Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2

American Journal of Physiology - Cell Physiology

Volumn 284, Issue 5 53-5, 2003, Pages

  Roosterman, Dirk ^a   Schmidlin, Fabien ^a   Bunnett, Nigel W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Desensitization; GTPases; Internalization; Recycling; Resensitization

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEINASE ACTIVATED RECEPTOR 2; RAB PROTEIN; TRYPSIN; TRYPTASE;

ARTICLE; CALCIUM MOBILIZATION; CELL MEMBRANE; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; DESENSITIZATION; ENDOCYTOSIS; ENDOSOME; GOLGI COMPLEX; HUMAN; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; SENSITIZATION; SIGNAL TRANSDUCTION;

EID: 0037405191     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00540.2002     Document Type: Article

References (31)

1. Bohm SK, Grady EF, and Bunnett NW. Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 322: 1-18, 1997.
2. Bohm SK, Khitin LM, Grady EF, Aponte G, Payan DG, and Bunnett NW. Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 271: 22003-22016, 1996.
3. Brass LF, Pizarro S, Ahuja M, Belmonte E, Blanchard N, Stadel JM, and Hoxie JA. Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J Biol Chem 269: 2943-2952, 1994.
4. Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, and Zerial M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70: 715-728, 1992.
5. Chen W, Feng Y, Chen D, and Wandinger-Ness A. Rab11 is required for trans-Golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor. Mol Biol Cell 9: 3241-3257, 1998.
6. Claing A, Laporte SA, Caron MG, and Lefkowitz RJ. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and β-arrestin proteins. Prog Neurobiol 66: 61-79, 2002.
7. DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, and Bunnett NW. β-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148: 1267-1281, 2000.
8. Dery O, Thoma MS, Wong H, Grady EF, and Bunnett NW. Trafficking of proteinase-activated receptor-2 and β-arrestin-1 tagged with green fluorescent protein. β-Arrestin-dependent endocytosis of a proteinase receptor. J Biol Chem 274: 18524-18535, 1999.
9. Garland AM, Grady EF, Lovett M, Vigna SR, Frucht MM, Krause JE, and Bunnett NW. Mechanisms of desensitization and resensitization of G protein-coupled neurokininl and neurokinin2 receptors. Mol Pharmacol 49: 438-446, 1996.
10. Gorvel JP, Chavrier P, Zerial M, and Gruenberg J. rab5 controls early endosome fusion in vitro. Cell 64: 915-925, 1991.
11. Grady EF, Garland AM, Gamp PD, Lovett M, Payan DG, and Bunnett NW. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell 6: 509-524, 1995.
12. Iwata K, Ito K, Fukuzaki A, Inaki K, and Haga T. Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors. Eur J Biochem 263: 596-602, 1999.
13. Kessler A, Tomas E, Immler D, Meyer HE, Zorzano A, and Eckel J. Rabll is associated with GLUT4-containing vesicles and redistributes in response to insulin. Diabetologia 43: 1518-1527, 2000.
14. Li JG, Benovic JL, and Liu-Chen LY. Mechanisms of agonist-induced down-regulation of the human K-opioid receptor: internalization is required for down-regulation. Mol Pharmacol 58: 795-801, 2000.
15. McConalogue K, Dery O, Lovett M, Wong H, Walsh JH, Grady EF, and Bunnett NW. Substance P-induced trafficking of β-arrestins. The role of β-arrestins in endocytosis of the neurokinin-1 receptor. J Biol Chem 274: 16257-16268, 1999.
16. McLauchlan H, Newell J, Morrice N, Osborne A, West M, and Smythe E. A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits. Curr Biol 8: 34-45, 1998.
17. Miaczynska M and Zerial M. Mosaic organization of the endocytic pathway. Exp Cell Res 272: 8-14, 2002.
18. Ren M, Xu G, Zeng J, De Lemos-Chiarandini C, Adesnik M, and Sabatini DD. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci USA 95: 6187-6192, 1998.
19. Roberts RL, Barbieri MA, Pryse KM, Chua M, Morisaki JH, and Stahl PD. Endosome fusion in living cells overexpressing GFP-rab5. J Cell Sci 112: 3667-3675, 1999.
20. Schmidlin F, Dery O, DeFea KO, Slice L, Patierno S, Sternini C, Grady EF, and Bunnett NW. Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor. JBiol Chem 276: 25427-25437, 2001.
21. 2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases. J Biol Chem 275: 27221-27228, 2000.
22. Shapiro MJ and Coughlin SR. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem 273: 29009-29014, 1998.
23. Somsel Rodman J and Wandinger-Ness A. Rab GTPases coordinate endocytosis. J Cell Sci 113: 183-192, 2000.
24. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, and Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6: 151-158, 2000.
25. Trejo J, Hammes SR, and Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci USA 95: 13698-13702, 1998.
26. Trischler M, Stoorvogel W, and Ullrich O. Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway. J Cell Sci 112: 4773-4783, 1999.
27. Ullrich O, Reinsch S, Urbe S, Zerial M, and Parton RG. Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 135: 913-924, 1996.
28. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, and Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 7: 821-826, 2001.
29. Vergnolle N, Wallace JL, Bunnett NW, and Hollenberg MD. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 22: 146-152, 2001.
30. Volpicelli LA, Lah JJ, and Levey AI. Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies. J Biol Chem 276: 47590-4798, 2001.
31. Zeigerer A, Lampson MA, Karylowski O, Sabatini DD, Adesnik M, Ren M, and McGraw TE. GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps. Mol Biol Cell 13: 2421-2435, 2002.