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0032580225
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Molecular clocks: Mastering time by gene regulation
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Sassone-Corsi P. Molecular clocks: mastering time by gene regulation. Nature. 392:1998;871-874.
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Nature
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Sassone-Corsi, P.1
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0029837870
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Components and connections of the circadian timing system in mammals
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Reuss S. Components and connections of the circadian timing system in mammals. Cell Tissue Res. 285:1996;353-378.
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Reuss, S.1
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Shedding light on the biological clock
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Foster RG. Shedding light on the biological clock. Neuron. 20:1998;829-832.
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Neuron
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Foster, R.G.1
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4
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0028891043
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Suppression of melatonin secretion in some blind patients by exposure to bright light
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Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 332:1995;6-11.
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Czeisler, C.A.1
Shanahan, T.L.2
Klerman, E.B.3
Martens, H.4
Brotman, D.J.5
Emens, J.S.6
Klein, T.7
Rizzo, J.F.8
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0032535952
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Extraocular circadian phototransduction in humans
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Campbell SS, Murphy PJ. Extraocular circadian phototransduction in humans. Science. 279:1998;396-399.
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Science
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Campbell, S.S.1
Murphy, P.J.2
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6
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0030862358
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Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function
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of special interest. The developmental expression patterns of all the principal components of retinal phototransduction in the rat pineal gland were studied via cRNA in situ hybridization. The authors found that all the components needed to reconstitute a functional phototransduction pathway are expressed in the majority of neonatal pinealocytes, although the expression levels of many of these components cecline dramatically during development.
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of special interest Blackshaw S, Snyder SH. Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function. J Neurosci. 17:1997;8074-8082 The developmental expression patterns of all the principal components of retinal phototransduction in the rat pineal gland were studied via cRNA in situ hybridization. The authors found that all the components needed to reconstitute a functional phototransduction pathway are expressed in the majority of neonatal pinealocytes, although the expression levels of many of these components cecline dramatically during development.
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(1997)
J Neurosci
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, pp. 8074-8082
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Blackshaw, S.1
Snyder, S.H.2
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7
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0015502984
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Indole metabolism in the pineal gland: A circadian rhythm in N-acetyltransferase activity
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Klein DC, Weller JL. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase activity. Science. 177:1972;532-533.
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Science
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Klein, D.C.1
Weller, J.L.2
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8
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0029560035
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Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland
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Borjigin J, Wang MM, Snyder SH. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Nature. 378:1995;783-785.
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Nature
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Borjigin, J.1
Wang, M.M.2
Snyder, S.H.3
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9
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0029593545
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Pineal serotonin N-acetyltransferase: Expression cloning and molecular analysis
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Coon SL, Roseboom PH, Baler R, Weller JL, Namboodiri MA, Koonin EV, Klein DC. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science. 270:1995;1681-1683.
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Science
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Coon, S.L.1
Roseboom, P.H.2
Baler, R.3
Weller, J.L.4
Namboodiri, M.A.5
Koonin, E.V.6
Klein, D.C.7
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10
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0030626244
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The melatonin rhythm-generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the pineal gland
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Klein DC, Coon SL, Roseboom PH, Weller JL, Bernard M, Gastel JA, Zatz M, Iuvone PM, Rodriguez IR, Begay V, et al. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res. 52:1997;307-357.
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Recent Prog Horm Res
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Klein, D.C.1
Coon, S.L.2
Roseboom, P.H.3
Weller, J.L.4
Bernard, M.5
Gastel, J.A.6
Zatz, M.7
Iuvone, P.M.8
Rodriguez, I.R.9
Begay, V.10
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11
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0027495101
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Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland
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Stehle JH, Foulkes NS, Molina CA, Simonneaux V, Pevet P, Sassone-Corsi P. Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature. 365:1993;314-320.
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Nature
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Stehle, J.H.1
Foulkes, N.S.2
Molina, C.A.3
Simonneaux, V.4
Pevet, P.5
Sassone-Corsi, P.6
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12
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0027741257
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Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
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Molina CA, Foulkes NS, Lalli E, Sassone-Corsi P. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell. 75:1993;875-886.
