Direct stimulation of the guanine nucleotide exchange activity of p115 RoGEF by Gα13

Science

Volumn 280, Issue 5372, 1998, Pages 2112-2114

  Hart, Matthew J ^a   Jiang, Xuejun ^b   Kozasa, Tohru ^b   Roscoe, William ^a   Singer, William D ^b   Gilman, Alfred G ^b   Sternweis, Paul C ^b   Bollag, Gideon ^a  

^a ONYX PHARMACEUTICALS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RHO FACTOR;

ANIMAL CELL; CELL STRAIN COS1; CYTOSKELETON; ENZYME ACTIVATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ALUMINUM COMPOUNDS; ANIMALS; COS CELLS; FLUORIDES; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; PROTEINS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0032568868     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5372.2112     Document Type: Review

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32. We thank S. Gutowski and J. Laidlaw for technical assistance. Supported by American Heart Association grant 96G105 (T.K.); the Bayer Corporation (Onyx); NIH grant GM34497 and the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology (A.G.G.); and NIH grant GM 31954, the Robert A. Welch Foundation, and the Alfred and Mabel Gilman Professorship in Molecular Pharmacology (P.C.S.).