Modulation of α-thrombin function by distinct interactions with platelet glycoprotein Ibα

Science

Volumn 301, Issue 5630, 2003, Pages 218-221

  Celikel, Reha ^a   McClintock, Richard A ^a   Roberts, James R ^a   Mendolicchio, G Loredana ^a   Ware, Jerry ^a   Varughese, Kottayil I ^b   Ruggeri, Zaverio M ^a  

^a Roon Res Ctr Arteriosclerosis T   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; ENZYMES; PATHOLOGY;

THROMBOSIS;

PROTEINS;

GLYCOPROTEIN; GLYCOPROTEIN IB ALPHA; THROMBIN; UNCLASSIFIED DRUG; FIBRINOGEN; LIGAND; RECOMBINANT PROTEIN; THROMBIN RECEPTOR;

BIOLOGY; PATHOLOGY;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; MOLECULAR BIOLOGY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; THROMBOCYTE ACTIVATION; BLOOD CLOTTING; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; THROMBOCYTE; THROMBOCYTE AGGREGATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BLOOD COAGULATION; BLOOD PLATELETS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FIBRINOGEN; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MUTATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; THROMBIN;

EID: 0037815126     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1084183     Document Type: Article

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30. We thank D. Mukhopadhyay for his assistance in data collection on the R-axis image plate system and the Stanford Synchrotron Radiation Laboratory for providing beam time for data collection. Supported by NIH grant nos. HL-42846, HL-31950, HL-48728 (Z.M.R.); HL-55375 (K.I.V.): and RR0833 (to the General Clinical Research Center of the Scripps Clinic and Research Foundation). Additional support was provided by the Stein Endowment Fund. Coordinates used in this paper are found in the Protein Data Bank (GpIbαN: accession no. 1P9A; α-thrombin: accession no. 1PPB; GpIbαN:α-thrombin complex: accession no. 100K).