Systems approaches to biological rhythms in Drosophila

Methods in Enzymology

Volumn 393, Issue , 2005, Pages 61-185

  Hall, Jeffrey C ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INSECT PROTEIN;

ALLELE; ANALYTIC METHOD; ANTENNA; AUTOANALYSIS; BEHAVIOR; BIOTECHNOLOGY; BRAIN NERVE CELL; BRAIN REGION; CELL DEATH; CELL INTERACTION; CELL TYPE; CHEMOSENSITIVITY; CHROMOSOME ANALYSIS; CHRONOBIOLOGY; CIRCADIAN RHYTHM; COMPUTER ANALYSIS; DROSOPHILA; EMBRYO DEVELOPMENT; ENVIRONMENTAL FACTOR; EXPERIMENT; FEEDBACK SYSTEM; FLY; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENOMICS; GENOTYPE; HABITUATION; HEAD; HISTOCHEMISTRY; HOMOZYGOSITY; INSECT; INSECT CELL; INSECT DEVELOPMENT; INSECT GENETICS; LARVA; LEARNING; LIFE CYCLE; MEMORY; METAMORPHOSIS; MOLECULAR BIOLOGY; MOLECULAR GENETICS; MOLECULE; NERVE CELL; NERVOUS SYSTEM; NERVOUS TISSUE; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; OSCILLATION; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REGULATORY MECHANISM; REVIEW; SENSITIZATION; SEQUENCE ANALYSIS; SEXUAL BEHAVIOR; SLEEP WAKING CYCLE; STRUCTURE ANALYSIS; TEMPERATURE; TISSUE; TRANSGENE;

ANIMALIA; ARENA; INSECTA;

EID: 16844379892     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)93004-8     Document Type: Article

References (349)

1. Akten B., Jauch E., Genova G.K., Kim E.Y., Edery I., Raabe T., Jackson F.R. A role for CK2 in the Drosophila circadian oscillator. Nature Neurosci. 6:2003;251-257
2. Allada R. Circadian clocks: A tale of two feedback loops. Cell. 112:2003;284-286
3. Allada R., Emery P., Takahashi J.S., Rosbash M. Stopping time: The genetics of fly and mouse circadian clocks. Annu. Rev. Neurosci. 24:2001;1091-1119
4. Allada R., Kadener S., Nandakumar N., Rosbash M. A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J. 22:2003;3367-3375
5. Allada R., White N.E., So W.V., Hall J.C., Rosbash M. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell. 93:1998;791-804
6. Alt S., Ringo J., Talyn B., Bray W., Dowse H. The period gene controls courtship song cycles in Drosophila melanogaster. Anim. Behav. 56:1998;87-97
7. qα isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. Proc. Natl. Acad. Sci. USA. 93:1996;12278-12282
8. Andretic R., Chaney S., Hirsh J. Requirement of circadian genes for cocaine sensitization in Drosophila. Science. 285:1999;1066-1068
9. Andretic R., Hirsh J. Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 97:2000;1873-1878
10. Arvanitogiannis A., Stewart J., Amir S. Conditioned stimulus control in the circadian system: Two tales tell one story. J. Biol. Rhythms. 15:2000;292-293
11. Ashmore L.J., Sathyanarayanan S., Silvestre D.W., Emerson M.M., Schotland P., Sehgal A. Novel insights into the regulation of the timeless protein. J. Neurosci. 23:2003;7810-7819
12. Baker B.S., Taylor B.J., Hall J.C. Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell. 105:2001;13-24
13. Baker J.D., McNabb S.L., Truman J.W. The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster. J. Exp. Biol. 202:1999;3037-3048
14. Bangs P., Franc N., White K. Molecular mechanisms of cell death and phagocytosis in Drosophila. Cell Death Differ. 7:2000;1027-1034
15. Bargiello T.A., Jackson F.R., Young M.W. Restoration of circadian behavioural rhythms by gene transfer in Drosophila. Nature. 312:1984;752-754
16. Bargiello T.A., Saez L., Baylies M.K., Gasic G., Young M.W., Spray D.C. The Drosophila clock gene per affects intercellular junctional communication. Nature. 328:1987;686-691
17. Bargiello T.A., Young M.W. Molecular genetics of a biological clock in Drosophila. Proc. Natl. Acad. Sci. USA. 81:1984;2142-2146
18. Beaver L.M., Giebultowicz J.M. Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14:2004;1492-1497
19. Beaver L.M., Gvakharia B.O., Vollintine T.S., Hege D.M., Stanewsky R., Giebultowicz J.M. Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 99:2002;2134-2139
20. Beaver L.M., Rush B.L., Gvakharia B.O., Giebultowicz J.M. Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster. J. Biol. Rhythms. 18:2003;463-472
21. Belvin M.P., Zhou H., Yin J.C.P. The Drosophila dCREB2 gene affects the circadian clock. Neuron. 22:1999;777-787
22. Bennett R. Circadian rhythm of visual sensitivity in Manduca sexta and its development from an ultradian rhythm. J. Comp. Physiol. A. 150:1983;164-174
23. Blanchardon E., Grima B., Klarsfeld A., Chélot E., Hardin P.E., Préat T., Rouyer F. Defining the role of Drosophila lateral neurons in the control of activity and eclosion rhythms by targeted genetic ablation and PERIOD overexpression. Eur. J. Neurosci. 13:2001;871-888
24. Blau J. The Drosophila circadian clock: What we know and what we don't know. Semin. Cell Dev. Biol. 12:2001;287-293
25. Blau J. A new role for an old kinase: CK2 and the circadian clock. Nature Neurosci. 6:2003;208-210
26. Blau J., Young M.W. Cycling vrille expression is required for a functional Drosophila clock. Cell. 99:1999;661-671
27. Brand A. GFP as a cell and developmental marker in the Drosophila nervous system. Methods Cell Biol. 58:1999;165-181
28. Brand A.H., Dormand E.L. The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system. Curr. Opin. Neurobiol. 5:1995;572-578
29. Brandes C., Plautz J.D., Stanewsky R., Jamison C.F., Straume M., Wood K.V., Kay S.A., Hall J.C. Novel features of Drosophila period transcription revealed by real-time luciferase reporting. Neuron. 16:1996;687-692
30. Brandstaetter R. Circadian lessons from peripheral clocks: Is the time of the mammalian pacemaker up? Proc. Natl. Acad. Sci. USA. 101:2004;5699-5700
31. Brett W.J. Persistent diurnal rhythmicity in Drosophila emergence. Ann. Entomol. Soc. Am. 48:1955;119-131
32. Busza A., Emery-Le M., Rosbash M., Emery P. Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science. 304:2004;1503-1506
33. Ceriani M.F., Darlington T.K., Staknis D., Más P., Petti A.A., Weitz C.J., Kay S.A. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 285:1999;553-556
34. Chang D.C., Reppert S.M. A novel C-terminal domain of Drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription. Curr. Biol. 13:2003;758-762
35. Chen D.-M., Christianson J.S., Sapp R.J., Stark W.S. Visual receptor cycle in normal and period mutant Drosophila: Microspectrophotometry, electrophysiology, and ultrastructural morphometry. Vis. Neurosci. 9:1992;125-135
36. Cheng Y., Hardin P.E. Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J. Neurosci. 18:1998;741-750
37. Choi Y.J., Lee G., Hall J.C., Park J.H. Comparative analysis of corazonin-encoding genes (Crz's) in four Drosophila species and functional insight into Crz-expressing neurons. J. Comp. Neurol. 2005;. In press.
