Molecular mechanisms of cell death and phagocytosis in Drosophila

Cell Death and Differentiation

Volumn 7, Issue 11, 2000, Pages 1027-1034

  Bangs, P ^a   Franc, N ^a   White, K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Apoptosis; Drosophila; Macrophage

Indexed keywords

AMINO ACID; CASPASE; CD36 ANTIGEN; ECDYSONE; EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN; PHOSPHATIDYLSERINE; PROTEIN BCL 2; PROTEIN P53; SCLEROPROTEIN; VITRONECTIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; BLOOD CELL; CELL DEATH; CELL KILLING; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME INHIBITION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; MACROPHAGE; MITOCHONDRION; MOLECULAR MODEL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA; HEXAPODA;

EID: 0033661587     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400754     Document Type: Review

References (99)

1. Genetic control of programmed cell death in the nematode C. elegans
2. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
3. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin - 1β-converting enzyme
4. Role of CED-4 in the activation of CED-3
5. Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
6. Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9
7. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3- induced apoptosis
8. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
9. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
10. Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma
11. Bcl-2 gene promotes heamopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
12. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
13. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
14. Programmed cell death during Drosophila embryogenesis
15. Genetic control of programmed cell death in Drosophila
16. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
17. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
18. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
19. Grim, a novel cell death gene in Drosophila
20. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
21. Cell killing by the Drosophila gene reaper
22. The proapoptotic function of Drosophila Hid is conserved in mammalian cells
23. Drosophila grim induces apoptosis in mammalian cells
24. Apoptosis induced by Drosophila Reaper and Grim in a human system
25. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER
26. Reaper-induced apoptosis in a vertebrate system
27. Activation of the reaper gene during ectopic cell killing in Drosophila
28. A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis
29. Drosophila p53 binds a damage response element at the reaperlocus
30. Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
31. Ras promotes cell survival in Drosophila by downregulating hid expression
32. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
33. Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos
34. Argos induces programmed cell death in the developing Drosophila eye by inhibition of the ras pathway
35. Control of midline glia development in the embryonic Drosophila CNS
36. Local induction of patterning and programmed cell death in the developing Drosophila retina
37. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
38. An exegesis of IAPs: Salvation and surprises from BIR motifs
39. IAP family proteins-suppressors of apoptosis
40. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster
41. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
42. A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1
43. The Drosophila Inhibitor of Apoptosis D-IAP1 suppresses cell death induced by the caspase drICE
44. The Drosophila caspase DRONC is regulated by DIAP1
45. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
46. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
47. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM
48. Inhibition of Reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs)
49. Distinct killing properties of the Drosophila reaper, head involution defective, and grim genes
50. Apoptotic activity of REAPER is distinct from signalling by the Tumor Necrosis Factor Receptor 1 death domain
51. Characterization of reaper and FADD-induced apoptosis in a lepidopteran cell line
52. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
53. Indentification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
54. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
55. Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
56. DRONC, an ecdysone-inducible Drosophila caspase
57. DCP-1, a Drosophila cell death protease essential for development
58. Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE
59. DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7
60. Comparative genomics of the eukaryotes
61. The Drosophila caspase DRONC is a glutamate/aspartate protease whose activity is regulated by DIAP1, HID and GRIM
62. DARK, a Drosophila homolog of Apaf-1/ced-4, functions in an evolutionarily conserved death pathway
63. Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim
64. Requirement for DCP-1 caspase during Drosophila oogenesis
65. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
66. HAC-1, a Drosophila homolog of APAF-1 and CED-4, functions in developmental and radiation-induced apoptosis
67. The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
68. Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death
69. Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery
70. The Drosophila genetic data base
71. ced-4- The third horseman of apoptosis
72. Scythe: A novel reaper-binding apoptotic regulator
73. Reaper-induced dissociation of a Scythe-sequestered cytochrome C-releasing activity
74. BCL-2 family members and the mitochondria in apoptosis
75. Altered cytochrome C display precedes apoptotic cell death in Drosophila
76. Cell death: The significance of apoptosis
77. Social controls on cell survival and cell death
78. Phagocytosis
79. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
80. Macrophages and glia participate in the removal of apoptotic neurons from the Drosophila embryonic nervous system
81. Embryonic origin of hemocytes and their relationship to cell death in Drosophila
82. Specification of Drosophila hematopoietic lineage by conserved transcription factors
83. A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
84. Glide/gcm is expressed and required in the scavenger cell lineage
85. Peroxidasin: A novel enzyme-matrix protein of Drosophila development
86. Macrophages induce apoptosis in normal cells in vivo
87. Recognition and phagocytosis of cells undergoing apoptosis
88. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
89. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
90. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis
91. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
92. A receptor for phosphatidylserine-specific clearance of apoptotic cells
93. Expression cloning of dSR-C1, a class C macrophage-specific scavenger receptor from Drosophila melanogaster
94. Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved
95. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
96. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
97. SRB1, a class B scavenger receptor, recognizes negatively charged liposomes and apoptotic cells
98. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs