-
1
-
-
0033231103
-
Insulin delivery with plasmid DNA
-
Abai, A.M., Hobart, P.M. and Barnhart, K.M. (1999) Insulin delivery with plasmid DNA. Hum. Gene Ther., 10: 2637-2649.
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 2637-2649
-
-
Abai, A.M.1
Hobart, P.M.2
Barnhart, K.M.3
-
2
-
-
0036323269
-
Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
-
Abraham, E.J., Leech, C.A., Lin, J.C., Zulewski, H. and Habener, J.F. (2002) Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology, 143: 3152-3161.
-
(2002)
Endocrinology
, vol.143
, pp. 3152-3161
-
-
Abraham, E.J.1
Leech, C.A.2
Lin, J.C.3
Zulewski, H.4
Habener, J.F.5
-
3
-
-
0036061575
-
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates
-
Adams, A.B., Shirasugi, N., Durham, M.M., Strobert, E., Anderson, D., Rees, P., Cowan, S., Xu, H., Blinder, Y., Cheung, M., Hollenbaugh, D., Kenyon, N.S., Pearson, T.C. and Larsen, C.P. (2002) Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes, 51: 265-270.
-
(2002)
Diabetes
, vol.51
, pp. 265-270
-
-
Adams, A.B.1
Shirasugi, N.2
Durham, M.M.3
Strobert, E.4
Anderson, D.5
Rees, P.6
Cowan, S.7
Xu, H.8
Blinder, Y.9
Cheung, M.10
Hollenbaugh, D.11
Kenyon, N.S.12
Pearson, T.C.13
Larsen, C.P.14
-
4
-
-
0036137987
-
Understanding autoimmune diabetes: Insights from mouse models
-
Adorini, L., Gregori, S. and Harrison, L.C. (2002) Understanding autoimmune diabetes: insights from mouse models. Trends Mol. Med., 8: 31-38.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 31-38
-
-
Adorini, L.1
Gregori, S.2
Harrison, L.C.3
-
5
-
-
0035995944
-
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes
-
Alexander, A.M., Crawford, M., Bertera, S., Rudert, W.A., Takikawa, O., Robbins, P.D. and Trucco, M. (2002) Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 51: 356-365.
-
(2002)
Diabetes
, vol.51
, pp. 356-365
-
-
Alexander, A.M.1
Crawford, M.2
Bertera, S.3
Rudert, W.A.4
Takikawa, O.5
Robbins, P.D.6
Trucco, M.7
-
6
-
-
1942489373
-
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes
-
Ashery-Padan, R., Zhou, X., Marquardt, T., Herrera, P., Toube, L., Berry, A. and Gruss, P. (2004) Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev. Biol., 269: 479-488.
-
(2004)
Dev. Biol.
, vol.269
, pp. 479-488
-
-
Ashery-Padan, R.1
Zhou, X.2
Marquardt, T.3
Herrera, P.4
Toube, L.5
Berry, A.6
Gruss, P.7
-
7
-
-
0035434048
-
Insulin production by human embryonic stem cells
-
Assady, S., Maor, G., Amit, M., Itskovitz-Eldor, J., Skorecki, K.L. and Tzukerman, M. (2001) Insulin production by human embryonic stem cells. Diabetes, 50: 1691-1697.
-
(2001)
Diabetes
, vol.50
, pp. 1691-1697
-
-
Assady, S.1
Maor, G.2
Amit, M.3
Itskovitz-Eldor, J.4
Skorecki, K.L.5
Tzukerman, M.6
-
8
-
-
0035928391
-
Type 1 diabetes: New perspectives on disease pathogenesis and treatment
-
Atkinson, M.A. and Eisenbarth, G.S. (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet, 358: 221-229.
-
(2001)
Lancet
, vol.358
, pp. 221-229
-
-
Atkinson, M.A.1
Eisenbarth, G.S.2
-
9
-
-
0028982203
-
Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation
-
Bach, J.F. (1995) Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulation. J. Autoimmun., 8: 439-463.
-
(1995)
J. Autoimmun.
, vol.8
, pp. 439-463
-
-
Bach, J.F.1
-
10
-
-
0015386234
-
Transplantation of intact pancreatic islets in rats
-
Ballinger, W.F. and Lacy, P.E. (1972) Transplantation of intact pancreatic islets in rats. Surgery, 72: 175-186.
-
(1972)
Surgery
, vol.72
, pp. 175-186
-
-
Ballinger, W.F.1
Lacy, P.E.2
-
11
-
-
0028260056
-
Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia
-
Barrou, Z., Seaquist, E.R. and Robertson, R.P. (1994) Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia. Diabetes, 43: 661-666.