38. Citri Y., Colot H.V., Jacquier A.C., Yu Q., Hall J.C., Baltimore D., Rosbash M. A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature. 326:1987;42-47
39. Clark A.C., del Campo M.L., Ewer J. Neuroendocrine control of larval ecdysis behavior in Drosophila: Complex regulation by partially redundant neuropeptides. J. Neurosci. 24:2004;4283-4292
40. Collins B.H., Rosato E., Kyriacou C.P. Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C. Proc. Natl. Acad. Sci. USA. 101:2004;1945-1950
41. Connolly J.B., Roberts I.J., Armstrong J.D., Kaiser K., Forte M., Tully T., O'Kane C.J. Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science. 274:1996;2104-2107
42. Cyran S.A., Buchsbaum A.M., Reddy K.L., Lin M.C., Glossop N.R., Hardin P.E., Young M.W., Storti R.V., Blau J. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell. 112:2003;329-341
43. Daan S. Learning and circadian behavior. J. Biol. Rhythms. 15:2000;296-299
44. Darlington T., Wager-Smith K., Ceriani M.F., Staknis D., Gekakis N., Steeves T., Weitz C., Takahashi J.S., Kay S.A. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors, per and tim. Science. 280:1998;1599-1603
45. Dauwalder B., Tsujimoto S., Moss J., Mattox W. The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev. 16:2002;2879-2892
46. de Groot M.H., Rusak B. Responses of the circadian system of rats to conditioned and unconditioned stimuli. J. Biol. Rhythms. 15:2000;277-291
47. Demetriades M.C., Thackeray J.R., Kyriacou C.P. Courtship song rhythms in Drosophila yakuba. Anim. Behav. 57:1999;379-386
48. DiBartolomeis S.M., Akten B., Genova G., Roberts M.A., Jackson F.R. Molecular analysis of the Drosophila miniature-dusky (m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin. Mol. Genet. Genom. 267:2002;564-576
49. Dissel S., Codd V., Fedic R., Garner K.J., Costa R., Kyriacou C.P., Rosato E. A constitutively active cryptochrome in Drosophila melanogaster. Nature Neurosci. 7:2004;834-840
50. Dow J.T., Davies S.A. Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiol. Rev. 83:2003;687-729
51. Dowse H.B., Dushay M.S., Hall J.C., Ringo J.M. High-resolution analysis of locomotor activity rhythms in disconnected, a visual-system mutant of Drosophila melanogaster. Behav. Genet. 19:1989;529-542
52. Dowse H.B., Ringo J.M. Comparisons between "periodograms" and spectral analysis: Apples are apples after all. J. Theor. Biol. 148:1991;139-144
53. Dubnau J. Neurogenetic dissection of conditioned behavior: Evolution by analogy or homology? J. Neurogenet. 17:2004;295-326
54. Duffield G.E. DNA microarray analyses of circadian timing: The genomic basis of biological time. J. Neuroendocrinol. 15:2003;991-1002
55. Dushay M.S., Rosbash M., Hall J.C. The disconnected visual system mutations in Drosophila drastically disrupt circadian rhythms. J. Biol. Rhythms. 4:1989;1-27
56. Edery I., Zwiebel L.J., Dembinska M.E., Rosbash M. Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. USA. 91:1994;2260-2264
57. Egan E.S., Franklin T.M., Hildebrand-Chae M.J., McNeil G.P., Roberts M.A., Schroeder A.J., Zhang X., Jackson F.R. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. J. Neurosci. 19:1999;3665-3673
58. Emery I.F., Noveral J.M., Jamison C.F., Siwicki K.K. Rhythms of Drosophila period gene expression in culture. Proc. Natl. Acad. Sci. USA. 94:1997;4092-4096
59. Emery P., So W.V., Kaneko M., Hall J.C., Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 95:1998;669-679
60. Emery P., Stanewsky R., Hall J.C., Rosbash M. Drosophila cryptochrome: A unique circadian-rhythm photoreceptor. Nature. 404:2000a;456-457
61. Emery P., Stanewsky R., Helfrich-Forster C., Emery-Le M., Hall J.C., Rosbash M. Drosophila CRY is a deep brain circadian photoreceptor. Neuron. 26:2000b;493-504
62. Etter P.D., Ramaswami M. The ups and downs of daily life: Profiling circadian gene expression in Drosophila. BioEssays. 24:2002;494-498
63. Ewer J., Frisch B., Hamblen-Coyle M.J., Rosbash M., Hall J.C. Expression of the period clock gene within different cells types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 12:1992;3321-3349
64. Ewer J., Reynolds S. Neuropeptide control of molting in insects. Pfaff D.W., Arnold A.P., Fahrbach S.E., Etgen A.M., Rubin R.T. "Hormones, Brain and Behavior" vol. 3:2002;1-92 Academic Press, San Diego
65. Flint K.K., Rosbash M., Hall J.C. Transfer of dye among salivary gland cells is not affected by genetic variations of the period clock gene in Drosophila melanogaster. J. Membr. Biol. 136:1993;333-342
66. Frank K.D., Zimmerman W.F. Action spectra for phase shifts of a circadian rhythm in Drosophila. Science. 163:1969;688-689
67. Frisch B., Hardin P.E., Hamblen-Coyle M.J., Rosbash M., Hall J.C. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron. 12:1994;555-570
68. Gailey D.A., Villella A., Tully T. Reassessment of the effects of biological rhythm mutations on learning in Drosophila melanogaster. J. Comp. Physiol. A. 169:1991;685-697
69. L. Science. 270:1995;811-815
70. George R., Lease K., Burnette J., Hirsh J. A "bottom-counting" video system for measuring cocaine-induced behaviors in Drosophila. Methods Enzymol. 393:(44):2005;837-847. (this volume).
