메뉴 건너뛰기




Volumn 7, Issue 1-2, 2005, Pages 79-100

Protease-activated receptors: Regulation of neuronal function

Author keywords

Hyperalgesia; Neurodegeneration; Neurogenic inflammation; Neuropeptides; Pain; Protease activated receptors; Proteases

Indexed keywords

BLOOD CLOTTING FACTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; EXOENZYME C3; G PROTEIN COUPLED RECEPTOR; HIRUDIN; ION CHANNEL; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROTRANSMITTER; PARTIAL AGONIST; PROTEASE NEXIN I; PROTEIN INHIBITOR; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR AGONIST; PROTEINASE ACTIVATED RECEPTOR ANTAGONIST; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

EID: 24644446948     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/nmm:7:1-2:079     Document Type: Review
Times cited : (46)

References (150)
  • 1
    • 0026454599 scopus 로고
    • Thrombin accumulation in brains of patients with Alzheimer's disease
    • Akiyama H., Ikeda K., Kondo H., and McGeer P. L. (1992) Thrombin accumulation in brains of patients with Alzheimer's disease. Neurosci. Lett. 146, 152-154.
    • (1992) Neurosci. Lett. , vol.146 , pp. 152-154
    • Akiyama, H.1    Ikeda, K.2    Kondo, H.3    McGeer, P.L.4
  • 2
    • 2342604388 scopus 로고    scopus 로고
    • Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
    • Amadesi S., Nie J., Vergnolle N., et al. (2004) Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J. Neurosci. 24, 4300-4312.
    • (2004) J. Neurosci. , vol.24 , pp. 4300-4312
    • Amadesi, S.1    Nie, J.2    Vergnolle, N.3
  • 3
    • 0028979999 scopus 로고
    • G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells
    • Aragay A. M., Collins L. R., Post G. R., et al. (1995) G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells. J. Biol. Chem. 270, 20,073-20,077.
    • (1995) J. Biol. Chem. , vol.270
    • Aragay, A.M.1    Collins, L.R.2    Post, G.R.3
  • 4
    • 0036193921 scopus 로고    scopus 로고
    • Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli
    • Asfaha S., Brussee V., Chapman K., Zochodne D. W., and Vergnolle N. (2002) Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br. J. Pharmacol. 135, 1101-1106.
    • (2002) Br. J. Pharmacol. , vol.135 , pp. 1101-1106
    • Asfaha, S.1    Brussee, V.2    Chapman, K.3    Zochodne, D.W.4    Vergnolle, N.5
  • 5
    • 0028237885 scopus 로고
    • G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts
    • Baffy G., Yang L., RajS., Manning D. R., and Williamson J. R. (1994) G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J. Biol. Chem. 269, 8483-8487.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8483-8487
    • Baffy, G.1    Yang, L.2    Raj, S.3    Manning, D.R.4    Williamson, J.R.5
  • 6
    • 10744225624 scopus 로고    scopus 로고
    • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    • Barbara G., Stanghellini V., De Giorgio R., et al. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126, 693-702.
    • (2004) Gastroenterology , vol.126 , pp. 693-702
    • Barbara, G.1    Stanghellini, V.2    De Giorgio, R.3
  • 7
    • 0042196170 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi
    • Barrios V. E., Jarosinski M. A., and Wright C. D. (2003) Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi. Biochem. Pharmacol. 66, 519-525.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 519-525
    • Barrios, V.E.1    Jarosinski, M.A.2    Wright, C.D.3
  • 8
    • 0028085095 scopus 로고
    • Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture
    • Beecher K. L., Andersen T. T., Fenton J. W. N., and Festoff B. W. (1994) Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. J. Neurosci. Res. 37, 108-115.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 108-115
    • Beecher, K.L.1    Andersen, T.T.2    Fenton, J.W.N.3    Festoff, B.W.4
  • 9
    • 0028923464 scopus 로고
    • The thrombin receptor in human platelets is coupled to a GTP binding protein of the G alpha q family
    • Benka M. L., Lee M., Wang G. R., et al. (1995) The thrombin receptor in human platelets is coupled to a GTP binding protein of the G alpha q family. FEBS Lett. 363, 49-52.
    • (1995) FEBS Lett. , vol.363 , pp. 49-52
    • Benka, M.L.1    Lee, M.2    Wang, G.R.3
  • 10
    • 0029786481 scopus 로고    scopus 로고
    • Mechanisms of desensitization and resensitization of proteinase-activated receptor-2
    • Bohm S. K., Khitin L. M., Grady E. F., Aponte G., Payan D. G., and Bunnett N. W. (1996a) Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J. Biol. Chem. 271, 22,003-22,016.
    • (1996) J. Biol. Chem. , vol.271
    • Bohm, S.K.1    Khitin, L.M.2    Grady, E.F.3    Aponte, G.4    Payan, D.G.5    Bunnett, N.W.6
  • 11
    • 0029929603 scopus 로고    scopus 로고
    • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
    • Bohm S. K., Kong W., Bromme D., et al. (1996b) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314, 1009-1016.
    • (1996) Biochem. J. , vol.314 , pp. 1009-1016
    • Bohm, S.K.1    Kong, W.2    Bromme, D.3
  • 12
    • 0036793557 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclooxygenase-dependent pathway
    • Buresi M. C., Buret A. G., Hollenberg M. D., and MacNaughton W. K. (2002) Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclooxygenase-dependent pathway. FASEB J. 16, 1515-1525.
    • (2002) FASEB J. , vol.16 , pp. 1515-1525
    • Buresi, M.C.1    Buret, A.G.2    Hollenberg, M.D.3    MacNaughton, W.K.4
  • 13
    • 0031613754 scopus 로고    scopus 로고
    • Colonic proteinases: Increased activity in patients withulcerative colitis
    • Bustos D., Negri G., De Paula J. A., et al. (1998) Colonic proteinases: increased activity in patients withulcerative colitis. Medicina (B Aires) 58, 262-264.
    • (1998) Medicina (B Aires) , vol.58 , pp. 262-264
    • Bustos, D.1    Negri, G.2    De Paula, J.A.3
  • 14
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E., Huang W., and Coughlin S. R. (2000) Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc. Natl. Acad. Sci. USA 97, 5255-5260.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 16
    • 0025255579 scopus 로고
    • Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1
    • Cavanaugh K. P., Gurwitz D., Cunningham D. D., and Bradshaw R. A. (1990) Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J. Neurochem. 54, 1735-1743.
