Distinct Conformations of Vitamin D Receptor/Retinoid X Receptor-α Heterodimers Are Specified by Dinucleotide Differences in the Vitamin D-Responsive Elements of the Osteocalcin and Osteopontin Genes

Molecular Endocrinology

Volumn 10, Issue 11, 1996, Pages 1444-1456

  Staal, A ^a,b   Van Wijnen, A J ^b   Birkenhager J C ^a   Pols, H A P ^a   Prahl, J ^c   DeLuca, H ^c   Gaub, Marie Pierre ^d   Lian, J B ^b   Stein, G S ^b   Van Leeuwen, J P T M ^a   Stein, J L ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d l'alimentation et l'Environnement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; DINUCLEOTIDE; DNA; MONOCLONAL ANTIBODY; NUCLEAR PROTEIN; OSTEOCALCIN; OSTEOPONTIN; RETINOID X RECEPTOR; VITAMIN D; VITAMIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; HORMONE RESPONSIVE ELEMENT; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT;

ANIMALS; ANTIBODIES; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; HUMANS; MICE; NUCLEIC ACID CONFORMATION; OSTEOCALCIN; OSTEOPONTIN; OSTEOSARCOMA; POINT MUTATION; PROTEIN CONFORMATION; RATS; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; SIALOGLYCOPROTEINS; STEROIDS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VITAMIN D;

ANIMALIA;

EID: 0030445914     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.10.11.8923469     Document Type: Article

References (63)