-
(1994)
Diabetes
, vol.43
, pp. 661-666
-
-
Barrou, Z.1
Seaquist, E.R.2
Robertson, R.P.3
-
12
-
-
2942659930
-
Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: A first-year review
-
Barshes, N.R., Lee, T., Goodpasture, S., Brunicardi, F.C., Alejandro, R., Ricordi, C., Soltes, G., Barth, M., Hamilton, D. and Goss, J.A. (2004) Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review. Transplant. Proc., 36: 1127-1129.
-
(2004)
Transplant. Proc.
, vol.36
, pp. 1127-1129
-
-
Barshes, N.R.1
Lee, T.2
Goodpasture, S.3
Brunicardi, F.C.4
Alejandro, R.5
Ricordi, C.6
Soltes, G.7
Barth, M.8
Hamilton, D.9
Goss, J.A.10
-
13
-
-
0036897164
-
A novel approach to increase human islet cell mass while preserving beta-cell function
-
Beattie, G.M., Montgomery, A.M., Lopez, A.D., Hao, E., Perez, B., Just, M.L., Lakey, J.R., Hart, M.E. and Hayek, A. (2002) A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes, 51: 3435-3439.
-
(2002)
Diabetes
, vol.51
, pp. 3435-3439
-
-
Beattie, G.M.1
Montgomery, A.M.2
Lopez, A.D.3
Hao, E.4
Perez, B.5
Just, M.L.6
Lakey, J.R.7
Hart, M.E.8
Hayek, A.9
-
14
-
-
0030449531
-
Decreased alloreactivity to human islets secreting recombinant viral interleukin 10
-
Benhamou, P.Y., Mullen, Y., Shaked, A., Bahmiller, D. and Csete, M.E. (1996) Decreased alloreactivity to human islets secreting recombinant viral interleukin 10. Transplantation, 62: 1306-1312.
-
(1996)
Transplantation
, vol.62
, pp. 1306-1312
-
-
Benhamou, P.Y.1
Mullen, Y.2
Shaked, A.3
Bahmiller, D.4
Csete, M.E.5
-
15
-
-
15644375700
-
Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets
-
Benhamou, P.Y., Moriscot, C., Richard, M.J., Beatrix, O., Badet, L., Pattou, F., Kerr-Conte, J., Chroboczek, J., Lemarchand, P. and Halimi, S. (1998) Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets. Diabetologia, 41: 1093-1100.
-
(1998)
Diabetologia
, vol.41
, pp. 1093-1100
-
-
Benhamou, P.Y.1
Moriscot, C.2
Richard, M.J.3
Beatrix, O.4
Badet, L.5
Pattou, F.6
Kerr-Conte, J.7
Chroboczek, J.8
Lemarchand, P.9
Halimi, S.10
-
16
-
-
0034653591
-
Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: Protective effects of sCR1 and heparin
-
Bennet, W., Sundberg, B., Lundgren, T., Tibell, A., Groth, C.G., Richards, A., White, D.J., Elgue, G., Larsson, R., Nilsson, B. and Korsgren, O. (2000) Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation, 69: 711-719.
-
(2000)
Transplantation
, vol.69
, pp. 711-719
-
-
Bennet, W.1
Sundberg, B.2
Lundgren, T.3
Tibell, A.4
Groth, C.G.5
Richards, A.6
White, D.J.7
Elgue, G.8
Larsson, R.9
Nilsson, B.10
Korsgren, O.11
-
17
-
-
0347363460
-
The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice
-
Berney, T., Pileggi, A., Molano, R.D., Poggioli, R., Zahr, E., Ricordi, C. and Inverardi, L. (2003) The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice. Transplantation, 76: 1669-1674.
-
(2003)
Transplantation
, vol.76
, pp. 1669-1674
-
-
Berney, T.1
Pileggi, A.2
Molano, R.D.3
Poggioli, R.4
Zahr, E.5
Ricordi, C.6
Inverardi, L.7
-
18
-
-
0037417958
-
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
-
Blyszczuk, P., Czyz, J., Kania, G., Wagner, M., Roll, U., St-Onge, L. and Wobus, A.M. (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc. Natl. Acad. Sci. U. S. A., 100: 998-1003.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 998-1003
-
-
Blyszczuk, P.1
Czyz, J.2
Kania, G.3
Wagner, M.4
Roll, U.5
St-Onge, L.6
Wobus, A.M.7
-
19
-
-
0027449197
-
A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
-
Bonner-Weir, S., Baxter, L.A., Schuppin, G.T. and Smith, F.E. (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720.
