Death to flies: Drosophila as a model system to study programmed cell death

Journal of Immunological Methods

Volumn 265, Issue 1-2, 2002, Pages 21-38

  Richardson, Helena ^a   Kumar, Sharad ^b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Antibody staining; Apoptosis; Caspases; Development; Dominant negative mutants; Drosophila; Ectopic expression; Genetic interactions; In situ TUNEL; Programmed cell death; RNA interference; Tyramide amplification

Indexed keywords

ADAPTOR PROTEIN; CASPASE; CYSTEINE PROTEINASE;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL COUNT; DEATH; DEVELOPMENT; DROSOPHILA MELANOGASTER; EVOLUTION; FLY; GENETIC ANALYSIS; IMMUNOHISTOCHEMISTRY; MAMMAL; MODEL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; TISSUE; WORM;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0036644078     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(02)00068-6     Document Type: Article

References (118)

1. An emerging blueprint for apoptosis in Drosophila
2. Programmed cell death during Drosophila embryogenesis
3. The Bcl-2 protein family: Arbiters of cell survival
4. The domains of death: Evolution of the apoptosis machinery
5. Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons
6. Death receptors: Signaling and modulation
7. Steroid regulation of programmed cell death during Drosophila development
8. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
9. Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
10. The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
11. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
12. Drosophila p53 binds a damage response element at the reaper locus
13. Biochemical pathways of caspase activation during apoptosis
14. Eggs to die for: Cell death during Drosophila oogenesis
15. Drosophila apoptosis and Bcl-2 genes: Outliers fly in
16. Grim, a novel cell death gene in Drosophila
17. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
18. The autosomal FLP-DNS technique for generating germline mosaics in Drosophila melanogaster
19. Proteases to die for
20. An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster
21. IAP family proteins - Suppressors of apoptosis
22. DRONC, an ecdysone inducible Drosophila caspase
23. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7
24. Strica, a novel Drosophila caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2
25. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
26. Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein
27. Interaction between the cellular and humoral immune response in Drosophila
28. Apoptosis in late stage Drosophila nurse cells does not require genes within the H99 deficiency
29. Programmed cell death in C. elegans
30. Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE
31. DrICE is an essential caspase required for apoptotic activity in Drosophila cells
32. Cell death inhibition-keeping caspases in check
33. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
34. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
35. Characterisation of the Drosophila Caspase, Damm
36. A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1
37. The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM
38. Understanding IAP function and regulation: A view from Drosophila
39. Sex, cell death, and the genome of C. elegans
40. DFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
41. BH3-only proteins - Essential initiators of apoptotic cell death
42. Genetics: A touch of elegance with RNAi
43. Gene silencing: Shrinking the black box of RNAi
44. Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death
45. CLARP, a death effector domain containing protein interacts with caspase-8 and regulates apoptosis
46. Steroid regulated programmed cell death during Drosophila metamorphosis
47. A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis
48. The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE
49. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
50. Use of dsRNA-mediated genetic interference to demonstrate frizzled and frizzled-2 act in the wingless pathway
51. Heritable gene silencing in Drosophila using double-stranded RNA
52. Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells
53. Mechanisms mediating caspase activation in apoptosis
54. The fly caspases
55. The ICE family of cysteine proteases as effectors of cell death
56. Ras promotes cell survival in Drosophila by downregulating hid expression
57. Steroid regulation of autophagic programmed cell death during development
58. E93 directs steroid-triggered programmed cell death in Drosophila
59. The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
60. P53, the cellular gatekeeper for growth and division
61. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
62. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
63. Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins
64. Twenty years of p53 research: Structural and functional aspects of the p53 protein
65. Requirement for DCP-1 caspase during Drosophila oogenesis
66. The Drosophila caspase DRONC is regulated by DIAP1
67. Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation
68. Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster
69. Apoptosis by death factor
70. PUMA, a novel proapoptotic gene, is induced by p53
71. Caspase structure, proteolytic substrates, and function during apoptotic cell death
72. Guardian ancestry: Fly p53 and damage-inducible apoptosis
73. Activation of the reaper gene during ectopic cell killing in Drosophila
74. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
75. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
76. An essential role for the caspase Dronc in developmentally programmed cell death in Drosophila
77. Advances in fluorescence in situ hybridization
78. The inhibitor of apoptosis protein-binding domain of smac is not essential for its proapoptotic activity
79. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
80. A targeted gene knockout in Drosophila
81. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
82. Comparative genomics of the eukaryotes
83. Programmed cell death and patterning in Drosophila
84. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
85. RNA interference - 2001
86. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
87. DCP-1, a Drosophila cell death protease essential for development
88. Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
89. Activation of the Drosophila NF-kB factor Relish by rapid endoproteolytic cleavage
90. Molecular characterization of mitochondrial apoptosis-inducing factor
91. A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina
92. Apoptosis in the pathogenesis and treatment of disease
93. Caspases: Enemies within
94. Scythe: A novel reaper-binding apoptotic regulator
95. Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity
96. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster
97. Preferential transposition of Drosophila P elements to nearby chromosomal sites
98. Cell death in development
99. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
100. Cell death regulation in Drosophila: Conservation of mechanism and unique insights
101. Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line
102. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM
103. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
104. Genetic control of programmed cell death in Drosophila
105. Specific interference with gene function by double-stranded RNA in early mouse development
106. Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes
107. The RHG motifs of Drosophila reaper and grim are important for their distinct cell death-inducing abilities
108. Analysis of genetic mosaics in developing and adult Drosophila tissues
109. Essential role of CED-4 oligomerisation in CED-3 activation and apoptosis
110. A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster
111. PUMA induces the rapid apoptosis of colorectal cancer cells
112. Apoptosis in the nervous system
113. Efficient and dispersed local P element transposition from Drosophila females
114. Evolutionarily conserved Bok proteins in the Bcl-2 family
115. Caspase knockouts: Matters of life and death
116. HAC-1, a Drosophila homolog of APAF-1/CED-4 functions in developmental and radiation-induced apoptosis
117. An APAF-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9