Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: A HuGE review

American Journal of Epidemiology

Volumn 161, Issue 10, 2005, Pages 901-915

  Masson, Lindsey F ^a   Sharp, L ^a   Cotton, S C ^a   Little, J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Breast neoplasms; Cytochrome P 450 CYP1A1; Epidemiology; Polymorphism, genetic

Indexed keywords

ASPARTIC ACID; CYTOCHROME P450 1A1; CYTOSINE; ESTROGEN; ISOLEUCINE; POLYCYCLIC AROMATIC HYDROCARBON; THREONINE; THYMINE; VALINE;

CANCER; PAH; POLLUTION EXPOSURE;

AFRICAN AMERICAN; AMINO ACID SUBSTITUTION; ASIAN; BREAST CANCER; BREAST TUMOR; CAUCASIAN; CLINICAL TRIAL; ETHNIC DIFFERENCE; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GEOGRAPHIC DISTRIBUTION; HORMONE SYNTHESIS; HUMAN; LIFESTYLE; META ANALYSIS; NUCLEIC ACID BASE SUBSTITUTION; REVIEW; SYSTEMATIC REVIEW; XENOBIOTIC METABOLISM;

AGE FACTORS; BREAST NEOPLASMS; CAUSALITY; COMORBIDITY; CYTOCHROME P-450 CYP1A1; ENVIRONMENT; FEMALE; GENOTYPE; HUMANS; MENARCHE; MENOPAUSE; MUTATION; POLYMORPHISM, GENETIC; RISK FACTORS; SMOKING; SURVIVAL ANALYSIS; WORLD HEALTH;

NORTH AMERICA; UNITED STATES; WESTERN HEMISPHERE; WORLD;

EID: 18544371988     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/kwi121     Document Type: Review

References (270)

1. Nebert DW. Role of genetics and drug metabolism in human cancer risk. Mutat Res 1991;247:267-81.
2. McManus ME, Burgess WM, Veronese ME, et al. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochrome P-450. Cancer Res 1990;50:3367-76.
3. Dannan GA, Porubek DJ, Nelson SD, et al. 17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement. Endocrinology 1986;118:1952-60.
4. Spink DC, Eugster HP, Lincoln DW II, et al. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 1992;293:342-8.
5. Kawajiri K, Watanabe J, Gotoh O, et al. Structure and drug inducibility of the human cytochrome P-450c gene. Eur J Biochem 1986;159:219-25.
6. Spink DC, Spink BC, Cao JQ, et al. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 1998;19:291-8.
7. Smith CAD, Smith G, Wolf CR. Genetic polymorphisms in xenobiotic metabolism. Eur J Cancer 1994;30A:1921-35.
8. Huang Z, Fasco MJ, Figge HL, et al. Expression of cytochromes P450 in human breast tissue and tumors. Drug Metab Dispos 1996;24:899-905.
9. McKay JA, Murray GI, Ah-See AK, et al. Differential expression of CYP1A1 and CYP1B1 in human breast cancer. Biochem Soc Trans 1996;24:327S.
10. Nebert DW, Ingelman-Sundberg M, Daly AK. Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. Drug Metab Rev 1999;31:467-87.
11. Human Cytochrome P 450 Allele Nomenclature Committee. CYP1A1 allele nomenclature. 2004. (http://www.imm.ki.se/CYPalleles/cyp1a1.htm).
12. Garte S. The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1. Carcinogenesis 1998;19:1329-32.
13. Cascorbi I, Brockmoller J, Roots I. A C 4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res 1996;56:4965-9.
14. Bale AE, Nebert DW, McBride OW. Subchromosomal localization of the dioxin-inducible P1450 locus (CYP1) and description of two RFLPs detected within a 3′ P1450 cDNA probe. Cytogenet Cell Genet 1987;46:574-5.
15. Spurr NK, Gough AC, Stevenson K, et al. Msp-1 polymorphism detected with a cDNA probe for the P-450 I family on chromosome 15. Nucleic Acids Res 1987;15:5901.
16. Crofts F, Cosma GN, Currie D, et al. A novel CYP1A1 gene polymorphism in African-Americans. Carcinogenesis 1993;14:1729-31.
17. Hayashi S, Watanabe J, Nakachi K, et al. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene. J Biochem 1991;110:407-11.
18. Garte S, Gaspari L, Alexandrie AK, et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev 2001;10:1239-48.
19. Song N, Tan W, Xing D, et al. CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China. Carcinogenesis 2001;22:11-16.
20. Sikdar N, Mahmud SA, Paul RR, et al. Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. Cancer Lett 2003;195:33-42.
21. Kotekar A, Bhisey R. CYP1A1z.ast;2 and CYP1A1*3 polymorphisms cosegregate in the Indian population. Anthropol Anz 2002;60:255-60.
22. Kiyohara C, Wakai K, Mikami H, et al. Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women. Int J Cancer 2003;107:139-44.
23. Gorai I, Tanaka K, Inada M, et al. Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. J Clin Endocrinol Metab 2003;88:799-803.