71. George H., Terracol R. The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. Genetics. 146:1997;1345-1363
72. Giebultowicz J.M. Insect circadian rhythms: Is it all in their heads? J. Insect Physiol. 45:1999;791-800
73. Giebultowicz J.M. Molecular mechanism and cellular distribution of insect circadian clocks. Annu. Rev. Entomol. 45:2000;767-791
74. Giebultowicz J.M. Peripheral clocks and circadian timing: Insights from insects. Phil. Trans. Roy. Soc. Lond. B. 356:2001;1791-1799
75. Giebultowicz J.M., Ivanchenko M., Vollintine T. Organization of the insect circadian system: Spatial and developmental of clock genes in peripheral tissues of Drosophila melanogaster. Denlinger D.L., Giebultowicz J., Saunders D.S. "Insect Timing: Circadian Rhythmicity and Seasonality" 2001;31-42 Elsevier Science B. V, Amsterdam
76. Giebultowicz J.M., Stanewsky R., Hall J.C., Hege D.M. Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host. Curr. Biol. 10:2000;107-110
77. Greenspan R.J., Tononi G., Cirelli C., Shaw P.J. Sleep and the fruit fly. Trends Neurosci. 24:2001;142-145
78. Grima B., Chélot E., Xia R., Rouyer F. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature. 431:2004;869-873
79. Grima B., Lamouroux A., Chélot E., Papin C., Limbourg-Bouchon B., Rouyer F. The F-box protein slimb controls the levels of clock proteins period and timeless. Nature. 420:2002;178-182
80. Hall J.C. Tripping along the trail to the molecular mechanisms of biological clocks. Trends Neurosci. 18:1995;230-240
81. Hall J.C. Molecular neurogenetics of biological rhythms. J. Neurogenet. 12:1998;115-181
82. Hall J.C. Cryptochrome: Sensory reception, transduction and clock functions subserving circadian systems. Curr. Opin. Neurobiol. 10:2000;456-466
83. Hall J.C. Genetics and molecular biology of rhythms in Drosophila and other insects. Adv. Genet. 48:2003a;1-286
84. Hall J.C. A neurogeneticist's manifesto. J. Neurogenet. 17:2003b;1-90
85. Hall J.C., Kyriacou C.P. Genetics of biological rhythms in Drosophila. Adv. Insect Physiol. 22:1990;221-298
86. - mutants. J. Neurogenet. 3:1986;249-291
87. Hamblen-Coyle M.J., Wheeler D.A., Rutila J.E., Rosbash M., Hall J.C. Behavior of period-altered circadian rhythm mutants of Drosophila in light:dark cycles. J. Insect Behav. 5:1992;417-446
88. Hardin P.E. Analysis of period mRNA cycling in Drosophila head and body tissues indicates that body oscillators behave differently from head oscillators. Mol. Cell. Biol. 4:1994;7211-7218
89. Hardin P.E., Hall J.C., Rosbash M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature. 343:1990;536-540
90. Hardin P.E., Hall J.C., Rosbash M. Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. EMBO J. 11:1992;1-6
91. Hardin P.E., Krishnan B., Houl J.H., Zheng H., Ng F.S., Dryer S.E., Glossop N.R. Central and peripheral oscillators in Drosophila. Novartis Found. Symp. 253:2003;150-160
92. Harms E., Young M.W., Saez L. CK1 and GSK3 in the Drosophila and mammalian circadian clock. Novartis Found. Symp. 253:2003;267-277
93. Hazelrigg T. GFP and other reporters. Sullivan W., Ashburner M., Hawley R.S. "Drosophila Protocols" 2000;313-343 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
94. Hege D.M., Stanewsky R., Hall J.C., Giebultowicz J.M. Rhythmic expression of a PER-reporter in the Malpighian tubules of decapitated Drosophila: Evidence for a brain-independent circadian clock. J. Biol. Rhythms. 12:1997;300-308
95. Helfrich C. Role of the optic lobes in the regulation of the locomotor activity rhythms in Drosophila melanogaster: Behavioral analysis of neural mutants. J. Neurogenet. 3:1986;321-343
96. Helfrich-Förster C. The period clock gene is expressed in CNS neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 92:1995;612-616
97. Helfrich-Förster C. Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of Drosophila melanogaster. J. Comp. Neurol. 380:1997;335-354
98. Helfrich-Förster C. Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: A brain-behavioral study of disconnected mutants. J. Comp. Physiol. A. 182:1998;435-453
99. Helfrich-Förster C. Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster-sex-specific differences suggest a different quality of activity. J. Biol. Rhythms. 15:2000;135-154
100. Helfrich-Förster C. The activity rhythm of Drosophila melanogaster is controlled by a dual oscillator system. J. Insect Physiol. 47:2001;877-887
101. Helfrich-Förster C. The circadian system of Drosophila melanogaster and its light input pathways. Zoology. 105:2002;297-312
102. Helfrich-Förster C. The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster. Microsc. Res. Tech. 62:2003;94-102
103. Helfrich-Förster C., Edwards T., Yasuyama K., Wisotzki B., Schneuwly S., Stanewsky R., Meinertzhagen I.A., Hofbauer A. The extraretinal eyelet of Drosophila: Development, ultrastructure, and putative circadian function. J. Neurosci. 22:2002a;9255-9266
104. Helfrich-Förster C., Homberg U. Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity. J. Comp. Neurol. 337:1993;177-190
105. Helfrich-Förster C., Stengl M., Homberg U. Organization of the circadian system in insects. Chronobiol. Int. 15:1998;567-594
106. Helfrich-Förster C., Täuber M., Park J.H., Mühlig-Versen M., Schneuwly S., Hofbauer A. Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster. J. Neurosci. 20:2000;3339-3353
107. Helfrich-Förster C., Winter C., Hofbauer A., Hall J.C., Stanewsky R. The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron. 30:2001;249-261
108. Helfrich-Förster C., Wülf J., de Belle J.S. Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster. J. Neurogenet. 16:2002b;73-109
109. Hendricks J.C. Sleeping flies don't lie: The use of Drosophila melanogaster to study sleep and circadian rhythms. J. Appl. Physiol. 94:2003;1660-1672
110. Hendricks J.C., Sehgal A. Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep. Sleep. 27:2004;334-342
111. Hirsh J. Decapitated Drosophila: A novel system for the study of biogenic amines. Adv. Pharmacol. 42:1998;945-948
112. Hirsh J. Time flies like an arrow: Fruit flies like crack? Pharmacogeno. J. 1:2001;97-100
113. Ho K.S., Sehgal A. Drosophila melanogaster: An insect model for fundamental studies of sleep. Methods Enzymol. 393:(41):2005;770-791. (this volume).
114. Hofbauer A., Buchner E. Does Drosophila have seven eyes? Naturwissenschaften. 76:1989;335-336
115. Homberg U., Reischig T., Stengl M. Neural organization of the circadian system of the cockroach Leucophaea maderae. Chronobiol. Int. 20:2003;577-591
116. Hu K.G., Reichert H., Stark W.S. Electrophysiological characterization of Drosophila ocelli. J. Comp. Physiol. A. 126:1978;15-24
117. Hunter-Ensor M., Ousley A., Sehgal A. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell. 84:1996;677-685
118. Husain Q.M., Ewer J. Use of targetable gfp-tagged neuropeptide for visualizing neuropeptide release following execution of a behavior. J. Neurobiol. 59:2004;181-191
119. Ishikawa T., Matsumoto A., Kato T. Jr., Togashi S., Ryo H., Ikenaga M., Todo T., Ueda R., Tanimura T. DCRY is a Drosophila photoreceptor protein implicated in light entrainment of circadian rhythm. Genes to Cells. 4:1999;57-65
120. Ivanchenko M., Stanewsky R., Giebultowicz J.M. Circadian photoreception in Drosophila: Functions of cryptochrome in peripheral and central clocks. J. Biol. Rhythms. 16:2001;205-215
121. Jackson F.R., Bargiello T.A., Yun S.H., Young M.W. Product of per locus of Drosophila shares homology with proteoglycans. Nature. 320:1986;185-188
122. Jackson F.R., Gailey D.A., Siegel R.W. Biological rhythm mutations affect an experience-dependent modification of male courtship behavior in Drosophila melanogaster. J. Comp. Physiol. A. 151:1983;545-552
123. Jackson F.R., Genova G.K., Huang Y., Kleyner Y., Suh J., Roberts M.A., Sundram V., Akten B. Genetic and biochemical strategies for identifying Drosophila genes that function in circadian control. Methods Enzymol. 393:(35):2005;661-680. (this volume).
