CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure

Carcinogenesis

Volumn 21, Issue 4, 2000, Pages 669-676

  Alexandrie, Anna Karin ^a,b   Warholm, Margareta ^a,b   Carstensen, Ulrica ^c   Axmon, Anna ^d   Hagmar, Lars ^d   Levin, Jan Olof ^b   Östman, Conny ^b,e   Rannug, Agneta ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYPYRENE; BIOLOGICAL MARKER; DNA; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DNA POLYMORPHISM; EXCRETION; GAS MASK; GENOTYPE; HUMAN; INDUSTRIAL WORKER; MAJOR CLINICAL STUDY; OCCUPATIONAL EXPOSURE; PARTICULATE MATTER; PRIORITY JOURNAL; REGRESSION ANALYSIS; SMOKING HABIT; URINE;

EID: 0034008024     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.4.669     Document Type: Article

References (45)

1. Carstensen, U., Hou, S.M., Alexandrie, A.K., Hogstedt, B., Tagesson, C., Warholm, M., Rannug, A., Lambert, B., Axmon, A. and Hagmar, L. (1999) Influence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbons. Scand. J. Work Environ. Health, 25, 351-360.
2. Carstcnsen, U., Yang, K., Levin, J.O., Ostman, C., Nilsson, T., Hemminki, K. and Hagmar, L. (1999) Genotoxic exposures of potroom workers. Scand. J. Work Environ. Health, 25, 24-32.
3. Kim, J.H., Stansbury, K.H., Walker, N.J., Trush, M.A., Strickland, P.T. and Sutter, T.R. (1998) Metabolism of benzo[a]pyrene and benzo[α]pyrene-7,8-diol by human cytochrome P450 1B1. Carcinogenesis, 19, 1847-1853.
4. Nelson, D.R., Koymans, L., Kamataki, T., Stegeman, J.J., Feyereisen, R., Waxman, D.J., Waterman, M.R., Gotoh, O., Coon, M.J., Estabrook, R.W., Gunsalus, I.C. and Nebert, D.W. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 6, 1-42.
5. Guengerich, F.P. (1993) The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals. Drug Metab. Dispos., 21, 1-6.
6. Bartsch, H., Castegnaro, M., Rojas, M., Camus, A.M., Alexandrov, K. and Lang, M. (1992) Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer. Tuxicol. Lett., 64-65, 477-483.
7. Kellermann, G., Shaw, C.R. and Luyten-Kellerman, M. (1973) Aryl hydrocarbon hydroxylase inducibilily and bronchogenic carcinoma. N. Engl. J. Med., 289, 934-937.
8. Bartsch, H., Rojas, M., Alexandrov, K., Camus, A.M., Castegnaro, M., Malaveille, C., Anttila, S., Hirvonen, K., Husgafvel-Pursiainen, K., Hietanen, E. et al. (1995) Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans. Pharmacogenetics, 5, S84-S90.
9. Rannug, A., Alexandrie, A.-K., Persson, I. and Ingelman Sundberg, M. (1995) Genetic polymorphism of cytochromes P4501A1, 2D6 and 2E1. Regulation and toxicological significance. J. Occup. Environ. Med., 37, 25-36.
10. Spivack, S.D., Fasco, M.J., Walker, V.E. and Kaminsky, L.S. (1997) The molecular epidemiology of lung cancer. Crit. Rev. Toxicol., 27, 319-365.
11. Rojas, M., Bouvier, G., Alexandrov, K., Cascorbi, I., Brockmöller, J., Likhachev, A., Pozharisski, K., Bouvier, G., Auburtin, G., Mayer, L., Koop-Schneider, A., Roots, I. and Bartsch, H. (1998) High benzo[α]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/MspI-GSTMI*0/*0 genotypes. Pharmacogenetics, 8, 109-118.
12. Przygodzki, R.M., Bennett, W.P., Guinee, D.G. Jr, Khan, M.A., Freedman, A., Shields, P.G., Travis, W.D., Jett, J.R., Tazelaar, H., Pairolero, P., Trastek, V., Liotta, L.A., Harris, C.C. and Caporaso, N.E. (1998) p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer. Pharmacogenetics, 8, 503-511.
13. Wormhoudt, L.W., Commandeur, J.N. and Vermeulen, N.P. (1999) Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. Crit. Rev. Toxicol., 29, 59-124.
14. Hassett, C., Aicher, L., Sidhu, J.S. and Omiecinski, C.J. (1994) Human microsomal epoxide hydrolase-genetic polymorphism and functional expression in vitro of amino acid variants. Hum. Mol. Genet., 3, 421-428.
15. Seidegard, J., Worachek, W.R., Pero, R.W. and Pearson, W.R. (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc. Natl Acad. Sci. USA, 85, 7293-7297.
16. McWilliams, J., Sanderson, B., Harris, E., Richen-Boe, K. and Henner, W. (1995) Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk. Cancer Epidemiol. Biomarkers Prev., 4, 589-594.
17. Warholm, M., Alexandrie, A.K., Hogberg, J., Sigvardsson, K. and Rannug, A. (1994) Polymorphic distribution of glutathione transferase activity with methyl chloride in human blood. Pharmacogenetics, 4, 307-311.
18. Warholm, M., Rane, A., Alexandrie, A.K., Monaghan, G. and Rannug, A. (1995) Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in a Swedish population. Pharmacogenetics, 5, 252-254.
19. Hengstler, J.G., Arand, M., Herrero, M.E. and Oesch, F. (1998) Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res., 154, 47-85.
20. Ali-Osman, F., Akande, O., Antoun, G., Mao, J.X. and Buolamwim, J. (1997) Molecular cloning, characterization and expression in Escherichia coli of full-lenglh cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J. Biol. Chem., 272, 10004-10012.