    • (1990) J. Neurochem. , vol.54 , pp. 1735-1743
    • Cavanaugh, K.P.1    Gurwitz, D.2    Cunningham, D.D.3    Bradshaw, R.A.4
  • 17
    • 0036840275 scopus 로고    scopus 로고
    • Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2
    • Cenac N., Coelho A. M., Nguyen C., et al. (2002) Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am. J. Pathol. 161, 1903-1915.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1903-1915
    • Cenac, N.1    Coelho, A.M.2    Nguyen, C.3
  • 18
    • 0037446646 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-induced colonic inflammation in mice: Possible involvement of afferent neurons, nitric oxide, and paracellular permeability
    • Cenac N., Garcia-Villar R., Ferrier L., et al. (2003) Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J. Immunol. 170, 4296-4300.
    • (2003) J. Immunol. , vol.170 , pp. 4296-4300
    • Cenac, N.1    Garcia-Villar, R.2    Ferrier, L.3
  • 19
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • Cheng T., Liu D., Griffin J. H., et al. (2003) Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med. 9, 338-342.
    • (2003) Nat. Med. , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3
  • 20
    • 0038383698 scopus 로고    scopus 로고
    • Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo
    • Choi S. H., Joe E. H., Kim S. U., and Jin B. K. (2003a) Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. J. Neurosci. 23, 5877-5886.
    • (2003) J. Neurosci. , vol.23 , pp. 5877-5886
    • Choi, S.H.1    Joe, E.H.2    Kim, S.U.3    Jin, B.K.4
  • 21
    • 0142250858 scopus 로고    scopus 로고
    • Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins
    • Choi S. H., Lee da Y., Ryu J. K., Kim J., Joe E. H., and Jin B. K. (2003b) Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins. Neurobiol. Dis. 14, 181-193.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 181-193
    • Choi, S.H.1    Lee Da, Y.2    Ryu, J.K.3    Kim, J.4    Joe, E.H.5    Jin, B.K.6
  • 22
    • 0035927651 scopus 로고    scopus 로고
    • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    • Chuang H. H., Prescott E. D., Kong H., et al. (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411, 957-962.
    • (2001) Nature , vol.411 , pp. 957-962
    • Chuang, H.H.1    Prescott, E.D.2    Kong, H.3
  • 23
    • 0036207250 scopus 로고    scopus 로고
    • Proteinases and proteinase-activated receptor 2: A possible role to promote visceral hyperalgesia in rats
    • Coelho A. M., Vergnolle N., Guiard B., Fioramonti J., and Bueno L. (2002) Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology 122, 1035-1047.
    • (2002) Gastroenterology , vol.122 , pp. 1035-1047
    • Coelho, A.M.1    Vergnolle, N.2    Guiard, B.3    Fioramonti, J.4    Bueno, L.5
  • 24
    • 0034748449 scopus 로고    scopus 로고
    • Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase
    • Compton S. J., Renaux B., Wijesuriya S. J., and Hollenberg M. D. (2001) Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. Br. J. Pharmacol. 134, 705-718.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 705-718
    • Compton, S.J.1    Renaux, B.2    Wijesuriya, S.J.3    Hollenberg, M.D.4
  • 25
    • 0036905071 scopus 로고    scopus 로고
    • Glycosylation of human proteinase-activated receptor-2 (hPAR2): Role in cell surface expression and signalling
    • Compton S. J., Sandhu S., Wijesuriya S. J., and Hollenberg M. D. (2002) Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling. Biochem. J. 368, 495-505.
    • (2002) Biochem. J. , vol.368 , pp. 495-505
    • Compton, S.J.1    Sandhu, S.2    Wijesuriya, S.J.3    Hollenberg, M.D.4
  • 26
    • 1842414265 scopus 로고    scopus 로고
    • Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
    • Corvera C. U., Dery O., and McConalogue K. (1997) Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J. Clin. Invest. 100, 1383-1393.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1383-1393
    • Corvera, C.U.1    Dery, O.2    McConalogue, K.3
  • 27
    • 0345004978 scopus 로고    scopus 로고
    • Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2
    • Corvera C. U., Dery O., McConalogue K., et al. (1999). Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J. Physiol. 517, 741-756.
    • (1999) J. Physiol. , vol.517 , pp. 741-756
    • Corvera, C.U.1    Dery, O.2    McConalogue, K.3
  • 28
    • 1842791710 scopus 로고    scopus 로고
    • Trypsin IV, a novel agonist of protease-activated receptors 2 and 4
    • Cottrell G. S., Amadesi S., Grady E. F., and Bunnett N. W. (2004) Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. J. Biol. Chem. 279, 13,532-13,539.
    • (2004) J. Biol. Chem. , vol.279
    • Cottrell, G.S.1    Amadesi, S.2    Grady, E.F.3    Bunnett, N.W.4
  • 29
    • 0034921205 scopus 로고    scopus 로고
    • Protease-activated receptors in vascular biology
    • Coughlin S. R. (2001) Protease-activated receptors in vascular biology. Thromb. Haemost. 86, 298-307.
    • (2001) Thromb. Haemost. , vol.86 , pp. 298-307
    • Coughlin, S.R.1
  • 31
    • 15444349901 scopus 로고    scopus 로고
    • Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues
    • D'Andrea M. R., Derian C. K., Leturcq D., et al. (1998) Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J. Histochem. Cytochem. 46, 157-164.
    • (1998) J. Histochem. Cytochem. , vol.46 , pp. 157-164
    • D'Andrea, M.R.1    Derian, C.K.2    Leturcq, D.3
  • 32
    • 2442468123 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
    • Dai Y., Moriyama T., Higashi T., et al. (2004). Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J. Neurosci. 24, 4293-4299.
    • (2004) J. Neurosci. , vol.24 , pp. 4293-4299
    • Dai, Y.1    Moriyama, T.2    Higashi, T.3
  • 33
    • 0034888212 scopus 로고    scopus 로고
    • Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism
    • de Garavilla L., Vergnolle N., Young S. H., et al. (2001) Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br. J. Pharmacol. 133, 975-987.
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 975-987
    • De Garavilla, L.1    Vergnolle, N.2    Young, S.H.3
  • 34
    • 0034689003 scopus 로고    scopus 로고
    • beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
    • DeFea K. A., Zalevsky J., Thoma M. S., Dery O., Mullins R. D., and Bunnett N. W. (2000) beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J. Cell Biol. 148, 1267-1281.
    • (2000) J. Cell Biol. , vol.148 , pp. 1267-1281
    • DeFea, K.A.1    Zalevsky, J.2    Thoma, M.S.3    Dery, O.4    Mullins, R.D.5    Bunnett, N.W.6
  • 35
    • 0031744875 scopus 로고    scopus 로고
    • Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
    • Dery O., Corvera C. U., Steinhoff M., and Bunnett N. W. (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 274, C1429-C1452.
