Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: Use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci

Carcinogenesis

Volumn 20, Issue 7, 1999, Pages 1235-1240

  Clairmont, Annette ^a   Sies, Helmut ^a   Ramachandran, Sudarshan ^b   Lear, John T ^c   Smith, Andrew G ^c   Bowers, Bill ^d   Jones, Peter W ^b   Fryer, Anthony A ^b   Strange, Richard C ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b KEELE UNIVERSITY   (United Kingdom)

^c UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^d ROYAL CORNWALL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GLUTATHIONE TRANSFERASE; HORMONE RECEPTOR; INTERMEDIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ARTICLE; BASAL CELL CARCINOMA; CANCER RISK; CONTROLLED STUDY; ENZYME POLYMORPHISM; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; STATISTICAL MODEL;

AGE FACTORS; ALLELES; BINOMIAL DISTRIBUTION; CARCINOMA, BASAL CELL; FEMALE; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MODELS, GENETIC; MULTIVARIATE ANALYSIS; NAD(P)H DEHYDROGENASE (QUINONE); POLYMORPHISM, GENETIC; RISK FACTORS; SEX FACTORS; SKIN NEOPLASMS;

EID: 0032804227     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.7.1235     Document Type: Article

References (26)

1. Karagas, M.R. and Greenberg, E.R. (1995) Unresolved issues in the epidemiology of basal cell and squamous cell skin cancer. In Mukhtar, H. (ed.) Skin Cancer: Mechanisms and Human Relevance. CRC Press, Boca Raton, FL, pp. 79-86.
2. Kricker, A., Armstrong, B.K., English, D.R. and Heenan, P.J. (1995) A doseresponse curve for sun exposure and basal cell carcinoma. Int. J. Cancer, 60, 482-488.
3. Lear, J.T., Tan, B.B., Smith, A.G., Bowers, W., Jones, P.W., Heagerty, A.H., Strange, R.C. and Fryer, A.A. (1997) Risk factors for basal cell carcinoma in the UK: case-control study in 806 patients. J. Royal Soc. Med., 90, 371-374.
4. Ramachandran, S., Lear, J.T., Ramsay, H., Smith, A.G., Bowers, B., Hutchinson, P.E., Jones, P.W., Fryer, A.A. and Strange, R.C. (1999) Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol. Biomarkers Prevent., 8, 61-67.
5. Heagerty, A.H.M., Fitzgerald, D., Smith, A., Bowers, B., Jones, P., Fryer, A., Zhao, L., Alldersea, J. and Strange, R.C. (1994) Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous malignancy. Lancet, 343, 266-268.
6. Lear, J.T., Heagerty, A.H.M., Smith, A. et al. (1996) Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. Carcinogenesis, 12, 1891-1896.
7. Lear, J.T., Smith, A.G., Heagerty, A.H.M., Bowers, B., Jones, P.W., Gilford, J., Alldersea, J., Strange, R.C. and Fryer, A.A. (1997) Truncal site and detoxifying enzyme polymorphisms significantly reduce time to presentation of further primary cutaneous basal cell carcinoma Carcinogenesis, 18, 1499-1503.
8. Yengi, L., Inskip, A., Gilford, J. et al. (1996) Polymorphism at the glutathione S-transferase locus GSTM3: interaction with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple basal cell carcinoma. Cancer Res., 56, 1974-1977.
9. Strange, R.C. and Fryer, A.A. (1999) The glutathione S-transferases: influence of polymorphism on susceptibility to cancer. In Boffetta, P., Caporaso, N., Cuzick, J., Lang, M. and Vineis, P. (eds) Metabolic Polymorphisms and Cancer. IARC Scientific Publications, Lyon, France (in press).
10. Xie, T., Belinsky, M., Xu, Y. and Jaiswal, A.K. (1995) ARE-and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants. J. Biol. Chem., 270, 6894-6900.
11. Waleh, N.S., Calaoagan, J., Murphy, B.J., Knapp, A.M., Sutherland, R.M. and Laderoute, K.K. (1998) The redox-sensitive human antioxidant responsive element induces gene expression under low oxygen conditions. Carcinogenesis, 19, 1333-1337.
12. Alvarez, S. and Boveris, A. (1997) Antioxidant adaptive response in human blood mononuclear cells exposed to UVB. J. Photochem. Photobiol. B Biol., 38, 152-157.
13. Eickelmann, P., Schulz, W.A., Rohde, D., Schmitz-Dräger, B. and Sies, H. (1994) Loss of heterozygosity at the NAD(P)H: NQO1 locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line. Biol. Chem. Hoppe-Seyler, 375, 439-445.
14. Rosvold, E.A., McGlynn, K.A., Lustbader, E.D. and Buetow, K.H. (1995) Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking. Pharmacogenetics, 5, 199-206.
15. Schulz, W.A., Krummeck, A., Rosinger, I., Eickelmann, P., Neuhaus, C., Ebert, T., Schmitz-Drager, B.J. and Sies, H. (1997) Increased frequency of a null allele for NAD(P)H:quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics, 7, 235-239.
16. Weincke, J.K., Spitz, M., McMillan, A. and Kelsey, K.T. (1997) Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism. Cancer Epidemiol. Biomarkers Prevent., 6, 87-92.
17. Valverde, P., Healy, E., Jackson, I., Rees, J.L. and Thody,A.J. (1995) Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nature Genet., 11, 328-330.
18. Box, N.F., Wyeth, J.R., O'Gorman, L.E., Martin, N.G. and Sturm, R.A. (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum. Mol. Genet., 6, 1891-1897.
19. Sturm, R.A., Box, N.F. and Ramsay, M. (1998) Human pigmentation genetics: the difference is only skin deep. Bioessays, 20, 1-11.
20. Ichii Jones, F., Ramachandran, S., Lear, J.T., Smith, A., Bowers, B., Ollier, W,E.R., Jones, P.W., Fryer, A.A. and Strange, R.C. (1999) The melanocyte stimulating hormone receptor polymorphism: association of the V92M and A294H alleles with basal cell carcinoma. Clin. Chim. Acta (in press).
21. Lear, J.T., Smith, A.G., Bowers, B., Heagerty, A.H.M., Jones, P.W., Gilford, J., Alldersea, J., Strange, R.C. and Fryer, A.A. (1997) Truncal tumour site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1 and cytochrome P450, CYP1A1 genotypes and their interaction. J. Invest. Dermat., 108, 519-522.
22. Ichii-Jones, F., Lear, J.T., Heagerty, A.H.M. et al. (1998) Susceptibility to malignant melanoma: influence of skin type and polymorphism in the melanocyte stimulating hormone receptor gene. J. Invest. Dermat., 111, 218-221.
23. Drinkwater, N.R. and Klotz, J.H. (1981) Statistical methods for the analysis of tumor multiplicity data. Cancer Res., 41, 113-119.
24. Hoy, E.E. (1996) Nonmelanoma skin carcinoma in Albuquerque, New Mexico. Cancer, 77, 2489-2495.
25. Frankel, W.N. and Schork, N.J. (1996) Who's afraid of epistasis? Nature Genet., 14, 371-373.
26. Fijnemann, R.J.A., Jansen, R.C., van der Valk, M.A. and Demant, P. (1998) High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. Cancer Res., 58, 4794-4798.