24. Inoue H, Kiyohara C, Marugame T, et al. Cigarette smoking, CYP1A1 Msp1 and GSTM1 genotypes, and colorectal adenomas. Cancer Res 2000;60:3749-52.
25. Miyoshi Y, Takahashi Y, Egawa C, et al. Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J 2002;8:209-15.
26. Nakachi K, Imai K, Hayashi S, et al. Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res 1991;51:5177-80.
27. Kihara M, Kihara M, Noda K. Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis 1995;16:2331-6.
28. Yu MW, Chiu YH, Yang SY, et al. Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers. Br J Cancer 1999;80:598-603.
29. Wu M, Lee J, Wu D, et al. Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan. Br J Cancer 2002;87:529-32.
30. Lin P, Wang SL, Wang HJ, et al. Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma. Br J Cancer 2000;82:852-7.
31. Cheng YJ, Chien YC, Hildesheim A, et al. No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2, and nasopharyngeal carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev 2003;12:179-80.
32. Huang CS, Shen CY, Chang KJ, et al. Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan. Br J Cancer 1999;80:1838-43.
33. Wu FY, Lee YJ, Chen DR, et al. Association of DNA-protein crosslinks and breast cancer. Mutat Res 2002;501:69-78.
34. Aynacioglu AS, Cascorbi I, Mrozikiewicz PM, et al. High frequency of CYP1A1 mutations in a Turkish population. Arch Toxicol 1998;72:215-18.
35. Sarmanova J, Tynkova L, Susova S, et al. Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics 2000;10:781-8.
36. Sarmanova J, Benesov K, Gut I, et al. Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Hum Mol Genet 2001;10:1265-73.
37. Lucas D, Menez C, Floch F, et al. Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic Caucasians. Alcohol Clin Exp Res 1996;20:1033-7.
38. Fontana X, Peyrottes I, Rossi C, et al. Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mul gene in primary breast cancers: an update with an additional 114 cases. Mutat Res 1998;403:45-53.
39. Richter-Hintz D, Their R, Steinwachs S, et al. Allelic variants of drug metabolizing enzymes as risk factors in psoriasis. J Invest Dermatol 2003;120:765-70.
40. Ko Y, Abel J, Harth V, et al. Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res 2001;61:4398-404.
41. Paraskevaidis A, Drakoulis N, Roots I, et al. Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne. Dermatology 1998;196:171-5.
42. Harth V, Bruning T, Abel J, et al. Real-time genotyping of cytochrome P4501A1 A4889G and T6235C polymorphisms. Mol Cell Probes 2001;15:93-7.
43. Matthias C, Bockmuhl U, Jahnke V, et al. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics 1998;8:91-100.
44. Brockmoller J, Cascorbi I, Kerb R, et al. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 1996;56:3915-25.
45. Dialyna IA, Arvanitis DA, Spandidos DA. Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. Int J Mol Med 2001;8:79-87.
46. Arvanitis DA, Koumantakis GE, Goumenou AG, et al. CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis. Fertil Steril 2003;79:702-9.
47. Taioli E, Mari D, Franceschi C, et al. Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. Biochem Biophys Res Commun 2001;280:1389-92.
48. van Lieshout EM, Roelofs HM, Dekker S, et al. Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barretts' esophagus and esophageal carcinoma. Cancer Res 1999;59:586-9.
49. Tefre T, Ryberg D, Haugen A, et al. Human CYP1A1 (cytochrome P1450) gene: lack of association between the MspI restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics 1991;1:20-5.
50. Mrozikiewicz PM, Cascorbi I, Brockmoller J, et al. CYP1A1 mutations 4887A, 4889G, 5639C and 6235C in the Polish population and their allelic linkage, determined by peptide nucleic acid-mediated PCR clamping. Pharmacogenetics 1997;7:303-7.
51. Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, et al. Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population. Eur J Clin Pharmacol 2003;59:303-12.
52. Alexandrie AK, Sundberg MI, Seidegard J, et al. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis 1994;15:1785-90.
53. Sachse C, Smith G, Wilkie MJV, et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis 2002;23:1839-49.
54. Nicholl DJ, Bennett P, Hiller L, et al. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. Neurology 1999;53:1415-21.
55. Brockton NT. Genetic polymorphisms in folate and xenobiotic metabolism and susceptibility to colorectal cancer. Aberdeen, United Kingdom: University of Aberdeen, 2002.
56. Krajinovic M, Ghardirian P, Richer C, et al. Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions. Int J Cancer 2001;92:220-5.
57. Krajinovic M, Labuda D, Richer C, et al. Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms. Blood 1999;93:1496-501.
58. Ishibe N, Stampfer M, Hunter DJ, et al. A prospective study of cytochrome P450 1A1 polymorphisms and colorectal cancer risk in men. Cancer Epidemiol Biomarkers Prev 2000;9:855-6.
59. Garcia-Closas M, Kelsey KT, Wiencke JK, et al. A case-control study of cytochrome P450 1A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States). Cancer Causes Control 1997;8:544-53.
60. Taioli E, Ford J, Trachman J, et al. Lung cancer risk and CYP1A1 genotype in African Americans. Carcinogenesis 1998;19:813-17.
