A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer

Carcinogenesis

Volumn 18, Issue 11, 1997, Pages 2127-2132

  Hunter, David J ^a,c,d   Hankinson, Susan E ^a   Hough, Heather ^e   Gertig, Dorota M ^a   Garcia Closas, Montserrat ^a   Spiegelman, Donna ^a   Manson, Joann E ^a   Colditz, Graham A ^a,c   Willett, Walter C ^a,c   Speizer, Frank E ^e   Kelsey, Karl ^a,b,c  

^a Department of Epidemiology ^*

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD CENTER FOR CANCER PREVENTION   (United States)

^d CHANNING LABORATORY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE;

ACETYLATION; ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CAUCASIAN; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; POSTMENOPAUSE; PREGNANCY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ACETYLATION; AGED; ARYLAMINE N-ACETYLTRANSFERASE; BREAST NEOPLASMS; FEMALE; GENOTYPE; HUMANS; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SMOKING;

EID: 0031418205     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.11.2127     Document Type: Article

References (38)

1. Kelsey, J.L. and Horn-Ross, P.L. (1993) Breast cancer: magnitude of the problem and descriptive epidemiology. Epidemiol. Rev., 15, 7-16.
2. Colditz, G.A. and Frazier, A.L. (1995) Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol. Biomarkers Prev., 4, 567-571.
3. Madigan, M.P., Ziegler, R.G., Benichou, J., Byrne, C. and Hoover, R.N. (.1995) Proportion of breast cancer cases in the United States explained by well-established risk factors. J. Natl Cancer Inst., 87, 1681-1685.
4. Davis, D.L., Bradlow, H.L., Wolff, M., Woodruff, T., Hoel, D.G. and Anton-Culver, H. (1993) Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ. Hlth Perspect., 101, 372-377.
5. Kelsey, J. (1993) Breast cancer epidemiology: summary and future directions. Epidemiol. Rev., 15, 256-263.
6. Russo, J. and Russo, I.H. (1987) Biological and molecular basis of mammary carcinogenesis. Lab. Invest., 57, 112-137.
7. Pfau, W., O'Hare, M.J., Grover, P.L. and Phillips, D.H. (1992) Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells. Carcinogenesis, 13, 907-909.
8. Calaf, G. and Russo, J. (1993) Transformation of human breast epithelial cells by chemical carcinogens. Carcinogenesis, 14, 483-492.
9. Vineis, P. and Caporaso, N. (1995) Tobacco and cancer: epidemiology and the laboratory. Environ. Hlth Perspect., 103, 156-160.
10. Perera, F.P., Estabrook, A., Hewer, A. et al. (1995) Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol. Biomarkers Prev., 4, 233-238.
11. Palmer, J.R. and Rosenberg, L. (1993) Cigarette smoking and the risk of breast cancer. Epidemiol. Rev., 15, 145-156.
12. Vineis, P., Bartsch, H., Caporoso, N. et al. (1994) Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens. Nature, 369, 154-156.
13. Hein, D.W. (1988) Acetylator genotype and arylamine-induced carcinogenesis. Biochim. Biophys. Acta, 948, 37-66.
14. Grimmer, G., Naujack, K-W. and Dettbarn, G. (1987) Gaschromatographic determination of polycyclic aromatic hydrocarbons, aza-arenes, aromatic amines in the particle and vapor phase of mainstream and sidestream smoke of cigarettes. Toxicol. Lett., 35, 117-124.
15. Raza, H., King, R.S., Squires, R.B. et al. (1996) Metabolism of 2-amino-α-carboline: A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. Drug Metab. Disposition, 24, 395-400.
16. Bartsch, H., Malaveille, C. Friesen, M., Kadlubar, F.F. and Vineis, P. (1993) Black(air-cured) and blond (flue-cured) tobacco cancer risk IV: Molecular dosimetry studies implicate aromatic amines as bladder carcinogens. Eur. J. Cancer, 29A, 1199-1207.