124. Jackson F.R., Schroeder A.J. A timely expression profile. Dev. Cell. 1:2001;730-731
125. Jackson F.R., Schroeder A.J., Roberts M.A., McNeill G.P., Kume K., Akten B. Cellular and molecular mechanisms of circadian control in insects. J. Insect Physiol. 47:2001;833-842
126. James A.A., Ewer J., Reddy P., Hall J.C., Rosbash M. Embryonic expression of the period clock gene in the central nervous system of Drosophila melanogaster. EMBO J. 5:1986;2313-2320
127. Jaramillo A.M., Zheng X., Zhou Y., Amado D.A., Sheldon A., Sehgal A., Levitan I.B. Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci. 5:(1):2004;3
128. Jauch E., Melzig J., Brkulj M., Raabe T. In vivo functional analysis of Drosophila protein kinase CK2 β subunit. Gene. 298:2002;29-39
129. Jefferis G.S., Marin E.C., Watts R.J., Luo L. Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Curr. Opin. Neurobiol. 12:2002;80-86
130. Judd B.H., Shen M.W., Kaufman T.C. The anatomy and function of a segment of the X chromosome of Drosophila melanogaster. Genetics. 71:1972;139-156
131. Kaiser W., Steiner-Kaiser J. Neuronal correlates of sleep, wakefulness and arousal in a diurnal insect. Nature. 301:1983;707-709
132. Kaneko M., Helfrich-Förster C., Hall J.C. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: Newly identified pacemaker candidates and novel features of clock gene product cycling. J. Neurosci. 17:1997;6745-6760
133. Short mutation on phase shifts induced by light pulses delivered to Drosophila larvae. J. Biol. Rhythms. 15:2000a;13-30
134. Kaneko M., Hall J.C. Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J. Comp. Neurol. 422:2000;66-94
135. Kaneko M., Park J.H., Cheng Y., Hardin P.E., Hall J.C. Disruption of synaptic transmission or clock-gene-product oscillations in circadian pacemaker cells of Drosophila cause abnormal behavioral rhythms. J. Neurobiol. 43:2000b;207-233
136. Kilduff T.S. What rest in flies can tell us about sleep in mammals. Neuron. 26:2000;295-298
137. Kitamoto T. Targeted expression of temperature-sensitive dynamin to study neural mechanisms of complex behavior in Drosophila. J. Neurogenet. 16:2002a;205-228
138. Kitamoto T. Conditional disruption of synaptic transmission induces male-male courtship behavior in Drosophila. Proc. Natl. Acad. Sci. USA. 99:2002b;13232-13237
139. Klarsfeld A., Leloup J.C., Rouyer F. Circadian rhythms of locomotor activity in Drosophila. Behav. Processes. 64:2003;161-175
140. Klarsfeld A., Malpel S., Michard-Vanhee C., Picot M., Chelot E., Rouyer F. Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J. Neurosci. 24:2004;1468-1477
141. Klemm E., Ninnemann H. Detailed action spectra for the delay phase shift in pupal emergence of Drosophila pseudoobscura. Photochem. Photobiol. 24:1976;364-371
142. Kloss B., Rothenfluh A., Young M.W., Saez L. Phosphorylation of PERIOD is influenced by cycling physical associations of DOUBLE-TIME, PERIOD, and TIMELESS in the Drosophila clock. Neuron. 30:2001;699-706
143. Ko H.W., Edery I. Analyzing the degradation of PERIOD protein by the ubiquitin-proteosome pathway in cultured Drosophila cells. Method Enzymol. 393:(18):2005;392-406. (this volume).
144. Ko H.W., Jiang J., Edery I. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature. 420:2002;673-678
145. Konopka R.J., Benzer S. Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 68:1971;2112-2116
146. Konopka R.J., Hamblen-Coyle M.J., Jamison C.F., Hall J.C. An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system. J. Biol. Rhythms. 9:1994;189-216
147. Konopka R.J., Kyriacou C.P., Hall J.C. Mosaic analysis in the Drosophila CNS of circadian and courtship-song rhythms affected by a period clock mutation. J. Neurogenet. 11:1996;117-139
148. Konopka R.J., Pittendrigh C., Orr D. Reciprocal behaviour associated with altered homeostasis and photosensitivity of Drosophila clock mutants. J. Neurogenet. 6:1989;1-10
149. Konopka R., Wells S., Lee T. Mosaic analysis of a Drosophila clock mutant. Mol. Gen. Genet. 190:1983;284-288
150. Konopka R.J., Smith R.F., Orr D. Characterization of Andante, a new Drosophila clock mutant, and its interactions with other clock mutants. J. Neurogenet. 7:1991;103-114
151. Krishnan B., Dryer S.E., Hardin P.E. Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature. 400:1999;375-378
152. Krishnan P., Dryer S.E., Hardin P.E. Measuring circadian rhythms in olfactory using electroantennograms. Methods Enzymol. 393:(25):2005;493-506. (this volume).
153. Krishnan B., Levine J.D., Lynch K.S., Dowse H.B., Funes P., Hall J.C., Hardin P.E., Dryer S.E. A novel role for cryptochrome in a Drosophila circadian oscillator. Nature. 411:2001;313-317
154. Kyriacou C.P., Hall J.C. Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc. Natl. Acad. Sci. USA. 77:1980;6929-6933
155. Kyriacou C.P., Hall J.C. The function of courtship song rhythms in Drosophila. Anim. Behav. 30:1982;794-801
156. Kyriacou C.P., Oldroyd M., Wood J., Sharp M., Hill M. Clock mutations alter developmental timing in Drosophila. Heredity. 64:1990;395-401
157. Lee C., Bae K., Edery I. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation and interactions with the PER-TIM complex. Neuron. 21:1998;857-867
158. Lee T., Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron. 22:1999;451-461
159. Lee T., Luo L. Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 24:2001;251-254. Review. (Erratum: Trends Neurosci. 24, 385.)
160. Lee G., Villella A., Taylor B.J., Hall J.C. New reproductive anomalies in fruitless-mutant Drosophila males: Extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs. J. Neurobiol. 47:2001;121-149
161. Levenbook L. The physiology of carbon dioxide transport in insect blood. III. The buffering capacity of Gastrophilus blood. J. Exp. Biol. 27:1950;184-191
162. Levine J.D. Sharing time on the fly. Curr. Opin. Cell Biol. 16:2004;210-216
163. Levine J.D., Casey C.I., Kalderon D.D., Jackson F.R. Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mtuant dunce. Neuron. 13:1994;967-974
164. Levine J.D., Funes P., Dowse H.B., Hall J.C. Resetting the circadian clock by social experience in Drosophila melanogaster. Science. 298:2002a;2010-2012
165. Levine J.D., Funes P., Dowse H.B., Hall J.C. Signal analysis of behavioral and molecular cycles. BMC Neurosci. 3:(1):2002b;1
166. Levine J.D., Funes P., Dowse H.B., Hall J.C. Advanced analysis of a cryptochrome mutation's effects on the robustness and phase of molecular cycles in isolated peripheral tissues of Drosophila. BMC Neurosci. 3:(1):2002c;5
167. Li X., Borjigin J., Snyder S.H. Molecular rhythms in the pineal gland. Curr. Opin. Neurobiol. 8:1998;648-651
168. Lin J.-M., Kilman V., Keegan K., Paddock B., Emery-Le M., Rosbash M., Allada R. A role for casein kinase 2α in the Drosophila circadian clock. Nature. 420:2002;816-820
169. Lin Y., Stormo G.D., Taghert P.H. The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system. J. Neurosci. 24:2004;7951-7957
170. Liu X., Lorenz L., Yu Q., Hall J.C., Rosbash M. Spatial and temporal expression of the period gene in Drosophila melanogaster. Genes Dev. 2:1988;228-238
171. Liu X., Yu Q., Huang Z., Zwiebel L.J., Hall J.C., Rosbash M. The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. Neuron. 6:1991;753-766
172. Liu X., Zwiebel L.J., Hinton D., Benzer S., Hall J.C., Rosbash M. The period gene encodes a predominantly nuclear protein in adult Drosophila. J. Neurosci. 12:1992;2735-2744
173. Livingstone M.S., Tempel B.L. Genetic dissection of monoamine neurotransmitter synthesis in Drosophila. Nature. 303:1983;67-70
174. Lorenz L.J., Hall J.C., Rosbash M. Expression of a Drosophila mRNA is under circadian clock control during pupation. Development. 107:1989;869-880
175. Lundkvist G.B., Block G.D. Role of neuronal membrane events in circadian rhythm generation. Methods Enzymol. 393:(33):2005;621-640. (this volume).
