Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster

Journal of Neuroscience

Volumn 20, Issue 9, 2000, Pages 3339-3353

  Helfrich Förster, Charlotte ^a   Täuber, Marcus ^b,d   Park, Jae H ^c   Mühlig Versen, Max ^b   Schneuwly, Stephan ^b   Hofbauer, Alois ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c BRANDEIS UNIVERSITY   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Circadian rhythms; Drosophila; Gene misexpression; Insects; Neuropeptides; Pigment dispersing factor

Indexed keywords

NEUROPEPTIDE;

ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; MALE; NERVE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

EID: 0142123778     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-09-03339.2000     Document Type: Article

References (58)

1. Albers HE, Liou S-Y, Stopa EG, Zoeller RT (1991) Interaction of colocalized neuropeptides: functional significance in the circadian timing system. J Neurosci 11:846-851.
2. Albers HE, Liou S-Y, Stopa EG, Zoeller RT (1992) Neurotransmitter colocalization and circadian rhythms. Prog Brain Res 92:289-307.
3. Aréchiga H, Cortes JL, Farcia U, Rodrigues-Sosa L (1985) Neuroendocrine correlates of circadian rhythmicity in Crustaceans. Am Zool 25:265-274.
4. Brand A (1995) GFP in Drosophila. Trends Genet 11:324-325.
5. Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415.
6. Brand AH, Manoukian AS, Perrimon N (1994) Ectopic expression in Drosophila. Methods Cell Biol 44:635-654.
7. Brown MH, Nunez AA (1989) Vasopressin-deficient rats show a reduced amplitude of the circadian sleep rhythm. Physiol Behav 46:759-762.
8. Dircksen H, Zahnow CA, Gaus G, Keller R, Rao KR, Riehm JP (1987) The ultrastructure of nerve endings containing pigment-dispersing hormone (PDH) in crustacean sinus glands: identification by an antiserum against synthetic PDH. Cell Tissue Res 250:377-387.
9. Dowse HB, Ringo JM (1987) Further evidence that the circadian clock in Drosophila is a population of coupled ultradian oscillators. J Biol Rhythms 2:65-76.
10. Dunlap JC (1999) Molecular bases for circadian clocks. Cell 96:271-290.
11. Dushay MS, Konopka RJ, Orr D, Greenacre ML, Kyriacou CP, Rosbash M, Hall JC (1990) Phenotypic and genetic analysis of clock, a new circadian rhythm mutant in Drosophila melanogaster. Genetics 125:557-578.
12. Fischer JA, Giniger E, Maniatis T, Ptashne M (1988) GAL4 activates transcription in Drosophila. Nature 332:853-865.
13. Freeman M (1996) Reiterative use of the EGF-receptor triggers differentiation of all cell-types in the Drosophila eye. Cell 87:651-660.
14. Fricker LD (1988) Carboxypeptidase E. Annu Rev Physiol 50:309-321.
15. Glaser WR (1978) Varianzanalyse. Stuttgart: Gustav Fischer Verlag.
16. Hall JC (1998) Molecular neurogenetics of biological rhythms. J Neurogenet 12:115-181.
17. Handler AM, Konopka RJ (1979) Transplantation of a circadian pacemaker in Drosophila. Nature 279:236-238.
18. Hanesch U, Fischbach K.-F, Heisenberg M (1989) Neuronal architecture of the central complex in Drosophila melanogaster. Cell Tissue Res 257:343-366.
19. Helfrich-Förster C (1995) The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc Natl Acad Sci USA 92:612-616.
20. Helfrich-Förster C (1997) Development of pigment-dispersing hormone immunoreactive neurons in the nervous system of Drosophila melanogaster. J Comp Neurol 380:335-354.
21. Helfrich-Förster C (1998) Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants. J Comp Physiol |A| 182:435-453.
22. Helfrich-Förster C (2000) Differential control of morning and evening components in the activity rhythm of Drosophila melanogaster: sex specific differences suggest a different quality of activity. J Biol Rhythms, in press.
23. Helfrich-Förster C, Homberg U (1993) Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity. J Comp Neurol 337:177-190.
24. Helfrich-Förster C, Stengl M, Homberg U (1998) Organization of the circadian system in insects. Chronobiol Int 15:567-594.
25. Hunter-Ensor M, Ousley A, Sehgal A (1996) Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84:677-685.
26. Inouye S-IT (1996) Circadian rhythms of neuropeptides in the suprachiasmatic nucleus. In: Progress in brain research (Buis RM, Kalsbeck A, Romijn HJ, Pennartz CMA, Mirmiran M, eds) pp 75-90. New York: Elsevier.
27. Ito K, Sass H, Urban J, Hofbauer A, Schneuwly S (1997) GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system. Cell Tissue Res 290:1-10.
