c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

Journal of Biological Chemistry

Volumn 280, Issue 16, 2005, Pages 16076-16087

  Jacob, Claire ^a   Cottrell, Graeme S ^a   Gehringer, Daphne ^a   Schmidlin, Fabien ^a   Grady, Eileen F ^a   Bunnett, Nigel W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; DEGRADATION; DISEASES; HEALTH CARE; IMMUNOLOGY; SIGNALING;

ENDOSOMES; IMMUNOBLOTTING; PHOSPHORYLATION; PLASMA MEMBRANE;

ENZYME KINETICS;

CBL PROTEIN; LYSINE; PROTEINASE ACTIVATED RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; DOWN REGULATION; ENDOSOME; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LYSOSOME; MUTATION; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SYNTHESIS; UBIQUITINATION; WILD TYPE;

DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LYSOSOMES; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, PAR-2; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

RICKETTSIA SP. PAR;

EID: 18144412332     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500109200     Document Type: Article

References (42)

1. Hicke, L., and Dunn, R. (2003) Annu. Rev. Cell Dev. Biol. 19, 141-172
2. Pickart, C. M. (2004) Cell 116, 181-190
3. Dikic, I., and Giordano, S. (2003) Curr. Opin. Cell Biol. 15, 128-135
4. Haj, F. G., Verveer, P. J., Squire, A., Neel, B. G., and Bastiaens, P. I. (2002) Science 295, 1708-1711
5. Benovic, J. L., DeBlasi, A., Stone, W. C., Caron, M. G., and Lefkowitz, R. J. (1989) Science 246, 235-240
6. Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G., and Lefkowitz, R. J. (1990) Science 248, 1547-1550
7. Levkowitz, G., Waterman, H., Zamir, E., Kam, Z., Oved, S., Langdon, W. Y., Beguinot, L., Geiger, B., and Yarden, Y. (1998) Genes Dev. 12, 3663-3674
8. de Melker, A. A., van der Horst, G., Calafat, J., Jansen, H., and Borst, J. (2001) J. Cell Sci. 114, 2167-2178
9. Longva, K. E., Blystad, F. D., Stang, E., Larsen, A. M., Johannessen, L. E., and Madshus, I. H. (2002) J. Cell Biol. 156, 843-854
10. Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P. P., and Dikic, I. (2003) Nat. Cell Biol. 5, 461-466
11. Miyake, S., Mullane-Robinson, K. P., Lill, N. L., Douillard, P., and Band, H. (1999) J. Biol. Chem. 274, 16619-16628
12. Lee, P. S., Wang, Y., Dominguez, M. G., Yeung, Y. G., Murphy, M. A., Bowtell, D. D., and Stanley, E. R. (1999) EMBO J. 18, 3616-3628
13. Petrelli, A., Gilestro, G. F., Lanzardo, S., Comoglio, P. M., Migone, N., and Giordano, S. (2002) Nature 416, 187-190
14. Peschard, P., Fournier, T. M., Lamorte, L., Naujokas, M. A., Band, H., Langdon, W. Y., and Park, M. (2001) Mol. Cell 8, 995-1004
15. Hicke, L., and Riezman, H. (1996) Cell 84, 277-287
16. Roth, A. F., and Davis, N. G. (1996) J. Cell Biol. 134, 661-674
17. Shenoy, S. K., McDonald, P. H., Kohout, T. A., and Lefkowitz, R. J. (2001) Science 294, 1307-1313
18. Marchese, A., and Benovic, J. L. (2001) J. Biol. Chem. 276, 45509-45512
19. Tanowitz, M., and Von Zastrow, M. (2002) J. Biol. Chem. 277, 50219-50222
20. Dupre, D. J., Chen, Z., Le Gouill, C., Theriault, C., Parent, J. L., Rola-Pleszczynski, M., and Stankova, J. (2003) J. Biol. Chem. 278, 48228-48235
21. Marchese, A., Raiborg, C., Santini, F., Keen, J. H., Stenmark, H., and Benovic, J. L. (2003) Dev. Cell 5, 709-722
22. Ossovskaya, V. S., and Bunnett, N. W. (2004) Physiol. Rev. 84, 579-621
23. Bohm, S. K., Khitin, L. M., Grady, E. F., Aponte, G., Payan, D. G., and Bunnett, N. W. (1996) J. Biol. Chem. 271, 22003-22016
24. Dery, O., Thoma, M. S., Wong, H., Grady, E. F., and Bunnett, N. W. (1999) J. Biol. Chem. 274, 18524-18535
25. DeFea, K. A., Zalevsky, J., Thoma, M. S., Dery, O., Mullins, R. D., and Bunnett, N. W. (2000) J. Cell Biol. 148, 1267-1281
26. Steinhoff, M., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., Mitchell, S. E., Williams, L. M., Geppetti, P., Mayer, E. A., and Bunnett, N. W. (2000) Nat. Med. 6, 151-158
27. Vergnolle, N., Bunnett, N. W., Sharkey, K. A., Brussee, V., Compton, S. J., Grady, E. F., Cirino, G., Gerard, N., Basbaum, A. I., Andrade-Gordon, P., Hollenberg, M. D., and Wallace, J. L. (2001) Nat. Med. 7, 821-826
28. Roosterman, D., Schmidlin, F., and Bunnett, N. W. (2003) Am. J. Physiol. 284, C1319-C1329
29. Scaife, R. M., and Langdon, W. Y. (2000) J. Cell Sci. 113, 215-226
30. Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., Kahn, M., Nelken, N. A., Coughlin, S. R., Payan, D. G., and Bunnett, N. W. (1996) Biochem. J. 314, 1009-1016
31. Compton, S. J., Sandhu, S., Wijesuriya, S. J., and Hollenberg, M. D. (2002) Biochem. J. 368, 495-505
32. Darmoul, D., Gratio, V., Devaud, H., and Laburthe, M. (2004) J. Biol. Chem. 279, 20927-20934
33. Galisteo, M. L., Dikic, I., Batzer, A. G., Langdon, W. Y., and Schlessinger, J. (1995) J. Biol. Chem. 270, 20242-20245
34. Kassenbrock, C. K., Hunter, S., Garl, P., Johnson, G. L., and Anderson, S. M. (2002) J. Biol. Chem. 277, 24967-24975
35. Wang, P., Gao, H., Ni, Y., Wang, B., Wu, Y., Ji, L., Qin, L., Ma, L., and Pei, G. (2003) J. Biol. Chem. 278, 6363-6370
36. Shenoy, S. K., and Lefkowitz, R. J. (2003) J. Biol. Chem. 278, 14498-14506
37. Luttrell, L. M., and Lefkowitz, R. J. (2002) J. Cell Sci. 115, 455-465
38. Brass, L. F., Pizarro, S., Ahuja, M., Belmonte, E., Blanchard, N., Stadel, J. M., and Hoxie, J. A. (1994) J. Biol. Chem. 269, 2943-2952
39. Grady, E. F., Garland, A. M., Gamp, P. D., Lovett, M., Payan, D. G., and Bunnett, N. W. (1995) Mol. Biol. Cell 6, 509-524
40. Trejo, J., Hammes, S. R., and Coughlin, S. R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13698-13702
41. Wang, Y., Zhou, Y., Szabo, K., Haft, C. R., and Trejo, J. (2002) Mol. Biol. Cell 13, 1965-1976
42. Whistler, J. L., Enquist, J., Marley, A., Fong, J., Gladher, F., Tsuruda, P., Murray, S. R., and Von Zastrow, M. (2002) Science 297, 615-620