Current understanding of the molecular actions of vitamin D

Physiological Reviews

Volumn 78, Issue 4, 1998, Pages 1193-1231

  Jones, Glenville ^a   Strugnell, Stephen A ^a   DeLuca, Hector F ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CALCITRIOL DERIVATIVE; CALCIUM ION; LEXACALCITOL; RETINOID X RECEPTOR; SEOCALCITOL; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; CALCIUM HOMEOSTASIS; DRUG DESIGN; EMBRYO DEVELOPMENT; KERATINOCYTE; MOUSE; NONHUMAN; PARATHYROID GLAND; PRIORITY JOURNAL; REVIEW; TARGET CELL; VITAMIN D DEFICIENCY; VITAMIN D METABOLISM;

EID: 0031755168     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1998.78.4.1193     Document Type: Review

References (368)

1. 3. Proc. Natl. Acad. Sci. USA 78: 4990-4994, 1981.
2. ABOU-SAMRA, A. B., H. JUPPNER, X. F. KONG, E. SCHIPANI, A. IIDA-KLEIN, H. KARGA, P. URENA, T. F. GARDELLA, J. T. POTTS, JR., AND H. M. KRONENBERG. Structure, function, and expression of the receptor for parathyroid hormone and parathyroid hormone-related peptide. Adv. Nephrol. 23: 247-264, 1994.
3. ADAMS, J. S. Extrarenal production and action of active vitamin D metabolites in human lymphoproliferative disases. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, p. 903-921.
4. 3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J. Exp. Med. 161: 755-765, 1985.
5. AKIYOSHI-SHIBATA, M., T. SAKAKI, Y. OHYAMA, M. NOSHIRO, K. OKUDA, AND Y. YABUSAKI. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase: a study with the mature enzyme expressed in Escherichia coli. Eur. J. Biochem. 224: 335-343, 1994.
6. 3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol. Cell. Biol. 15: 5789-5799, 1994.
7. ANDERSSON, S., D. L. DAVIS, H. DAHLBACK, AND H. JORNVALL. Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264: 8222-8229, 1989.
8. 3 in rat liver microsomes. J. Biol. Chem. 258: 6777-6781, 1983.
9. 3 in pig liver. J. Steroid Mol. Biol. 51: 97-106, 1994.
10. 3, 1α-hydroxylase activity. Biochem. Biophys. Res. Commun. 215: 136-141, 1995.
11. BAGGIOLINI, E. G., J. J. PARTRIDGE, S. J. SHIVEY, G. A. TRUITT, AND M. R. VSKOKOVIC. Cholecalciferol 23-yne derivatives, their pharmaceutical compositions, their use in the treatment of calcium-related diseases, and their antitumor activity, US 4,804,502. Chem. Abstr. 111: 58160d, 1989.
12. BAKER, A. R., D. P. MCDONNELL, M. HUGHES, T. M. CRISP, D. J. MANGELSDORF, M. R. HAUSSLER, J. W. PIKE, J. SHINE, AND B. W. O'MALLEY. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA 85: 3294-3298, 1988.
13. 3. J. Am. Chem. Soc. 95: 2748-2749, 1973.
14. BAUER, G. C. H., A. CARLSSON, AND B. LINDQUIST. Evaluation of accretion, resorption, and exchange reactions in the skeleton. Kungl. Fysiograf. Sallskapets I. Lund Forhandlingar 25: 3-18, 1955.
15. 3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 35: 8465-8472, 1996.
16. BECKMAN, M. J., J. P. GOFF, T. A. REINHARDT, D. C. BEITZ, AND R. L. HORST. In vivo regulation of rat intestinal 24-hydroxylase: potential new role of calcitonin. Endocrinology 135: 11951-1955, 1994.
17. BELSEY, R. E., H. F. DELUCA, AND J. T. POTTS. Selective binding properties of vitamin D transport proteins in chick plasma in vitro. Nature 247: 208-209, 1974.
18. BERGINER, V. M., S. SHANY, D. ALKALAY, J. BERGINER, S. DEKEL, G. SALEN, G. S. TINT, AND D. GAZIT. Osteoporosis and increased bone fractures in cerebrotendinous xanthomatosis. Metabolism 42: 69-74, 1993.
19. 3 in human peripheral blood mononuclear cells. Presence in monocytes and induction in T lymphocytes following activation. J. Clin. Endocrinol. 57: 1308-1311, 1983.
20. BHATTACHARYYA, M. H., AND H. F. DELUCA. The regulation of the rat liver calciferol-25-hydroxylase. J. Biol. Chem. 248: 2969-2973, 1973.
21. BIKLE, D. D. Vitamin D and skin. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 25, p. 379-394.
22. 3 production by human keratinocytes: kinetics and regulation. J. Clin. Invest. 78: 557-566, 1986.
23. BINDERUP, E., M. J. CALVERLY, AND L. BINDERUP. Synthesis and biological activity of 1-hydroxylated vitamin D analogues with polyunsaturated side chains. In: Vitamin D: Gene Regulation, Structure-function Analysis and Clinical Application, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Berlin: de Gruyter, 1991, p. 192-193.
24. BINDERUP, L., AND E. BRAMM. Effects of a novel vitamin D analog MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem. Pharmacol. 37: 889-895, 1988.
25. 3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem. Pharmacol. 42: 1569-1575, 1991.
26. 3 and its analogs. J. Bone Miner. Res. 9: 1277-1288, 1994.
27. BLANCO, J. C. G., I. M. WANG, S. Y. TSAI, M. J. TSIA, B. W. O'MALLEY, P. W. JURUTKA, M. R. HAUSSLER, AND K. OZATO. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proc. Natl. Acad. Sci. USA 92: 1535-1539, 1995.
28. 3. Biochemistry 7: 3317-3322, 1968.
29. 2 vitamin D analogs: E-ring analogs. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 59-64.
30. BOUILLON, R., K. ALLEWAERT, D. Z. XIANG, B. K. TAN, AND H. VAN BAELEN. Vitamin D analogs with low affinity for the vitamin D binding protein: enhanced in vitro and decreased in vivo activity. J. Bone Miner. Res. 6: 1051-1057, 1991.
31. BOUILLON, R., W. H. OKAMURA, AND A. W. NORMAN. Structure-function relationships in the vitamin D endocrine system. Endocr. Rev. 16: 200-257, 1995.
32. BOURGUET, W., M. RUFF, P. CHAMBON, H. GRONEMEYER, AND D. MORAS. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375: 377-382, 1995.
33. 3. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 26, p. 395-421.
34. 3: Nicolaysen's endogenous factor. In: Endocrinology 1971, edited by S. Taylor. London: Heinemann, 1972, p. 468-476.
35. BOYLE, I. T., L. MIRAVET, R. W. GRAY, M. F. HOLICK, AND H. F. DELUCA. The response of intestinal calcium transport to 25-hydroxyvitamin D in nephrectomized rats. Endocrinology 90: 605-608, 1972.
36. 3. J. Neuroimmunol. 61: 151-160, 1995.
37. BROMMAGE, R., AND H. F. DELUCA. A maternal defect is responsible for the growth failure in vitamin D-deficient rat pups. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E216-E220, 1984.
38. 3. Endocr. Rev. 6: 491-511, 1985.
39. 2+-sensing receptor from bovine parathyroid. Nature 366: 575-580, 1993.
40. 3 cooperate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes. Leukemia 8: 806-815, 1994.
41. 3 action. J. Biol. Chem. 265: 10025-10029, 1990.
42. 3 receptor. Proc. Natl. Acad. Sci. USA 85: 9499-9502, 1988.
43. BURNS, K., B. DUGGAN, E. A. ATKINSON, K. S. FAMULSKI, M. NEMER, R. C. BLEACKLEY, AND M. MICHALAK. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 367: 476-480, 1994.
44. CALI, J. J., AND D. W. RUSSELL. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis. J. Biol. Chem. 266: 7774-7778, 1991.
