Activation of G12/G13 results in shape change and Rho/Rho-kinase- mediated myosin light chain phosphorylation in mouse platelets

Journal of Cell Biology

Volumn 144, Issue 4, 1999, Pages 745-754

  Klages, Birgit ^a   Brandt, Ursula ^a   Simon, Melvin I ^b   Schultz, Günter ^a   Offermanns, Stefan ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

G protein; Myosin light chain phosphorylation; Platelet; Platelet shape change; Rho kinase

Indexed keywords

MYOSIN LIGHT CHAIN; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; THROMBOXANE A2 RECEPTOR; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN SERINE THREONINE KINASE; RHO GTPASE ACTIVATING PROTEIN; RHO GTPASE-ACTIVATING PROTEIN; RHO KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE; THROMBIN; THROMBOXANE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; THROMBOCYTE SHAPE; ANIMAL; BLOOD; CELL SIZE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE; THROMBOCYTE AGGREGATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; BLOOD PLATELETS; CELL SIZE; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, ELECTRON, SCANNING; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; PLATELET AGGREGATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, THROMBOXANE; THROMBIN;

EID: 0033593667     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.144.4.745     Document Type: Article

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