    • (1998) Am. J. Physiol. , vol.274
    • Dery, O.1    Corvera, C.U.2    Steinhoff, M.3    Bunnett, N.W.4
  • 36
    • 0039843091 scopus 로고    scopus 로고
    • Trafficking of proteinase-activated receptor-2 and β-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor
    • Dery O., Thoma M. S., Wong H., Grady E. F., and Bunnett N. W. (1999) Trafficking of proteinase-activated receptor-2 and β-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor. J. Biol. Chem. 274, 18,524-18,535.
    • (1999) J. Biol. Chem. , vol.274
    • Dery, O.1    Thoma, M.S.2    Wong, H.3    Grady, E.F.4    Bunnett, N.W.5
  • 37
    • 0025857712 scopus 로고
    • Prothrombin mRNA is expressed by cells of the nervous system
    • Dihanich M., Kaser M., Reinhard E., Cunningham D., and Monard D. (1991) Prothrombin mRNA is expressed by cells of the nervous system. Neuron 6, 575-581.
    • (1991) Neuron , vol.6 , pp. 575-581
    • Dihanich, M.1    Kaser, M.2    Reinhard, E.3    Cunningham, D.4    Monard, D.5
  • 38
    • 4644225447 scopus 로고    scopus 로고
    • Stimulation of PAR-2 excites and sensitizes rat cutaneous C-nociceptors to heat
    • Ding-Pfennigdorff D., Averbeck B., and Michaelis M. (2004) Stimulation of PAR-2 excites and sensitizes rat cutaneous C-nociceptors to heat. Neuroreport 15, 2071-2075.
    • (2004) Neuroreport , vol.15 , pp. 2071-2075
    • Ding-Pfennigdorff, D.1    Averbeck, B.2    Michaelis, M.3
  • 39
    • 0032557654 scopus 로고    scopus 로고
    • Signaling pathways involved in thrombin-induced cell protection
    • Donovan F. M. and Cunningham D. D. (1998) Signaling pathways involved in thrombin-induced cell protection. J. Biol. Chem. 273, 12,746-12,752.
    • (1998) J. Biol. Chem. , vol.273
    • Donovan, F.M.1    Cunningham, D.D.2
  • 40
    • 16944366731 scopus 로고    scopus 로고
    • Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities
    • Donovan F. M., Pike C. J., Cotman C. W., and Cunningham D. D. (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J. Neurosci. 17, 5316-5326.
    • (1997) J. Neurosci. , vol.17 , pp. 5316-5326
    • Donovan, F.M.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 41
    • 0030007646 scopus 로고    scopus 로고
    • Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system
    • Festoff B. W., Smirnova I. V., Ma J., and Citron B. A. (1996) Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system. Semin. Thromb. Hemost. 22, 267-271.
    • (1996) Semin. Thromb. Hemost. , vol.22 , pp. 267-271
    • Festoff, B.W.1    Smirnova, I.V.2    Ma, J.3    Citron, B.A.4
  • 42
    • 0036828264 scopus 로고    scopus 로고
    • Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine
    • Gao C., Liu S., Hu H. Z., et al. (2002) Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine. Gastroenterology 123, 1554-1564.
    • (2002) Gastroenterology , vol.123 , pp. 1554-1564
    • Gao, C.1    Liu, S.2    Hu, H.Z.3
  • 43
    • 0032578046 scopus 로고    scopus 로고
    • Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons
    • Gill J. S., Pitts K., Rusnak F. M., Owen W. G., and Windebank A. J. (1998) Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons. Brain Res. 797, 321-327.
    • (1998) Brain Res. , vol.797 , pp. 321-327
    • Gill, J.S.1    Pitts, K.2    Rusnak, F.M.3    Owen, W.G.4    Windebank, A.J.5
  • 44
    • 0034660448 scopus 로고    scopus 로고
    • Potentiation of NMDA receptor function by the serine protease thrombin
    • Gingrich M. B., Junge C. E., Lyuboslavsky P., and Traynelis S. F. (2000) Potentiation of NMDA receptor function by the serine protease thrombin. J. Neurosci. 20, 4582-4595.
    • (2000) J. Neurosci. , vol.20 , pp. 4582-4595
    • Gingrich, M.B.1    Junge, C.E.2    Lyuboslavsky, P.3    Traynelis, S.F.4
  • 45
    • 0033798625 scopus 로고    scopus 로고
    • Intestinal type 2 proteinase-activated receptors: Expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport
    • Green B. T., Bunnett N. W., Kulkarni-Narla A., Steinhoff M., and Brown D. R. (2000) Intestinal type 2 proteinase-activated receptors: expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport. J. Pharmacol. Exp. Ther. 295, 410-416.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 410-416
    • Green, B.T.1    Bunnett, N.W.2    Kulkarni-Narla, A.3    Steinhoff, M.4    Brown, D.R.5
  • 46
    • 0011811083 scopus 로고
    • Thrombin modulates and reverses neuroblastoma neurite outgrowth
    • Gurwitz D. and Cunningham D. D. (1988) Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc. Natl. Acad. Sci. USA 85, 3440-3444.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3440-3444
    • Gurwitz, D.1    Cunningham, D.D.2
  • 47
    • 4444301767 scopus 로고    scopus 로고
    • Trypsin mediates nociception via the proteinase-activated receptor 2: A potentially novel role in pancreatic pain
    • Hoogerwerf W. A., Shenoy M., Winston J. H., Xiao S. Y., He Z., and Pasricha P. J. (2004) Trypsin mediates nociception via the proteinase-activated receptor 2: A potentially novel role in pancreatic pain. Gastroenterology 127, 883-891.
    • (2004) Gastroenterology , vol.127 , pp. 883-891
    • Hoogerwerf, W.A.1    Shenoy, M.2    Winston, J.H.3    Xiao, S.Y.4    He, Z.5    Pasricha, P.J.6
  • 48
    • 0035890075 scopus 로고    scopus 로고
    • The proteinase-activated receptor 2 is involved in nociception
    • Hoogerwerf W. A., Zou L., Shenoy M., et al. (2001) The proteinase-activated receptor 2 is involved in nociception. J. Neurosci. 21, 9036-9042.
    • (2001) J. Neurosci. , vol.21 , pp. 9036-9042
    • Hoogerwerf, W.A.1    Zou, L.2    Shenoy, M.3
  • 50
    • 0036758636 scopus 로고    scopus 로고
    • Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: Potential mechanism for thermal hyperalgesia
    • Hu H. J., Bhave G., and Gereau R. W. T. (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. J. Neurosci. 22, 7444-7452.
    • (2002) J. Neurosci. , vol.22 , pp. 7444-7452
    • Hu, H.J.1    Bhave, G.2    Gereau, R.W.T.3
  • 51
    • 0026504693 scopus 로고
    • Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor
    • Hung D. T., Vu T. H., Nelken N. A., and Coughlin S. R. (1992a) Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J. Cell Biol. 116, 827-832.
