Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2

Clinical and Experimental Pharmacology and Physiology

Volumn 29, Issue 4, 2002, Pages 360-361

  Kawabata, Atsufumi ^a   Kinoshita, Mitsuhiro ^a   Kuroda, Ryotaro ^a   Kakehi, Kazuaki ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

Protease activated receptor 2; Vanilloid receptor 1

Indexed keywords

CAPSAZEPINE; PROTEINASE ACTIVATED RECEPTOR 2; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MOLECULAR INTERACTION; MUCUS SECRETION; NONHUMAN; RAT; STOMACH MUCUS; STOMACH SECRETION;

ANIMALS; CAPSAICIN; GASTRIC MUCOSA; MALE; NEURAL INHIBITION; NEURONS, AFFERENT; RATS; RATS, WISTAR; RECEPTOR, PAR-2; RECEPTORS, DRUG; RECEPTORS, THROMBIN; TRPV CATION CHANNELS;

EID: 0036122072     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2002.03641.x     Document Type: Article

References (6)

1. Molecular cloning of a potential proteinase activated receptor
2. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
3. Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
4. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
5. Induction of vanilloid receptor channel activity by protein kinase C
6. Antinociception induced by civamide, an orally active capsaicin analogue