) J Clin Invest , vol.91 , pp. 94-98
    • McNamara, C.A.1    Sarembock, I.J.2    Gimple, L.W.3    Fenton Jr., J.W.4    Coughlin, S.R.5    Owens, G.K.6
  • 137
    • 0031975236 scopus 로고    scopus 로고
    • Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells
    • Loppnow H, Bil R. Hirt S, Schonbeck U, Herzberg M, Werdan K, Rietschel ET, Brandt E, Flad HD. Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells. Blood 1998; 91: 134-41.
    • (1998) Blood , vol.91 , pp. 134-141
    • Loppnow, H.1    Bil, R.2    Hirt, S.3    Schonbeck, U.4    Herzberg, M.5    Werdan, K.6    Rietschel, E.T.7    Brandt, E.8    Flad, H.D.9
  • 141
    • 0037253347 scopus 로고    scopus 로고
    • PARticipation in inflammation
    • Coughlin SR, Camerer E. PARticipation in inflammation. J Clin Invest 2003; 111: 25-27.
    • (2003) J Clin Invest , vol.111 , pp. 25-27
    • Coughlin, S.R.1    Camerer, E.2
  • 142
    • 0034614895 scopus 로고    scopus 로고
    • Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
    • Cunningham MA, Rondeau E. Chen X, Coughlin SR, Holdsworth SR. Tipping PG. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 2000; 191: 455-62.
    • (2000) J Exp Med , vol.191 , pp. 455-462
    • Cunningham, M.A.1    Rondeau, E.2    Chen, X.3    Coughlin, S.R.4    Holdsworth, S.R.5    Tipping, P.G.6
  • 145
    • 0032543264 scopus 로고    scopus 로고
    • Antibody to thrombin receptor inhibits neoin-timal smooth muscle cell accumulation without causing inhibition of platelet aggregation or altering hemostatic parameters after angioplasty in rat
    • Takada M, Tanaka H, Yamada T, Ito O, Kogushi M, Yanagimachi M, Kawamura T, Musha T, Yoshida F, Ito M, Kobayashi H, Yoshitake S, Saito I. Antibody to thrombin receptor inhibits neoin-timal smooth muscle cell accumulation without causing inhibition of platelet aggregation or altering hemostatic parameters after angioplasty in rat. Circ Res 1998; 82: 980-7.
    • (1998) Circ Res , vol.82 , pp. 980-987
    • Takada, M.1    Tanaka, H.2    Yamada, T.3    Ito, O.4    Kogushi, M.5    Yanagimachi, M.6    Kawamura, T.7    Musha, T.8    Yoshida, F.9    Ito, M.10    Kobayashi, H.11    Yoshitake, S.12    Saito, I.13
  • 152
    • 2942524371 scopus 로고    scopus 로고
    • Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis
    • Pawlinski R, Mackman N. Tissue factor, coagulation proteases. and protease-activated receptors in endotoxemia and sepsis. Crit Care Med 2004; 32 (Suppl. 5): S293-7.
    • (2004) Crit Care Med , vol.32 , Issue.SUPPL. 5
    • Pawlinski, R.1    Mackman, N.2
  • 153
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-2.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 157
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000; 407: 258-64.
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 158
    • 28344457457 scopus 로고    scopus 로고
    • Activated Protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of Protease Activated Receptor-1
    • Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated Protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of Protease Activated Receptor-1. Blood 2003; 13: 13.
    • (2003) Blood , vol.13 , pp. 13
    • Domotor, E.1    Benzakour, O.2    Griffin, J.H.3    Yule, D.4    Fukudome, K.5    Zlokovic, B.V.6
  • 159
    • 0038682435 scopus 로고    scopus 로고
    • Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor
    • Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor. Biochem J 2003; 373 (Pt 1): 65-70.
    • (2003) Biochem J , vol.373 , Issue.PART 1 , pp. 65-70
    • Mosnier, L.O.1    Griffin, J.H.2
  • 161
    • 17444410423 scopus 로고    scopus 로고
    • Proteinase-activated receptor 1 (PAR-1) and cell apoptosis
    • Flynn AN, Buret AG. Proteinase-activated receptor 1 (PAR-1) and cell apoptosis. Apoptosis 2004; 9: 729-737.
    • (2004) Apoptosis , vol.9 , pp. 729-737
    • Flynn, A.N.1    Buret, A.G.2
  • 162
    • 17044427680 scopus 로고    scopus 로고
    • Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    • Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005; 105: 3178-84.
    • (2005) Blood , vol.105 , pp. 3178-3184
    • Feistritzer, C.1    Riewald, M.2
  • 165
    • 0029854371 scopus 로고    scopus 로고
    • Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
    • Cui J, O'Shea KS, Purkayastha A, Saunders TL, Ginsburg D. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature 1996; 384: 66-8.
    • (1996) Nature , vol.384 , pp. 66-68
    • Cui, J.1    O'Shea, K.S.2    Purkayastha, A.3    Saunders, T.L.4    Ginsburg, D.5
  • 166
    • 0031015426 scopus 로고    scopus 로고
    • Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency
    • Offermanns S, Mancino V, Revel JP, Simon MI. Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science 1997; 275: 533-6.