176. Ma J., Ptashne M. The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80. Cell. 50:1987;137-142
177. Majercak J., Chen W.F., Edery I. Splicing of the period gene 3′-terminal intron is regulated by light, circadian clock factors, and phospholipase C. Mol. Cell. Biol. 24:2004;3359-3372
178. Majercak J., Kalderon D., Edery I. Drosophila melanogaster deficient in protein kinase a manifests behavior-specific arrhythmia but normal clock function. Mol. Cell. Biol. 17:1997;5915-5922
179. Majercak J., Sidote D., Hardin P.E., Edery I. How a circadian clock adapts to seasonal decreases in temperature and day length. Neuron. 24:1999;219-230
180. Malpel S., Klarsfeld A., Rouyer F. Larval optic nerve and adult extra-retinal photoreceptors sequentially associate with clock neurons during Drosophila brain development. Development. 129:2002;1443-1453
181. Malpel S., Klarsfeld A., Rouyer F. Circadian synchronization and rhythmicity in larval photoperception-defective mutants of Drosophila. J. Biol. Rhythms. 19:2004;10-21
182. S flies: Evidence for light-mediated delay of the negative feedback loop in Drosophila. EMBO J. 15:1996;6877-6886
183. Martin J.-R., Keller A., Sweeney S.T. Targeted expression of tetanus toxin: A new tool to study the neurobiology of behavior. Adv. Genet. 47:2002;1-47
184. Martinek S., Inonog S., Manoukian A.S., Young M.W. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell. 105:2001;769-779
185. rit lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization. Mol. Cell. Biol. 19:1999;4343-4354
186. McBride S.M., Giuliani G., Choi C., Krause P., Correale D., Watson K., Baker G., Siwicki K.K. Mushroom body ablation impairs short-term memory and long-term memory of courtship conditioning in Drosophila melanogaster. Neuron. 24:1999;967-977
187. McCall K., Peterson J.S. Detection of apoptosis in Drosophila. Methods Mol. Biol. 282:2004;191-206
188. McClung C., Hirsh J. The trace amine tyramine is essential for sensitization to cocaine in Drosophila. Curr. Biol. 9:1999;853-860
189. McDonald M.J., Rosbash M. Microarray analysis and organization of circadian gene expression in Drosophila. Cell. 107:2001;567-578
190. McNabb S.L., Baker J.D., Agapite J., Steller H., Riddiford L.M., Truman J.W. Disruption of behavioral sequence by targeted death of pepidergic neurons in Drosophila. Neuron. 19:1997;813-823
191. Mealey-Ferrara M.L., Montalvo A.G., Hall J.C. Effects of combining a cryptochrome mutation with other visual-system variants on entrainment of locomotor and adult-emergence rhythms in Drosophila. J. Neurogenet. 17:2003;171-221
192. 0 mutants of Drosophila melanogaster. J. Neurogenet. 15:2001;221-231
193. Merrow M., Brunner M., Roenneberg T. Assignment of circadian function for the Neurospora clock gene frequency. Nature. 399:1999;584-586
194. Merrow M., Roenneberg T. Enhanced phenotyping of complex traits with a circadian clock model. Methods Enzymol. 393:(10):2005;248-263. (this volume).
195. Moses K., Rubin G.M. glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev. 5:1991;583-593
196. Murata T., Matsumoto A., Tomioka K., Chiba Y. Ritsu: A rhythm mutant from a natural population of Drosophila melanogaster. J. Neurogenet. 9:1995;239-249
197. Myers E.M., Yu J., Sehgal A. Circadian control of eclosion: Interaction between a central and peripheral clock in Drosophila melanogaster. Curr. Biol. 13:2003;526-533
198. Myers M.P., Wager-Smith K., Rothenfluh-Hilfiker A., Young M.W. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science. 271:1996;1736-1740
199. Naidoo N., Song W., Hunter-Ensor M., Sehgal A. A role for the proteosome in the light response of the timeless clock protein. Science. 285:1999;1737-1741
200. Nash H.A., Scott R.L., Lear B.C., Allada R. An unusual cation channel mediates photic control of locomotion in Drosophila. Curr. Biol. 12:2002;2152-2158
201. Nawathean P., Rosbash M. The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol. Cell. 13:2004;213-223
202. Newby L.M., Jackson F.R. Drosophila ebony mutants have altered circadian activity rhythms but normal eclosion rhythms. J. Neurogenet. 7:1991;85-101
203. Newby L.M., Jackson F.R. A new biological rhythm mutant of Drosophila melanogaster that identifies a gene with an essential embryonic function. Genetics. 135:1993;1077-1090
204. Nitabach M.N., Blau J., Holmes T.C. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 109:2002;485-495
205. Nitabach M.N., Holmes T.C., Blau J. Membranes, ions, and clocks: Testing the Njus-Salzman-Hastings model of the circadian oscillator. Methods Enzymol. 393:(34):2005;643-661. (this volume).
206. Nitz D.A., van Swinderen B., Tononi G., Greenspan R.J. Electrophysiological correlates of rest and activity in Drosophila melanogaster. Curr. Biol. 12:2002;1934-1940
207. Ohata K., Nishiyama H., Tsukahara Y. Action spectrum of the circadian clock photoreceptor in Drosophila melanogaster. Touitou Y. "Biological Clocks, Mechanisms and Applications" 1998;167-170 Elsevier Science B. V, Amsterdam
208. Oishi K., Shiota M., Sakamoto K., Kasamatsu M., Ishida N. Feeding is not a more potent Zeitgeber than the light-dark cycle in Drosophila. Neuroreport. 15:2004;739-743
209. Okamura H. Integration of molecular rhythms in the mammalian circadian system. Novartis Found Symp. 253:2003;161-170
210. Okano S., Kanno S., Takao M., Eker A.P.M., Isono K., Tsukahara Y., Yasui A. A putative blue-light receptor from Drosophila melanogaster. Photochem. Photobiol. 69:1999;108-113
211. Orr D.P.-Y. "Genetic Analysis of the Circadian Clock System of Drosophila melanogaster." 1982;California Institute of Technology, Pasadena, CA. Ph.D. thesis
212. Ousley A., Zafarulluh K., Chen Y., Emerson M., Hickman L., Sehgal A. Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies. Genetics. 148:1998;815-825
213. Page T.L. Extraretinal photoreceptors in entrainment and photoperiodism in invertebrates. Experientia. 38:1982;1001-1013
214. Page T.L., Koelling E. Circadian rhythm in olfactory response in the antennae controlled by the optic lobe in the cockroach. J. Insect Physiol. 49:2003;697-707
215. Pak W.L., Leung H.T. Genetic approaches to visual transduction in Drosophila melanogaster. Receptors Channels. 9:(3):2003;149-167
216. Park J.H. Downloading central clock information in Drosophila. Mol. Neurobiol. 26:2002;217-233
217. Park J.H., Hall J.C. Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J. Biol. Rhythms. 13:1998;219-228
218. Park J.H., Helfrich-Förster C., Lee G., Liu L., Rosbash M., Hall J.C. Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc. Natl. Acad. Sci. USA. 97:2000a;3608-3613
219. Park S.K., Sedore S.A., Cronmiller C., Hirsh J. Type II cAMP-dependent protein kinase-deficient Drosophila are viable but show developmental, circadian, and drug response phenotypes. J. Biol. Chem. 275:2000b;20588-20596
220. Park J.H., Schroeder A.J., Helfrich-Förster C., Jackson F.R., Ewer J. Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior. Development. 130:2003;2645-2656
221. Pearn M.T., Randall L.L., Shortridge R.D., Burg M.G., Pak W.L. Molecular, biochemical, and electrophysiological characterization of Drosophila norpA mutants. J. Biol. Chem. 271:1996;4937-4945
222. Peirson S.N., Thompson S., Hankins M.W., Foster R.G. Mammalian photoentrainment: Results, methods, and approaches. Methods Enzymol. 393:(37):2005;695-724. (this volume).