45. CALVERLEY, M. J. Synthesis of MC-903, a biologically active vitamin D metabolite analog. Tetrahedron 43: 4609-4619, 1987.
46. CALVERLEY, M. J., E. BINDERUP, AND L. BINDERUP. The 20-epi modification in the vitamin D series: selective enhancement of "non-classical" receptor-mediated effects. In: Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Berlin: de Gruyter, 1991, p. 163-164.
47. CALVERLEY, M. J., AND G. JONES. Vitamin D. In: Antitumor Steroids, edited by B. R. T. Toronto. Orlando, FL: Academic, 1992, p. 193-270.
48. CANDELIERE, G. A., P. W. JURUTKA, M. R. HAUSSLER, AND R. ST-ARNAUD. A composite element binding the vitamin D receptor, retinoid X receptor α, and a member of CTF/NF-1 family of transcription factors mediates the vitamin D responsiveness of the c-fos promoter. Mol. Cell. Biol. 16: 584-92, 1996.
49. 3 reversibly blocks the progression of relapsing encephalomyelitis. Proc. Natl. Acad. Sci. USA 93: 7861-7864, 1996.
50. 3 prevents and ameliorates symptoms in two experimental models of human arthritis. J. Nutr. 128: 68-72, 1998.
51. 3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-β1 and IL-4. J. Immunol. 160: 5314-5319, 1998.
52. 3. J. Biol. Chem. 268: 27371-27380, 1993.
53. 3: interplay with retinoid and thyroid hormone signalling. Eur. J. Biochem. 231: 517-527, 1995.
54. CARLBERG, C., I. BENDIK, A. WYSS, E. MEIER, L. J. STURZEN-BECKER, J. F. GRIPPO, AND W. HUNZIKER. Two nuclear signalling pathways for vitamin D. Nature 361: 657-660, 1993.
55. 3 (VD) analogues MC903, EB1089, and KH1060 activate the VD receptor: homodimers show higher ligand sensitivity than heterodimers with retinoid X receptors. J. Steroid Biochem. Mol. Biol. 51: 137-142, 1994.
56. 3. Miner. Electrolye Metab. 1: 198-207, 1978.
57. CHAMBERS, T. J., AND C. J. MAGNUS. Calcitonin alters behaviour of isolated osteoclasts. J. Pathol. 136: 27-39, 1982.
58. CHAMBON, P. A decade of molecular biology of retinoic acid receptors. FASEB J. 10: 940-954, 1996.
59. CHEN, H., R. J. LIN, R. L. SCHLITZ, D. CHAKRAVART, A. NASH, L. NAGY, M. L. PRIVALSKY, Y. NAKATANI, AND R. M. EVANS. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580, 1997.
60. CHEN, J. D., AND R. M. EVANS. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457, 1995.
61. 3 24-hydroxylase gene and identification of two vitamin D-responsive elements. Biochim. Biophys. Acta 1263: 1-9, 1995.
62. 3 24-hydroxylase cDNA. Proc. Natl. Acad. Sci. USA 90: 4543-4547, 1993.
63. CHEN, T. C., L. CASTILLO, M. KORYCKA-DAHL, AND H. F. DELUCA. Role of vitamin D metabolites in phosphate transport of rat intestine. J. Nutr. 104: 1056-1060, 1974.
64. CHENG, L., A. W. NORRIS, B. F. TATE, M. ROSENBERGER, J. F. GRIPPO, AND E. LI. Characterization of the ligand binding domain of human retinoid X receptor α expressed in Escherichia coli. J. Biol. Chem. 269: 18662-18667, 1994.
65. CHERTOW, B. S., W. I. SIVITZ, N. G. BARANETSKY, S. A. CLARK, A. WAITE, AND H. F. DELUCA. Cellular mechanisms of insulin release. The effects of vitamin D deficiency and repletion of the rat insulin secretion. Endocrinology 113: 1511-1518, 1983.
66. CHERTOW, B. S., W. I. SIVITZ, N. G. BARANETSKY, M. B. CORDLE, AND H. F. DELUCA. Islet insulin release and net calcium retention in vitro in vitamin D-deficient rats. Diabetes 35: 771-775, 1986.
67. 3. Mol. Endocrinol. 9: 1814-1824, 1995.
68. 28K. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 13, p. 209-221.
69. CHRISTAKOS, S., R. GILL, S. LEE, AND H. LI. Molecular aspects of the calbindins. J. Nutr. 122: 678-682, 1992.
70. COOKE, N. C., AND J. G. HADDAD. Vitamin D binding protein. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, p. 87-101.
71. COTT, D. K., R. K. HALL, AND D. K. GRANNER. Retinoid receptors cause distortion of the retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter. Biochem. J. 310: 483-490, 1995.
72. 3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting. Proc. Natl. Acad. Sci. USA 82: 7825-7829, 1985.
73. 3 receptor. Biochim. Biophys. Acta 1167: 29-36, 1993.
74. 9k gene. Proc. Natl. Acad. Sci. USA 89: 603-607, 1992.
75. DARWISH, H. M., AND H. F. DELUCA. Recent advances in the molecular biology of vitamin D action. Prog. Nucleic Acid Res. Mol. Biol. 53: 321-344, 1996.
76. 3 receptor to positive and negative vitamin D response elements. Arch. Biochem. Biophys. 334: 223-234, 1996.
77. DARWISH, H. M., J. KRISINGER, M. STROM, AND H. F. DELUCA. Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine. Proc. Natl. Acad. Sci. USA 84: 6108-6111, 1987.
78. 2 vitamin D analogs. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 3-10.
79. DELUCA, H. F. Active compounds. In: The Vitamins. Chemistry, Physiology, Pathology, Methods, edited by W. H. Sebrell, Jr., and R. S. Harris. New York: Academic, 1971, chapt. IV, p. 223-232.
80. DELUCA, H. F. Vitamin D: metabolism and function. In: Monographs on Endocrinology, edited by F. Gross, M. M. Grumbach, A. Labhart, M. B. Lipsett, T. Mann, L. T. Samuels, and J. Zander. New York: Springer-Verlag, 1979, p. 1-78.
81. DELUCA, H. F. The transformation of a vitamin into a hormone: the vitamin D story. In: The Harvey Lectures. New York: Academic, 1981, ser. 75, p. 333-379.
82. 3. Annu. Rev. Biochem. 45: 631-666, 1976.
83. DELVIN, E. E., AND A. ARABIAN. Kinetics and regulation of 25-hydroxycholecalciferol 1α-hydroxylase from cells isolated from human term decidua. Eur. J. Biochem. 164: 659-662, 1987.
84. 3. Proc. Natl. Acad. Sci. USA 87: 369-373, 1990.
85. 3. Proc. Natl. Acad. Sci. USA 89: 8097-8101, 1992.
86. 3 is due to reduced catabolism and altered protein binding. Biochem. Pharmacol. 47: 987-993, 1994.
87. DILWORTH, F. J., G. R. WILLIAMS, A.-M. KISSMEYER, J. LOGSTED-MIELSEN, E. BINDERUP, M. J. CALVERLEY, H. L. J. MAKIN, AND G. JONES. The vitamin D analog KH1060 is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity. Endocrinology 138: 5485-5496, 1997.
88. 3. Endocrinology 112: 200-206, 1983.
89. DUSSO, A. S., L. NEGREA, S. GUNAWARDHANA, S. LOPEZ-HILKER, J. FINCH, T. MORI, Y. NISHII, E. SLATOPOLSKY, AND A. J. BROWN. On the mechanisms for the selective action of vitamin D analogs. Endocrinology 128: 1687-1692, 1991.
90. DYSON, E., H. M. SUCOV, S. W. KUBALAK, G. W. SCHMID-SCHONBEIN, F. A. DELANL, R. M. EVANS, J. J. ROSS, AND K. R. CHIEN. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor α -/- mice. Proc. Natl. Acad. Sci. USA 92: 7386-7390, 1995.