61. Xu X, Kelsey KT, Wiencke JK, et al. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev 1996;5:687-92.
62. Terry KL, Titus-Ernstoff L, Garner EO, et al. Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk. Cancer Epidemiol Biomarkers Prev 2003;12:187-90.
63. Taioli E, Bradlow HL, Garbers SV, et al. Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk. Cancer Detect Prevent 1999;23:232-7.
64. Duell EJ, Holly EA, Bracci PM, et al. A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk. J Natl Cancer Inst 2002;94:297-306.
65. Bailey LR, Roodi N, Verrier CS, et al. Breast cancer and CYP1A1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans. Cancer Res 1998;58:65-70.
66. da Fonte de Amorim LM, Rossini A, Mendonca GAS, et al. CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women. Cancer Lett 2002;181:179-86.
67. London SJ, Yuan JM, Coetzee GA, et al. CYP1A1 I462V genetic polymorphisms and lung cancer risk in a cohort of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2000;9:987-91.
68. Chan DK, Mellick GD, Buchanan DD, et al. Lack of association between CYP1A1 polymorphism and Parkinson's disease in a Chinese population. J Neural Transm 2002;109:35-9.
69. Buch S, Kotekar A, Kawle D, et al. Polymorphisms at CYP and GST gene loci. Prevalence in the Indian population. Eur J Clin Pharmacol 2001;57:553-5.
70. Oyama T, Mitsudomi T, Kawamoto T, et al. Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese. Int Arch Occup Environ Health 1995;67:253-6.
71. Oyama T, Kawamoto T, Mizoue T, et al. p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. Int J Oncol 1997;11:305-9.
72. Murata M, Shiraishi T, Fukutome K, et al. Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan. Jpn J Clin Oncol 1998;28:657-60.
73. Hayashi S, Watanabe J, Kawajiri K. High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and Mu-class glutathione S-transferase genes. Jpn J Cancer Res 1992;83:866-70.
74. Lee CY, Lee JY, Kang JW, et al. Effects of genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 on the urinary levels of 1-hydroxypyrene and 2-naphthol in aircraft maintenance workers. Toxicol Lett 2001;123:115-24.
75. Yang M, Jang JY, Kim S, et al. Genetic effects on urinary 1-hydroxypyrene levels in a Korean population. Carcinogenesis 2003;24:1085-9.
76. Aktas D, Guney I, Alikasifoglu M, et al. CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm. Gynecol Oncol 2002;86:124-8.
77. Ratnasinghe D, Tangrea JA, Stewart C, et al. Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking-lung cancer association. Anticancer Res 2001;21:1295-300.
78. Roddam PL, Rollinson S, Kane E, et al. Poor metabolizers at the Cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Pharmacogenetics 2000;10:605-15.
79. Basham VM, Pharoah PD, Healey CS, et al. Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk. Carcinogenesis 2001;22:1797-800.
80. Cantlay AM, Lamb D, Gillooly M, et al. Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer. J Clin Pathol Mol Pathol 1995;48:M210-14.
81. Ambrosone CB, Freudenheim JL, Graham S, et al. Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk. Cancer Res 1995;55:3483-5.
82. Evans AJ, Henner WD, Eilers KM, et al. Polymorphisms of GSTT1 and related genes in head and neck cancer risk. Head Neck 2004;26:63-70.
83. Rebbeck TR, Rosvold EA, Duggan DJ, et al. Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer. Cancer Epidemiol Biomarkers Prev 1994;3:511-14.
84. Longuemaux S, Delomenie C, Gallou C, et al. Candidate genetic modifiers of individual susceptibility to renal cell carcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes. Cancer Res 1999;59:2903-8.
85. London SJ, Daly AK, Fairbrother KS, et al. Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res 1995;55:6035-7.
86. Tabor HK, Risch NJ, Myers RM. Opinion: candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 2002;3:391-7.
87. Garte S, Ganguly S, Taioli E. Effect of genotype on steady-state CYP1A1 gene expression in human peripheral lymphocytes. Biochem Pharmacol 2003;65:441-5.
88. Cosma G, Crofts F, Currie D, et al. Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene. Cancer Epidemiol Biomarkers Prev 1993;2:53-7.
89. Landi MT, Bertazzi PA, Shields PG, et al. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics 1994;4:242-6.
90. Rumsby PC, Yardley-Jones A, Anderson D, et al. Detection of CYP1A1 mRNA levels and CYP1A1 MspI polymorphisms as possible biomarkers of exposure and susceptibility in smokers and non-smokers. Teratog Carcinog Mutagen 1996;16:65-74.
91. Whyatt RM, Bell DA, Jedrychowski W, et al. Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. Carcinogenesis 1998;19:1389-92.
92. Crofts F, Taioli E, Trachman J, et al. Functional significance of different human CYP1A1 genotypes. Carcinogenesis 1994;15:2961-3.
93. Kawajiri K, Nakachi K, Imai K, et al. The CYP1A1 gene and cancer susceptibility. Crit Rev Oncol Hematol 1993;14:77-87.
94. Persson I, Johansson I, Ingelman-Sundberg M. In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. Biochem Biophys Res Commun 1997;231:227-30.