223. Peixoto A.A., Hennessy J.M., Townson I., Hasan G., Rosbash M., Costa R., Kyriacou C.P. Molecular coevolution within a Drosophila clock gene. Proc. Natl. Acad. Sci. USA. 95:1998;4475-4480
224. Peng Y., Stoleru D., Levine J.D., Hall J.C., Rosbash M. Drosophila free-running rhyhtms require intercellular communication. Pub. Lib. Sci. Biol. 1:2003;32-40
225. Perrimon N., Lanjuin A., Arnold C., Noll E. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. Genetics. 144:1996;1681-1692
226. Petersen G., Hall J.C., Rosbash M. The period gene of Drosophila carries species-specific behavioral instructions. EMBO J. 7:1988;3939-3947
227. Petri B., Stengl M. Pigment dispersing hormone shifts the phase of the circadian pacemaker of the cockroach Leucophaea maderae. J. Neurosci. 17:1997;4087-4093
228. Petri B., Stengl M. Phase response curves of a molecular model oscillator: Implications for mutual coupling of paired oscillators. J. Biol. Rhythms. 16:2001;125-141
229. Phelps C.B., Brand A.H. Ectopic gene expression in Drosophila using GAL4 system. Methods. 14:1998;367-379
230. Philip A.V. Mitotic sister-chromatid separation: What Drosophila mutants can tell us. Trends Cell Biol. 8:1998;150
231. Plautz J.D., Kaneko M., Hall J.C., Kay S.A. Independent photoreceptive circadian clocks throughout Drosophila. Science. 278:1997a;1632-1635
232. Plautz J.D., Straume M., Stanewsky R., Jamison C.F., Brandes C., Dowse H.B., Hall J.C., Kay S.A. Quantitative analysis of Drosophila period gene transcription in living animals. J. Biol. Rhythms. 12:1997b;204-217
233. Pollock V.P., Radford J.C., Pyne S., Hasan G., Dow J.A., Davies S.A. NorpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. J. Exp. Biol. 206:2003;901-911
234. Price J.L. Drosophila melanogaster: A model system for molecular chronobiology. Sehgal A. "Molecular Biology of Circadian Rhythms" 2004;33-74 Wiley, New York
235. Price J.L. Genetic screen for clock mutants in Drosophila. Methods Enzymol. 393:(3):2005;35-60. (this volume).
236. Price J.L., Blau J., Rothenfluh A., Abodeely M., Kloss B., Young M.W. double-time is a new Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 94:1998;83-95
237. Price J.L., Dembinska M.E., Young M.W., Rosbash M. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. EMBO J. 14:1995;4044-4049
238. Rachidi M., Lopes C., Benichou J.-C., Rouyer F. Analysis of period circadian expression in the Drosophila head by in situ hybridization. J. Neurogenet. 11:1997;255-263
239. Reddy P., Zehring W.A., Wheeler D.A., Pirrotta V., Hadfield C., Hall J.C., Rosbash M. Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell. 38:1984;701-710
240. Reddy P., Jacquier A.C., Abovich N., Petersen G., Rosbash M. The period clock locus of D. melanogaster codes for a proteoglycan. Cell. 46:1986;53-61
241. Renn S.C.P., Park J.H., Rosbash M., Hall J.C., Taghert P.H. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell. 99:1999;791-802
242. Richardson H., Kumar S. Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods. 265:2002;21-38
243. Rieger D., Stanewsky R., Helfrich-Förster C. Cryptochrome, compound eyes, Hofbauer-Buchner eyelets, and ocelli play different roles in the entrainment and masking pathway of the locomotor activity rhythm in the fruit fly Drosophila melanogaster. J. Biol. Rhythms. 18:2003;377-391
244. Ritchie M.G., Halsey E.J., Gleason J.M. Drosophila song as a species-specific mating signal and the behavioural importance of Kyriacou & Hall cycles in D. melanogaster song. Anim. Behav. 58:1999;649-657
245. Robinow S., White K. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22:1991;443-461
246. Rothenfluh A., Abodeely M., Price J.L., Young M.W. Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila. Genetics. 156:2000a;665-675
247. Rothenfluh A., Abodeely M., Young M.W. Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. Curr. Biol. 10:2000b;1399-1402
248. Rothenfluh A., Young M.W., Saez L. A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron. 26:2000c;505-514
249. Rouyer F., Rachidi M., Pikielny C., Rosbash M. A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock. EMBO J. 16:1997;3944-3954
250. SL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle. J. Biol. Rhythms. 13:1998a;380-392
251. Rutila J.E., Suri V., Le M., So W.V., Rosbash M., Hall J.C. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell. 93:1998b;805-814
252. SL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron. 17:1996;921-929
253. Saez L., Young M.W. In situ localization of the per clock protein during development of Drosophila melanogaster. Mol. Cell. Biol. 8:1988;5378-5385
254. Saez L., Young M.W. Regulated nuclear localization of the Drosophila clock proteins PERIOD and TIMELESS. Neuron. 17:1996;911-920
255. Saez L., Young M.W., Baylies M.K., Gasic G., Bargiello T.A., Spray D.C. Per: No link to gap junctions. Nature. 360:1992;542
256. Sakai T., Tamura T., Kitamoto T., Kidokoro Y. A clock gene, period, plays a key role in long-term memory in Drosophila. Proc. Natl. Acad. Sci. USA. 101:2004;16058-16063
257. Sakai T., Ishida N. Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. USA. 98:2001;9221-9225
258. Sakura M., Takasuga K., Watanabe M., Eguchi E. Diurnal and circadian rhythm in compound eye of cricket (Gryllus bimaculatus): Changes in structure and photon capture efficiency. Zool. Sci. 20:2003;833-840
259. Sarov-Blat L., So W.V., Liu L., Rosbash M. The Drosophila takeout gene is a novel link between circadian rhythms and feeding behavior. Cell. 101:2000;647-656
260. Sathyanarayanan S., Zheng X., Xiao R., Sehgal A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell. 116:2004;603-615
261. Sato T.K., Panda S., Kay S.A., Hogenesch J.B. DNA arrays: Applications and implications for circadian biology. J. Biol. Rhythms. 18:2003;96-105
262. Sauer S., Kinkelin M., Herrmann E., Kaiser W. The dynamics of sleep-like behaviour in honey bees. J. Comp. Physiol. 189:2003;599-607. A
263. Sauman I., Reppert S.M. Circadian clock neurons in the silkmoth Antheraea pernyi: Novel mechanism of Period protein regulation. Neuron. 17:1996;889-900
264. Sauman I., Reppert S.M. Brain control of embryonic circadian rhythms in the silkmoth Antheraea pernyi. Neuron. 20:1998;741-748
265. Sauman I., Tasi T., Roca A.L., Reppert S.M. Period protein is necessary for circadian control of egg hatching behavior in the silkmoth Antheraea pernyi. Neuron. 20:1996;901-909