91. 3 and the regulation of human cancer cell replication. Proc. Soc. Exp. Biol. Med. 191: 221-226, 1989.
92. ELAROUSSI, M. A., J. M. PRAHL, AND H. F. DELUCA. The avian vitamin D receptors: primary structures and their origins. Proc. Natl. Acad. Sci. USA 91: 11596-11600, 1994.
93. 2 partially dissociates between preservation of cancellous bone mass and effects on calcium homeostasis in ovarectomized rats. Calcif. Tissue Int. 60: 449-456, 1997.
94. 3. Biochemistry 18: 3977-3983, 1979.
95. EVANS, R. M. The steroid and thyroid hormone receptor superfamily. Science 240: 889-895, 1988.
96. FELDMAN, D., F. H. GLORIEUX, AND W. PIKE. Vitamin D. San Diego, CA: Academic, 1997, p. 1-1285.
97. FIESER, L. F., AND M. FIESER. Steroids. New York: Reinhold, 1959, p. 144-146.
98. FORMAN, B. M., K. UMESONO, H. CHEN, AND R. M. EVANS. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81: 541-550, 1995.
99. FRASER, D., S. W. KOOH, P. KIND, M. F. HOLICK, Y. TANAKA, AND H. F. DELUCA. Pathogenesis of hereditary vitamin D dependency rickets. N. Engl. J. Med. 289: 817-822, 1973.
100. FRASER, D. R., AND E. KODICEK. Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature 228: 764-766, 1970.
101. FRIEDLANDER, G., AND C. AMIEL. Cellular mode of action of parathyroid hormone. Adv. Nephrol 23: 265-279, 1994.
102. FU, G. K., D. LIN, M. Y. H. ZHANG, D. D. BIKLE, C. H. L. SHACKLETON, W. L. MILLER, AND A. A. PORTALE. Cloning of human 25-hydroxyvitamin D-1α-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol. Endocrinol. 11: 1961-1970, 1997.
103. FU, G. K., A. A. PORTALE, AND W. L. MILLER. Complete structure of the human gene for the vitamin D 1α-hydroxylase, P450c1α. DNA Cell Biol. 16: 1499-1507, 1997.
104. 3 in vivo and in the perfused rat liver. FEBS Lett. 65: 211-214, 1976.
105. GALANTE, L., K. W. COLSTON, S. J. MACAULEY, AND I. MACINTYRE. Effect of calcitonin on vitamin D metabolism. Nature 238: 271-273, 1972.
106. 2 on calcium homeostasis in postmenopausal osteopenic women. J. Bone Miner. Res. 9: 607-614, 1994.
107. 3 on calcium balance and bone turnover and its effect on vertebral fracture rate. Metabolism 39: 30-34, 1990.
108. GALLAGHER, J. C., B. L. RIGGS, R. R. RECKER, AND D. GOLDGAR. The effect of calcitriol on patients with postmenopausal osteoporosis with special reference to fracture frequency. Proc. Soc. Exp. Biol. Med. 191: 287-292, 1989.
109. GARABEDIAN, M., M. F. HOLICK, H. F. DELUCA, AND I. T. BOYLE. Control of 25-hydroxycholecalciferol metabolism by the parathyroid glands. Proc. Natl. Acad. Sci. USA 69: 1673-1676, 1972.
110. 3 in parathyroidectomized rats. Endocrinology 94: 1022-1027, 1974.
111. 3 endocrine complex. How are they regulated at the molecular level? J. Bone Miner. Res. 5: 897-903, 1990.
112. GHAZARIAN, J. G., C. R. JEFCOATE, J. C. KNUTSON, W. ORME-JOHNSON, AND H. F. DELUCA. Mitochondrial cytochrome P-450. A component of chick kidney 25-hydroxycholecalciferol-1α-hydroxylase. J. Biol. Chem. 249: 3026-3033, 1974.
113. 3- and butyrate-inducible responses. Proc. Natl. Acad. Sci. USA 84: 2984-2988, 1993.
114. GOLDEN, P., A. GREENWALT, K. MARTIN, E. BELLORIN-FONT, R. MAZEY, S. KLAHR, AND E. SLATOPOLSKY. Lack of direct effect of 1,25-dihydroxycholecalciferol on parathyroid hormone secretion by normal bovine parathyroid glands. Endocrinology 107: 602-607, 1980.
115. GOLDEN, P., R. MAZEY, A. GREENWALT, K. MARTIN, AND E. SLATOPOLSKY. Vitamin D: a direct effect on the parathyroid gland? Miner. Electrolyte Metab. 2: 1-6, 1979.
116. 3 in healthy adults. J. Clin. Endocrinol. Metab. 46: 756-765, 1978.
117. GRAY, R. W., J. L. OMDAHL, J. G. GHAZARIAN, AND H. F. DELUCA. 25-Hydroxycholecalciferol-1α-hydroxylase: subcellular distribution and properties. J. Biol. Chem. 247: 7528-7532, 1972.
118. 3-25-hydroxylase (CYP27) lacks a classical VDRE but contains silencer sequence (Abstract). J. Bone Miner. Res. 9: S289, 1994.
119. GUO, Y.-D., S. STRUGNELL, D. W. BACK, AND G. JONES. Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions. Proc. Natl. Acad. Sci. USA 90: 8668-8672, 1993.
120. HA, I., W. S. LANE, AND D. REINBERG. Cloning of a human gene encoding the general transcription initiation factor IIB. Nature 352: 689-695, 1991.
121. HALLORAN, B. P., AND H. F. DELUCA. Vitamin D deficiency and reproduction in rats. Science 204: 73-74, 1979.
122. HALLORAN, B. P., AND H. F. DELUCA. Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J. Nutr. 110: 1573-1580, 1980.
123. 3. Arch. Biochem. Biophys. 208: 477-486, 1981.
124. HANSEN, K., M. J. CALVERLEY, AND L. BINDERUP. Synthesis and biological activity of 22-oxa vitamin D analogues. In: Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Berlin: de Gruyter, 1991, p. 161-162.
125. HARMEYER, J., AND H. F. DELUCA. Calcium-binding protein and calcium absorption after vitamin D administration. Biochem. J. 170: 93-102, 1969.
126. HARRISON, H. E., AND H. C. HARRISON. Intestinal transport of phosphate: action of vitamin D. calcium, and potassium. Am. J. Physiol. 201: 1007-1012, 1961.
127. HAUSSLER, M. R. Vitamin D receptors: nature and function. Annu. Rev. Nutr. 6: 527-562, 1986.
128. HAUSSLER, M. R., P. W. JURUTKA, J. C. HSIEH, P. D. THOMPSON, S. H. SELZNICK, C. A. HAUSSLER, AND G. K. WHITFIELD. New understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone. Bone 17, Suppl.: 33S-38S, 1995.
129. 3 25-hydroxylase of rat liver mitochondria. J. Biochem. 103: 863-866, 1988.
130. HEANEY, R. P. Vitamin D: role in the calcium economy. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 31, p. 485-497.
131. HEINZEL, T., R. M. LAVINSKY, T.-M. MULLEN, M. SODERSTROM, C. D. LAHERTY, J. TORCHIA, W.-M. YANK, G. BRARD, S. D. NGO, AND J. R. DAVIE. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387: 43-48, 1997.
132. 3 1α-hydroxylase. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, p. 57-68.
133. 3 in chick parathyroid glands. Biochem. Biophys. Res. Commun. 62: 781-788, 1975.
134. HEYMAN, R. A., D. J. MANGELSDORF, J. A. DYCK, R. B. STEIN, G. EICHELE, R. M. EVANS, AND C. THALLER. 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68: 397-406, 1992.
135. 3 modulates phosphorylation of serine 205 in the human vitamin D receptor: site-directed mutagenesis of this residue promotes alternative phosphorylation. Biochemistry 33: 4300-4311, 1994.
