A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

Genes and Development

Volumn 12, Issue 12, 1998, Pages 1787-1800

  Rachez, Christophe ^a   Suldan, Zalman ^a   Ward, Jeremy ^a   Chang, Chao Pei Betty ^a   Burakov, Darya ^a   Erdjument Bromage, Heidye ^b   Tempst, Paul ^b   Freedman, Leonard P ^a  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Cell free transcription; Ligand binding domain; Nuclear receptor coactivators; VDR transactivation; Vitamin D3 receptor

Indexed keywords

VITAMIN D RECEPTOR;

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; GENE ACTIVATION; GENE OVEREXPRESSION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

EID: 0032525781     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.12.1787     Document Type: Article

References (56)

1. Anzick, S.L., J. Kononen, R.L. Walker, D.O. Azorsa, M.M. Tanner, X.Y. Guan, G. Sauter, O.P. Kallioniemi, J.M. Trent, and P.S. Meltzer. 1997. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277: 965-968.
2. Baker, A.R., D.P. McDonnell, M. Hughes, T.M. Crisp, D.J. Mangelsdorf, M.R. Haussler, J.W. Pike, J. Shine, and B.W. O'Malley. 1988. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. 85: 3294-3298.
3. Barettino, D.M.V. Ruiz, and H.G. Stunnenberg. 1994. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J. 13: 3039-3049.
4. Blanco, J., I. Wang, S. Tsai, M. Tsai, B. O'Malley, P. Jurutka, M. Haussler, and K. Ozato. 1995. Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proc. Natl. Acad. Sci. 92: 1535-1539.
5. Bourguet, W., M. Ruff, P. Chambon, H. Groyenmeyer, and D. Moras. 1995. Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375: 377-388.
6. Brownell, J. and C. Allis. 1995. An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei. Proc. Natl. Acad. Sci. 92: 6364-6368.
7. Cavailles, V., S. Dauvois, F. L'Horset, G. Lopez, S. Hoare, P.J. Kushner, and M.G. Parker. 1995. Nuclear factor RIP140 modulates transcriptional activates by the estrogen receptor. EMBO J. 14: 3741-3751.
8. Chen, H.W., R.J. Lin, R.L. Schiltz, D. Chakravarti, A. Nash, L. Nagy, M.L. Privalsky, Y. Nakatani, and R.M. Evans. 1997. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580.
9. Chen, J.D. and R.M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
10. Cheskis, B. and L.P. Freedman. 1997. Modulation of steroid/ nuclear receptor dimerization and DNA binding by ligands. In Molecular biology of steroid and nuclear hormone receptors) (ed. L.P. Freedman, pp. 133-158. Birkhauser, Boston, MA.
11. 3. Mol. Endocribol. 9: 1814-1824.
12. Danielian, P.S., R. White, J.A. Lees, and M.G. Parker. 1992. Identification of a conseved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11: 1025-1033.
13. Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mamalian nuclei. Nucleic Acids Res. 11: 1475-1489.
14. Durand, B., M. Saunders, C. Gaundon, B. Roy, R. Losson, and P. Chambon. 1994. Activation function (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13: 5370-5382.
15. Fondell, J.D., H. Ge, and R.G. Roeder. 1996. Ligand induction of a transcriptionally active thyroid hormone receptor co-activator complex. Proc. Natl. Acad. Sci. 93: 8329-8333.
16. Forman, B.M., K. Umesono, J. Chen, and R.M. Evans. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81: 541-550.
17. Freedman, L.P., ed. 1997. Molecular biology of steroid and nuclear hormone receptors. Birkhauser, Boston, MA.
18. 3 receptor in the absence of the retinoid-X receptor. Mol. Endocrinol. 8: 265-273.
19. Glass, C.K., D.W. Rose, and M.G. Rosenfeld. 1997. Nuclear receptor coactivators. Curr. Opin. Cell Biol. 9: 222-232.
20. Hanstein, B., R. Eckner, J. DiRenzo, S. Halachmi, H. Liu, B. Searcy, R. Kurokawa, and M. Brown. 1996. p300 is a component of an estrogen receptor coactivator complex. Proc. Natl. Acad. Sci. 93: 11540-11545.
21. Heery, D.M., E. Kalkhoven, S. Hoare, and M.G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387: 733-736.
22. Heinzel, T., R.M. Lavinsky, T.M. Mullen, M. Soderstrom, C.D. Laherty, J. Torchia, W.M. Yang, G. Brard, S.D. Ngo, J.R. Davie, E. Seto, R.N. Eisenman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld. 1997. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387: 43-48.
23. Hong, H., K. Kohli, M.J. Garabedian, and M.R. Stallcup. 1997. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17: 2735-2744.
24. Horlein, A.J., A.M. Naar, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Y. Kamei, M. Soderstrom, C.K. Glass, and M.G. Rosenfeld. 1995. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-403.
25. Horwitz, K.B., T.A. Jackson, D.L. Bain, J.K. Richer, G.S. Takimoto, and L. Tung. 1996. Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10: 1167-1177.
26. Jurutka, P., J.-C. Hsieh, L. Remus, G. Whitfield, C. Haussler, J. Blanco, K. Ozato, and M. Haussler. 1997. Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from homrone binding, heterodimeric DNA binding, and interaction with TFIIB. J. Biol. Chem. 272: 14592-14599.
27. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. Kurokawa, B. Gloss, S.-C. Lin, R.A. Heyman, D.W. Rose, C.K. Glass, and M.G. Rosenfeld. 1996. A CBP-integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414.
28. Le Douarin, B., C. Zechel, J.-M. Gamier, Y. Lutz, L. Tora, B. Pierrat, D. Heery, H. Gronenmyer, P. Chambon, and R. Losson. 1995. The N-terminal part of TIF1, a putative mediator of the ligand dependent activation function (AF-2) of nuclear receptors, is fused to B-Raf in the oncogenic protein T18. EMBO J. 14: 2020-2033.
29. Lee, J.W., F. Ryan, J.C. Swaffield, S.A. Johnston, and D.D. Moore. 1995. Interaction of thyroid-hormone receptor with a conserved transcriptional mediator. Nature 374: 91-94.
30. Lemon, B.D. and L.P. Freedman. 1996. Selective effects of ligands on vitamin D3 receptor-and retinoid X receptor-mediated gene activation in vivo. Mol. Cell. Biol. 16: 1006-1016.
31. Lemon, B.D., J.D. Fondell, and L.P. Freedman. 1997. Retinoid X receptor: Vitamin D-3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D-3-dependent cell-free transcription. Mol. Cell. Biol. 17: 1923-1937.
32. Li, H., P.J. Gomes, and J.D. Chen. 1997. RAC3, a steroid/ nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. 94: 8479-8484.
33. Lui, M., P. Tempst, and H. Erdjument-Bromage. 1996. Methodical analysis of protein-nitrocellulose interactions to design a refined digestion protocol. Anal. Biochem. 241: 156-166.
34. MacDonald, P., D. Sherman, D. Dowd, S.J. Jefcoat, and R. DeLisle. 1995. The vitamin D receptor interacts with general transcription factor IIB. J. Biol. Chem. 270: 4748-4752.
35. Masuyama, H., C.M. Brownfield, R. St. Arnaud, and P.N. MacDonald. 1997. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction. Mol. Endocrinol. 11: 1507-1517.
36. May, M., G. Mengus, A.C. Lavigne, P. Chambon, and I. Davidson. 1996. Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors. EMBO J. 15: 3093-3104.
37. Mengus, G., M. May, L. Carre, P. Chambon, and I. Davidson. 1997. Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. Genes & Dev. 11: 1381-1395.
38. Nagase, T., N. Seki, A. Tanaka, K. Ishikawa, and N. Nomura. 1995. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 2: 167-174.
39. Nagy, L., H.Y. Kao, D. Chakravarti, R.J. Lin, C.A. Hassig, D.E. Ayer, S.L. Schreiber, and R.M. Evans. 1997. Nuclear receptor repression mediated by a complex containing SMRT, mSinSA, and histone deacetylase. Cell 89: 373-380.
40. Ogryzko, V., R. Schlitz, V. Russanova, B. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959.
41. Onate, S., S. Tsai, M.-J. Tsai, and B. O'Malley. 1995. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270: 1354-1357.
42. Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature 335: 683-689.
43. Ptashne, M. and A. Gann. 1997. Transcriptional activation by recruitment. Nature 386: 569-577.
44. Renaud, J.-P., N. Rochel, M. Ruff, V. Vivat, P. Chambon, H. Groyenmeyer, and D. Moras. 1995. Crystal structure of the RAR-g ligand-binding domain bound to all-trans retinoic acid. Nature 378: 681-689.
45. Sande, S. and M. Privalsky. 1996. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol. Endocrinol. 10: 813-825.
46. Spencer, T.E., G. Jenster, M.M. Burcin, C.D. Allis, J.X. Zhou, C.A. Mizzen, N.J. McKenna, S.A. Onate, S.Y. Tsai, M.J. Tsai, and B.W. Omalley. 1997. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389: 194-198.
47. Takeshita, A., P.M. Yen, S. Misiti, G.R. Cardona, Y. Liu, and W.W. Chin. 1996. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137: 3594-3597.
48. Takeshita, A., G.R. Cardona, N. Koibuchi, C.S. Suen, and W.W. Chin. 1997. TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J. Biol. Chem. 272: 27629-27634.
49. Tempst, P., S. Geromanos, C. Elicone, and H. Erdjument-Bromage. 1994. Improvements in microsequencer performances for low picomole sequence analysis. Methods: Companion Methods Enzymol. 6: 248-261.
50. Torchia, J., D.W. Rose, J. Inostroza, Y. Kamei, S. Westin, C.K. Glass, and M.G. Rosenfeld. 1997. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387: 677-684.
51. Valcarcel, R., M. Meyer, M. Meisterernst, and H. Stunnenberg. 1997. Requirement of cofactor for RXR/RAR-mediated transcriptional activation in vitro. Biochim. Biophys. Acta 1350: 229-234.
52. Voegel, J.J., M.J. Heine, C. Zechel, P. Chambon, and H. Gronemeyer. 1996. TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15: 3667-3675.
53. vom Baur, E., C. Zechel, D. Heery, M. Heine, J. Gamier, V. Vivat, B. Le Douarin, H. Gronemeyer, P. Chambon, and R. Losson. 1996. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 15: 110-124.
54. Wagner, R.L., J.W. Apriletti, M.E. McGrath, B.L. West, J.D. Baxter, and R.J. Fletterick. 1995. A structural role for hormone in the thyroid hormone receptor. Nature 378: 690-697.
55. Yang, X.J., V.V. Ogryzko, J. Nishikawa, B.H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319-324.
56. Yeh, S. and C. Chang. 1996. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. 93: 5517-5521.