    • (1992) J. Cell Biol. , vol.116 , pp. 827-832
    • Hung, D.T.1    Vu, T.H.2    Nelken, N.A.3    Coughlin, S.R.4
  • 52
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung D. T., Wong Y. H., Vu T. K., and Coughlin S. R. (1992b) The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J. Biol. Chem. 267, 20,831-20,834.
    • (1992) J. Biol. Chem. , vol.267
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.K.3    Coughlin, S.R.4
  • 53
    • 33750866137 scopus 로고    scopus 로고
    • Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs
    • Iaccarino G., Rockman H. A., Shotwell K. F., Tomhave E. D., and Koch W. J. (1998) Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs. Am. J. Physiol. 275, H1298-H1306.
    • (1998) Am. J. Physiol. , vol.275
    • Iaccarino, G.1    Rockman, H.A.2    Shotwell, K.F.3    Tomhave, E.D.4    Koch, W.J.5
  • 54
    • 0030979972 scopus 로고    scopus 로고
    • Protease-activated receptor 3 is a second thrombin receptor in humans
    • Ishihara H., Connolly A. J., Zeng D., et al. (1997) Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386, 502-506.
    • (1997) Nature , vol.386 , pp. 502-506
    • Ishihara, H.1    Connolly, A.J.2    Zeng, D.3
  • 55
    • 0028009801 scopus 로고
    • Inhibition of thrombin receptor signaling by a G protein coupled receptor kinase. Functional specificity among G protein coupled receptor kinases
    • Ishii K., Chen J., Ishii M., et al. (1994) Inhibition of thrombin receptor signaling by a G protein coupled receptor kinase. Functional specificity among G protein coupled receptor kinases. J. Biol. Chem. 269, 1125-1130.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1125-1130
    • Ishii, K.1    Chen, J.2    Ishii, M.3
  • 56
    • 18144412332 scopus 로고    scopus 로고
    • c-Cbl Mediates Ubiquitination, Degradation, and Down-regulation of Human Protease-activated Receptor 2
    • Jacob C., Cottrell G. S., Gehringer D., Schmidlin F., Grady E. F., and Bunnett N. W. (2005) c-Cbl Mediates Ubiquitination, Degradation, and Down-regulation of Human Protease-activated Receptor 2. J. Biol. Chem. 280, 16,076-16,087.
    • (2005) J. Biol. Chem. , vol.280
    • Jacob, C.1    Cottrell, G.S.2    Gehringer, D.3    Schmidlin, F.4    Grady, E.F.5    Bunnett, N.W.6
  • 57
    • 0028021308 scopus 로고
    • Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
    • Jalink K., van Corven E. J., Hengeveld T., Morii N., Narumiya S., and Moolenaar W. H. (1994) Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol. 126, 801-810.
    • (1994) J. Cell Biol. , vol.126 , pp. 801-810
    • Jalink, K.1    Van Corven, E.J.2    Hengeveld, T.3    Morii, N.4    Narumiya, S.5    Moolenaar, W.H.6
  • 58
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius D. and Basbaum A. I. (2001) Molecular mechanisms of nociception. Nature 413, 203-210.
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 59
    • 2942608168 scopus 로고    scopus 로고
    • Protease-activated receptor-1 in human brain: Localization and functional expression in astrocytes
    • Junge C. E., Lee C. J., Hubbard K. B., et al. (2004) Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp. Neurol. 188, 94-103.
    • (2004) Exp. Neurol. , vol.188 , pp. 94-103
    • Junge, C.E.1    Lee, C.J.2    Hubbard, K.B.3
  • 60
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn M. L., Zheng Y. W., Huang W., et al. (1998) A dual thrombin receptor system for platelet activation. Nature 394, 690-694.
    • (1998) Nature , vol.394 , pp. 690-694
    • Kahn, M.L.1    Zheng, Y.W.2    Huang, W.3
  • 61
    • 0033968332 scopus 로고    scopus 로고
    • The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells
    • Kaufmann R., Patt S., Zieger M., et al. (2000) The two-receptor system PAR-1/PAR-4 mediates alpha-thrombin-induced [Ca(2+)](i) mobilization in human astrocytoma cells. J. Cancer Res. Clin. Oncol. 126, 91-94.
    • (2000) J. Cancer Res. Clin. Oncol. , vol.126 , pp. 91-94
    • Kaufmann, R.1    Patt, S.2    Zieger, M.3
  • 62
    • 3242783977 scopus 로고    scopus 로고
    • Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats
    • Kawabata A., Itoh H., Kawao N., et al. (2004) Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats. Neuroreport 15, 1617-1621.
    • (2004) Neuroreport , vol.15 , pp. 1617-1621
    • Kawabata, A.1    Itoh, H.2    Kawao, N.3
  • 63
    • 0037171067 scopus 로고    scopus 로고
    • Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats
    • Kawabata A., Kawao N., Kuroda R., Itoh H., and Nishikawa H. (2002a) Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats. Neuroreport 13, 511-514.
    • (2002) Neuroreport , vol.13 , pp. 511-514
    • Kawabata, A.1    Kawao, N.2    Kuroda, R.3    Itoh, H.4    Nishikawa, H.5
  • 64
    • 0035953151 scopus 로고    scopus 로고
    • Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
    • Kawabata A., Kawao N., Kuroda R., Tanaka A., Itoh H., and Nishikawa H. (2001a) Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. Neuroreport 12, 715-719.
    • (2001) Neuroreport , vol.12 , pp. 715-719
    • Kawabata, A.1    Kawao, N.2    Kuroda, R.3    Tanaka, A.4    Itoh, H.5    Nishikawa, H.6
  • 65
    • 0035996861 scopus 로고    scopus 로고
    • The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats
    • Kawabata A., Kawao N., Kuroda R., Tanaka A., and Shimada C. (2002b) The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Peptides 23, 1181-1183.
    • (2002) Peptides , vol.23 , pp. 1181-1183
    • Kawabata, A.1    Kawao, N.2    Kuroda, R.3    Tanaka, A.4    Shimada, C.5
  • 66
    • 0036122072 scopus 로고    scopus 로고
    • Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2
    • Kawabata A., Kinoshita M., Kuroda R., and Kakehi K. (2002c) Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2. Clin. Exp. Pharmacol. Physiol. 29, 360-361.
    • (2002) Clin. Exp. Pharmacol. Physiol. , vol.29 , pp. 360-361
    • Kawabata, A.1    Kinoshita, M.2    Kuroda, R.3    Kakehi, K.4
  • 67
    • 0034983372 scopus 로고    scopus 로고
    • The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
    • Kawabata A., Kinoshita M., Nishikawa H., et al. (2001b) The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J. Clin. Invest. 107, 1443-1450.
