Molecular and functional comparison of 1,25-dihydroxyvitamin D3 and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4

Journal of Cellular Biochemistry

Volumn 94, Issue 5, 2005, Pages 917-943

  Jurutka, Peter W ^a,b   Thompson, Paul D ^a,c   Whitfield, G Kerr ^a   Eichhorst, Kristina R ^a   Hall, Neal ^a   Dominguez, Carlos Encinas ^a   Hsieh, Jui Cheng ^a   Haussler, Carol A ^a   Haussler, Mark R ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b ARIZONA STATE UNIVERSITY WEST   (United States)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Coactivators; Colon cancer; Detoxification; Ligand generated nuclear receptor conformation; Mediator; Retinoid X receptor; Vitamin D responsive elements

Indexed keywords

BILE ACID; CALCITRIOL; CYTOCHROME P450 3A4; LITHOCHOLIC ACID; PROTEIN; PROTEIN TRIP1; RETINOID X RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; LIGAND; PRIMER DNA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN HT29; COLON; CONTROLLED STUDY; DETOXIFICATION; DIMERIZATION; ENZYME INDUCTION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; REPORTER GENE; TRANSCRIPTION INITIATION; TWO HYBRID SYSTEM; VITAMIN D RESPONSIVE ELEMENT; CELL LINE; COLON TUMOR; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROMOTER REGION; TRANSACTIVATION; TUMOR CELL LINE; WESTERN BLOTTING;

MAMMALIA;

BASE SEQUENCE; BLOTTING, WESTERN; CALCITRIOL; CELL LINE; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; HUMANS; LIGANDS; LITHOCHOLIC ACID; PROMOTER REGIONS (GENETICS); RECEPTORS, CALCITRIOL; TRANS-ACTIVATION (GENETICS);

EID: 21344465789     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20359     Document Type: Article

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