Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

Nature Medicine

Volumn 9, Issue 3, 2003, Pages 338-342

  Cheng, Tong ^a   Liu, Dong ^a   Griffin, John H ^b   Fernández, José A ^b   Castellino, Francis ^c   Rosen, Elliot D ^c   Fukudome, Kenji ^d   Zlokovic, Berislav V ^a,e  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d SAGA UNIVERSITY   (Japan)

^e Socratech Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL PROTEIN C RECEPTOR; INHIBITOR OF APOPTOSIS PROTEIN; NEUROPROTECTIVE AGENT; PROTEIN BCL 2; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN CELL; BRAIN ISCHEMIA; CELL PROTECTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; LASER DOPPLER FLOWMETRY; MICROVASCULATURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE; TUMOR SUPPRESSOR GENE; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD COAGULATION FACTORS; BRAIN; BRAIN ISCHEMIA; CASPASE 3; CASPASES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; IN SITU NICK-END LABELING; MICE; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PROTEIN C; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE; RECEPTORS, THROMBIN; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; RICKETTSIA SP. PAR;

EID: 0037352279     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm826     Document Type: Article

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