266. Sauman I., Tsai T., Roca A.L., Reppert S.M. Erratum. Neuron. 27:(1):2000;. [last page of issue].
267. Sawin E.P., Dowse H.B., Hamblen-Coyle M.J., Hall J.C., Sokolowski M.B. A search for locomotor activity rhythms in Drosophila melanogaster larvae. J. Insect Behav. 7:1994;249-262
268. Schibler U., Ripperger J., Brown S.A. Peripheral circadian oscillators in mammals: Time and food. J. Biol. Rhythms. 18:2003;250-260
269. Schibler U., Sassone-Corsi P. A web of circadian pacemakers. Cell. 111:2002;119-122
270. Sehgal A., Price J.L., Man B., Young M.W. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 263:1994;1603-1606
271. Sehgal A., Price J., Young M.W. Ontogeny of a biological clock in Drosophila. Proc. Natl. Acad. Sci. USA. 89:1992;1423-1427
272. Sehgal A., Rothenfluh-Hilfiker A., Hunter-Ensor M., Chen Y., Myers M.P., Young M.W. Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation. Science. 270:1995;808-810
273. Sehgal A., Price J.L. Genetic and molecular approaches used to analyze rhythms. Sehgal A. "Molecular Biology of Circadian Rhythms" 2004;17-29 Wiley, New York
274. Shafer O.T., Levine J.D., Truman J.W., Hall J.C. Flies by night: Effects of changing day length on Drosophila's circadian clock. Curr. Biol. 14:2004;424-432
275. Shafer O.T., Rosbash M., Truman J.W. Sequential nuclear accumulation of the clock proteins Period and Timeless in the pacemaker neurons of Drosophila melanogaster. J. Neurosci. 22:2002;5946-5954
276. Shannon M.P., Kaufman T.C., Shen M.W., Judd B.H. Lethality patterns and morphology of selected lethal and semi-lethal mutations in the zeste-white region of Drosophila melanogaster. Genetics. 72:1972;615-638
277. Shaw P. Awakening to the behavioral analysis of sleep in Drosophila. J. Biol. Rhythms. 18:2003;4-11
278. Shaw P.J., Tononi G., Greenspan R.J., Robinson D.F. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 417:2002;287-291
279. Shin H.-S., Bargiello T.A., Clark B.R., Jackson F.R., Young M.W. An unusual coding sequence form a Drosophila clock gene is conserved in vertebrates. Nature. 317:1985;445-448
280. Shirasu N., Shimohigashi Y., Tominaga Y., Shimohigashi M. Molecular cogs of the insect circadian clock. Zool. Sci. 20:2003;947-955
281. Sidote D., Majercak J., Parikh V., Edery I. Differential effects of light and heat on the Drosophila circadian clock proteins PER and TIM. Mol. Cell. Biol. 18:1998;2004-2013
282. Siwicki K.K., Eastman C., Petersen G., Rosbash M., Hall J.C. Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythm changes in the visual system. Neuron. 1:1988;141-150
283. Siwicki K.K., Flint K.K., Hall J.C., Rosbash M., Spray D.C. The Drosophila period gene and dye coupling in larval salivary glands: A re-evaluation. Biol. Bull. 183:1992;340-341
284. Siwicki K.K., Ladewski L. Associative learning and memory in Drosophila: Beyond olfactory conditioning. Behav. Processes. 64:2003;225-238
285. Smith R.F., Konopka R.J. Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus. Mol. Gen. Genet. 183:1981;243-251
286. Smith R.F., Konopka R.J. Effects of dosage alterations at the per locus on the circadian clock of Drosophila. Mol. Gen. Genet. 185:1982;30-36
287. So W.V., Rosbash M. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J. 16:1997;7146-7155
288. So W.V., Sarov-Blat L., Kotarski C.K., McDonald M.J., Allada R., Rosbash M. takeout, a novel Drosophila gene under circadian clock transcriptional regulation. Mol. Cell. Biol. 20:2000;6935-6944
289. Stanewsky R. Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54:2003;111-147
290. Stanewsky R. Analysis of rhythmic gene expression in adult Drosophila using the firefly-luciferase reporter gene. Rosato E. "Circadian Rhythms: Reviews and Protocols" 2005;Humana Press, Totowa, NJ. In Press.
291. Stanewsky R., Frisch B., Brandes C., Hamblen-Coyle M.J., Rosbash M., Hall J.C. Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: Mapping elements of the PER protein involved in circadian cycling. J. Neurosci. 17:1997a;676-696
292. Stanewsky R., Jamison C.F., Plautz J.D., Kay S.A., Hall J.C. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J. 16:1997b;5006-5018
293. b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell. 95:1998;681-692
294. Stanewsky R., Lynch K.S., Brandes C., Hall J.C. Mapping of elements involved in regulating normal period and timeless RNA expression patterns in Drosophila melanogaster. J. Biol. Rhythms. 17:2002;293-306
295. Stempfl T., Vogel M., Szabo G., Wülbeck C., Liu J., Hall J.C., Stanewsky R. Identification of circadian-clock regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Genetics. 160:2002;571-593
296. Stengl M., Hatt H., Breer H. Peripheral processes in insect olfaction. Annu. Rev. Physiol. 54:1992;665-681
297. Stoleru D., Peng Y., Agosto J., Rosbash M. Coupled oscillators control morning and evening locomotor behavior in Drosophila. Nature. 431:2004;862-868
298. Sturtevant A.H. Reminiscences of T. H. Morgan (published in the year cited, but based on notes taken of a lecture delivered by Sturtevant at Woods Hole, MA, 1967). Genetics. 159:2001;1-5
299. Suri V., Hall J.C., Rosbash M. Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. J. Neurosci. 20:2000;7547-7555
300. Suri V., Qian Z., Hall J.C., Rosbash M. Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron. 21:1998;225-234
301. Taghert P.H., Hewes R.S., Park J.H., O'Brien M.A., Han M., Peck M.E. Multiple amidated neuropeptides are required for normal circadian rhythmicity in Drosophila. J. Neurosci. 21:2001;6673-6686
302. Tanoue S., Krishnan P., Krishnan B., Dryer S.E., Hardin P.E. Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Curr. Biol. 14:2004;638-649
303. Tauber E., Eberl D.F. Acoustic communication in Drosophila. Behav. Processes. 64:2003;197-210
304. Tauber E., Roe H., Costa R., Hennessy J.M., Kyriacou C.P. Temporal mating isolation driven by a behavioral gene in Drosophila. Curr. Biol. 13:2003;140-145
305. Tischkau S.A., Gillette M.U. Oligodeoxynucleotide methods for analyzing the circadian clock in the suprachiasmatic nucleus. Methods Enzymol. 393:(31):2005;591-608. (this volume).
