Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries

Journal of Cardiovascular Pharmacology

Volumn 38, Issue 1, 2001, Pages 108-119

  Hamilton, Justin R ^a   Moffatt, James D ^a   Frauman, Albert G ^a,b   Cocks, Thomas M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Clinical Pharmacology and Therapeutics Unit   (Australia)

Author keywords

Endothelium dependent relaxation; Human pulmonary artery; Nitric oxide; Protease activated receptor; Thrombin; Trypsin

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLYCYLTYROSYLPROLYLGLYCYLGLUTAMYLVALINE; MESSENGER RNA; PEPTIDE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; SERYLLEUCYLISOLEUCYLGLUTAMYLLYSYLVALINE; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; TRYPSIN; UNCLASSIFIED DRUG;

ADULT; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CLINICAL ARTICLE; ENDOTHELIUM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PULMONARY ARTERY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TACHYPHYLAXIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; HEMOSTATICS; HUMANS; MALE; MIDDLE AGED; PULMONARY ARTERY; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; THROMBIN; TRYPSIN; VASODILATION;

EID: 0034936715     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200107000-00012     Document Type: Article

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