136. 3 in long bones of rats. Calcif. Tissue Int. 38: 79-86, 1986.
137. 3 active on bone in anephric rats. Science 176: 1146-1147, 1972.
138. 3 made in the kidney. Biochemistry 11: 4251-4255, 1972.
139. HOLICK, M. F., H. K. SCHNOES, H. F. DELUCA, T. SUDA, AND R. J. COUSINS. Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in the intestine. Biochemistry 10: 2799-2804, 1971.
140. HOLLIS, B. W. Detection of vitamin D and its major metabolites. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, p. 587-606.
141. 3 synthesis in rats. Endocrinology 101: 969-974, 1977.
142. HORLEIN, A. J., A. M. NAAR, T. HEINZEL, J. TORCHIA, B. GLOSS, R. KUROKAWA, A. RYAN, Y. KAMEI, M. SODERSTROM, AND C. K. GLASS. Ligand-dependent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-404, 1995.
143. 2 in mammals. Biochemistry 29: 578-582, 1990.
144. 3. Endocrinology 113: 1950-1957, 1983.
145. 3 receptors in parathyroid glands. Preliminary characterization of cytoplasmic and nuclear binding components. J. Biol. Chem. 252: 1065-1073, 1978.
146. HUTCHINSON, K. A., L. C. SCHERRER, M. J. CZAR, L. F. STANCATO, Y. H. CHOW, R. JOVE, AND W. B. PRATT. Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex. Ann. NY Acad. Sci. 684: 35-48, 1993.
147. 3. Bone 16: 129-135, 1995.
148. 3. Biochim. Biophys. Acta 1264: 26-28, 1995.
149. JARNAGIN, K., R. BROMMAGE, H. F. DELUCA, S. YAMADA, AND H. TAKAYAMA. 1- But not 24-hydroxylation of vitamin D is required for growth and reproduction in rats. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E290-E297, 1983.
150. JEHAN, F., AND H. F. DELUCA. Cloning and characterization of the mouse vitamin D receptor promoter. Proc. Natl. Acad. Sci. USA 94: 10138-10143, 1997.
151. JEHAN-KIMMEL, C., H. M. DARWISH, S. A. STRUGNELL, B. A. WIEFLING, AND H. F. DELUCA. Binding of vitamin D receptor to vitamin D response elements induces DNA distortion (Abstract). J. Bone Miner. Res. 11: S312, 1996.
152. JENSTER, G., T. E. SPENCER, M. M. BURCIN, S. Y. TSAI, M.-J. TSAI, AND B. W. O'MALLEY. Steroid receptor induction of gene transcription: a two-step model. Proc. Natl. Acad. Sci. USA 94: 7879-7884, 1997.
153. 9k gene. Complete structure and implications on steroid hormone regulation. J. Mol. Biol. 235: 1231-1238, 1994.
154. JIN, C. H., S. A. KERNER, M. H. HONG, AND J. W. PIKE. Transcriptional activation and dimerization functions in the human vitamin D receptor. Mol. Endocrinol. 10: 945-957, 1996.
155. JIN, C. H., AND J. W. PIKE. Human vitamin D receptor dependent transactivation in Saccharomyces cerevisiae requires retinoid X receptor. Mol. Endocrinol. 10: 196-205, 1996.
156. 2 in normal and immortalized human epidermal cells. Biochem. Pharmacol. 52: 133-140, 1996.
157. JONES, G., AND M. J. CALVERLEY. A dialogue on analogues: newer vitamin-D drugs for use in bone disease, psoriasis, and cancer. Trends Endocrinol. Metab. 4: 297-303, 1993.
158. JONES, G., N. EDWARDS, D. VRIEZEN, C. PORTEOUS, D. J. H. TRAFFORD, J. CUNNINGHAM, AND H. L. J. MAKIN. Isolation and identification of seven metabolites of 25-hydroxydihydrotachysterol 3 formed in the isolated perfused rat kidney: a model for the study of side-chain metabolism of vitamin D. Biochemistry 27: 7070-7079, 1988.
159. 3. Biochemistry 23: 3749-3754, 1984.
160. 3 produced in the kidney. J. Biol. Chem. 258: 12920-12929, 1983.
161. 2 and 24,25-dihydroxyvitamin
162. JURUTKA, P. W., J. C. HSIEH, S. NAKAJIMA, C. A. HAUSSLER, G. K. WHITFIELD, AND M. R. HAUSSLER. Human vitamin D receptor phosphorylation by casein kinase II at Ser-208 potentiates transcriptional activation. Proc. Natl. Acad. Sci. USA 93: 3519-3524, 1996.
163. 3 receptor binding site in the rat atrial natriuretic factor promoter. Biochem. Biophys. Res. Commun. 218: 882-886, 1996.
164. KAMEI, Y., T. KAWADA, T. FUKUWATARI, T. ONO, S. KATO, AND E. SUGIMOTO. Cloning and sequencing of the gene encoding the mouse vitamin D receptor. Gene 152: 281-282, 1995.
165. KAMEI, Y., L. XU, T. HEINZEL, J. TORCHIA, R. KUROKAWA, B. GLOSS, S. C. LIN, R. HEYMAN, D. W. ROSE, AND C. K. GLASS. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414, 1996.
166. 3 are differentially modified by 9-cis retinoic acid. Cancer Res. 56: 623-632, 1996.
167. KATO, S., H. ENDOH, Y. MASUHIRO, T. KITAMOTO, S. UCHIYAMA, H. SASAKI, S. MASUSHIGE, Y. GOTOH, E. NISHIDA, AND H. KAWASHIMA. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270: 1491-1494, 1995.
168. 3 24-hydroxylase (CYP24) promoter. J. Biol. Chem. 271: 29715-29721, 1996.
169. 3 dependency of vitamin D receptor-retinoid X receptor-vitamin D-responsive element complex. Arch. Biochem. Biophys. 341: 75-80, 1997.
170. KISSMEYER, A.-M., E. BINDERUP, L. BINDERUP, C. M. HANSEN, N. R. ANDERSEN, N. J. SCHROEDER, H. L. J. MAKIN, V. N. SHANKAR, AND G. JONES. The metabolism of the vitamin D analog EB1089: identification of in vivo and in vitro metabolites and their biological activities. Biochem. Pharmacol. 53: 1087-1097, 1997.
171. KISSMEYER, A.-M., I. S. MATHIASEN, S. LATINI, AND L. BINDERUP. Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP). Endocrine 3: 263-266, 1995.
172. 3. Biochim. Biophys. Acta 338: 489-495, 1974.
173. 3 signalling. Nature 355: 446-449, 1992.
174. 3-24-hydroxylase. Subcellular location and properties. Biochemistry 13: 1543-1548, 1974.
175. 2 in rats: comparison with calcitriol and calcipotriol. Biochem. Pharmacol. 53: 829-837, 1997.
176. 3 in rats. J. Biochem. 115: 373-380, 1994.
177. 3 enhances the expression of transforming growth factor β1 and its latent form binding protein in cultured breast carcinoma cells. Cancer Res. 55: 1540-1546, 1995.
178. 2. Biochemistry 27: 5785-5790, 1988.
179. KOUZARIDES, T., AND A. J. BANNISTER. The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643, 1997.
180. KOWARSKI, S., AND D. SCHACHTER. Effects of vitamin D on phosphate transport and incorporation into mucosal constituents of rat intestinal mucosa. J. Biol. Chem. 244: 211-217, 1969.
181. KRAGBALLE, K., B. T. GJERTSEN, D. DE HOOP, T. KARLSMARK, P. C. VAN DE KERKHOF, O. LARKO, C. NIEBOER, J. ROED-PETERSEN, A. STRAND, AND G. TIKJOB. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 337: 193-196, 1991.
182. 3-responsive repressor sequences in the rat parathyroid hormone-related peptide gene. J. Biol. Chem. 271: 16310-16316, 1996.