95. Zhang ZY, Fasco MJ, Huang L, et al. Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis. Cancer Res 1996;56:3926-33.
96. Cosma G, Crofts F, Taioli E, et al. Relationship between genotype and function of the human CYP1A1 gene. J Toxicol Environ Health 1993;40:309-16.
97. Kiyohara C, Hirohata T, Inutsuka S. The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene. Jpn J Cancer Res 1996;87:18-24.
98. Kiyohara C, Nakanishi Y, Inutsuka S, et al. The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population. Pharmacogenetics 1998;8:315-23.
99. Jacquet M, Lambert V, Baudoux E, et al. Correlation between P450 CYP1A1 inducibility, MspI genotype and lung cancer incidence. Eur J Cancer 1996;32A:1701-6.
100. Wedlund PJ, Kimura S, Gonzalez FJ, et al. I462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of East Mediterranean descent. Pharmacogenetics 1994;4:21-6.
101. Daly AK, Fairbrother KS, Smart J. Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. Toxicol Lett 1998;102-103:143-7.
102. Smart J, Daly AK. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics 2000;10:11-24.
103. Firozi PF, Bondy ML, Sahin AA, et al. Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2 and GSTM1 in breast cancer. Carcinogenesis 2002;23:301-6.
104. Li D, Wang M, Firozi PF, et al. Characterization of a major aromatic DNA adduct detected in human breast tissues. Environ Mol Mutagen 2002;39:193-200.
105. Li D, Walcott FL, Chang P, et al. Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer. Cancer Res 2002;62:4566-70.
106. Brockstedt U, Krajinovic M, Richer C, et al. Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPS), myeloperoxidase (MPO), quinone oxidoreductase (NQ01), and glutathione S-transferases (GSTs). Mutat Res 2002;516:41-7.
107. Zhu J, Chang P, Bondy ML, et al. Detection of 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2003;12:830-7.
108. Li D, Firozi PF, Zhang W, et al. DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer. Mutat Res 2002;513:37-48.
109. Cheng YW, Chen CY, Lin P, et al. DNA adduct level in lung tissue may act as a risk biomarker of lung cancer. Eur J Cancer 2000;36:1381-8.
110. Cheng YW, Hsieh LL, Lin PP, et al. Gender difference in DNA adduct levels among nonsmoking lung cancer patients. Environ Mol Mutagen 2001;37:304-10.
111. Schoket B, Papp G, Levay K, et al. Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. Mutat Res 2001;482:57-69.
112. Rojas M, Alexandrov K, Cascorbi I, et al. High benzo(a)-pyrene diol-epoxide DNA adduct levels in lung and blood cells from subjects with combined CYP1A1 MspI/MspI-GSTM1*0/*0 genotypes. Pharmacogenetics 1998;8:109-18.
113. Ichiba M, Hagmar L, Rannug A, et al. Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps. Carcinogenesis 1994;15:1347-52.
114. Zhang J, Ichiba M, Feng Y, et al. Aromatic DNA adducts in coke-oven workers, in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes. Int Arch Occup Environ Health 2000;73:127-35.
115. Hemminki K, Dickey C, Karlsson S, et al. Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis 1997;18:345-50.
116. Kuljukka-Rabb T, Nylund L, Vaaranrinta R, et al. The effect of relevant genotypes on PAH exposure-related biomarkers. J Expo Anal Environ Epidemiol 2002;12:81-91.
117. Grzybowska E, Butkiewicz D, Motykiewicz G, et al. The effect of the genetic polymorphisms of CYP1A1, CYP2D6, GSTM1 and GSTP1 on aromatic DNA adduct levels in the population of healthy women. Mutat Res 2000;469:271-7.
118. Palli D, Vineis P, Russo A, et al. Diet, metabolic polymorphisms and DNA adducts: the EPIC-Italy cross-sectional study. Int J Cancer 2000;87:444-51.
119. Whyatt RM, Perera FP, Jedrychowski W, et al. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiol Biomarkers Prev 2000;9:207-12.
120. Teixeira JP, Gaspar J, Martinho G, et al. Aromatic DNA adduct levels in coke oven workers: correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1. Mutat Res 2002;517:147-55.
121. Rojas M, Cascorbi I, Alexandrov K, et al. Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. Carcinogenesis 2000;21:35-41.
122. Mooney LA, Bell DA, Santella RM, et al. Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogenesis 1997;18:503-9.
123. Matsui A, Ikeda T, Enomoto K, et al. Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett 2000;151:87-95.
124. Hong YC, Lee KH, Yi CH, et al. Genetic susceptibility of term women to oxidative damage. Toxicol Lett 2002;129:255-62.
125. Hong YC, Park HS, Ha EH. Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters. Occup Environ Med 2000;57:370-5.
126. Kim YD, Lee CH, Nan HM, et al. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. J Occup Health 2003;45:160-7.
127. Miyoshi Y, Ando A, Hasegawa S, et al. Association of genetic polymorphisms in CYP19 and CYP1A1 with the oestrogen receptor-positive breast cancer risk. Eur J Cancer 2003;39:2531-7.