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Cell
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Molina, C.A.1
Foulkes, N.S.2
Lalli, E.3
Sassone-Corsi, P.4
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14
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0028803671
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Circadian expression of transcription factor Fra-2 in the rat pineal gland
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Baler R, Klein DC. Circadian expression of transcription factor Fra-2 in the rat pineal gland. J Biol Chem. 270:1995;27319-27325.
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J Biol Chem
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Baler, R.1
Klein, D.C.2
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16
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0030010140
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Adaptive inducibility of CREM as transcriptional memory of circadian rhythms
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Foulkes NS, Duval G, Sassone-Corsi P. Adaptive inducibility of CREM as transcriptional memory of circadian rhythms. Nature. 381:1996;83-85.
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Nature
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Foulkes, N.S.1
Duval, G.2
Sassone-Corsi, P.3
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17
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0032539699
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A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX
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of outstanding interest. This paper reports the identification of PIRE in PINA, NAT, and HIOMT promoters. PIRE is recognized by a nuclear factor that is present in the pineal gland and retina, but not other tissues. The tissue-specific binding activity of PIRE is at least in part attribute to CRX, which is the first transcription factor shown to control the tissue-specific transcription of melatonin synthesis genes. The presence of PIRE sites in a series of pineal/retina-specific genes (see also annotation [19,21]) suggests a general role for CRX as a 'master' transcription factor. These findings uncover another aspect of melatonin synthesis regulation, namely its spatial specificity.
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of outstanding interest Li X, Chen S, Wang Q, Zack DJ, Snyder SH, Borjigin J. A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. Proc Natl Acad Sci USA. 95:1998;1876-1881 This paper reports the identification of PIRE in PINA, NAT, and HIOMT promoters. PIRE is recognized by a nuclear factor that is present in the pineal gland and retina, but not other tissues. The tissue-specific binding activity of PIRE is at least in part attribute to CRX, which is the first transcription factor shown to control the tissue-specific transcription of melatonin synthesis genes. The presence of PIRE sites in a series of pineal/retina-specific genes (see also annotation [19,21]) suggests a general role for CRX as a 'master' transcription factor. These findings uncover another aspect of melatonin synthesis regulation, namely its spatial specificity.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1876-1881
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Li, X.1
Chen, S.2
Wang, Q.3
Zack, D.J.4
Snyder, S.H.5
Borjigin, J.6
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18
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0027452091
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The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
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Bull PC, Thomas GR, Rommens JM, Forbes JR, Cox DW. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat Genet. 5:1993;327-337.
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(1993)
Nat Genet
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Bull, P.C.1
Thomas, G.R.2
Rommens, J.M.3
Forbes, J.R.4
Cox, D.W.5
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19
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0030725687
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Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation
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of outstanding interest. See annotation [21].
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of outstanding interest Furukawa T, Morrow EM, Cepko CL. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell. 91:1997;531-541 See annotation [21].
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(1997)
Cell
, vol.91
, pp. 531-541
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Furukawa, T.1
Morrow, E.M.2
Cepko, C.L.3
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20
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0030669568
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Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
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of outstanding interest. See annotation [21].
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of outstanding interest Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, et al. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell. 91:1997;543-553 See annotation [21].
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(1997)
Cell
, vol.91
, pp. 543-553
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Freund, C.L.1
Gregory-Evans, C.Y.2
Furukawa, T.3
Papaioannou, M.4
Looser, J.5
Ploder, L.6
Bellingham, J.7
Ng, D.8
Herbrick, J.A.9
Duncan, A.10
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21
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0030781996
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Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
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of special interest. of outstanding interest. These three recent papers [19-21] report the molecular cloning of CRX from retina. CRX has been shown to play a role in photoreceptor development and differentiation [19,21]. Among all the known transcription factors required for the mammalian eye development. CRX is the only one that is expressed exclusively in the retina and pineal. CRX expression predates that of any known photoreceptor-specific markers, and peaks at the time of maximal rod cell proliferation [19,21]. Furthermore, overexpression of CRX increased clones containing exclusively rod photoreceptors [21]. These data indicate that CRX helps to specify photoreceptor cell fate. See also annotation [23].
