메뉴 건너뛰기




Volumn 85, Issue 6, 2003, Pages 1359-1367

Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice

Author keywords

Chemotherapy; Creatine; Huntington's disease

Indexed keywords

CREATINE; HUNTINGTIN; UBIDECARENONE;

EID: 0038115294     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01706.x     Document Type: Article
Times cited : (154)

References (44)
  • 3
    • 0035968856 scopus 로고    scopus 로고
    • Lipoic acid improves survival in transgenic mouse models of Huntington's disease
    • Andreassen O. A., Ferrante R. J., Dedeoglu A. and Beal M. F. (2001c) Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Neuroreport 29, 3371-3373.
    • (2001) Neuroreport , vol.29 , pp. 3371-3373
    • Andreassen, O.A.1    Ferrante, R.J.2    Dedeoglu, A.3    Beal, M.F.4
  • 5
    • 0034237719 scopus 로고    scopus 로고
    • Energetics in the pathogenesis of neurodegenerative diseases
    • Beal M. F. (2000) Energetics in the pathogenesis of neurodegenerative diseases. TINS 23, 298-304.
    • (2000) TINS , vol.23 , pp. 298-304
    • Beal, M.F.1
  • 6
    • 0027204154 scopus 로고
    • Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
    • Beal M. F., Brouillet E., Jenkins B., Henshaw R., Rosen B. and Hyman B. T. (1993) Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J. Neurochem. 61, 1147-1150.
    • (1993) J. Neurochem. , vol.61 , pp. 1147-1150
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.3    Henshaw, R.4    Rosen, B.5    Hyman, B.T.6
  • 7
    • 0033840819 scopus 로고    scopus 로고
    • Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in sport?
    • Benzi G. (2000) Is there a rationale for the use of creatine either as nutritional supplementation or drug administration in humans participating in sport? Pharmacol. Res. 41, 255-264.
    • (2000) Pharmacol. Res. , vol.41 , pp. 255-264
    • Benzi, G.1
  • 8
    • 0035668684 scopus 로고    scopus 로고
    • Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease
    • Bogdanov M. B., Andreassen O. A., Dedeoglu A., Ferrante R. J. and Beal M. F. (2001) Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease. J. Neurochem. 79, 1246-1249.
    • (2001) J. Neurochem. , vol.79 , pp. 1246-1249
    • Bogdanov, M.B.1    Andreassen, O.A.2    Dedeoglu, A.3    Ferrante, R.J.4    Beal, M.F.5
  • 9
    • 0029118136 scopus 로고
    • Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
    • Brouillet E., Hantraye P., Ferrante R. J., Dolan R., Leroy-Willig A., Kowall N. W. and Beal M. F. (1995) Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc. Natl Acad. Sci. USA 92, 7105-7109.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7105-7109
    • Brouillet, E.1    Hantraye, P.2    Ferrante, R.J.3    Dolan, R.4    Leroy-Willig, A.5    Kowall, N.W.6    Beal, M.F.7
  • 10
    • 0032903802 scopus 로고    scopus 로고
    • Oxidative stress in Huntington's disease
    • Browne S. E., Ferrante R. J. and Beal M. F. (1999) Oxidative stress in Huntington's disease. Brain Pathol. 9, 147-163.
    • (1999) Brain Pathol. , vol.9 , pp. 147-163
    • Browne, S.E.1    Ferrante, R.J.2    Beal, M.F.3
  • 11
    • 0029007479 scopus 로고
    • Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices
    • Carter A. J., Muller R. E., Pschom U. and Stransky W. (1995) Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices. J. Neurochem. 6, 2691-2699.
    • (1995) J. Neurochem. , vol.6 , pp. 2691-2699
    • Carter, A.J.1    Muller, R.E.2    Pschom, U.3    Stransky, W.4
  • 15
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia M., Sapp E., Chase K. O., Davies S. W., Bates G. P., Vonsattel J. P. and Aronin N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3    Davies, S.W.4    Bates, G.P.5    Vonsattel, J.P.6    Aronin, N.7
  • 20
    • 0027724925 scopus 로고
    • Functional aspects of creatine kinase in brain