183. 3 receptor gene expression and enhances hormone action. Mol. Endocrinol. 6: 198-206, 1992.
184. KRONENBERG, H., T. IGARASHI, M. W. FREEMAN, T. OKAZAKI, S. J. BRAND, K. M. WIREN, AND J. T. POTTS, JR. Structure and expression of the human parathyroid hormone gene. Rec. Prog. Horm. Res. 42: 641-663, 1986.
185. 3. Physiol. Rev. 64: 478-504, 1984.
186. KUMAR, R. Vitamin D and the kidney. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 17, p. 275-292.
187. 3-24-hydroxylase. J. Biol. Chem. 253: 3804-3809, 1978.
188. KUREK-TYRLIK, A., F. Z. MAKAEV, J. WICHA, V. ZHABINSKII, AND M. J. CALVERLEY. Pivoting 20-normal and 20-epi calcitriols: synthesis and crystal structure of a "doucle side chain" analogue. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 31-32.
189. KUROKAWA, R., J. DIRENZO, M. BOEHM, J. SUGARMAN, B. GLOSS, M. G. ROSENFELD, R. A. HEYMAN, AND C. K. GLASS. Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371: 528-531, 1994.
190. KWIECINSKI, G. G., G. I. PETRIE, AND H. F. DELUCA. Vitamin D is necessary for reproductive functions in the male rat. J. Nutr. 119: 741-744, 1989.
191. 3 restores fertility of vitamin D-deficient female rats. Am J. Physiol. 256 (Endocrinol. Metab. 19): E483-E487, 1989.
192. LABUDA, M., K. MORGAN, AND F. H. GLORIEUX. Mapping autosomal recessive vitamin D dependency type I to chromosome 12q14 by linkage analysis. Am. J. Human Genet. 47: 28-36, 1990.
193. 2. Science 186: 1038-1040, 1974.
194. LEE, M. S., S. A. KLIEWER, J. PROVENCAL, P. E. WRIGHT, AND R. M. EVANS. Structure of the retinoid X receptor α DNA-binding domain: a helix required for homodimeric DNA binding. Science 260: 1117-1121, 1993.
195. 3 in immunosuppression: lessons from autoimmunity and transplantation. In: Vitamin D, edited by D, Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 69, p. 1167-1181.
196. 3. J. Cell Biochem. 49: 26-31, 1992.
197. 3 receptor- and retinoid X receptor-mediated gene activation in vivo. Mol. Cell. Biol. 16: 1006-1016, 1996.
198. 3. J. Biol. Chem. 269: 4934-4939, 1994.
199. 3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev. 10: 142-153, 1996.
200. 3 analogues and their 20-epi homologues with the vitamin D receptor. J. Biol. Chem. 272: 3336-3345, 1997.
201. 3 in uremic patients. Contr. Nephrol. 18: 212-217, 1980.
202. 3 in osteosarcoma cell line UMR-106. Characterization of products. J. Biol. Chem. 262: 14394-14401, 1987.
203. 3 in target cells. Proceedings of the First International Congress on Vitamins and Biofactors in Life Science. J. Nutr. Sci. Vitaminol. Special Issue: 75-78, 1992.
204. LUPISELLA, J. A., J. E. DRISCOLL, W. J. METZLER, AND P. R. RECZEK. The ligand binding domain of the human retinoic acid receptor γ is predominantly α-helical with a Trp residue in the ligand binding site. J. Biol. Chem. 270: 24884-24890, 1995.
205. 3-activated expression of the rat osteocalcin gene. Mol. Cell. Biol. 13: 5907-5917, 1993.
206. MACDONALD, P. N., D. R. SHERMAN, D. R. DOWD, J. R. JEFCOAT, AND R. K. DELISLE. The vitamin D receptor interacts with general transcription factor IIβ. J. Biol. Chem. 270: 4748-4752, 1995.
207. MADHOK, T. C., AND H. F. DELUCA. Characteristics of the rat liver microsomal enzyme system converting cholecalciferol to 25-hydroxycholecalciferol. Evidence for participation of cytochrome P-450. Biochem. J. 184: 491-499, 1979.
208. 3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation. Biochem. J. 262: 173-180, 1989.
209. MALLOY, P. J., J. W. PIKE, AND D. FELDMAN. Hereditary 1,25-dihydroxyvitamin D resistant rickets. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, p. 765-787.
210. MANGELSDORF, D. J., AND R. M. EVANS. The RXR heterodimers and orphan receptors. Cell 83: 841-850, 1995.
211. MANGELSDORF, D. J., E. S. ONG, J. A. DYCK, AND R. M. EVANS. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345: 224-229, 1990.
212. MARTIN, T. J. The roles of PTHrP in normal physiology and in cancer. In: The First International Forum on Calcified Tissue and Bone Metabolism, edited by T. Suda. Tokyo: Chugai, 1993, p. 48-53.
213. MASUDA, S., V. BYFORD, R. KREMER, H. L. J. MAKIN, N. KUBODERA, Y. NISHII, A. OKAZAKI, T. OKANO, T. KOBAYASHI, AND G. JONES. In vitro metabolism of the vitamin D analog, 22-oxacalcitriol, using cultured osteosarcoma, hepatoma and keratinocyte cell lines. J. Biol. Chem. 271: 8700-8708, 1996.
214. 3 in target cells (Abstract). J. Bone Miner. Res. 11: S420, 1996.
215. MASUDA, S., S. STRUGNELL, M. J. CALVERLY, H. L. J. MAKIN, R. KREMER, AND G. JONES. In vitro metabolism of the anti-psoriatic vitamin D analog, calcipotriol, in two cultured human keratinocyte models. J. Biol. Chem. 269: 4794-4803, 1994.
216. MASUYAMA, H., C. M. BROWNFIELD, R. ST.-ARNAUD, AND P. N. MACDONALD. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol. Endocrinol. 11: 1507-1517, 1997.
217. MASUYAMA, H., S. C. JEFCOAT, JR., AND P. N. MACDONALD. The N-terminal domain of transcription factor TFIIB is required for direct interaction with the vitamin D receptor and participates in vitamin D-mediated transcription. Mol. Endocrinol. 11: 218-228, 1997.
218. 3 prevents insulitis in NOD mice. Diabetes 41: 1491-1495, 1992.
219. MCDONNELL, D. P., D. J. MANGELSDORF, J. W. PIKE, M. R. HAUSSLER, AND B. W. O'MALLEY. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235: 1214-1217, 1987.
220. 3 receptor regulate osteocalcin gene expression. Mol. Endocrinol. 3: 635-644, 1989.
221. MCSHEEY, P. M., AND T. J. CHAMBERS. Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology 119: 1654-1659, 1986.
222. 3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption. J. Clin. Invest. 80: 425-429, 1987.
223. 3 receptors on osteoclasts of calcium-deficient chicken despite demonstrable receptors on circulating monocytes. J. Clin. Invest. 77: 312-314, 1986.
224. 3 metabolism in a human osteosarcoma cell line and human bone cells. J. Bone Miner. Res. 5: 597-607, 1990.
225. 2+-sensing receptor messenger ribonucleic acid and protein. Endocrinology 136: 3087-3092, 1995.
226. MIYAMOTO, K., R. A. KESTERSON, H. YAMAMOTO, Y. TAKETANI, E. NISHIWAKII, S. TATSUMI, Y. INOUE, K. MORITA, E. TAKEDA, AND J. W. PIKE. Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol. Endocrinol. 11: 1165-1179, 1997.
227. 3. J. Biol. Chem. 272: 14115-14119, 1997.
228. 3 induces differentiation of human myeloid leukemia cells. Biochem. Biophys. Res. Commun. 102: 937-943, 1981.
229. 3 1α-hydroxylase. Biochem. Biophys. Res. Commun. 239: 527-533, 1997.
230. 3 analogs potently induce the human osteocalcin gene promoter stably transfectd into rat osteosarcoma cells (ROSCO-2). J. Bone Miner. Res. 6: 893-899, 1991.