-
(1993)
Diabetes
, vol.42
, pp. 1715-1720
-
-
Bonner-Weir, S.1
Baxter, L.A.2
Schuppin, G.T.3
Smith, F.E.4
-
20
-
-
0034608816
-
In vitro cultivation of human islets from expanded ductal tissue
-
Bonner-Weir, S., Taneja, M., Weir, G.C., Tatarkiewicz, K., Song, K.H., Sharma, A. and O'Neil, J.J. (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. U. S. A., 97: 7999-8004.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 7999-8004
-
-
Bonner-Weir, S.1
Taneja, M.2
Weir, G.C.3
Tatarkiewicz, K.4
Song, K.H.5
Sharma, A.6
O'Neil, J.J.7
-
21
-
-
0036070177
-
Pancreatic stem cells
-
Bonner-Weir, S. and Sharma, A. (2002) Pancreatic stem cells. J. Pathol., 197: 519-526.
-
(2002)
J. Pathol.
, vol.197
, pp. 519-526
-
-
Bonner-Weir, S.1
Sharma, A.2
-
22
-
-
0038621437
-
Gene- and cell-based therapeutics for type I diabetes mellitus
-
Bottino, R., Lemarchand, P., Trucco, M. and Giannoukakis, N. (2003) Gene- and cell-based therapeutics for type I diabetes mellitus. Gene Ther., 10: 875-889.
-
(2003)
Gene Ther.
, vol.10
, pp. 875-889
-
-
Bottino, R.1
Lemarchand, P.2
Trucco, M.3
Giannoukakis, N.4
-
23
-
-
0036461351
-
Rapid failure of pig islet transplantation in non human primates
-
Cantarovich, D., Blancho, G., Potiron, N., Jugeau, N., Fiche, M., Chagneau, C., Letessier, E., Boeffard, F., Loth, P., Karam, G., Soulillou, J.P. and Le Mauff, B. (2002) Rapid failure of pig islet transplantation in non human primates. Xenotransplantation, 9: 25-35.
-
(2002)
Xenotransplantation
, vol.9
, pp. 25-35
-
-
Cantarovich, D.1
Blancho, G.2
Potiron, N.3
Jugeau, N.4
Fiche, M.5
Chagneau, C.6
Letessier, E.7
Boeffard, F.8
Loth, P.9
Karam, G.10
Soulillou, J.P.11
Le Mauff, B.12
-
24
-
-
0027958044
-
Anti-CD3 anti-body induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud, L., Thervet, E., Primo, J. and Bach, J.F. (1994) Anti-CD3 anti-body induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. U. S. A., 91: 123-127.
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
25
-
-
0037313086
-
CD3-specific antibody-induced active tolerance: From bench to bedside
-
Chatenoud, L. (2003) CD3-specific antibody-induced active tolerance: from bench to bedside. Nat. Rev. Immunol., 3: 123-132.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 123-132
-
-
Chatenoud, L.1
-
26
-
-
0029058252
-
Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector
-
Chen, R., Doiron, B. and Kahn, A. (1995) Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector. FEBS Lett., 365: 223-226.
-
(1995)
FEBS Lett.
, vol.365
, pp. 223-226
-
-
Chen, R.1
Doiron, B.2
Kahn, A.3
-
27
-
-
0033693585
-
Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells
-
Chen, R., Meseck, M., McEvoy, R.C. and Woo, S.L. (2000) Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Gene Ther., 7: 1802-1809.
-
(2000)
Gene Ther.
, vol.7
, pp. 1802-1809
-
-
Chen, R.1
Meseck, M.2
McEvoy, R.C.3
Woo, S.L.4
-
28
-
-
0034984540
-
Auto-regulated hepatic insulin gene expression in type 1 diabetic rats
-
Chen, R., Meseck, M.L. and Woo, S.L. (2001) Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol. Ther. 3: 584-590.
-
(2001)
Mol. Ther.
, vol.3
, pp. 584-590
-
-
Chen, R.1
Meseck, M.L.2
Woo, S.L.3
-
29
-
-
0034623757
-
Glucose-dependent insulin release from genetically engineered K cells
-
Cheung, A.T., Dayanandan, B., Lewis, J.T., Korbutt, G.S., Rajotte, R.V., Bryer-Ash, M., Boylan, M.O., Wolfe, M.M. and Kieffer, T.J. (2000) Glucose-dependent insulin release from genetically engineered K cells. Science, 290: 1959-1962.