306. Tobler I. Effect of forced locomotion on the rest-activity cycle of the cockroach. Behav. Brain Res. 8:1983;351-360
307. Toma D.P., White K.P., Hirsch J., Greenspan R.J. Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nature Genet. 31:2002;349-353
308. Tomioka K., Sakamoto M., Harui Y., Matsumoto N., Matsumoto A. Light and temperature cooperate to regulate the circadian locomotor rhythm of wild type and period mutants of Drosophila melanogaster. J. Insect Physiol. 44:1998;587-596
309. Truman J.W. Extraretinal photoreception in insects. Photochem. Photobiol. 23:1976;215-225
310. Truman J.W. The eclosion hormone system of insects. Prog. Brain Res. 92:1992;361-374
311. Truman J.W., Morton D.B. The eclosion hormone system: An example of coordination of endocrine activity during the molting cycle of insects. Prog. Clin. Biol. Res. 342:1990;300-308
312. Turek F.W., Van Reeth O. Altering the mammalian circadian clock with the short-acting benzodiazepine, triazolam. Trends Neurosci. 11:1988;535-541
313. Ueda H.R., Matsumoto A., Kawamura M., Iino M., Tanimura T., Hashimoto S. Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. J. Biol. Chem. 277:2002;14048-14052
314. van Gelder R.N. Nonvisual ocular photoreception in the mammal. Methods Enzymol. 393:(39):2005;744-753. (this volume).
315. van Swinderen B., Andretic R. Arousal in Drosophila. Behav. Processes. 64:2003;133-144
316. van Swinderen B., Hall J.C. Analysis of conditioned courtship in dusky-Andante rhythm mutants of Drosophila. Learn. Mem. 2:1995;49-61
317. van Swinderen B., Nitz D.A., Greenspan R.J. Uncoupling of brain activity from movement defines arousal states in Drosophila. Curr. Biol. 14:2004;81-87
318. Veleri S., Brandes C., Helfrich-Förster C., Hall J.C., Stanewsky R. A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain. Curr. Biol. 13:2003;1758-1767
319. Villella A., Gailey D.A., Berwald B., Ohshima S., Barnes P.T., Hall J.C. Extended reproductive roles of the fruitless gene in Drosophila melanogaster revealed by behavioral analysis of new fru mutants. Genetics. 147:1997;1107-1130
320. Vosshall L.B., Young M.W. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. Neuron. 15:1995;345-360
321. Walker J.R., Hogenesch J.B. RNA profiling in circadian biology. Methods Enzymol. 393:(16):2005;364-374. (this volume).
322. Walsh D.K., Imalzumi T., Kay S.A. Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells. Methods Enzymol. 393:(11):2005;267-286. (this volume).
323. Weber F., Kay S.A. A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett. 555:2003;341-345
324. Wheeler D.A., Hamblen-Coyle M.J., Dushay M.S., Hall J.C. Behavior in light-dark cycles of Drosophila mutants that are blind, arrhythmic, or both. J. Biol. Rhythms. 8:1993;67-94
325. Wheeler D.A., Kyriacou C.P., Greenacre M.L., Yu Q., Rutila J.E., Rosbash M., Hall J.C. Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science. 251:1991;1082-1085
326. Whitfield N., Strong B. "I Heard It through the Grapevine." 1967;Motown Music, Detroit, MI
327. Whitmore D., Block G.D. Cellular aspects of molluskan biochronometry. Semin. Cell Dev. Biol. 7:1996;781-789
328. Williams D.W., Tyrer M., Shepherd D. Tau and tau reporters disrupt central projections of sensory neurons in Drosophila. J. Comp. Neurol. 428:2000;630-640
329. Williams J.A., Su H.S., Bernards A., Field J., Sehgal A. A circadian output in Drosophila mediated by Neurofibromatosis-1 and Ras/MAPK. Science. 293:2001;2251-2256
330. Wolfner M.F. Sex determination: Sex on the brain? Curr. Biol. 13:2003;R101-R103
331. blund mutant affects behavioral rhythms but not periodic eclosion. Genetics. 2005;. In press.
332. Yang Z., Sehgal A. Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron. 29:2001;453-467
333. Yao K.-M., White K. Neural specificity of elav expression: Defining a Drosophila promoter for directing expression to the nervous system. J. Neurochem. 63:1994;41-51
334. Yasuyama K., Meinertzhagen I.A. Extraretinal photoreceptors at the compound eye's posterior margin in Drosophila melanogaster. J. Comp. Neurol. 412:1999;193-202
335. b muation reveals two circadian clocks that drive locomotor rhythm and have different responsiveness to light. J. Insect Physiol. 50:2004;478-488
336. Young M.W., Judd B.H. Nonessential sequences, genes and the polytene chromosome bands of Drosophila melanogaster. Genetics. 88:1978;723-742
337. Yu Q., Jacquier A.C., Citri Y., Hamblen M., Hall J.C., Rosbash M. Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 84:1987;784-788
338. Yu W., Hardin P.E. Use of firefly luciferase activity assays to monitor circadian molecular rhythms in vivo. Rosato E. "Circadian Rhythms: Reviews and Protocols" 2005;Humana Press, Totowa, NJ. In press.
339. Zatz M. Melatonin synthesis: Trekking toward the heart of darkness in the chick pineal. Semin. Cell. Dev. Biol. 7:1996;811-820
340. Zehring W.A., Wheeler D.A., Reddy P., Konopka R.J., Kyriacou C.P., Rosbash M., Hall J.C. P-element transformation with period locus DNA restores rhythmicity to mutant arrhythmic Drosophila melanogaster. Cell. 39:1984;369-376
341. Zeng H., Hardin P.E., Rosbash M. Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J. 13:1994;3590-3598
342. Zeng H., Qian Z., Myers M.P., Rosbash M. A light-entrainment mechanism for the Drosophila circadian clock. Nature. 380:1996;129-135
343. Zerr D.M., Hall J.C., Rosbash M., Siwicki K.K. Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J. Neurosci. 10:1990;2749-2762
344. Zhao J., Kilman V.L., Keegan K.P., Peng Y., Emery P., Rosbash M., Allada R. Drosophila Clock can generate ectopic circadian clocks. Cell. 113:2003;755-766
345. Zhu L., McKay R.R., Shortridge R.D. Tissue-specific expression of phospholipase C encoded by the norpA gene of Drosophila melanogaster. J. Biol. Chem. 268:1993;15994-16001
346. Zilian O., Frei E., Burke R., Brentrup D., Gutjahr T., Bryant P.J., Noll M. double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Development. 126:1999;5409-5420
347. Zimmerman W.F., Goldsmith T.H. Photosensitivity of the circadian rhythm and of visual receptors in carotenoid-depleted Drosophila. Science. 171:1971;1167-1169
348. Zimmerman W.F., Pittendrigh C.S., Pavlidis T. Temperature compensation of the circadian oscillation in Drosophila pseudoobscura and its entrainment by temperature cycles. J. Insect Physiol. 14:1968;669-684
349. Zordan M., Osterwalder N., Rosato E., Costa R. Extra ocular photic entrainment in Drosophila melanogaster. J. Neurogenet. 15:2001;97-116