231. 3. Miner. Electrolyte Metab. 19: 78-85, 1993.
232. MUNDER, M., I. M. HERZBERG, C. ZIEROLD, V. E. MOSS, K. HANSON, M. CLAGETT-DAME, AND H. F. DELUCA. Identification of the porcine intestinal accessory factor that enables DNA sequence recognition by vitamin D receptor. Proc. Natl. Acad. Sci. USA 92: 2795-2799, 1995.
233. 3 analogues. Chem. Pharm. Bull. 34: 4410-4413, 1986.
234. NAGY, L., H.-Y. KAO, D. CHAKRAVARTI, R. J. LIN, C. A. HASSIG, D. E. AYER, S. L. SCHREIBER, AND R. M. EVANS. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89: 373-380, 1997.
235. 3 and its 1-hydroxy derivative. Arch. Biochem. Biophys. 241: 173-178, 1985.
236. 3 receptor. J. Biol. Chem. 271: 5143-5149, 1996.
237. NAKAJIMA, S., J. C. HSIEH, P. N. MACDONALD, M. A. GALLIGAN, C. A. HAUSSLER, G. K. WHITFIELD, AND M. R. HAUSSLER. The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element. Mol. Endocrinol. 8: 159-172, 1994.
238. 3. Biochemistry 22: 5848-5853, 1983.
239. NAVEH-MANY, T., AND J. SILVER. Parathyroid hormone synthesis, secretion and action. In: Kidney Stones: Medical and Surgiral Management, edited by F. L. Coe, M. J. Favus, C. Pak, J. Parks, and G. Preminger. New York: Raven, 1996, p. 175-199.
240. NICOLAYSEN, R., AND N. EEG-LARSEN. The biochemistry and physiology of vitamin D. Vitamin Horm. 11: 29-60, 1953.
241. NIKOLOV, D. B., H. CHEN, E. D. HALAY, A. HOFFMAN, G. ROEDER, AND S. K. BURLEY. Crystal structure of a human TATA box-binding protein/TATA element complex. Proc. Natl. Acad. Sci. USA 93: 4862-4867, 1996.
242. NISHII, Y., K. SATO, AND T. KOBAYASHI. The development of vitamin D analogues for the treatment of osteoporosis. Osteoporosis Int. 1, Suppl.: S190-S193, 1993.
243. NISHIKAWA, J.-I., M. KITAUA, I. MASAYOSHI, AND T. NISHIHARA. Vitamin D receptor contains multiple dimerization interfaces that are functionally different. Nucleic Acids Res. 23: 606-611, 1995.
244. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. USA 87: 9995-9999, 1990.
245. 3: a case study of transcaltachia (rapid hormonal stimulation of intestinal calcium transport). In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 15, p. 233-258.
246. 3 are both indispensable for calcium and phosphorus homeostasis. Life Sci. 27: 229-231, 1980.
247. 3 present in intestine and kidney. J. Biol. Chem. 257: 8261-8271, 1982.
248. 3 24-hydroxylase. FEBS Lett. 278: 195-198, 1991.
249. 3. J. Biol. Chem. 266: 8690-8695, 1991.
250. 3 24-hydroxylase gene. J. Biol. Chem. 269: 10545-10550, 1994.
251. 3 based on the provitamin D skeleton. Ann. NY Acad. Sci. 761: 344-348, 1995.
252. 3. J. Biol. Chem. 263: 2203-2208, 1988.
253. OKUDA, K. I., E. USUI, AND Y. OHYAMA. Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism. J. Lipid Res. 36: 1641-1652, 1995.
254. ONATE, S. A., S. Y. TSAI, M. J. TSAI, AND B. W. O'MALLEY. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357, 1995.
255. 3. Bone Miner. Res. 3: 47-52, 1987.
256. ORNOY, A., D. GOODWIN, D. NOFF, AND S. EDELSTEIN. 24,25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation. Nature 276: 517-519, 1978.
257. ORR, W. J., L. E. HOLT, JR., L. WILKINS, AND F. H. BOONE. The calcium and phosphorus metabolism in rickets, with special reference to ultraviolet ray therapy. Am. J. Dis. Child. 26: 362-372, 1923.
258. OTT, S., AND C. H. CHESNUT. Calcitriol treatment is not effective in post-menopausal osteoporosis. Ann. Intern. Med. 118: 267-274, 1989.
259. 2. Proc. Natl. Acad. Sci. USA 75: 2080-2081, 1978.
260. 3 are associated with enhanced activation of the vitamin D receptor. J. Biol. Chem. 270: 10551-10558, 1995.
261. 3, a novel vitamin D-related compound with potential therapeutic activity. Tetrahedron Lett. 31: 1823-1824, 1990.
262. PERLMANN, T., K. UMESONO, P. N. RANGARAJAN, B. N. FORMAN, AND R. M. EVANS. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors. Mol. Endocrinol. 9: 1166-1179, 1996.
263. PIEDRAFITA, F. J., M. A. ORTIZ, AND M. PFAHL. Thyroid hormone receptor β mutants associated with generalized resistance to thyroid hormone show defects in their ligand-sensitive repression function. Mol. Endocrinol. 9: 1533-1548, 1995.
264. PILLAI, S., AND D. D. BIKLE. Role of intracellular free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D. J. Cell. Physiol. 146: 94-100, 1991.
265. 3 receptor homodimer. J. Cell. Biochem. 60: 322-333, 1996.
266. 3 limits the homologous up-regulation of its receptor in rat osteosarcomacells. Biochim. Biophys. Acta 970: 122-129, 1988.
267. POTTS, J. T., JR. Biological surprises and evolutionary links in the calcium field. Parathyroid hormone (PTH): past, present and future. In: PTH and PTHrP, edited by T. Suda. Tokyo: Chugai, 1993, p. 6-11.
268. PROVVEDINI, D. M., C. M. RULOT, R. E. SOBOL, C. D. TSOUKAS, AND S. C. MANOLAGAS. 1α,25-Dihydroxyvitamin D, receptors in human thymic and tonsillar lymphocytes. J. Bone Miner. Res. 2: 239-241, 1987.
269. QAW, F., M. J. CALVERLEY, N. J. SCHROEDER, D. J. H. TRAFFORD, H. L. J. MAKIN, AND G. JONES. In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1,25- and 1,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity. J. Biol. Chem. 268: 282-292, 1993.
270. RAISZ, L. G., C. L. TRUMMEL, M. F. HOLICK, AND H. F. DELUCA. 1,25-Dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science 175: 768-769, 1972.
271. RASMUSSEN, H., AND H. F. DELUCA Calcium homeostasis. Ergebnisse Physiol. 53: 107-173, 1963.
272. RASMUSSEN, H., H. F. DELUCA, C. ARNAUD, C. HAWKER, AND M. VON STEDINGK. The relationship between vitamin D and parathyroid hormone. J. Clin. Invest. 42: 1940-1946, 1963.
273. RASTINEJAD, F., T. PERLMANN, R. M. EVANS, AND P. B. SIGLER. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375: 203-211, 1995.
274. 3 receptor regulate osteocalcin gene expression. J. Biol. Chem. 271: 2012-2017, 1996.
275. RECKER, R., P. SCHOENFELD, J. LETTERI, E. SLATOPOLSKY, R. GOLDSMITH, AND A. BRICKMAN. The efficacy of calcifediol in renal osteodystrophy. Arch. Intern. Med. 138: 857-863, 1978.
276. 3 through A-ring modification. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 139-146.
277. 3 through C-24 oxidation pathway. Biochemistry 28: 1763-1769, 1989.
278. 3 synthesis in vivo. J. Biol. Chem. 258: 3615-3617, 1983.
279. 3 metabolism limits receptor occupancy and target cell responsiveness. J. Biol. Chem. 264: 15917-15921, 1989.
