Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia

Pharmacogenetics

Volumn 10, Issue 7, 2000, Pages 605-615

  Roddam, P L ^a   Rollinson, S ^a   Kane, E ^a   Roman, E ^a   Moorman, A ^a   Cartwright, R ^a   Morgan, G J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Adult acute leukaemia; Cytochrome P450; Polymorphism and predisposition

Indexed keywords

CYTOCHROME P450 2C19; DEBRISOQUINE 4 HYDROXYLASE; ETHOXYRESORUFIN DEETHYLASE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CANCER RISK; CHROMOSOME ABERRATION; CIGARETTE SMOKING; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG METABOLISM; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; HUMAN; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; MIDDLE AGE; MIXED FUNCTION OXYGENASES; POLYMORPHISM (GENETICS); RISK FACTORS; SUPPORT, NON-U.S. GOV'T;

EID: 0033790667     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200010000-00004     Document Type: Article

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