-
(2000)
Science
, vol.290
, pp. 1959-1962
-
-
Cheung, A.T.1
Dayanandan, B.2
Lewis, J.T.3
Korbutt, G.S.4
Rajotte, R.V.5
Bryer-Ash, M.6
Boylan, M.O.7
Wolfe, M.M.8
Kieffer, T.J.9
-
30
-
-
10744233909
-
Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
-
Choi, J.B., Uchino, H., Azuma, K., Iwashita, N., Tanaka, Y., Mochizuki, H., Migita, M., Shimada, T., Kawamori, R. and Watada, H. (2003) Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia, 46: 1366-1374.
-
(2003)
Diabetologia
, vol.46
, pp. 1366-1374
-
-
Choi, J.B.1
Uchino, H.2
Azuma, K.3
Iwashita, N.4
Tanaka, Y.5
Mochizuki, H.6
Migita, M.7
Shimada, T.8
Kawamori, R.9
Watada, H.10
-
31
-
-
0033202734
-
Pancreatic transplantation: A review
-
Cicalese, L., Giacomoni, A., Rastellini, C. and Benedetti, E. (1999) Pancreatic transplantation: a review. Int. Surg., 84: 305-312.
-
(1999)
Int. Surg.
, vol.84
, pp. 305-312
-
-
Cicalese, L.1
Giacomoni, A.2
Rastellini, C.3
Benedetti, E.4
-
32
-
-
0037428479
-
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2
-
Cissell, M.A., Zhao, L., Sussel, L., Henderson, E. and Stein, R. (2003) Transcription factor occupancy of the insulin gene in vivo Evidence for direct regulation by Nkx2.2. J. Biol. Chem., 278: 751-756.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 751-756
-
-
Cissell, M.A.1
Zhao, L.2
Sussel, L.3
Henderson, E.4
Stein, R.5
-
33
-
-
0035344152
-
K cells: A novel target for insulin gene therapy for the prevention of diabetes
-
Corbett, J.A. (2001) K cells: a novel target for insulin gene therapy for the prevention of diabetes. Trends Endocrinol. Metab., 12: 140-142.
-
(2001)
Trends Endocrinol. Metab.
, vol.12
, pp. 140-142
-
-
Corbett, J.A.1
-
34
-
-
0025374590
-
Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells
-
D'Ambra, R., Surana, M., Efrat, S., Starr, R.G. and Fleischer, N. (1990) Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology, 126: 2815-2822.
-
(1990)
Endocrinology
, vol.126
, pp. 2815-2822
-
-
D'Ambra, R.1
Surana, M.2
Efrat, S.3
Starr, R.G.4
Fleischer, N.5
-
35
-
-
4143098466
-
Causes of limited survival of microencapsulated pancreatic islet grafts
-
de Groot, M., Schuurs, T.A. and van Schilfgaarde, R. (2004) Causes of limited survival of microencapsulated pancreatic islet grafts. J. Surg. Res., 121: 141-150.
-
(2004)
J. Surg. Res.
, vol.121
, pp. 141-150
-
-
de Groot, M.1
Schuurs, T.A.2
van Schilfgaarde, R.3
-
36
-
-
17744372474
-
Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo
-
de la Tour, D., Halvorsen, T., Demeterco, C., Tyrberg, B., Itkin-Ansari, P., Loy, M., Yoo, S.J., Hao, E., Bossie, S. and Levine, F. (2001) Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol. Endocrinol., 15: 476-483.
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 476-483
-
-
de la Tour, D.1
Halvorsen, T.2
Demeterco, C.3
Tyrberg, B.4
Itkin-Ansari, P.5
Loy, M.6
Yoo, S.J.7
Hao, E.8
Bossie, S.9
Levine, F.10
-
37
-
-
0030948708
-
IL-10 and TGF-beta gene transfer to rodent islets: Effect on xenogeneic islet graft survival in naive and B-cell-deficient mice
-
Deng, S., Ketchum, R.J., Yang, Z.D., Kucher, T., Weber, M., Shaked, A., Naji, A. and Brayman, K.L. (1997) IL-10 and TGF-beta gene transfer to rodent islets: effect on xenogeneic islet graft survival in naive and B-cell-deficient mice. Transplant. Proc., 29: 2207-2208.
-
(1997)
Transplant. Proc.
