PARticipation in inflammation

Journal of Clinical Investigation

Volumn 111, Issue 1, 2003, Pages 25-27

  Coughlin, Shaun R ^a   Camerer, Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN;

ARTHRITIS; BINDING AFFINITY; BINDING KINETICS; BLOOD CLOTTING; CELL ADHESION; CELL KINETICS; CELL MIGRATION; CELL PROLIFERATION; CELL TYPE; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; MAST CELL DEGRANULATION; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TISSUE REPAIR;

EID: 0037253347     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17564     Document Type: Note

References (20)

1. Ferrell, W.R., et al. 2003. Essential role for proteinase activated receptor-2 in arthritis. J. Clin. Invest. 111:35-41. doi: 10.1172/JCI200316913.
2. Coughlin, S.R. 2000. Thrombin signaling and protease-activated receptors. Nature. 407:258-264.
3. Vergnolle, N., Wallace, J.L., Bunnett, N.W., and Hollenberg, M.D. 2001. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends. Pharmacol. Sci. 22:146-152.
4. Fiorucci, S., and Distrutti, E. 2002. Role of PAR2 in pain and inflammation. Trends. Pharmacol. Sci. 23:153-155.
5. Weiss, E.J., Hamilton, J.R., Lease, K.E., and Coughlin, S.R. 2002. Protection against thrombosis in mice lacking PAR3. Blood. 100:3240-3244.
6. Cook, J.J., et al. 1995. An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey. Circulation. 91:2961-2971.
7. Riewald, M., Petrovan, R.J., Donner, A., Mueller, B.M., and Ruf, W. 2002. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science. 296:1880-1882.
8. Steinhofff, M., et al. 2000. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 6:151-158.
9. Vergnolle, N., et al. 2001. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat. Med. 7:821-826.
10. Cirino, G., et al. 1996. Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183:821-827.
11. Steinhoff, M., et al. 1999. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp. Dermatol. 8:282-294.
12. Mari, B., et al. 1994. Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. J. Biol. Chem. 269:8517-8523.
13. Uehara, A., Sugawara, S., Muramoto, K., and Takada, H. 2002. Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2. J. Immunol. 169:4594-4603.
14. Lindner, J.R., et al. 2000. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J. Immunol. 165:6504-6510.
15. Schmidlin, F., et al. 2002. Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J. Immunol. 169:5315-5321.
16. Kawagoe, J., et al. 2002. Effect of protease-acti vated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn. J. Pharmacol. 88:77-84.
17. Marty, I., et al. 2001. Amelioration of collagen-induced arthritis by thrombin inhibition. J. Clin. Invest. 107:631-640.
18. Fiorucci, S., et al. 2001. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc. Natl. Acad. Sci. USA. 98:13936-13941.
19. Milia, A.F., et al. 2002. Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia. Circ. Res. 91:346-352.
20. Cocks, T.M., et al. 1999. A protective role for protease-activated receptors in the airways. Nature. 398:156-160.