    • (2001) J. Clin. Invest. , vol.107 , pp. 1443-1450
    • Kawabata, A.1    Kinoshita, M.2    Nishikawa, H.3
  • 68
    • 0037019916 scopus 로고    scopus 로고
    • Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion
    • Kawabata A., Kuroda R., Nishida M., et al. (2002d) Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci. 71, 2435-2446.
    • (2002) Life Sci. , vol.71 , pp. 2435-2446
    • Kawabata, A.1    Kuroda, R.2    Nishida, M.3
  • 69
    • 1842732512 scopus 로고    scopus 로고
    • Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2
    • Kawao N., Ikeda H., Kitano T., et al. (2004) Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2. J. Pharmacol. Sci. 94, 277-285.
    • (2004) J. Pharmacol. Sci. , vol.94 , pp. 277-285
    • Kawao, N.1    Ikeda, H.2    Kitano, T.3
  • 71
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
    • Klages B., Brandt U., Simon M. I., Schultz G., and Offermanns S. (1999) Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J. Cell Biol. 144, 745-754.
    • (1999) J. Cell Biol. , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 72
    • 0030741026 scopus 로고    scopus 로고
    • Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2
    • Kong W., McConalogue K., Khitin L. M., et al. (1997) Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc. Natl. Acad. Sci. USA 94, 8884-8889.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8884-8889
    • Kong, W.1    McConalogue, K.2    Khitin, L.M.3
  • 73
    • 0035941170 scopus 로고    scopus 로고
    • Agonists of proteinase-activated receptor 2 excite guinea pigileal myenteric neurons
    • Linden D. R., Manning B. P., Bunnett N. W., and Mawe G. M. (2001) Agonists of proteinase-activated receptor 2 excite guinea pigileal myenteric neurons. Eur. J. Pharmacol. 431, 311-314.
    • (2001) Eur. J. Pharmacol. , vol.431 , pp. 311-314
    • Linden, D.R.1    Manning, B.P.2    Bunnett, N.W.3    Mawe, G.M.4
  • 74
    • 0032508557 scopus 로고    scopus 로고
    • Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
    • Lourbakos A., Chinni C., Thompson P., et al. (1998) Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett. 435, 45-48.
    • (1998) FEBS Lett. , vol.435 , pp. 45-48
    • Lourbakos, A.1    Chinni, C.2    Thompson, P.3
  • 75
    • 0034923238 scopus 로고    scopus 로고
    • Arginine-specific protease from porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion
    • Lourbakos A., Potempa J., Travis J., et al. (2001) Arginine-specific protease from porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect. Immun. 69, 5121-5130.
    • (2001) Infect. Immun. , vol.69 , pp. 5121-5130
    • Lourbakos, A.1    Potempa, J.2    Travis, J.3
  • 77
    • 0036228009 scopus 로고    scopus 로고
    • Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut
    • Miller H. R. and Pemberton A. D. (2002) Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunology 105, 375-390.
    • (2002) Immunology , vol.105 , pp. 375-390
    • Miller, H.R.1    Pemberton, A.D.2
  • 78
    • 0032054444 scopus 로고    scopus 로고
    • Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV
    • Minn A., Schubert M., Neiss W. F., and Muller-Hill B. (1998) Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV. Glia 22, 338-347.
    • (1998) Glia , vol.22 , pp. 338-347
    • Minn, A.1    Schubert, M.2    Neiss, W.F.3    Muller-Hill, B.4
  • 79
    • 0030783689 scopus 로고    scopus 로고
    • Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases
    • Mirza H., Schmidt V. A., Derian C. K., Jesty J., and Bahou W. F. (1997) Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases. Blood 90, 3914-3922.
    • (1997) Blood , vol.90 , pp. 3914-3922
    • Mirza, H.1    Schmidt, V.A.2    Derian, C.K.3    Jesty, J.4    Bahou, W.F.5
  • 80
    • 0346118925 scopus 로고    scopus 로고
    • Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    • Mohapatra D. P. and Nau C. (2003) Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J. Biol. Chem. 278, 50,080-50,090.
    • (2003) J. Biol. Chem. , vol.278
    • Mohapatra, D.P.1    Nau, C.2
  • 81
    • 15444346942 scopus 로고    scopus 로고
    • Interactions of mast cell tryptase with thrombin receptors and PAR-2
    • Molino M., Barnathan E. S., Numerof R., et al. (1997) Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 272, 4043-4049.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4043-4049
    • Molino, M.1    Barnathan, E.S.2    Numerof, R.3
  • 82
    • 0033822556 scopus 로고    scopus 로고
    • Thrombin-induced activation of cultured rodent microglia
    • Moller T., Hanisch U. K., and Ransom B. R. (2000) Thrombin-induced activation of cultured rodent microglia. J. Neurochem. 75, 1539-1547.
    • (2000) J. Neurochem. , vol.75 , pp. 1539-1547
    • Moller, T.1    Hanisch, U.K.2    Ransom, B.R.3
  • 83
    • 0038002035 scopus 로고    scopus 로고
    • Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle
    • Mule F., Baffi M. C., Capparelli A., and Pizzuti R. (2003) Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle. Br. J. Pharmacol. 139, 598-604.
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 598-604
    • Mule, F.1    Baffi, M.C.2    Capparelli, A.3    Pizzuti, R.4
  • 84
    • 1642574390 scopus 로고    scopus 로고
    • Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon
    • Mule F., Pizzuti R., Capparelli A., and Vergnolle N. (2004) Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon. Gut 53, 229-234.
    • (2004) Gut , vol.53 , pp. 229-234
    • Mule, F.1    Pizzuti, R.2    Capparelli, A.3    Vergnolle, N.4
  • 86
    • 0031844717 scopus 로고    scopus 로고
    • Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion
    • Niclou S. P., Suidan H. S., Pavlik A., Vejsada R., and Monard D. (1998) Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion. Eur. J. Neurosci. 10, 1590-1607.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1590-1607
    • Niclou, S.P.1    Suidan, H.S.2    Pavlik, A.3    Vejsada, R.4    Monard, D.5
  • 87
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
    • O'Brien P. J., Prevost N., Molino M., et al. (2000) Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J. Biol. Chem. 275, 13,502-13,509.
    • (2000) J. Biol. Chem. , vol.275
    • O'Brien, P.J.1    Prevost, N.2    Molino, M.3
  • 88
    • 0035952734 scopus 로고    scopus 로고
    • In vivo functions of heterotrimeric G proteins: Studies in Gα-deficient mice
    • Offermanns S. (2001) In vivo functions of heterotrimeric G proteins: studies in Gα-deficient mice. Oncogene 20, 1635-1642.
