Protease-activated receptors in vascular biology

Thrombosis and Haemostasis

Volumn 86, Issue 1, 2001, Pages 298-307

  Coughlin, S R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelial cells; Platelets; Receptors; Signaling; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR; G PROTEIN COUPLED RECEPTOR; PROTEINASE; RECEPTOR; THROMBIN;

BIOLOGY; BLOOD CLOTTING; BLOOD VESSEL; CELL ACTIVATION; CELL ACTIVITY; CONFERENCE PAPER; ENDOTHELIUM CELL; HEMOSTASIS; HUMAN; INFLAMMATION; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOSIS; TISSUE INJURY;

EID: 0034921205     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616227     Document Type: Conference Paper

References (102)

1. Overview of hemostasis
2. Inflammation, sepsis, and coagulation
3. Inducible endothelial functions in inflammation and coagulation
4. Tissue factor expression by monocytes: Regulation and pathophysiological roles
5. Blood-borne tissue factor: Another view of thrombosis
6. Sol Sherry lecture in thrombosis: How thrombin "talks" to cells: Molecular mechanisms and roles in vivo
7. Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets
8. Signaling through G proteins in platelets: To the integrins and beyond
9. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
10. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
11. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
12. Integrin affinity modulation
13. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane
14. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140
15. Defects in hemostasis in P-selectin-deficient mice
16. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
17. Regulation of vascular endothelial barrier function
18. Thrombin function as an inflammatory mediator through activation of its receptor
19. How the protease thrombin talks to cells
20. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
21. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization
22. Thrombin receptor activation: Confirmation of the intramolecular tethered liganding hypothesis and discvery of an alternative intermolecular liganding mode
23. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
24. Defective platelet activation in G alpha(q)-deficient mice
25. Activation of G12/G13 results in shape change and rho/rho kinase-mediated myosin light chain phosphorylation in mouse platelets
26. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
27. Mechanisms of beta-adrenergic receptor desensitization and resensitization
28. Internalization and recycling of activated thrombin receptors
29. Inhibition of thrombin receptor signaling by a G protein-coupled receptor kinase. Functional specificity among G protein-coupled receptor kinases
30. Intracellular targeting and trafficking of thrombin receptors: A novel mechanism for resensitization of a G protein-coupled receptor
31. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting
32. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling
33. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling
34. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: Evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand
35. Development of potent thrombin receptor antagonist peptides
36. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor
37. Ticlopidine and clopidogrel
38. Identification and biological activity of the active metabolite of clopidogrel
39. Protease-activated receptor 3 is a second thrombin receptor in humans
40. Cloning and characterization of human protease-activated receptor 4
41. A dual thrombin receptor system for platelet activation
42. Molecular cloning of a potential novel proteinase activated receptor
43. Interactions of mast cell tryptase with thrombin receptors and PAR-2
44. Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active
45. Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa
46. PAR3 is a cofactor for PAR4 activation by thrombin
47. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
48. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation
49. Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminants
50. Cathepsin G is a strong platelet agonist released by neutrophils
51. Cathepsin G activates protease-activated receptor-4 in human platelets
52. Protease-activated receptors 1 and 4 are shutoff with distinct tempos after activation by thrombin
53. Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
54. A dual thrombin receptor system for platelet activation
55. Structure-function analysis of protease-activated receptor-4 tethered tigand peptides: Determinants of specificity and utility in assays of receptor function
56. Platelet glycocalicin: Interaction with thrombin and role as thrombin receptor on the platelet surface
57. The glycoprotein Ib-IX-V complex in platelet adhesion and signaling
58. Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome
59. Variant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complex
60. Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin
61. The platelet glycoprotein Ib-IX complex
62. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha
63. Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of PAR-1 on intact platelets
64. Generation and rescue of a murine model of platelet dysfunction: The Bernard-Soulier syndrome
65. Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides
66. Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation and regulation by protein kinases
67. Role of the thrombin receptor in development and evidence for a second receptor
68. Platelet-activating factor (PAF): Signalling and adhesion in cell-cell interactions
69. Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
70. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
71. Delayed onset of inflammation in protease-activated receptor-2-deficient mice
72. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
73. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
74. Role of tissue factor in embryonic blood vessel development
75. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
76. Prothrombin deficiency results in embryonic and neonatal lethality in mice
77. Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice
78. On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors
79. Thrombin signalling and protease-activated receptors
80. Domains specifying thrombin-receptor interaction
81. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity
82. Crystallographic structures of thrombin complexed with thrombin receptor peptides: Existence of expected and novel binding modes
83. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate both phosphoinositide hydrolysis and inhibit adenylyl cyclase
84. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
85. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor. G protein coupling
86. p115, RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
87. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha3
88. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimetric G proteins to Rho
89. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: Role of Rho porteins in endothelial barrier function
90. 13 deficiency
91. Activation of the B1 isozyme of phospholipase C by a subunits of the Gq class of G proteins
92. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
93. G protein beta gamma subunits
94. Signalling through phosphoinositide 3-kinases: The lipids centre stage
95. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
96. Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation
97. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin
98. Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells
99. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
100. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
101. Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
102. Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency