Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer

American Journal of Human Genetics

Volumn 69, Issue 1, 2001, Pages 138-147

  Ritchie, Marylyn D ^a   Hahn, Lance W ^a   Roodi, Nady ^a   Bailey, L Renee ^a   Dupont, William D ^a   Parl, Fritz F ^a   Moore, Jason H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ESTROGEN METABOLISM; GENE EXPRESSION; GENE LOCUS; GENETIC POLYMORPHISM; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; SIBLING; STATISTICAL ANALYSIS;

EID: 0034973569     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/321276     Document Type: Article

References (42)

1. Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk
2. Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer
3. Breast cancer and CYP1A1, GSTM1, and GSTT1 polymorphisms: Evidence of a lack of association in Caucasians and African Americans
4. A C4887A polymorphism in exon 7 of human CYP1A1: Population frequency, mutation linkages, and impact on lung cancer susceptibility
5. Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators
6. Estrogen and the risk of breast cancer
7. Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53297 women with breast cancer and 100239 women without breast cancer from 54 epidemiological studies
8. Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer
9. The risk of determining risk with multivariable models
10. Influence of exogenous estrogens, proliferative breast disease, and other variables on breast cancer risk
11. Who's afraid of epistasis?
12. Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: Association of polymorphisms with functional differences in estrogen hydroxylation activity
13. Breast cancer
14. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene
15. Breast cancer epidemiology
16. Reproductive and hormonal risk factors
17. Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders
18. An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer
19. A complete enumeration and classification of two-locus disease models
20. Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer
21. Catechol-O-methyltransferase and breast cancer risk
22. Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones
23. A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation
24. A simulation study of the number of events per variable in logistic regression analysis
25. In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility
26. Reversal of relation between body mass and endogenous estrogen concentrations with menopausal status
27. Genetics of CYP1A1: Coamplification of specific alleles by polymerase chain reaction and association with breast cancer
28. Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion
29. Sequence analysis and homology modeling suggest primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1
30. Genetic polymorphism of catechol-O-methyltransferase (COMT): Correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland
31. Epistasis and complex traits
32. Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk
33. Epistasis as a genetic constraint within populations and an accelerant of adaptive divergence among them
34. Gene deletion of glutathione S-transferase O: Correlation with induced genetic damage and potential role in endogenous mutagenesis
35. The Genometric Analysis Simulation Program (G.A.S.P.): A software tool for testing and investigating methods in statistical genetics
36. Molecular mechanisms of estrogen carcinogenesis
37. Prospective study of relative weight and risk of breast cancer: The Breast Cancer Detection Demonstration Project follow-up study, 1979 to 1987-1989