    • (2001) Oncogene , vol.20 , pp. 1635-1642
    • Offermanns, S.1
  • 89
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns S., Laugwitz K. L., Spicher K., and Schultz G. (1994) G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc. Natl. Acad. Sci. USA 91, 504-508.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.L.2    Spicher, K.3    Schultz, G.4
  • 90
    • 0031015426 scopus 로고    scopus 로고
    • Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency
    • Offermanns S., Mancino V., Revel J. P., and Simon M. I. (1997a) Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency. Science 275, 533-536.
    • (1997) Science , vol.275 , pp. 533-536
    • Offermanns, S.1    Mancino, V.2    Revel, J.P.3    Simon, M.I.4
  • 91
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G alpha(q)-deficient mice
    • Offermanns S., Toombs C. F., Hu Y. H., and Simon M. I. (1997b) Defective platelet activation in G alpha(q)-deficient mice. Nature 389, 183-186.
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 92
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: Contribution to physiology and disease
    • Ossovskaya V. S. and Bunnett N. W. (2004) Protease-activated receptors: contribution to physiology and disease. Physiol. Rev. 84, 579-621.
    • (2004) Physiol. Rev. , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 93
    • 0037059795 scopus 로고    scopus 로고
    • Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation
    • Paing M. M., Stutts A. B., Kohout T. A., Lefkowitz R. J., and Trejo J. (2002) β-Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J. Biol. Chem. 277, 1292-1300.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1292-1300
    • Paing, M.M.1    Stutts, A.B.2    Kohout, T.A.3    Lefkowitz, R.J.4    Trejo, J.5
  • 94
    • 0034175489 scopus 로고    scopus 로고
    • Thrombomodulin as a new marker of lesion-induced astrogliosis: Involvement of thrombin through the G protein-coupled protease-activated receptor-1
    • Pindon A., Berry M., and Hantai D. (2000) Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G protein-coupled protease-activated receptor-1. J. Neurosci. 20, 2543-2550.
    • (2000) J. Neurosci. , vol.20 , pp. 2543-2550
    • Pindon, A.1    Berry, M.2    Hantai, D.3
  • 95
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N., Zwick E., Daub H., et al. (1999) EGF receptor transactivation by G protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402, 884-888.
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 97
    • 0036616952 scopus 로고    scopus 로고
    • PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia
    • Rathee P. K., Distler C., Obreja O., et al. (2002) PKA/AKAP/VR-1 module: a common link of Gs-mediated signaling to thermal hyperalgesia. J. Neurosci. 22, 4740-4745.
    • (2002) J. Neurosci. , vol.22 , pp. 4740-4745
    • Rathee, P.K.1    Distler, C.2    Obreja, O.3
  • 98
    • 0037335786 scopus 로고    scopus 로고
    • Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons
    • Reed D. E., Barajas-Lopez C., Cottrell G., et al. (2003) Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J. Physiol. 547, 531-542.
    • (2003) J. Physiol. , vol.547 , pp. 531-542
    • Reed, D.E.1    Barajas-Lopez, C.2    Cottrell, G.3
  • 99
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M., Petrovan R. J., Donner A., Mueller B. M., and Ruf W. (2002) Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296, 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 100
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
    • Riewald M. and Ruf W. (2001) Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc. Natl. Acad. Sci. USA 98, 7742-7747.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 101
    • 0037405191 scopus 로고    scopus 로고
    • Rab5a and rablla mediate agonist-induced trafficking of protease-activated receptor 2
    • Roosterman D., Schmidlin F., and Bunnett N. W. (2003) Rab5a and rablla mediate agonist-induced trafficking of protease-activated receptor 2. Am. J. Physiol. Cell Physiol. 284, C1319-C1329.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Roosterman, D.1    Schmidlin, F.2    Bunnett, N.W.3
  • 102
    • 0034730753 scopus 로고    scopus 로고
    • Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B
    • Ryu J., Pyo H., Jou I., and Joe E. (2000) Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. J. Biol. Chem. 275, 29,955-29,959.
    • (2000) J. Biol. Chem. , vol.275
    • Ryu, J.1    Pyo, H.2    Jou, I.3    Joe, E.4
  • 104
    • 0032831916 scopus 로고    scopus 로고
    • Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy
    • Santos J., Bayarri C., Saperas E., et al. (1999) Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. Gut 45, 553-558.
    • (1999) Gut , vol.45 , pp. 553-558
    • Santos, J.1    Bayarri, C.2    Saperas, E.3
  • 105
    • 0029021942 scopus 로고
    • Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes
    • Santulli R. J., Derian C. K., Darrow A. L., et al. (1995) Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc. Natl. Acad. Sci. USA 92, 9151-9155.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9151-9155
    • Santulli, R.J.1    Derian, C.K.2    Darrow, A.L.3
  • 106
    • 0034022706 scopus 로고    scopus 로고
    • Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2
    • Sawada K., Nishibori M., Nakaya N., Wang Z., and Saeki K. (2000) Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2. J. Neurochem. 74, 1731-1738.
    • (2000) J. Neurochem. , vol.74 , pp. 1731-1738
    • Sawada, K.1    Nishibori, M.2    Nakaya, N.3    Wang, Z.4    Saeki, K.5
  • 107
    • 0028819780 scopus 로고
    • Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum
    • Scudamore C. L., Thornton E. M., McMillan L., Newlands G. F., and Miller H. R. (1995) Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J. Exp. Med. 182, 1871-1881.
    • (1995) J. Exp. Med. , vol.182 , pp. 1871-1881
    • Scudamore, C.L.1    Thornton, E.M.2    McMillan, L.3    Newlands, G.F.4    Miller, H.R.5
  • 108
    • 0032849082 scopus 로고    scopus 로고
    • Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin
    • Shu X. and Mendell L. M. (1999) Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett. 274, 159-162.
    • (1999) Neurosci. Lett. , vol.274 , pp. 159-162
    • Shu, X.1    Mendell, L.M.2
  • 109
    • 0034958701 scopus 로고    scopus 로고
    • Neuroprotective signal transduction in model motor neurons exposed to thrombin: G protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis
    • Smirnova I. V., Citron B. A., Arnold P. M., and Festoff B. W. (2001) Neuroprotective signal transduction in model motor neurons exposed to thrombin: G protein modulation effects on neurite outgrowth, Ca(2+) mobilization, and apoptosis. J. Neurobiol. 48, 87-100.
    • (2001) J. Neurobiol. , vol.48 , pp. 87-100
    • Smirnova, I.V.1    Citron, B.A.2    Arnold, P.M.3    Festoff, B.W.4
  • 110
    • 0031813736 scopus 로고    scopus 로고
    • Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons
    • Smirnova I. V., Zhang S. X., Citron B. A., Arnold P. M., and Festoff B. W. (1998) Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons. J. Neurobiol. 36, 64-80.
