Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 18, 2000, Pages 9984-9989

  Yang, Jing ^a   Wu, Jie ^a   Kowalska, Anna M ^a   Dalvi, Ashutosh ^a   Prevost, Nicolas ^a   O'Brien, Peter J ^a   Manning, David ^a   Poncz, Mortimer ^a   Lucki, Irwin ^a   Blendy, Julie A ^a   Brass, Lawrence F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; ANTIDEPRESSANT AGENT; CELL SURFACE RECEPTOR; COCAINE; CYCLIC AMP; GREEN FLUORESCENT PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; PROSTACYCLIN;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE UPTAKE; CONTROLLED STUDY; DEPRESSION; DRUG RESPONSE; IN VIVO STUDY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOPHARMACOLOGY; SWIMMING; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOEMBOLISM;

ANIMALS; BLOOD PLATELETS; BRAIN; COCAINE; COLLAGEN; CYCLIC AMP; EPINEPHRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; LUNG; MALE; MICE; MICE, KNOCKOUT; MORPHINE; MOTOR ACTIVITY; PLATELET ACTIVATION; PLATELET AGGREGATION; PSYCHOTROPIC DRUGS; SIGNAL TRANSDUCTION; THROMBOEMBOLISM;

ANIMALIA;

EID: 0034730185     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.180194597     Document Type: Article

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