128. Adonis M, Martinez V, Riquelme R, et al. Susceptibility and exposure biomarkers in people exposed to PAHs from diesel exhaust. Toxicol Lett 2003;144:3-15.
129. Alexandrie AK, Warholm M, Carstensen U, et al. CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. Carcinogenesis 2000;21:669-76.
130. Wu MT, Huang SL, Ho CK, et al. Cytochrome P450 1A1 MspI polymorphism and urinary 1-hydroxypyrene concentrations in coke-oven workers. Cancer Epidemiol Biomarkers Prev 1998;7:823-9.
131. Gil L, Martinez V, Riquelme R, et al. Occupational and environmental levels of mutagenic PAHs and respirable particulate matter associated with diesel exhaust in Santiago, Chile. J Occup Environ Med 2003;45:984-92.
132. Nerurkar PV, Okinaka L, Aoki C, et al. CYP1A1, GSTM1, and GSTP1 genetic polymorphisms and urinary 1-hydroxypyrene excretion in non-occupationally exposed individuals. Cancer Epidemiol Biomarkers Prev 2000;9:1119-22.
133. Apostoli P, Neri G, Lucas D, et al. Influence of genetic polymorphisms of CYP1A1 and GSTM1 on the urinary levels of 1-hydroxypyrene. Toxicol Lett 2003;144:27-34.
134. Pan G, Hanaoka T, Yamano Y, et al. A study of multiple biomarkers in coke oven workers - a cross-sectional study in China. Carcinogenesis 1998;19:1963-8.
135. Nan HM, Kim H, Lim HS, et al. Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations. Carcinogenesis 2001;22:787-93.
136. Yang M, Kunugita N, Kitagawa K, et al. Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphisms of drug-metabolizing enzymes. Cancer Epidemiol Biomarkers Prev 2001;10:589-93.
137. Kawamoto T, Koga M, Oyama T, et al. Habitual and genetic factors that affect urinary background levels of biomarkers for organic solvent exposure. Arch Environ Contam Toxicol 1996;30:114-20.
138. Ursin G, Ma H, Wu AH, et al. Mammographic density and breast cancer in three ethnic groups. Cancer Epidemiol Biomarkers Prev 2003;12:332-8.
139. Boyd NF, Lockwood GA, Byng JW, et al. Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998;7:1133-44.
140. Haiman CA, Hankinson SE, De Vivo I, et al. Polymorphisms in steroid hormone pathway genes and mammographic density. Breast Cancer Res Treat 2003;77:27-36.
141. GLOBOCAN. 2002 - Cancer incidence, mortality and prevalence worldwide, 2005. (http://www-depdb.iarc.fr/globocan/GLOBOframe.htm).
142. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999;80:827-41.
143. Pike MC, Spicer DV, Dahmoush L, et al. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 1993;15:17-35.
144. Parkin DM, Whelan SL, Ferlay J, et al, eds. Cancer incidence in five continents. Vol VIII. Lyon, France: International Agency for Research on Cancer, 2002. (IARC scientific publication no. 155).
145. Coleman MP, Esteve J, Damiecki P, et al. Trends in cancer incidence and mortality. IARC Sci Publ 1993;121:1-806.
146. Easton DF. The inherited component of cancer. Br Med Bull 1994;50:527-35.
147. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.
148. Bishop DT. Family history of breast cancer: how important is it? J Med Genet 1992;29:152-3.
149. Colditz GA, Willett WC, Hunter DJ, et al. Family history, age and risk of breast cancer. JAMA 1993;270:338-43.
150. Weber BL, Garber JE. Family history and breast cancer: probabilities and possibilities. JAMA 1993;270:1602-3.
151. Henderson BE, Pike MC, Bernstein L, et al. Breast cancer. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer epidemiology and prevention. 2nd ed. New York, NY: Oxford University Press, 1996:1022-39.
152. Beral V: Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419-27.
153. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
154. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Collaborative Group on Hormonal Factors in Breast Cancer. Lancet 1996;347:1713-27.
155. Newcomer LM, Newcomb PA, Trentham-Dietz A, et al. Oral contraceptive use and risk of breast cancer by histologic type. Int J Cancer 2003;106:961-4.
156. Weight control and physical activity. IARC handbooks of cancer prevention. Vol. 6. Lyon, France: International Agency for Research on Cancer, 2002.
157. Smith-Warner SA, Spiegelman D, Yaun SS, et al. Alcohol and breast cancer in women. A pooled analysis of cohort studies. JAMA 1998;279:535-40.
158. Morris JJ, Seifter E. The role of aromatic hydrocarbons in the genesis of breast cancer. Med Hypotheses 1992;38:177-84.
159. MacNicoll AD, Easty GC, Neville AM, et al. Metabolism and activation of carcinogenic polycyclic hydrocarbons by human mammary cells. Biochem Biophys Res Commun 1980;95:1599-606.
160. Li DH, Wang MY, Dhingra K, et al. Aromatic DNA adducts in adjacent tissues of breast cancer patients-clues to breast cancer etiology. Cancer Res 1996;56:287-93.
161. Davis DL, Bradlow HL, Wolff M, et al. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 1993;101:372-7.
162. Yuspa SH, Poirier MC. Chemical carcinogenesis: from animal models to molecular models in one decade. Adv Cancer Res 1988;50:25-70.