    • (1998) J. Neurobiol. , vol.36 , pp. 64-80
    • Smirnova, I.V.1    Zhang, S.X.2    Citron, B.A.3    Arnold, P.M.4    Festoff, B.W.5
  • 112
    • 0029134929 scopus 로고
    • Opposing actions of thrombin and protease nexin-1 on amyloid β-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons
    • Smith-Swintosky V. L., Zimmer S., Fenton J. W., II, and Mattson M. P. (1995a) Opposing actions of thrombin and protease nexin-1 on amyloid β-peptide toxicity and on accumulation of peroxides and calcium in hippocampal neurons. J. Neurochem. 65, 1415-1418.
    • (1995) J. Neurochem. , vol.65 , pp. 1415-1418
    • Smith-Swintosky, V.L.1    Zimmer, S.2    Fenton II, J.W.3    Mattson, M.P.4
  • 114
    • 0035827339 scopus 로고    scopus 로고
    • A genomic perspective on human proteases
    • Southan C. (2001) A genomic perspective on human proteases. FEBS Lett. 498, 214-218.
    • (2001) FEBS Lett. , vol.498 , pp. 214-218
    • Southan, C.1
  • 115
    • 0023332815 scopus 로고
    • Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves
    • Stead R. H., Tomioka M., Quinonez G., Simon G. T., Felten S. Y., and Bienenstock J. (1987) Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc. Natl. Acad. Sci. USA 84, 2975-2979.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 2975-2979
    • Stead, R.H.1    Tomioka, M.2    Quinonez, G.3    Simon, G.T.4    Felten, S.Y.5    Bienenstock, J.6
  • 116
    • 0033971235 scopus 로고    scopus 로고
    • Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
    • Steinhoff M., Vergnolle N., Young S. H., et al. (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 6, 151-158.
    • (2000) Nat. Med. , vol.6 , pp. 151-158
    • Steinhoff, M.1    Vergnolle, N.2    Young, S.H.3
  • 117
    • 0034053127 scopus 로고    scopus 로고
    • The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations
    • Striggow F., Riek M., Breder J., Henrich-Noack P., Reymann K. G., and Reiser G. (2000) The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc. Natl. Acad. Sci. USA 97, 2264-2269.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2264-2269
    • Striggow, F.1    Riek, M.2    Breder, J.3    Henrich-Noack, P.4    Reymann, K.G.5    Reiser, G.6
  • 118
    • 0028059276 scopus 로고
    • Granzyme a released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes
    • Suidan H. S., Bouvier J., Schaerer E., Stone S. R., Monard D., and Tschopp J. (1994) Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. Proc. Natl. Acad. Sci. USA 91, 8112-8116.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8112-8116
    • Suidan, H.S.1    Bouvier, J.2    Schaerer, E.3    Stone, S.R.4    Monard, D.5    Tschopp, J.6
  • 119
    • 0035879347 scopus 로고    scopus 로고
    • Interaction of mite allergens der p3 and der p9 with protease-activated receptor-2 expressed by lung epithelial cells
    • Sun G., Stacey M. A., Schmidt M., Mori L., and Mattoli S. (2001) Interaction of mite allergens der p3 and der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167, 1014-1021.
    • (2001) J. Immunol. , vol.167 , pp. 1014-1021
    • Sun, G.1    Stacey, M.A.2    Schmidt, M.3    Mori, L.4    Mattoli, S.5
  • 120
    • 0042904881 scopus 로고    scopus 로고
    • Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation
    • Suo Z., Wu M., Citron B. A., Gao C., and Festoff B. W. (2003) Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation. J. Biol. Chem. 33, 31,177-31,183.
    • (2003) J. Biol. Chem. , vol.33
    • Suo, Z.1    Wu, M.2    Citron, B.A.3    Gao, C.4    Festoff, B.W.5
  • 121
    • 0034691187 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells
    • Tiruppathi C., Yan W., Sandoval R., et al. (2000) G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Proc. Natl. Acad. Sci. USA 97, 7440-7445.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7440-7445
    • Tiruppathi, C.1    Yan, W.2    Sandoval, R.3
  • 122
    • 0035810934 scopus 로고    scopus 로고
    • Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
    • Tominaga M., Wada M., and Masu M. (2001) Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc. Natl. Acad. Sci. USA 98, 6951-6956.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6951-6956
    • Tominaga, M.1    Wada, M.2    Masu, M.3
  • 123
    • 0034613356 scopus 로고    scopus 로고
    • Protease-activated receptor-1 down-regulation: A mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits
    • Trejo J., Altschuler Y., Fu H. W., Mostov K. E., and Coughlin S. R. (2000) Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J. Biol. Chem. 275, 31,255-31,265.
    • (2000) J. Biol. Chem. , vol.275
    • Trejo, J.1    Altschuler, Y.2    Fu, H.W.3    Mostov, K.E.4    Coughlin, S.R.5
  • 124
    • 85047696992 scopus 로고    scopus 로고
    • Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
    • Trevisani M., Smart D., Gunthorpe M. J., et al. (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat. Neurosci. 5, 546-551.
    • (2002) Nat. Neurosci. , vol.5 , pp. 546-551
    • Trevisani, M.1    Smart, D.2    Gunthorpe, M.J.3
  • 125
    • 17344365478 scopus 로고    scopus 로고
    • Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation
    • Turgeon V. L., Lloyd E. D., Wang S., Festoff B. W., and Houenou L. J. (1998) Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation. J. Neurosci. 18, 6882-6891.
    • (1998) J. Neurosci. , vol.18 , pp. 6882-6891
    • Turgeon, V.L.1    Lloyd, E.D.2    Wang, S.3    Festoff, B.W.4    Houenou, L.J.5
  • 126
    • 0031031775 scopus 로고    scopus 로고
    • i oscillations in rat glioma cells
    • i oscillations in rat glioma cells. Pflugers Arch. 433, 312-320.
    • (1997) Pflugers Arch. , vol.433 , pp. 312-320
    • Ubl, J.J.1    Reiser, G.2
  • 127
    • 0031539290 scopus 로고    scopus 로고
    • Characteristics of thrombin-induced calcium signals in rat astrocytes
    • Ubl J. J. and Reiser G. (1997b) Characteristics of thrombin-induced calcium signals in rat astrocytes. Glia 21, 361-369.
    • (1997) Glia , vol.21 , pp. 361-369
    • Ubl, J.J.1    Reiser, G.2
  • 129
    • 0037797300 scopus 로고    scopus 로고
    • Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2
    • Uehara A., Muramoto K., Takada H., and Sugawara S. (2003) Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. J. Immunol. 170, 5690-5696.