28. Jin X, Shearman LP, Weaver DR, Zylka MJ, DeVries GJ, Reppert SM (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 96:57-68.
29. Kaneko M (1998) Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations. Curr Opin Neurobiol 8:652-658.
30. Kaneko M, Helfrich-Förster C, Hall JC (1997) Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling. J Neurosci 17:6745-6760.
31. Klein DC, Moore RY, Reppert SM (1991) Suprachiasmatic nucleus. The mind's clock. New York: Oxford UP.
32. Kloss B, Price JL, Saez L, Blau J, Rothenfluh A, Wesley CS, Young MW (1998) The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Ie. Cell 94:97-107.
33. Kolhekar AS, Roberts MS, Jiang N, Johnson RC, Mains RE, Eipper BA, Taghert PH (1997) Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. J Neurosci 17:1363-1376.
34. Konopka RJ, Hamblen-Coyle MJ, Jamison C, Hall JC (1994) An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system. J Biol Rhythms 9:189-216.
35. Loh YP, Snell CR, Cool DR (1997) Receptor-mediated targeting of hormones to secretory granules: role of carboxypeptidase E. Trends Endocrinol Metab 8:130-137.
36. Löhr J, Klein J, Webster SG, Dircksen H (1993) Quantification, immunoaffinity purification and sequence analysis of a pigment-dispersing hormone of the shore crab Carcinus maenas (L.). Biochem Physiol [B] 104:699-706.
37. Nässel DR, Elekes K (1985) Serotonergic terminal in the neural sheath of the blowfly nervous system: electron microscopical immunocytochemistry and 5,7-dihydroxytryptamine labelling. Neuroscience 15:293-307.
38. Park JH, Hall JC (1998) Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J Biol Rhythms 13:219-228.
39. Park JH, Helfrich-Förster C, Lee G-H, Liu L, Rosbash M, Hall JC (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci USA, in press.
40. Petri B, Stengl M (1997) Pigment-dispersing hormone shifts the phase of the circadian pacemaker of the cockroach Leucophaea maderae. J Neurosci 17:4087-4093.
41. Petri B, Stengl M, Würden S, Homberg U (1995) Immunocytochemical characterization of the accessory medulla in the cockroach Leucophaea maderae. Cell Tissue Res 282:3-19.
42. Poeck B, Hofbauer A, Pflugfelder GO (1993) Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system. Development 117:1017-1029.
43. Pyza E, Meinertzhagen IA (1996) Neurotransmitters regulate rhythmic size changes amongst cells in the fly's optic lobe. J Comp Physiol [A] 178:33-45.
44. Rao KR, Riehm JP (1993) Pigment-dispersing hormones. Ann NY Acad Sci 680:78-88.
45. Renn S, Park JH, Rosbash M, Hall JC, Taghert PH (1999) A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 99:791-802.
46. Reghunandanan V, Reghunandanan R, Singh PI (1993) Neurotransmitters of the suprachiasmatic nucleus: role in the regulation of circadian rhythms. Prog Neurobiol 41:647-655.
47. Reppert SM, Schwartz WJ, UhIGR (1987) Arginine vasopressin: a novel peptide rhythm in cerebrospinal fluid. Trends Neurosci 10:76-80.
48. Robinow S, White K (1988) The locus elay of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev Biol 126:244-303.
49. Robinow S, White K (1991) Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J Neurobiol 22:443-461.
50. Rouyer F, Rachidi M, Pikielny C, Rosbash M (1997) A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock. EMBO J 16:3944-3954.
51. Schlamp CL, Nickells RW (1996) Light and dark cause a shift in the spatial expression of a neuropeptide-processing enzyme in the rat retina. J Neurosci 16:2164-2171.
52. Sokolove PG, Bushell WN (1978) The chi square periodogram: its utility for analysis of circadian rhythms. J Theor Biol 72:131-160.
53. Stengl M, Homberg U (1994) Pigment-dispersing hormone-immunoreactive neurons in the cockroach Leucophaea maderae share properties with circadian pacemaker neurons. J Comp Physiol [A] 175:203-213.
54. Udupi V, Gomez P, Song L, Varlamow O, Reed JT, Leiter EH, Fricker LD, Greeley GH (1997) Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation. Endocrinology 138:1959-1963.
55. Van Gelder RN, Krasnow MA (1996) A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. EMBO J 15:1625-1631.
56. Würden S, Homberg U (1995) Immunocytochemical mapping of serotonin and neuropeptides in the accessory medulla of the locust, Schistocerca gregaria. J Comp Neurol 362:305-319.
57. Yao K-M, Samson M-L. Reeves R, White K (1992) Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J Neurobiol 24:723-739.
58. Zar JH (1984) Biostatistical analysis. Englewood Cliffs, NJ: Prentice-Hall.