    • Hemmer W. and Wallimann T. (1993) Functional aspects of creatine kinase in brain. Dev. Neurosci. 15, 249-260.
    • (1993) Dev. Neurosci. , vol.15 , pp. 249-260
    • Hemmer, W.1    Wallimann, T.2
  • 21
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group. (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 22
    • 0034006477 scopus 로고    scopus 로고
    • Non-linear decrease over time in N-acetylaspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice
    • Jenkins B. G., Klivenyi P., Kustermann E., Andreassen O. A., Ferrante R. J., Rosen B. R. and Beal M. F. (2000) Non-linear decrease over time in N-acetylaspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J. Neurochem. 74, 2108-2119.
    • (2000) J. Neurochem. , vol.74 , pp. 2108-2119
    • Jenkins, B.G.1    Klivenyi, P.2    Kustermann, E.3    Andreassen, O.A.4    Ferrante, R.J.5    Rosen, B.R.6    Beal, M.F.7
  • 23
    • 0009534249 scopus 로고    scopus 로고
    • Placebo-controlled trial of creatine in Huntington's disease
    • Kieburtz K. (2001) Placebo-controlled trial of creatine in Huntington's disease. Neurol. Abstract. 56, A386.
    • (2001) Neurol. Abstract , vol.56
    • Kieburtz, K.1
  • 25
    • 0031044805 scopus 로고    scopus 로고
    • Energy metabolism defects in Huntington's disease and possible therapy with coenzyme Q10
    • Koroshetz W. J., Jenkins B. G., Rosen B. R. and Beal M. F. (1997) Energy metabolism defects in Huntington's disease and possible therapy with coenzyme Q10. Ann. Neurol. 41, 160-165.
    • (1997) Ann. Neurol. , vol.41 , pp. 160-165
    • Koroshetz, W.J.1    Jenkins, B.G.2    Rosen, B.R.3    Beal, M.F.4
  • 28
    • 0026357457 scopus 로고
    • 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin
    • Ludolph A. C., He F., Spencer P. S., Hammerstad J. and Sabri M. (1991) 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. Can. J. Neurol. Sci. 4, 492-498.
    • (1991) Can. J. Neurol. Sci. , vol.4 , pp. 492-498
    • Ludolph, A.C.1    He, F.2    Spencer, P.S.3    Hammerstad, J.4    Sabri, M.5
  • 32
    • 0001477910 scopus 로고    scopus 로고
    • Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain
    • O'Gorman E., Beutner G., Wallimann T and Brdiczka D. (1996) Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim. Biophys. Acta 1276, 161-170.
    • (1996) Biochim. Biophys. Acta , vol.1276 , pp. 161-170
    • O'Gorman, E.1    Beutner, G.2    Wallimann, T.3    Brdiczka, D.4
  • 39
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tamopolsky M. A. and Beal M. F. (2001) Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann. Neurol. 5, 561-574.
    • (2001) Ann. Neurol. , vol.5 , pp. 561-574
    • Tamopolsky, M.A.1    Beal, M.F.2
  • 40
    • 0037849404 scopus 로고    scopus 로고
    • Oral creatine supplementation in patients with Huntington's disease
    • Verbessem P. (2002) Oral creatine supplementation in patients with Huntington's disease. Neurol. Abstract. 58, A334.
    • (2002) Neurol. Abstract , vol.58
    • Verbessem, P.1
  • 42
    • 0026585611 scopus 로고
    • Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis
    • Wallimann T., Wyss M., Brdiczka D., Nicolay K. and Eppenberger H. M. (1992) Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem. J. 281, 21-40.
    • (1992) Biochem. J. , vol.281 , pp. 21-40
    • Wallimann, T.1    Wyss, M.2    Brdiczka, D.3    Nicolay, K.4    Eppenberger, H.M.5
  • 43
    • 0037129967 scopus 로고    scopus 로고
    • Health implications of creatine: Can oral creatine supplementation protect against neurological and atherosclerotic disease?
    • Wyss M. and Schulze A. (2002) Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? Neuroscience 2, 243-260.
    • (2002) Neuroscience , vol.2 , pp. 243-260
    • Wyss, M.1    Schulze, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.