17. Lang, N.P., Butler, M.A., Massengill, J. et al. (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol. Biomarkers Prev. 3, 675-682.
18. Bell, D.A., Stephens, E.A., Castranio, T. et al. (1995) Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT-1) increases risk of colorectal cancer. Cancer Res., 55, 3537-3542.
19. Lin, H.J., Han, C-Y., Lin, B.K. and Hardy, S. (1993) Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 asians, blacks, hispanics, and whites: application to metabolic epidemiology. Am. J. Hum. Genet., 52, 827-834.
20. Paulsen, J.E., Steffensen, I.-L., Namork, E., Hein, D.W. and Alexander, J. (1996) Effect of acetylator genotype on 3,2′-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters. Carcinogenesis, 17, 459-465.
21. Bulovskaya, L.N., Krupkin, R.G., Bochina, T.A., Shipkova, A.A. and Pavlova, M.V. (1978) Acetylator phenotype in patients with breast cancer. Oncology, 35, 185-188.
22. Philip, P.A., Rogers, H.J., Millis, R.R., Rubens, R.D. and Cartwright, R.A. (1987) Acetylator status and its relationship to breast cancer and other diseases of the breast. Eur. J. Cancer Clin. Oncol., 23, 1701-1706.
23. Ladero, J.M., Fernandez, M.J., Palmeiro, R. et al. (1987) Hepatic acetylator polymorphism in breast cancer patients. Oncology, 44, 341-344.
24. Webster, D.J.T., Flook, D., Jenkins, J., Hutchings, A. and Routledge, P.A. (1989) Drug acetylation in breast cancer. Br. J. Cancer, 60, 236-237.
25. Ilett, K.F., Detchon, P., Ingram, D.M. and Castleden, W.M. (1990) Acetylation phenotype is not associated with breast cancer. Cancer Res., 50, 6649-6651.
26. Agundez, J.A.G., Ladero, J.M., Olivera, M., Abildua, R., Roman, J.M. and Benitez, J. (1995) Genetic analysis of the arylamine N-acetyltransferase polymorphism in breast cancer patients. Oncology, 52, 7-11.
27. Ambrosone, C.B., Freudenheim, J.L., Graham, S. et al. (1996) Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. J. Am. Med. Assoc., 276, 1494-1501.
28. Colditz, G.A., Hankinson, S.E., Hunter, D.J. et al. (1995) The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. New Engl. J. Med., 332, 1589-1593.
29. Bell, D.A., Taylor, J.A., Butler, M.A. et al. (1993) Genotype/phenotype discordance for human arylamine N-acelyltransferase (NAT-2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis, 41, 1689-1692.
30. Vatsis, K.P., Weber, W.W., Bell, D.A. et al. (1995) Nomenclature for N-acetyltransferases. Pharmacogenetics, 5, 1-17.
31. Kelsey, KT., Hankinson, SE., Colditz, G. et al. (1995) Glutathione S-transferase class μ deletion polymorphism and breast cancer; results from prevalent vs. incident cases. Cancer Epidemiol. Biomarkers Prev. (in press).
32. Palmer, J.R., Rosenberg, L., Clarke, E.A. et al. (1991) Breast cancer and cigarette smoking: a hypothesis. Am. J. Epidemiol., 134, 1-13.
33. Brinton, L.A., Schairer, C., Stanford, J.L. et al. (1986) Cigarette smoking and breast cancer. Am. J. Epidemiol., 123, 614-622.
34. Adami, H-O., Lund, E., Bergstrom, R. et al. (1988) Cigarette smoking, alcohol consumption and risk of breast cancer in young women. Br. J. Cancer, 58, 832-837.
35. Field, N.A., Baptiste, M.S., Nasca, P.C. et al. (1992) Cigarette smoking and breast cancer. Int. J. Epidemiol., 21, 842-848.
36. Chu, S.Y., Stroup, N.E., Wingo, P.A. et al. (1990) Cigarette smoking and the risk of breast cancer. Am. J. Epidemiol., 131, 244-253.
37. London, S.J., Colditz, G.A., Stampfer, M.J. et al (1989) Prospective study of smoking and the risk of breast cancer. J. Natl Cancer Inst., 81, 1625-1631.
38. Smith, P.G. and Day, N.E. (1984) The design of case-control studies: The influence of confounding and interaction effects. Int. J. Epidemiol., 13, 356-365.