163. Hemminki K, Pershagen G. Cancer risk of air pollution: epidemiological evidence. Environ Health Perspect 1994;102:187-92.
164. Tobacco smoking. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 38. Lyon, France: International Agency for Research on Cancer, 1986.
165. Bennicke K, Conrad C, Sabroe S, et al. Cigarette smoking and breast cancer. BMJ 1995;310:1431-3.
166. Hirose K, Tajima K, Hamajima N, et al. A large scale, hospital based case-control study of risk factors of breast cancer according to menopausal status. Jpn J Cancer Res 1995;86:146-54.
167. Ambrosone CB, Freudenheim JL, Graham S, et al. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA 1996;276:1494-501.
168. Morabia A, Bernstein M, Héritier S, et al. Relation of breast cancer with passive and active exposure to tobacco smoke. Am J Epidemiol 1996;143:918-28.
169. Baron JA, Newcomb PA, Longnecker MP, et al. Cigarette smoking and breast cancer. Cancer Epidemiol Biomarkers Prev 1996:5:399-403.
170. Hunter DJ, Hankinson SE, Hough H, et al. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 1997;18:2127-32.
171. Khuder SA, Mutgi AB, Nugent S. Smoking and breast cancer: a meta-analysis. Rev Environ Health 2001;16:253-61.
172. Palmer JR, Rosenberg L, Clarke EA, et al. Breast cancer and cigarette smoking: a hypothesis. Am J Epidemiol 1991;134:1-13.
173. Terry PD, Rohan TE. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol Biomarkers Prev 2002;11:953-71.
174. Tredaniel J, Boffetta P, Saracci R, et al. Environmental tobacco smoke and the risk of cancer in adults. Eur J Cancer 1993;29A:2058-68.
175. Khuder SA, Simon VJ Jr. Is there an association between passive smoking and breast cancer? Eur J Epidemiol 2000;16:1117-21.
176. Tobacco smoke and involuntary smoking. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 83. Lyon, France: International Agency for Research on Cancer, 2004.
177. Vineis P, McMichael A. Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer. Cancer Causes Control 1996;7:479-86.
178. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Menasha, WI: Banta Book Group, 1997.
179. Boyd NF, Stone J, Vogt KN, et al. Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer 2003;89:1672-85.
180. De Stefani E, Ronco A, Mendilaharsu M, et al. Meat intake, heterocyclic
181. Jarvinen R, Knekt P, Seppanen R, et al. Diet and breast cancer risk in a cohort of Finnish women. Cancer Lett 1997;114:251-3.
182. Zheng W, Gustafson DR, Sinha R, et al. Well-done meat intake and the risk of breast cancer. J Natl Cancer Inst 1998;90:1724-9.
183. Dai Q, Shu XO, Jin F, et al. Consumption of animal foods, cooking methods, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2002;11:801-8.
184. Nakachi K, Imai K, Hayashi S, et al. Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res 1993;53:2994-9.
185. Ishibe N, Hankinson SE, Colditz GA, et al. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Res 1998;58:667-71.
186. Huang CS, Chern HD, Chang KJ, et al. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res 1999;59:4870-5.
187. Taioli E, Trachman J, Chen X, et al. A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women. Cancer Res 1995;55:3757-8.
188. Ritchie MD, Hahn LW, Roodi N, et al. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001;69:138-47.
189. StataCorp. Stata statistical software, release 7.0. College Station, TX: Stata Corporation, 2001.
190. Higgins JP, Thompson SG, Decks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
191. Goode EL, Dunning AM, Kuschel B, et al. Effect of germline genetic variation on breast cancer survival in a population-based study. Cancer Res 2002;62:3052-7.
192. Vineis P, Veglia F, Benhamou S, et al. CYP1A1 T3801C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls. Int J Cancer 2003;104:650-7.
193. Le Marchand L, Guo C, Benhamou S, et al. Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States). Cancer Causes Control 2003;14:339-46.
194. Taioli E, Gaspari L, Benhamou S, et al. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. Int J Epidemiol 2003;32:60-3.
195. Hung RJ, Boffetta P, Brockmoller J, et al. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis. Carcinogenesis 2003;24:875-82.
196. Kelsey KT, Wiencke JK, Spitz MR. A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans. Carcinogenesis 1994;15:1121-4.
197. Gsur A, Haidinger G, Hollaus P, et al. Genetic polymorphisms of CYP1A1 and GSTM1 and lung cancer risk. Anticancer Res 2001;21:2237-42.
198. Sato M, Sato T, Izumo T, et al. Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Carcinogenesis 1999;20:1927-31.
199. Sato M, Sato T, Izumo T, et al. Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes. Oral Oncol 2000;36:267-71.
200. Kao SY, Wu CH, Lin SC, et al. Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use. J Oral Pathol Med 2002;31:505-11.
201. Tanimoto K, Hayashi S, Yoshiga K, et al. Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose. Oral Oncol 1999;35:191-6.
202. Sreelekha TT, Ramadas K, Pandey M, et al. Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. Oral Oncol 2001;37:593-8.