21. Zimniak, P., Nanduri, B., Pikula, S., Bandorowicz-Pikula, J., Singhal, S.S., Srivastava, S.K., Awasthi, S. and Awasthi, Y.C. (1994) Naturally occurring human glulathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur. J. Biochem., 224, 893-899.
22. Sundberg, K., Johansson, A.S., Stenberg, G., Widersten, M., Seidel, A., Mannervik, B. and Jernstrom, B. (1998) Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis, 19, 433-436.
23. Levin, J.O. (1995) First international workshop on hydroxypyrene as a biomarker for PAH exposure in man - summary and conclusions. Sci. Total Environ., 163, 164-168.
24. Angerer, J., Mannschreck, C. and Gundel, J. (1997) Biological monitoring and biochemical effect monitoring of exposure to polycyclic aromatic hydrocarbons. Int. Arch. Occup. Environ. Health, 70, 365-377.
25. Jongeneelen, F.J. (1997) Methods for routine biological monitoring of carcinogenic PAH-mixtures. Sci. Total Environ., 199, 141-149.
26. VanRooij, J.G., Bodelier-Bade, M.M. and Jongeneelen, F.J. (1993) Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. Br. J. Ind. Med., 50, 623-632.
27. Brzeznicki, S., Jakubowski, M. and Czerski, B. (1997) Elimination of 1-hydroxypyrene after human volunteer exposure to polycyclic aromatic hydrocarbons. Int. Arch. Occup. Environ. Health, 70, 257-260.
28. Östman, C., Bemgård, A. and Colmsjö, A. (1992) On-line liquid chromatography-gas Chromatography for automated clean up and analysis of polycyclic aromatic hydrocarbons. J. High Res. Chromatogr., 15, 437-443.
29. Jongeneelen, F.J., Anzion, R.B. and Henderson, P.T. (1987) Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J. Chromatogr., 413, 227-232.
30. Hayashi, S., Watanabe, J., Nakachi, K. and Kawajiri, K. (1991) Genetic-linkage of lung cancer-associated Mspl polymorphisms with amino acid replacement in the heme binding region of the human cytochrome-P4501A1 gene. J. Biochem., 110, 407-411.
31. Alexandrie, A.K., Ingelman-Sundberg, M., Seidegard, J., Tornling, G. and Rannug, A. (1994) Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis, 15, 1785-1790.
32. Brockmoller, J., Gross, D., Kerb, R., Drakoulis, N. and Roots, I. (1992) Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class Mu gene detected by polymerase chain reaction. Biochem. Pharmacol., 43, 647-650.
33. Pemble, S., Schroeder, K.R., Spencer, S.R., Meyer, DJ., Hallier, E., Bolt, H.M., Ketterer, B. and Taylor, J.B. (1994) Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J., 300, 271-276.
34. Armstrong, B.G., Tremblay, C.G., Cyr, D. and Theriault, G.P. (1986) Estimating the relationship between exposure to tar volatiles and the incidence of bladder cancer in aluminum smelter workers. Scand. J. Work Environ. Health, 12, 486-493.
35. Armstrong, B., Tremblay, C., Baris, D. and Theriault, G. (1994) Lung cancer mortality and polynuclear aromatic hydrocarbons: a case-cohort study of aluminum production workers in Arvida, Quebec, Canada. Am. J. Epidemiol., 139, 250-262.
36. WHO (1987) Air quality guidelines for Europe. WHO Regional Publication. European Series No. 23. World Health Organization, Copenhagen, Denmark.
37. Gilbert, N.L. and Viau, C. (1997) Biological monitoring of environmental exposure to PAHs in the vicinity of a Soderberg aluminium reduction plant. Occup. Environ. Med., 54, 619-621.
38. Elovaara, E. (1995) Oxidation of pyrene in human liver and lungs. Hum. Exp. Toxicol., 14, 821.
39. Wu, M.T., Huang, S.L., Ho, C.K., Yeh, Y.F. and Christiani, D.C. (1998) Cytochrome P450 1A1 Msp1 polymorphism and urinary 1-hydroxypyrene concentrations in coke-oven workers. Cancer Epidemiol. Biomarkers Prev., 7, 823-829.
40. Pan, G., Hanaoka, T., Yamano, Y., Hara, K., Ichiba, M., Wang, Y., Zhang, J., Feng, Y., Shujuan, Z., Guan, D., Gao, G., Liu, N. and Takahashi, K. (1998) A study of multiple biomarkers in coke oven workers-a cross-sectional study in China. Carcinogenesis, 19, 1963-1968.
41. Merlo, F., Andreassen, A., Weston, A., Pan, C.F., Haugen, A., Valerio, F., Reggiardo, G., Fontana, V., Garte, S., Puntoni, R. and Abbondandolo, A. (1998) Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons. Cancer Epidemiol. Biomarkers Prev., 7, 147-155.
42. Costa, DJ., Slott, V., Binkova, B., Myers, S.R.J. and Lewtas, J. (1998) Influence of GSTM1 and NAT2 genotypes on the relationship between personal exposure to PAH and biomarkers of internal dose. Biomarkers, 3, 411-424.
43. Vaury, C., Laine, R., Noguiez, P., Decoppet, P., Jaulin, C., Praz, F., Pompon, D. and Amorgueret, M. (1995) Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription. Cancer Res., 55, 5520-5523.
44. Hayashi, S., Watanabe, J. and Kawajiri, K. (1992) High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and Mu-class glutathione S-transferase genes. Jpn. J. Cancer Res., 83, 866-870.
45. Kihara, M., Kihara, M. and Noda, K. (1995) Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis, 16, 2331-2336.