Glycosylation and the activation of proteinase-activated receptor 2 (PAR2) by human mast cell tryptase

British Journal of Pharmacology

Volumn 134, Issue 4, 2001, Pages 705-718

  Compton, Steven J ^a   Renaux, Bernard ^a   Wijesuriya, Suranga J ^a   Hollenberg, Morley D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Glycosylation; PAR2; Tryptase

Indexed keywords

HEPARIN; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 ANTAGONIST; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; ENZYME GLYCOSYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAST CELL; PRIORITY JOURNAL;

EID: 0034748449     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704303     Document Type: Article

References (45)

1. Proteinase-activated receptor 2 (PAR(2)): Development of a ligand- binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)derived peptide ligands
2. Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2
3. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
4. Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells
5. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL- 8 production and intercellular adhesion molecule-1 expression
6. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
7. Mast cell proteases as new targets for therapeutic intervention in asthma
8. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells
9. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists
10. Mast cell tryptase regulates rat colonic myocytes through proteinase- activated receptor 2
11. Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2
12. Membrane sialic acid and the mechanism of insulin action in adipose tissue cells. Effects of digestion with neuraminidase
13. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
14. The role of cell surface sialic acid in insulin receptor function and insulin action
15. Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: Selective enhancement of eosinophil recruitment by histamine
16. Human mast cell tryptase: A stimulus of microvascular leakage and mast cell activation
17. Human mast cell tryptase betaI: Evaluation of its substrate specificity and demonstration of its importance in bacterial infections of the lung
18. Protease-activated receptor 3 is a second thrombin receptor in humans
19. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
20. A dual thrombin receptor system for platelet activation
21. Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: Activation of PAR2 by PAR1 targeted ligands
22. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2
23. Asparagine-linked oligosaccharides are localized to single extracytosolic segments in multi-span membrane glycoproteins
24. Cloning and characterization of a second complementary DNA for human tryptase
25. Mitogenic responses mediated through the proteinase-activated receptor- 2 are induced by expressed forms of mast cell alpha or beta-tryptases
26. Interactions of mast cell tryptase with thrombin receptors and PAR-2
27. PAR3 is a cofactor for PAR4 activation by thrombin
28. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
29. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
30. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore
31. Mast cell tryptase is a mitogen for cultured fibroblasts
32. Contractile actions of proteinase-activated receptor-derived polypeptides in guineapig gastric and lung parenchymal strips: Evidence for distinct receptor systems
33. Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
34. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer
35. Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells
36. Tryptase from human pulmonary mast cells. Purification and characterization
37. Analysis of the role of N-glycosylation in cell-surface expression and binding properties of angiotensin II type-2 receptor of rat pheochromocytoma cells
38. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
39. Tunicamycin inhibition of polyisoprenyl N-acetylglucosaminyl pyrophosphate formation in calf-liver microsomes
40. Tunicamycin inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells
41. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
42. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw
43. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
44. Production and characterization of monoclonal antibodies specific for human mast cell tryptase
45. Cloning and characterization of human protease-activated receptor 4