The tim(SL) mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants

Neuron

Volumn 17, Issue 5, 1996, Pages 921-929

  Rutila, Joan E ^a   Zeng, Hongkui ^a   Le, Myai ^a   Curtin, Kathryn D ^a,b   Hall, Jeffrey C ^a   Rosbash, Michael ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; DROSOPHILA PROTEIN; MESYLIC ACID ETHYL ESTER; MUTAGENIC AGENT; NUCLEAR PROTEIN; PERIOD PROTEIN, INSECT; TIMELESS PROTEIN, DROSOPHILA;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MUTAGENESIS; CHROMOSOME; CIRCADIAN RHYTHM; CONTROLLED STUDY; DROSOPHILA; GENE; IMMUNOHISTOCHEMISTRY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TEMPERATURE; ANIMAL; CHROMOSOME MAP; ENHANCER REGION; FEMALE; GENE EXPRESSION; GENETIC SCREENING; GENETICS; MALE; MUTAGENESIS; PHENOTYPE; PHYSIOLOGY; PROMOTER REGION;

ALLELES; ANIMALS; CHROMOSOME MAPPING; CIRCADIAN RHYTHM; DROSOPHILA; DROSOPHILA PROTEINS; ENHANCER ELEMENTS (GENETICS); ETHYL METHANESULFONATE; FEMALE; GENE EXPRESSION; GENES, INSECT; GENETIC SCREENING; MALE; MUTAGENESIS; MUTAGENS; NUCLEAR PROTEINS; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTEINS; TEMPERATURE;

EID: 0030273893     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80223-8     Document Type: Article

References (31)

1. Aronson, B.D., Johnson, K.A., Loros, J.J., and Dunlap, J.C. (1994). Negative feedback defines a circadian clock: autoregulation of the clock gene frequency. Science 263, 1578-1584.
2. Baylies, M.K., Bargiello, T.A., Jackson, F.R., and Young, M.W. (1987). Changes in abundance and structure of the per gene product can alter periodicity of the Drosophila clock. Nature 326, 390-392.
3. Curtin, K., Huang, Z.J., and Rosbash, M. (1995). Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron 14, 365-372.
4. Edery, I., Zwiebel, L.J., Dembinska, M.E., and Rosbash, M. (1994). Temporal phosphorylation of the Drosophila period protein. Proc. Natl. Acad. Sci. USA 91, 2260-2264.
5. Ewer, J., Rosbash, M., and Hall, J.C. (1988). An inducible promoter fused to the period gene in Drosophila conditionally rescues adult per-mutant arrhythmicity. Nature 333, 82-84.
6. Ewer, J., Frisch, B., Hamblen-Coyle, M.J., Rosbash, M., and Hall, J.C. (1992). Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 12, 3321-3349.
7. Frisch, B., Hardin, P.E., Hamblen-Coyle, M.J., Rosbash, M., and Hall, J.C. (1994). A promoterless DNA fragment from the period locus rescues behavioral rhythmicity and mediates cyclical gene expression in a restricted subset of the Drosophila nervous system. Neuron 12, 555-570.
8. L. Science 270, 811-815.
9. Gyuris, J., Golemis, E., Chertkov, H., and Brent, R. (1993). Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75, 791-803.
10. - mutants. J. Neurogenet. 3, 249-291.
11. Hamblen-Coyle, M.J., Wheeler, D.A., Rutila, J.E., Rosbash, M., and Hall, J.C. (1992). Behavior of period-altered circadian rhythm mutants of Drosophila in light:dark cycles. J. Insect Behav. 5, 417-446.
12. Hardin, P.E., Hall, J.C., and Rosbash, M. (1990). Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536-540.
13. Hardin, P.E., Hall, J.C., and Rosbash, M. (1992). Circadian oscillations in period gene mRNA levels are transcriptionally regulated. Proc. Natl. Acad. Sci. USA 89, 11711-11715.
14. Huang, Z.J., Curtin, K., and Rosbash, M. (1995). PER protein interactions and temperature compensation of a circadian clock in Drosophila. Science 267, 1169-1172.
15. Hunter-Ensor, M., Ousley, A., and Sehgal, A. (1996). Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84, 677-685.
16. Konopka, R.J., and Benzer, S. (1971). Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 68, 2112-2116.
17. Konopka, R.J., Pittendrigh, C., and Orr, D. (1989). Recriprocal behavior associated with altered homeostasis and photosensitivity of Drosophila clock mutants. J. Neurogenet. 6, 1-10.
18. Konopka, R.J., Hamblen-Coyle, M.J., Jamison, C.F., and Hall, J.C. (1994). An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system. J. Biol. Rhythms 9, 189-216.
19. Lee, C., Parikh, V., Itsukaichi, T., Bae, K., and Edery, I. (1996). Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 271, 1740-1744.
20. Liu, X., Zwiebel, L.J., Hinton, D., Benzer, S., Hall, J.C., and Rosbash, M. (1992). The period gene encodes a predominantly nuclear protein in adult Drosophila. J. Neurosci. 12, 2735-2744.
21. Myers, M.P., Wager-Smith, K., Wesley, C.S., Young, M.W., and Sehgal, A. (1995). Positional cloning and sequence analysis of the Drosophila clock gene timeless. Science 270, 805-808.
22. Myers, M.P., Wager-Smith, K., Rothenfluh-Hilfiker, A., and Young, M.W. (1996). Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 277, 1736-1740.
23. Price, J.L., Dembinska, M.E., Young, M.W., and Rosbash, M. (1995). Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. EMBO J. 14, 4044-4049.
24. Sehgal, A., Price, J.L., Man, B., and Young, M.W. (1994). Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 263, 1603-1606.
25. Sehgal, A., Rothenfluh-Hilfiker, A., Hunter-Ensor, M., Chen, Y., Myers, M., and Young, M.W. (1995). Circadian oscillations and autoregulation of timeless RNA. Science 270, 808-810.
26. Siwicki, K.K., Eastman, C., Petersen, G., Rosbash, M., and Hall, J.C. (1988). Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system. Neuron 1, 141-150.
27. Vosshall, L.B., Price, J.L., Sehgal, A., Saez, L., and Young, M.W. (1994). Specific block in nuclear localization of period protein by a second clock mutation, timeless. Science 263, 1606-1609.
28. Zatz, M. (1992). Perturbing the pacemaker in the chick pineal. Disc. Neurosci. 8, 67-73.
29. Zeng, H., Hardin, P.E., and Rosbash, M. (1994). Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J. 13, 3590-3598.
30. Zeng, H., Qian, Z., Myers, M.P., and Rosbash, M. (1996). A light-entrainment mechanism for the Drosophila circadian clock. Nature 380, 129-135.
31. Zerr, D.M., Hall, J.C., Rosbash, M., and Siwicki, K.K. (1990). Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J. Neurosci. 10, 2749-2762.