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of special interest Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. of outstanding interest Neuron. 19:1997;1017-1030 These three recent papers [19-21] report the molecular cloning of CRX from retina. CRX has been shown to play a role in photoreceptor development and differentiation [19,21]. Among all the known transcription factors required for the mammalian eye development. CRX is the only one that is expressed exclusively in the retina and pineal. CRX expression predates that of any known photoreceptor-specific markers, and peaks at the time of maximal rod cell proliferation [19,21]. Furthermore, overexpression of CRX increased clones containing exclusively rod photoreceptors [21]. These data indicate that CRX helps to specify photoreceptor cell fate. See also annotation [23].
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(1997)
Neuron
, vol.19
, pp. 1017-1030
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Chen, S.1
Wang, Q.L.2
Nie, Z.3
Sun, H.4
Lennon, G.5
Copeland, N.G.6
Gilbert, D.J.7
Jenkins, N.A.8
Zack, D.J.9
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22
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0031447030
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Mutations in the cone-rod homeobox gene are associated with the conerod dystrophy photoreceptor degeneration
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of special interest. See annotation [23].
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of special interest Swain PK, Chen S, Wang QL, Affatigato LM, Coats CL, Brady KD, Fishman GA, Jacobson SG, Swaroop A, Stone E, et al. Mutations in the cone-rod homeobox gene are associated with the conerod dystrophy photoreceptor degeneration. Neuron. 19:1997;1329-1336 See annotation [23].
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(1997)
Neuron
, vol.19
, pp. 1329-1336
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Swain, P.K.1
Chen, S.2
Wang, Q.L.3
Affatigato, L.M.4
Coats, C.L.5
Brady, K.D.6
Fishman, G.A.7
Jacobson, S.G.8
Swaroop, A.9
Stone, E.10
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23
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0032037626
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De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
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of outstanding interest. of special interest. Both cone - rod dystrophy (CORD) [20,22] and Leber congenital amaurosis (LCA) [23] were mapped to mutations in CRX. The autosomal-dominant form of CORD has been assigned to four loci, among which CRX is so far the only identified gene related to this disease. LCA is a clinically heterogenous group of childhood retinal degeneration inherited in an autosomal-recessive manner. These findings indicate that CRX is not only essential for photoreceptor development [19,21], but also required for the maintenance of normal cone and rod function. See also annotation [21].
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of outstanding interest Freund CL, Wang QL, Chen S, Muskat BL, Wiles CD, Sheffield VC, Jacobson SG, McInnes RR, Zack DJ, Stone EM. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. of special interest Nat Genet. 18:1998;311-312 Both cone - rod dystrophy (CORD) [20,22] and Leber congenital amaurosis (LCA) [23] were mapped to mutations in CRX. The autosomal-dominant form of CORD has been assigned to four loci, among which CRX is so far the only identified gene related to this disease. LCA is a clinically heterogenous group of childhood retinal degeneration inherited in an autosomal-recessive manner. These findings indicate that CRX is not only essential for photoreceptor development [19,21], but also required for the maintenance of normal cone and rod function. See also annotation [21].
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(1998)
Nat Genet
, vol.18
, pp. 311-312
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Freund, C.L.1
Wang, Q.L.2
Chen, S.3
Muskat, B.L.4
Wiles, C.D.5
Sheffield, V.C.6
Jacobson, S.G.7
McInnes, R.R.8
Zack, D.J.9
Stone, E.M.10
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24
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0024296388
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A1 protein alters the DNA binding specificity of α2 receptor
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Goutte C, Johnson AD. a1 protein alters the DNA binding specificity of α2 receptor. Cell. 52:1998;875-882.
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(1998)
Cell
, vol.52
, pp. 875-882
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Goutte, C.1
Johnson, A.D.2
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