203. Park JY, Muscat JE, Ren Q, et al. CYP1A1 and GSTM1 polymorphisms and oral cancer risk. Cancer Epidemiol Biomarkers Prev 1997;6:791-7.
204. Morita S, Yano M, Tsujinaka T, et al. Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Int J Cancer 1999;80:685-8.
205. Katoh T, Kaneko S, Kohshi K, et al. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer 1999;83:606-9.
206. Hahn M, Hagedorn G, Kuhlisch E, et al. Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. Oral Oncol 2002;38:486-90.
207. Worrall SF, Corrigan M, High A, et al. Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6. Pharmacogenetics 1998;8:433-9.
208. Hori H, Kawano T, Endo M, et al. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. J Clin Gastroenterol 1997;25:568-75.
209. Jahnke V, Matthias C, Fryer A, et al. Glutathione S-transferase and cytochrome P450 polymorphism as risk factors for squamous cell carcinoma of the larynx. Am J Surg 1996;172:671-3.
210. Oude Ophuis MB, van Lieshout EMM, Roelofs HMJ, et al. Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions. Cancer 1998;82:936-43.
211. Gronau S, Koenig-Greger D, Jerg M, et al. Gene polymorphisms in detoxification enzymes as susceptibility factor for head and neck cancer? Otolaryngol Head Neck Surg 2003;128:674-80.
212. McWilliams JE, Evans AJ, Beer TM, et al. Genetic polymorphisms in head and neck cancer risk. Head Neck 2000;22:609-17.
213. Olshan AF, Weissler MC, Watson MA, et al. GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev 2000;9:185-91.
214. Roth MJ, Dawsey SM, Wang GQ, et al. Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China. Cancer Lett 2000;156:73-81.
215. Nimura Y, Yokoyama S, Fujimori M, et al. Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking. Cancer 1997;80:852-7.
216. Sivaraman L, Leatham MP, Yee J, et al. CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Res 1994;54:3692-5.
217. Fritsch E, Bruning T, Jonkmanns C, et al. Detection of cytochrome P450 1B1 Bfr I polymorphism: genotype distribution in healthy German individuals and in patients with colorectal carcinoma. Pharmacogenetics 1999;9:405-8.
218. Butler WJ, Ryan P, Roberts-Thomson IC. Metabolic genotypes and risk for colorectal cancer. J Gastroenterol Hepatol 2001;16:631-5.
219. Dolzan V, Ravnik-Glavac M, Breskvar K. Genetic polymorphisms of xenobiotic metabolizing enzymes in human colorectal cancer. Radiol Oncol 1998;32:35-9.
220. Kiss I, Sandor J, Pajkos G, et al. Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-tranferase M1 enzymes. Anticancer Res 2000;20:519-22.
221. Ye Z, Parry JM. Genetic polymorphisms in the cytochrome P450 1A1, glutathione S-transferase M1 and T1, and susceptibility to colon cancer. Teratog Carcinog Mutagen 2002;22:385-92.
222. Suzuki K, Matsui H, Nakazato H, et al. Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study. Cancer Lett 2003;195:177-83.
223. Acevedo C, Opazo JL, Huidobro C, et al. Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people. Prostate 2003;57:111-17.
224. Beer TM, Evans AJ, Hough KM, et al. Polymorphisms of GSTP1 and related genes and prostate cancer risk. Prostate Cancer Prostatic Dis 2002;5:22-7.
225. Kinoshita M, Seno T, Shin S, et al. Polymorphic genotypes of enzymes involved in carcinogen metabolism as risk factors for the development of human cervical cancer. Jpn J Clin Chem 1994;23:195-202.
226. Kim JW, Lee CG, Park YG, et al. Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. Cancer 2000;88:2082-91.
227. Esteller M, Garcia A, Martinez-Palones JM, et al. Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci. Br J Cancer 1997;75:1385-8.
228. Esteller M, Garcia A, Martinez-Palones JM, et al. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. Carcinogenesis 1997;18:2307-11.
229. Esteller M, Garcia A, Martinez-Palones JM, et al. Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation. Am J Clin Pathol 1999;111:336-42.
230. Goodman MT, McDuffie K, Hernandez B, et al. CYP1A1, GSTM1, and GSTT1 polymorphisms and the risk of cervical squamous intraepithelial lesions in a multiethnic population. Gynecol Oncol 2001;81:263-9.
231. Yengi L, Inskip A, Gilford J, et al. Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma. Cancer Res 1996;56:1974-7.
232. Clairmont A, Sies H, Ramachandran S, et al. Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci. Carcinogenesis 1999;20:1235-40.
233. Krajinovic M, Labuda D, Mathonnet G, et al. Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. Clin Cancer Res 2002;8:802-10.
234. Balta G, Yuksek N, Ozyurek E, et al. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003;73:154-60.
235. Garte S, Taioli E, Crost F, et al. Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia. Leuk Res 2000;24:971-4.
236. Tsukasaki K, Miller CW, Kubota T, et al. Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers. Cancer Res 2001;61:3770-4.
237. Kerridge I, Lincz L, Scorgie F, et al. Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. Br J Haematol 2002;118:477-81.