1. Darwish H, DeLuca HF 1993 Vitamin-D regulated gene expression. Crit Rev Eukary Gene Expr 3:89-116
2. Weinberger C, Bradley DJ 1990 Gene regulation by receptors binding lipid-soluble substances. Annu Rev Physiol 52:823-840
3. Tsai M-J, O'Malley BW 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
4. Freedman L, Luisi BF 1993 On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective. J Cell Biochem 51:140-150
5. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Näär AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG 1991 RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266
6. Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM 1992 Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature 355:446-449
7. Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Gamier JM, Mader S, Chambon P 1992 Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395
8. Marks MS, Hallenbeck PL, Nagata T, Segars JH, Appella E, Nikodem VM, Ozato K 1992 H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J 11:1419-1435
9. Bugge TJ, Pohl J, Lonnoy O, Stunnenberg HG 1992 RXRα, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J 11:1409-1418
10. Schrader M, Bendik I, Becker-Andre M, Carlberg C 1993 Interaction between retinoic acid and vitamin D signaling pathways. J Biol Chem 268:17830-17836
11. 3 receptors. Cell 65:1255-1266
12. Näär AM, Boutin JM, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG 1991 The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell 65:1267-1279
13. Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker W 1993 Two nuclear signalling pathways for vitamin D. Nature 361:657-660
14. 3 receptor in the absence of the retinoid × receptor. Mol Endocrinol 8:265-273
15. Nishikawa J, Kitaura M, Matsumoto M, Imagawa M, Nishihara T 1994 Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer. Nucleic Acids Res 22:2902-2907
16. Kerner SA, Scott RA, Pike JW 1989 Sequence elements in the human osteocalcin gene confer basal activation and inducible response to vitamin D3. Proc Natl Acad Sci USA 86:4455-4459
17. Ozono K, Liao J, Kerner SA, Scott RA, Pike JW 1990 The vitamin D-responsive element in the human osteocalcin gene. J Biol Chem 265:21881-21888
18. 3. Proc Natl Acad Sci USA 87:369-373
19. Markose ER, Stein JL, Stein GS, Lian JB 1990 Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene. Proc Natl Acad Sci USA 87:1701-1705
20. 3-mediated transcriptional activation. Mol Endocrinol 6:557-562
21. Breen EC, van Wijnen AJ, Lian JB, Stein GS, Stein JL 1994 In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D dependent transcriptional upregulation in intact cells. Proc Natl Acad Sci USA 91:12902-12906
22. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999
23. 3 24-hydroxylase gene. J Biol Chem 269:10545-10550
24. 24 gene. Nucleic Acids Res 22:2410-2416
25. Zierold C, Darwish HM, DeLuca HF 1995 Two vitamin D response elements function in the rat 1,25-dihydroxyvitamin D 24-hydroxylase promoter. J Biol Chem 270:1675-1678
26. Kahlen JP, Carlberg C 1994 Identification of a vitamin D receptor homodimer-type response element in the rat calcitriol 24-hydroxylase gene promoter. Biochem Biophys Res Commun 202:1366-1372
27. Gill RK, Christakos S 1993 Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses. Proc Natl Acad Sci USA 90:2984-2988
28. Cao X, Ross FP, Zhang L, MacDonald PN, Chappel J, Teitelbaum SL 1993 Cloning of the promoter for the avian integrin beta 3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3. J Biol Chem 268:27371-27380
29. 3. Proc Natl Acad Sci USA 87:9751-9755
30. Bortell R, Owen TA, Bidwell JP, Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS 1992 Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci USA 89:6119-6123
31. Bortell R, Owen TA, Shalhoub V, Heinrichs A, Aronow MA, Rochette-Egly C, Lutz Y, Stein JL, Lian JB, Stein GS 1993 Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements. Proc Natl Acad Sci USA 90:2300-2304
32. 3-activated expression of the rat osteocalcin gene. Mol Cell Biol 13:5907-5917
33. Ross TK, Darwish HM, Moss VE, DeLuca HF 1993 Vitamin D-influenced gene expression via a ligand-independent, receptor-DNA complex intermediate. Proc Natl Acad Sci USA 90:9257-9260
34. Shakoori AR, van Wijnen AJ, Bortell R, Owen TA, Stein JL, Lian JB, Stein GS 1994 Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells. J Cell Biochem 55:218-229
35. Cheskis B, Freedman LP 1994 Ligand modulates the conversion of DNA bound vitamin D receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol Cell Biol 14:3329-3338
36. Schrader M, Muller KM, Carlberg C 1994 Specificity and flexibility of vitamin D signaling: modulation of the activation of natural vitamin D response elements by thyroid hormone. J Biol Chem 269:5501-5504
37. Matkovits T, Christakos S 1995 Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation. Mol Endocrinol 9:232-242
38. Whitfield GK, J-C Hsieh, Nakajima S, MacDonald PN, Thompson PD, Jurutka P, Haussler CA, Haussler MR 1995 A highly conserved region in the hormone binding domain of the human vitamin D receptor contains residues vital for heterodimerization with retinoid X receptor and for transcriptional activation. Mol Endocrinol 9:1166-1179
39. 3. J Biol Chem 269:2971-2981
40. 3 are associated with enhanced activation of the vitamin D receptor. J Biol Chem 270:10551-10588
41. 3 receptor. Arch Biochem Biophys 286:466-472
42. 3 receptor-mediated enhancement of osteocalcin gene transcription: effects of perturbing phosphorylation pathways by okadaic acid and staurosporine. Endocrinology 136:5685-5693
43. 3 enhancement of osteocalcin and osteopontin transcription: reduced interactions of VDR/ RXR complexes with vitamin D response elements. Endocrinology 137:1991-2000
44. Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB 1995 Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol 9:679-690
45. Mader S, Chen J-Y, Chen Z, White J, Chambon P, Gronemeyer H 1993 The patterns of binding of RAR, RXR and TR homo and heterodimers to direct repeats are dictated by the binding specificities of the DNA binding domains. EMBO J 12:5029-5041
46. Perlmann T, Rangarajan PN, Umesono K, Evans RM, 1993 Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev 7:1411-1422
47. Kurokawa R, Yu VC, Näär A, Kyakumoto S, Han Z, Silverman S, Rosenfeld MG, Glass CK 1993 Differential orientations of the DNA binding domain and C-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev 7:1423-1435
48. Kurokawa R, DiRenzo J, Boehm M, Sugarman J, Gloss B, Rosenfeld MG, Heyman RA, Glass CK 1994 Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding. Nature 371:528-531
49. Schrader M, Muller KM, Nayeri S, Kahlen JP, Carlberg C 1994 Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation. Nature 370:382-386
50. Zechel C, Shen XQ, Chen JY, Chen ZP, Chambon P, Gronemeyer H 1994 The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J 13:1425-1433
51. Schrader M, Nayeri S, Kahlen JP, Muller KM, Carlberg C 1995 Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation. Mol Cell Biol 15:1154-1161
52. Yang YZ, Subauste JS, Koenig RJ 1995 Retinoid X receptor α binds with the highest affinity to an imperfect direct repeat response element. Endocrinology 136:2896-2903
53. Rastinejad F, Perlmann T, Evans RM, Sigler PB 1995 Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375:203-211
54. Jin CH, Pike JW 1994 Ordered binding of human vitamin D and retinoid X receptor complexes to asymmetric vitamin D responsive elements. In: Norman AW, Bouillon R, Thomaset M (eds) Vitamin D, A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications: Proceedings of the Ninth Workshop on Vitamin D. Walter de Gruyter, Berlin, pp 241-242
55. Luisi BF, Xu WX, Otnikowski Z, Freedman LP, Yamamoto KR, Sigler PB 1991 Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352:497-505
56. Blanco JC, Wang IM Tsai SY, Tsai MJ, O'Malley BW, Jurutka PW, Haussler MR, Ozato K 1995 Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-independent transcription. Proc Natl Acad Sci USA 92:1535-1539
57. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL 1994 Transcriptional control of the tissue-specific developmentally regulated osteocalcin gene requires a binding motif for the MSX-family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-12891
58. Heinrichs AAJ, Banerjee C, Bortell R, Owen TA, Stein JL, Stein GS, Lian JB 1993 Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation. J Cell Biochem 53:240-250
59. Towler DA, Bennett CD, Rodan GA 1994 Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinol 8:614-624
60. Towler DA, Rutledge SJ, Rodan GA 1994 Msx-1/Hox8.1: a transcriptional regulator of the rat osteocalcin promoter. Mol Endocrinol 8:1484-1493
61. Owen TA, Bortell R, Yocum SA, Smock SL, Zhang M, Abate C, Shalhoub V, Aronin N, Wright KL, van Wijnen AJ, Stein JL, Curran T, Lian JB, Stein GS 1990 Coordinate occupancy of AP-1 sites in the vitamin D responsive and CCAAT box elements by fos-jun in the osteocalcin gene: a model for phenotype suppression of transcription. Proc Natl Acad Sci USA 87:9990-9994
62. Banerjee C, Stein JL, van Wijnen AJ, Frenkel B, Lian JB, Stein GST GF-β 1 responsiveness of the rat osteocalcin gene is mediated by an AP-1 binding site. Endocrinology 137:2001-2011
63. Rochette-Egly C, Lutz Y, Saunders M, Scheuer I, Gaub M-P, Chambon P 1991 Retinoic acid receptor γ: specific immunodetection and phosphorylation. J Cell Biol 115: 535-545