    • (2003) J. Immunol. , vol.170 , pp. 5690-5696
    • Uehara, A.1    Muramoto, K.2    Takada, H.3    Sugawara, S.4
  • 130
    • 0029012029 scopus 로고
    • Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults
    • Vaughan P. J., Pike C. J., Cotman C. W., and Cunningham D. D. (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J. Neurosci. 15, 5389-5401.
    • (1995) J. Neurosci. , vol.15 , pp. 5389-5401
    • Vaughan, P.J.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 131
    • 0028566867 scopus 로고
    • Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease
    • Vaughan P. J., Su J., Cotman C. W., and Cunningham D. D. (1994) Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res. 668, 160-170.
    • (1994) Brain Res. , vol.668 , pp. 160-170
    • Vaughan, P.J.1    Su, J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 132
    • 0035425705 scopus 로고    scopus 로고
    • Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    • Vellani V., Mapplebeck S., Moriondo A., Davis J. B., and McNaughton P. A. (2001 ) Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J. Physiol. 534, 813-825.
    • (2001) J. Physiol. , vol.534 , pp. 813-825
    • Vellani, V.1    Mapplebeck, S.2    Moriondo, A.3    Davis, J.B.4    McNaughton, P.A.5
  • 133
    • 2442526798 scopus 로고    scopus 로고
    • Modulation of visceral pain and inflammation by protease-activated receptors
    • Vergnolle N. (2004) Modulation of visceral pain and inflammation by protease-activated receptors. Br. J. Pharmacol. 141, 1264-1274.
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 1264-1274
    • Vergnolle, N.1
  • 134
    • 0034927070 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
    • Vergnolle N., Bunnett N. W., Sharkey K. A., et al. (2001a) Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat. Med. 7, 821-826.
    • (2001) Nat. Med. , vol.7 , pp. 821-826
    • Vergnolle, N.1    Bunnett, N.W.2    Sharkey, K.A.3
  • 136
    • 0032560576 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2 (PAR2)-activating peptides: Identification of a receptor distinct from PAR2 that regulates intestinal transport
    • Vergnolle N., Macnaughton W. K., Al-Ani B., Saifeddine M., Wallace J. L., and Hollenberg M. D. (1998) Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc. Natl. Acad. Sci. USA 95, 7766-7771.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7766-7771
    • Vergnolle, N.1    Macnaughton, W.K.2    Al-Ani, B.3    Saifeddine, M.4    Wallace, J.L.5    Hollenberg, M.D.6
  • 138
    • 0031717365 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho proteins in endothelial barrier function
    • Vouret-Craviari V., Boquet P., Pouyssegur J., and Van Obberghen-Schilling E. (1998) Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol. Biol. Cell 9, 2639-2653.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2639-2653
    • Vouret-Craviari, V.1    Boquet, P.2    Pouyssegur, J.3    Van Obberghen-Schilling, E.4
  • 139
  • 140
    • 0036006726 scopus 로고    scopus 로고
    • Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling
    • Wang H., Ubl J. J., and Reiser G. (2002a) Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. Glia 37, 53-63.
    • (2002) Glia , vol.37 , pp. 53-63
    • Wang, H.1    Ubl, J.J.2    Reiser, G.3
  • 141
    • 0036838021 scopus 로고    scopus 로고
    • Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    • Wang H., Ubl J. J., Stricker R., and Reiser G. (2002b) Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am. J. Physiol. Cell Physiol. 283, C1351-C1364.
    • (2002) Am. J. Physiol. Cell Physiol. , vol.283
    • Wang, H.1    Ubl, J.J.2    Stricker, R.3    Reiser, G.4
  • 142
    • 0035985175 scopus 로고    scopus 로고
    • Down-regulation of protease-activated receptor-1 is regulated by sorting nexin1
    • Wang Y., Zhou Y., Szabo K., Haft C. R., and Trejo J. (2002c) Down-regulation of protease-activated receptor-1 is regulated by sorting nexin1. Mol. Biol. Cell 13, 1965-1976.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1965-1976
    • Wang, Y.1    Zhou, Y.2    Szabo, K.3    Haft, C.R.4    Trejo, J.5
  • 143
    • 0028914068 scopus 로고
    • Cellular localization of thrombin receptor mRNA in rat brain: Expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA
    • Weinstein J. R., Gold S. J., Cunningham D. D., and Gall C. M. (1995) Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J. Neurosci. 15, 2906-2919.
    • (1995) J. Neurosci. , vol.15 , pp. 2906-2919
    • Weinstein, J.R.1    Gold, S.J.2    Cunningham, D.D.3    Gall, C.M.4
  • 144
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann C., Gibson S., Jarpe M. B., and Johnson G. L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143-180.
    • (1999) Physiol. Rev. , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 145
    • 0027743598 scopus 로고
    • Cloning of the cDNA encoding human brain trypsinogen and characterization of its product
    • Wiegand U., Corbach S., Minn A., Kang J., and Muller-Hill B. (1993) Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene 136, 167-175.
    • (1993) Gene , vol.136 , pp. 167-175
    • Wiegand, U.1    Corbach, S.2    Minn, A.3    Kang, J.4    Muller-Hill, B.5
  • 147
    • 0032499696 scopus 로고    scopus 로고
    • Cloning and characterization of human protease-activated receptor 4
    • Xu W. F., Andersen H., Whitmore T. E., et al. (1998) Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. USA 95, 6642-6646.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6642-6646
    • Xu, W.F.1    Andersen, H.2    Whitmore, T.E.3
  • 148
    • 0035132174 scopus 로고    scopus 로고
    • Mucosal pathophysiology and inflammatory changes in the late phase of the intestinal allergic reaction in the rat
    • Yang P. C., Berin M. C., Yu L., and Perdue M. H. (2001) Mucosal pathophysiology and inflammatory changes in the late phase of the intestinal allergic reaction in the rat. Am. J. Pathol. 158, 681-690.
    • (2001) Am. J. Pathol. , vol.158 , pp. 681-690
    • Yang, P.C.1    Berin, M.C.2    Yu, L.3    Perdue, M.H.4
  • 149
    • 0141478668 scopus 로고    scopus 로고
    • PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors
    • Zhao A. and Shea-Donohue T. (2003) PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G696-G703.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.285
    • Zhao, A.1    Shea-Donohue, T.2
  • 150
    • 0033614984 scopus 로고    scopus 로고
    • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    • Zygmunt P. M., Petersson J., Andersson D. A., et al. (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457.
    • (1999) Nature , vol.400 , pp. 452-457
    • Zygmunt, P.M.1    Petersson, J.2    Andersson, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.