238. Soucek P, Sarmanova J, Kristensen VN, et al. Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Int Arch Occup Environ Health 2002;75:S86-92.
239. Trizna Z, de Andrade M, Kyritsis AP, et al. Genetic polymorphisms in glutathione S-transferase mu and theta, N-acetyltransferase, and CYP1A1 and risk of gliomas. Cancer Epidemiol Biomarkers Prev 1998;7:553-5.
240. Lee HC, Yoon YB, Kim CY. Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer. Korean J Intern Med 1997;12:128-36.
241. Okada T, Kawashima K, Fukushi S, et al. Association between a cytochrome P450 CYP1A1 genotype and incidence of lung cancer. Pharmacogenetics 1994;4:333-40.
242. Liu G, Ghadirian P, Vesprini D, et al. Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma. Br J Cancer 2000;82:1646-9.
243. Fritsche E, Schuppe HC, Dohr O, et al. Increased frequencies of cytochrome P4501A1 polymorphisms in infertile men. Andrologia 1998;30:125-8.
244. von Schmiedeberg S, Fritsche E, Ronnau AC, et al. Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. Adv Exp Med Biol 1999;455:147-52.
245. Gardlo K, Selimovic D, Bolsen K, et al. Cytochrome P4501A1 polymorphisms in a Caucasian population with porphyria cutanea tarda. Exp Dermatol 2003;12:843-8.
246. Yen J, Tsai W, Chen C, et al. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Immunol Lett 2003;88:113-16.
247. Yen JH, Chen CJ, Tsai WC, et al. Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan. Hum Immunol 2003;64:366-73.
248. Hadfield RM, Manek S, Weeks DE, et al. Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1. Mol Hum Reprod 2001;7:1073-8.
249. Iizuka S, Kosugi Y, Isaka K, et al. Could polymorphisms of N-acetyltransferase 2 (NAT2), glutathione S-transferase M1 (GSTM1), and cytochrome P450 (CYP1A1) be responsible for genetic predisposition to endometriosis among Japanese? Zasshi/Tokyo Ika Daigaku 2003;61:59-66.
250. Takakubo F, Yamamoto M, Ogawa N, et al. Genetic association between cytochrome P4501A1 gene and susceptibility to Parkinson's disease. J Neural Transm 1996;103:843-9.
251. Kurth MC, Kurth JH. Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease. Am J Med Genet 1993;48:166-8.
252. Ivaschenko TE, Sideleva OG, Baranov VS. Glutathione-S-transferase mu and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J Mol Med 2002;80:39-43.
253. Binkova B, Smerhovsky Z, Strejc P, et al. DNA-adducts and atherosclerosis: a study of accidental and sudden death males in the Czech Republic. Mutat Res 2002;501:115-28.
254. de Jong DJ, van der Logt EM, van Schaik A, et al. Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase. Gut 2003;52:547-51.
255. Kimura K, Isashiki Y, Sonoda S, et al. Genetic association of manganese Superoxide dismutase with exudative age-related macular degeneration. Am J Opthalmol 2000;130:769-73.
256. Zusterzeel PLM, Nelen WLDM, Roelofs HMJ, et al. Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss. Mol Hum Reprod 2000;6:474-8.
257. van Rooij IALM, Wegerif MJM, Roelofs HMJ, et al. Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction. Epidemiology 2001;12:502-7.
258. Smith PG, Day NE. The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol 1984;13:356-65.
259. Khoury MJ, Beaty TH, Hwang SJ. Detection of genotype-environment interaction in case-control studies of birth defects: how big a sample size? Teratology 1995;51:336-43.
260. McKinney JD, Waller CL. Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 1994;102:290-7.
261. Norback DH, Weltman RH. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ Health Perspect 1985;60:97-105.
262. Laden F, Ishibe N, Hankinson SE, et al. Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev 2002;11:1560-5.
263. Moysich KB, Shields PG, Freudenheim JL, et al. Polychlorinated biphenyls, cytochrome P4501A1 polymorphism, and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 1999;8:41-4.
264. Vaury C, Lain, R, Noguiez P, et al. Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription. Cancer Res 1995;55:5520-3.
265. Mitrunen K, Hirvonen A. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 2003;544:9-41.
266. Sharp L, Cardy AH, Cotton SC, et al. CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors: a HuGE review. Am J Epidemiol 2004;160:729-40.
267. Little J, Bradley L, Bray MS, et al. Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. Am J Epidemiol 2002;156:300-10.
268. Ishibe N, Wiencke JK, Zuo Z, et al. Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans. Cancer Epidemiol Biomarkers Prev 1997;6:1075-80.
269. Garte S, Zocchetti C, Taioli E. Gene-environment interactions in the application of biomarkers of cancer susceptibility in epidemiology. In: Toniolo P, Boffetta P, Shuker DEG, et al, eds. Application of biomarkers in cancer epidemiology. Lyon, France: International Agency for Research on Cancer, 1997:251-64.
270. Botto LD, Khoury MJ. Commentary: facing the challenge of gene-environment interaction: the two-by-four table and beyond. Am J Epidemiol 2001;153:1016-20.