280. RENAUD, J. P., N. ROCHEL, M. RUFF, V. VIVAT, P. CHAMBON, H. GRONEMEYER, AND D. MORAS. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid. Nature 378: 681-689, 1995.
281. RENNO, T., M. KRAKOWSKI, C. PICCIRILLO, J. LIN, AND T. OWENS. TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis: regulation by Th1 cytokines. J. Immunol. 154: 944-953, 1995.
282. 3 metabolism by the isolated perfused rat kidney. Am. J. Physiol. 239 (Endocrinol. Metab. 2): E12-E20, 1980.
283. 3 receptor in insect cells using the baculovirus expression system. Proc. Natl. Acad. Sci. USA 88: 6555-6559, 1991.
284. RUBIN, R. P., G. B. WEISS, AND J. W. PUTNEY, JR. (Editors). Calcium in Biological Systems. New York: Plenum, 1985, p. 1-737.
285. 3 of transcription of the pre-proparathyroid hormone gene. Endocrinology 119: 2864-2867, 1986.
286. 3 25-hydroxylation in human liver. J. Biol. Chem. 259: 10936-10946, 1984.
287. SAITOU, M., S. NARUMIYA, AND A. KAKIZUKA. Alteration of a single amino acid residue in retinoic acid receptor causes a dominant negative phenotype. J. Biol. Chem. 269: 19101-19107, 1994.
288. SASAKI, H., H. HARADA, Y. HANADA, H. MORINO, M. SUZAWA, E. SHIMPO, T. KATSUMATA, Y. MASUHIRO, K. MATSUDA, AND K. EBIHARA. Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene suppression. Biochemistry 34: 370-377, 1995.
289. 3 by leukemic cells. J. Steroid Biochem. Mol. Biol. 57: 117-124, 1996.
290. SCHNEIDER, H., J. H. FEYEN, K. SEUWEN, AND N. R. MOVVA. Cloning and functional expression of a human parathyroid hormone receptor. Eur. J. Pharmacol. 246: 149-155, 1993.
291. 3 response element identified in the mouse c-fos promoter. Biochem. Biophys. Res. Commun. 230: 646-651, 1997.
292. SCHRADER, M., K. M. MULLER, AND C. CARLBERG. Specificity and flexibility of vitamin D signalling. J. Biol. Chem. 269: 5501-5504, 1994.
293. 3 receptor-retinoid X receptor heterodimer-mediated transactivation. Mol. Cell. Biol. 15: 1154-1161, 1995.
294. SEEMAN, E., C. TSALAMANDRIS, S. BASS, AND G. PEARCE. Present and future of osteoporosis therapy. Bone 17, Suppl.: 23S-29S, 1995.
295. 3. Tetrahedron Lett. 40: 4147-4150, 1972.
296. SHANKAR, V. N., F. J. DILWORTH, H. L. J. MAKIN, N. J. SCHROEDER, D. A. J. TRAFFORD, A.-M. KISSMEYER, M. J. CALVERLEY, E. BINDERUP, AND G. JONES. Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain. Biochem. Pharmacol. 53: 783-793, 1997.
297. 3 in regulating parathyroid gland function. Proc. Soc. Exp. Biol. Med. 191: 233-237, 1989.
298. 3 in rat kidney but not in intestine. J. Biol. Chem. 267: 13757-13762, 1992.
299. 3-1α-hydroxylase cDNA. Proc. Natl. Acad. Sci. USA 94: 12920-12925, 1998.
300. 3 in vivo? A reexamination. Proc. Natl. Acad. Sci. USA 80: 1746-1750, 1983.
301. SIEGAL, N., N. WOMGSURAWAT, AND H. J. ARMBRECHT. Parathyroid hormone stimulates dephosphorylation of the renodoxin component of the 25-hydroxyvitamin D3-1α-hydroxylase from rat renal cortex. J. Biol. Chem. 261: 16998-17003, 1986.
302. SILVER, J., AND H. M. KRONENBERG. Parathyroid hormone - molecular biology and regulation. In: Principles of Bone Biology, edited by J. B. Bilezikian, L. G. Raisz, and G. A. Rodan. San Diego, CA: Academic, 1996, chapt. 24, p. 325-337.
303. SILVER, J., E. MOALLEM, R. KILAV, E. EPSTEIN, A. SELA, AND T. NAVEH-MANY. New insights into the regulation of parathyroid hormone synthesis and secretion in chronic renal failure. Nephrol. Dial. Transplant. 11, Suppl. 3: 2-5, 1996.
304. SILVER, J., AND T. NAVEH-MANY. Vitamin D and the parathyroid glands. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 23, p. 353-367.
305. SILVER, J., T. NAVEH-MANY, H. MAYER, H. J. SCHMEIZER, AND M. M. POPVTZER. Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J. Clin. Invest. 78: 1296-1301, 1986.
306. 3 in rat skin. Proc. Natl. Acad. Sci. USA 77: 5822-5826, 1980.
307. 3 in the rat. Proc. Soc. Exp. Biol. Med. 178: 432-436, 1985.
308. 2 suppresses PTH secretion in uremic rats in the absence of hypercalcemia (Abstract). J. Bone Miner. Res: S167, 1995.
309. SLATOPOLSKY, E., C. WEERTS, J. THIELAND, R. HORST, H. HARTER, AND K. MARTIN. Marked suppression of secondary hyperparathyroidism by I.V. administration of 1,25-dihydroxycholecalciferol in uremic patients. J. Clin. Invest. 74: 2136-2141, 1984.
310. 3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J. Invest. Dermatol. 86: 709-714, 1986.
311. SONE, T., K. OZONO, AND J. W. PIKE. A 55-kilodalton accessory factor facilitates vitamin D receptor binding. Mol. Endocrinol. 5: 1578-1586, 1991.
312. 28k in the mouse (Abstract). J. Bone Miner. Res. 12, Suppl.: S123, 1997.
313. SPENCER, R., M. CHARMAN, P. W. WILSON, AND D. E. M. LAWSON. The relationship between vitamin D-stimulated calcium transport and intestinal
314. ST. ARNAUD, R., A. ARABIAN, AND F. H. GLORIEUX. Abnormal bone development in mice deficient for the vitamin D 24-hydroxylase gene (Abstract). J. Bone Miner. Res. 11: S126, 1996.
315. 3 in intramembranous ossification (Abstract). J. Bone Miner. Res. 12: S111, 1997.
316. ST. ARNAUD, R., A. ARABIAN, R. TRAVERS, AND F. H. GLORIEUX. Abnormal intramembranous ossification in mice deficient for the vitamin D 24-hydroxylase gene. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 635-639.
317. ST. ARNAUD, R., S. MESSERLIAN, J. M. MOIR, J. L. OMDAHL, AND F. H. GLORIEUX. The 25-hydroxyvitamin D 1α-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J. Bone Miner. Res. 12: 1552-1559, 1997.
318. STEIN, G. S., J. B. LIAN, J. L. STEIN, A. J. VAN WIJNEN, B. FRENKEL, AND M. MONTECINO. Mechanisms regulating osteoblast proliferation and differentiation. In: Bone Biology, edited by J. P. Bilezekian, G. Raisz, and G. A. Rodan. San Diego, CA: Academic, 1996, chapt. 5, p. 69-86.
319. STERN, P. A monolog on analogs. Calcif. Tissue Int. 33: 1-4, 1981.
320. 3 interactions with local factors in bone remodeling. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 22, p. 341-352.
321. 2 made in the human hepatoma, Hep3B. Biochem. J. 310: 233-241, 1995.
322. STRUGNELL, S. A., AND H. F. DELUCA. The vitamin D receptor-structure and transcriptional activation. Proc. Soc. Exp. Biol. Med. 215: 223-228, 1997.
323. STRUGNELL, S. A., B. A. WIEFLING, AND H. F. DELUCA. Vitamin D receptor ligand-binding domain expressed as a fusion protein (Abstract). J. Bone Miner. Res. 10: S396, 1995.