    • (1997) Science , vol.275 , pp. 533-536
    • Offermanns, S.1    Mancino, V.2    Revel, J.P.3    Simon, M.I.4
  • 167
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung DT, Wong YH, Vu T-KH, Coughlin SR. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 1992:353:20831-4.
    • (1992) J Biol Chem , vol.353 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.-K.H.3    Coughlin, S.R.4
  • 168
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns S, Laugwitz K-L, Spicher K, Schultz G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci U S A 1994; 91: 504-508.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.-L.2    Spicher, K.3    Schultz, G.4
  • 171
    • 0033605294 scopus 로고    scopus 로고
    • A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
    • Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem 1999; 274: 5868-79.
    • (1999) J Biol Chem , vol.274 , pp. 5868-5879
    • Fukuhara, S.1    Murga, C.2    Zohar, M.3    Igishi, T.4    Gutkind, J.S.5
  • 172
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G 12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets
    • Klages B, Brandt U, Simon MI, Schultz G, Offermanns S. Activation of G 12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144: 745-54.
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 173
    • 0031717365 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
    • Vouret-Craviari V, Boquet P, Pouyssegur J, Van Obberghen-Schilling E. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol Biol Cell 1998; 9: 2639-53.
    • (1998) Mol Biol Cell , vol.9 , pp. 2639-2653
    • Vouret-Craviari, V.1    Boquet, P.2    Pouyssegur, J.3    Van Obberghen-Schilling, E.4
  • 174
    • 0025860413 scopus 로고
    • Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins
    • Taylor S, Chae H, Rhee S-G, Exton J. Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins. Nature 1991; 350: 516-8.
    • (1991) Nature , vol.350 , pp. 516-518
    • Taylor, S.1    Chae, H.2    Rhee, S.-G.3    Exton, J.4
  • 177
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999; 11: 219-25.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 178
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-8.
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3    Leserer, M.4    Abraham, R.5    Wallasch, C.6    Ullrich, A.7
  • 179
    • 0030020873 scopus 로고    scopus 로고
    • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation
    • Ali H, Tomhave ED, Richardson RM, Haribabu B, Snyderman R. Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. J Biol Chem 1996; 271: 3200-6.
    • (1996) J Biol Chem , vol.271 , pp. 3200-3206
    • Ali, H.1    Tomhave, E.D.2    Richardson, R.M.3    Haribabu, B.4    Snyderman, R.5
  • 180
    • 0028222277 scopus 로고
    • Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin
    • Colotta F, Sciacca FL, Sironi M, Luini W, Rabiet MJ, Mantovani A. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am J Pathol 1994; 144: 975-85.
    • (1994) Am J Pathol , vol.144 , pp. 975-985
    • Colotta, F.1    Sciacca, F.L.2    Sironi, M.3    Luini, W.4    Rabiet, M.J.5    Mantovani, A.6
  • 181
    • 0030004297 scopus 로고    scopus 로고
    • Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells
    • Ueno A, Murakami K, Yamanouchi K, Watanabe M, Kondo T. Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells. Immunology 1996; 88: 76-81.
    • (1996) Immunology , vol.88 , pp. 76-81
    • Ueno, A.1    Murakami, K.2    Yamanouchi, K.3    Watanabe, M.4    Kondo, T.5
  • 184
    • 0026495238 scopus 로고
    • Eeukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
    • Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C. Hsu YM, Sajer SA, Furie B. Eeukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 1992; 359: 848-51.
    • (1992) Nature , vol.359 , pp. 848-851
    • Palabrica, T.1    Lobb, R.2    Furie, B.C.3    Aronovitz, M.4    Benjamin, C.5    Hsu, Y.M.6    Sajer, S.A.7    Furie, B.8
  • 185
    • 15844401726 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
    • Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996; 271: 14910-5.
    • (1996) J Biol Chem , vol.271 , pp. 14910-14915
    • Nystedt, S.1    Ramakrishnan, V.2    Sundelin, J.3
  • 186
    • 0034651718 scopus 로고    scopus 로고
    • Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
    • Esmon CT. Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? Blood 2000; 95: 1113-1116.
    • (2000) Blood , vol.95 , pp. 1113-1116
    • Esmon, C.T.1
  • 187
    • 0030859367 scopus 로고    scopus 로고
    • Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency
    • Inbal A, Kenet G, Zivelin A, Yermiyahu T, Bronstein T, Sheinfeld T, Tamari H, Gitel S, Eshel G. Duchemin J, Aiach M, Seligsohn U. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. Thromb Haemost 1997; 77: 1086-9.
    • (1997) Thromb Haemost , vol.77 , pp. 1086-1089
    • Inbal, A.1    Kenet, G.2    Zivelin, A.3    Yermiyahu, T.4    Bronstein, T.5    Sheinfeld, T.6    Tamari, H.7    Gitel, S.8    Eshel, G.9    Duchemin, J.10    Aiach, M.11    Seligsohn, U.12


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