A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules

Journal of Molecular Medicine

Volumn 83, Issue 5, 2005, Pages 343-352

  Tanaka, Motomasa ^a,b   Machida, Yoko ^b   Nukina, Nobuyuki ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Amyloid; Huntington disease; Polyglutamine; Trehalose

Indexed keywords

ANTIOXIDANT; ARYLBUTYRIC ACID DERIVATIVE; ASPARTYLGLUTAMYLVALYLASPARTYL FLUORMETHYL KETONE; ATAXIN 1; ATAXIN 3; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BN 82451; BUTYRIC ACID; CYCLODEXTRIN; CYSTAMINE; DICHLOROACETIC ACID; DISACCHARIDE; HISTONE DEACETYLASE INHIBITOR; HUNTINGTIN; LITHIUM CHLORIDE; MINOCYCLINE; MITHRAMYCIN; MUTANT PROTEIN; MYOGLOBIN; PEPTIDE; POLYGLUTAMINE; PROTEIN INHIBITOR; RAPAMYCIN DERIVATIVE; REMACEMIDE; TAUROURSODEOXYCHOLIC ACID; THIOCTIC ACID; TREHALOSE; UNCLASSIFIED DRUG; VORINOSTAT; AMYLOID;

AUTOSOMAL DOMINANT DISORDER; HUMAN; HUNTINGTON CHOREA; IN VITRO STUDY; MOTOR DYSFUNCTION; NONHUMAN; NUCLEOTIDE REPEAT; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; SPINOCEREBELLAR ATAXIA 1; SPINOCEREBELLAR ATAXIA 3; SPINOCEREBELLAR DEGENERATION; TRANSGENIC MOUSE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; FORECASTING; METABOLISM; PATHOLOGY;

AMYLOID; ANIMALS; DISEASE MODELS, ANIMAL; FORECASTING; HUMANS; HUNTINGTON DISEASE; MODELS, BIOLOGICAL; PEPTIDES; TREHALOSE;

EID: 23044445857     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-004-0632-2     Document Type: Review

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