324. 3 identified by thaw-mount autoradiography. In: Hormonal Control of Calcium Metabolism, edited by D. V. Cohn, R. V. Talmage, and J. L. Matthews. Amsterdam: Excerpta Medica, 1981, p. 222-229.
325. 3 in intestinal tract, stomach, kidney, skin, pituitary and parathyroid. Science 206: 1188-1190, 1979.
326. 3 potentiates the keratinocyte response to calcium. J. Biol. Chem. 269: 14723-14729, 1994.
327. 3 preferentially active on bone. Biochemistry 9: 2917-2922, 1970.
328. SUDA, T., AND N. TAKAHASHI. Vitamin D and osteoclastogenesis. In: Vitamin D, edited by D, Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 21, p. 329-340.
329. SUDA, T., N. TAKAHASHI, AND T. J. MARTIN. Modulation of osteoclast differentiation: update 1995. Endocr. Rev. 4: 266-270, 1995.
330. 3 generated by in vitro incubation with kidney homogenates. Biochemistry 20: 1681-1686, 1981.
331. 28k gene: identification of the vitamin D-responsive promoter region. Biochem. Biophys. Res. Commun. 204: 889-897, 1994.
332. 3 1α-hydroxylase and vitamin D synthesis. Science 277: 1827-1830, 1997.
333. TALMAGE, R. V. Morphological and physiological consideration in a new concept of calcium transport in bone. Am. J. Anat. 129: 467-476, 1970.
334. TANAKA, H., E. ABE, C. MIYAURA, T. KURIBAYASHI, K. KONNO, Y. NISHII, AND T. SUDA. 1α,25-Dihydroxycholecalciferol and a human myeloid leukemia cell line (HL-60). The presence of a cytosol receptor and induction of differentiation. Biochem. J. 204: 713-719, 1982.
335. 3. J. Biol. Chem. 252: 1421-1424, 1977.
336. TANAKA, Y., AND H. F. DELUCA. The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch. Biochem. Biophys. 154: 566-574, 1973.
337. 3. Science 183: 1198-1200, 1974.
338. 3. Effect of blocking of 24-hydroxylation on the functions of vitamin D. J. Biol. Chem. 254: 7163-7167, 1979.
339. 3 in the rat. Endocrinology 92: 417-422, 1973.
340. 3-24-hydroxylase. Arch. Biochem. Biophys. 171: 521-526, 1975.
341. 3 in patients with primary hyperparathyroidism. Bone Miner. Res. 1: 137-142, 1986.
342. 9K. In: Vitamin D, edited by D. Feldman, F. H. Glorieux, and J. W. Pike. San Diego, CA: Academic, 1997, chapt. 14, p. 223-232.
343. TILYARD, M. W., G. F. S. SPEARS, J. THOMSON, AND S. DOVEY. Treatment of post-menopausal osteoporosis with calcium. N. Engl. J. Med. 326: 357-362, 1992.
344. 3-24-hydroxylase activity in Caco-2 cells. An in vitro model of intestinal vitamin D catabolism. Endocrinology 126: 2868-2875, 1990.
345. TORCHIA, J., D. W. ROSE, J. INOSTROZA, Y. KAMEL, S. WESTIN, C. K. GLASS, AND M. G. ROSENFELD. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684, 1997.
346. 3-25-hydroxylase: tissue occurrence and lack of regulation. Arch. Biochem. Biophys. 155: 47-57, 1973.
347. TURNER, R. T., J. E. PUZAS, M. D. FORTE, G. E. LESTER, T. K. GRAY, G. A. HOWARD, AND D. J. BAYLINK. In vitro synthesis of 1α,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells. Proc. Natl. Acad. Sci. USA 77: 5720-5724, 1980.
348. UHLAND-SMITH, A. An Investigation of the Role of Vitamin D in Reproduction, Growth and Development (PhD thesis). Madison: Univ. of Wisconsin, 1992.
349. 3 receptors. Cell 65: 1255-1266, 1991.
350. 3, analog with two side-chains, In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Univ. of California, 1997, p. 19-21.
351. 3 25-hydroxylase from rat liver mitochondria. Fed. Eur. Biol. Sci. Lett. 262: 135-138, 1990.
352. 3 analog, KH1060. Proc. Natl. Acad. Sci. USA 93: 10685-10690, 1996.
353. 3 analog KH1060 induce similar conformational changes as KH1060 itself (Abstract). J. Bone Miner. Res. 12: S453, 1997.
354. VLAHECEVIC, Z. R., S. K. JAIRATH, D. M. HEUMAN, R. T. STRAVITZ, P. B. HYLEMON, N. G. AVADHANI, AND W. M. PANDAK Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids. Am. J. Physiol. 270 (Gastrintest. Liver Physiol. 33): G646-G652, 1996.
355. VOM BAUR, E., C. ZECHEL, D. HEERY, M. J. S. HEINE, J. M. GARNIER, V. VIVAT, B. LE DOUARIN, H. GRONEMEYER, P. CHAMBON, AND R. LOSSON. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 15: 110-124, 1996.
356. WAGNER, R. L., J. W. APRILETTI, M. E. MCGRATH, B. L. WEST, J. D. BAXTER, AND R. J. FLETTERICK. A structural role for hormone in the thyroid hormone receptor. Nature 378: 690-697, 1995.
357. WASSERMAN, R. H., AND J. J. FEHER. Vitamin D-dependent calcium-binding proteins. In: Calcium Binding Proteins and Calcium Function, edited by R. H. Wasserman, R. A. Corradino, E. Carafoli, R. H. Kretsinger, D. H. MacLennan, and S. L. Siegel. New York: Elsevier/North-Holland, 1977, p. 292-302.
358. 3 signal transduction. Nucleic Acids Res. 23: 3268-3274, 1995.
359. WHITFIELD, G. K., J. C. HSIEH, S. NAKAJIMA, P. N. MACDONALD, P. D. THOMPSON, P. W. JURUTKA, C. A. HAUSSLER, AND M. R. HAUSSLER. A highly conserved region in the hormone-binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation. Mol. Endocrinol. 9: 1166-1179, 1995.
360. 3 and thyroid hormone in three osteosarcoma cell lines. Endocrinology 136: 4304-4314, 1995.
361. WURTZ, J.-M., B. GUILLOT, AND D. MORAS. 3-D model of the ligand-binding domain of the vitamin D receptor based on the crystal structure of holo-RAR. In: Vitamin D. Chemistry, Biology and Clinical Applications of the Steroid Hormone, edited by A. W. Norman, R. Bouillon, and M. Thomasset. Riverside: Univ. of California, 1997, p. 165-172.
362. YAMAMOTO, M., Y. KAWANOKE, H. TAKAHASHI, E. SHIMAZAWA, S. KIMURA, AND E. OGATA. Vitamin D deficiency and renal calcium transport in the rat. J. Clin. Invest. 74: 507-513, 1984.
363. 2 suppress immunoglobulin production and thymic lymphocyte proliferation in vivo. Biochim. Biophys. Acta 1158: 269-286, 1993.
364. YANG, S., C. SMITH, J. M. PRAHL, AND H. F. DELUCA. Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch. Biochem. Biophys. 303: 98-106, 1983.
365. YOSHIZAWA, T., Y. HANDA, Y. UEMATSU, S. TAKEDA, K. SEKINE, Y. YOSHIHARA, T. KAWAKAMI, K. ARIOKA, H. SATO, AND Y. UCHIYAMA. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nature Genet. 16: 391-396, 1997.
366. ZECHEL, C., X. Q. SHEN, J. Y. CHEN, Z. P. CHEN, P. CHAMBON, AND H. GRONEMEYER. The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J. 13: 1425-1433, 1994.
367. 3. J. Biol. Chem. 272: 19027-19034, 1997.
368. ZIEROLD, C., H. M. DARWISH, AND H. F. DELUCA. Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter. J. Biol. Chem. 270: 1675-1678, 1995.