, vol.29
, pp. 2207-2208
-
-
Deng, S.1
Ketchum, R.J.2
Yang, Z.D.3
Kucher, T.4
Weber, M.5
Shaked, A.6
Naji, A.7
Brayman, K.L.8
-
38
-
-
0035650959
-
Growth and development of the islets of Langerhans: Implications for the treatment of diabetes mellitus
-
Docherty, K. (2001) Growth and development of the islets of Langerhans: implications for the treatment of diabetes mellitus. Curr. Opin. Pharmacol., 1: 641-650.
-
(2001)
Curr. Opin. Pharmacol.
, vol.1
, pp. 641-650
-
-
Docherty, K.1
-
39
-
-
0028206043
-
Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter
-
Doiron, B., Cuif, M.H., Kahn, A. and Diaz-Guerra, M.J. (1994) Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter. J. Biol. Chem., 269: 10213-10216.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10213-10216
-
-
Doiron, B.1
Cuif, M.H.2
Kahn, A.3
Diaz-Guerra, M.J.4
-
40
-
-
0035656779
-
Hepatic insulin production for type 1 diabetes
-
Dong, H. and Woo, S.L. (2001) Hepatic insulin production for type 1 diabetes. Trends Endocrinol. Metab., 12: 441-446.
-
(2001)
Trends Endocrinol. Metab.
, vol.12
, pp. 441-446
-
-
Dong, H.1
Woo, S.L.2
-
41
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor, Y., Brown, J., Martinez, O.I. and Melton, D.A. (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature, 429: 41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
42
-
-
0034511895
-
Beta-granule transport and exocytosis
-
Easom, R.A. (2000) Beta-granule transport and exocytosis. Semin. Cell. Dev. Biol., 11: 253-266.
-
(2000)
Semin. Cell. Dev. Biol.
, vol.11
, pp. 253-266
-
-
Easom, R.A.1
-
43
-
-
0028938747
-
Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene
-
Efrat, S., Fusco-DeMane, D., Lemberg, H., al Emran, O. and Wang, X. (1995) Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc. Natl. Acad. Sci. U. S. A., 92: 3576-3580.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 3576-3580
-
-
Efrat, S.1
Fusco-DeMane, D.2
Lemberg, H.3
al Emran, O.4
Wang, X.5
-
44
-
-
0036302888
-
Cell replacement therapy for type 1 diabetes
-
Efrat, S. (2002) Cell replacement therapy for type 1 diabetes. Trends Mol. Med., 8: 334-339.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 334-339
-
-
Efrat, S.1
-
45
-
-
4444231441
-
Generation of surrogate beta cells from tissue stem cells
-
Efrat, S. (2004) Generation of surrogate beta cells from tissue stem cells. Curr. Diab. Rep., 4: 298-303.
-
(2004)
Curr. Diab. Rep.
, vol.4
, pp. 298-303
-
-
Efrat, S.1
-
46
-
-
4243869718
-
Production of mature human insulin by retrovirally engineered fibroblasts and primary rat hepatocytes
-
Falqui, L. (1996) Production of mature human insulin by retrovirally engineered fibroblasts and primary rat hepatocytes. Esp. Clin. Endocrinol. Diabetes, 104: A37.
-
(1996)
Esp. Clin. Endocrinol. Diabetes
, vol.104
-
-
Falqui, L.1
-
47
-
-
0033587485
-
Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin
-
Falqui, L., Martinenghi, S., Severini, G.M., Corbella, P., Taglietti, M.V., Arcelloni C., Sarugeri, E., Monti, L.D., Paroni, R., Dozio, N., Pozza, G. and Bordignon, C. (1999) Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin. Hum. Gene Ther., 10: 1753-1762.
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 1753-1762
-
-
Falqui, L.1
Martinenghi, S.2
Severini, G.M.3
Corbella, P.4
Taglietti, M.V.5
Arcelloni, C.6
Sarugeri, E.7
Monti, L.D.8
Paroni, R.9
Dozio, N.10
Pozza, G.11
Bordignon, C.12
-
48
-
-
0034068602
-
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
-
Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N. and Karasik, A. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med., 6: 568-572.
-
(2000)
Nat. Med.
, vol.6
, pp. 568-572
-
-
Ferber, S.1
Halkin, A.2
Cohen, H.3
Ber, I.4
Einav, Y.5
Goldberg, I.6
Barshack, I.7
Seijffers, R.8
Kopolovic, J.9
Kaiser, N.10
Karasik, A.11
-
49
-
-
0022619110
-
Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial
-
Feutren, G., Papoz, L., Assan, R., Vialettes, B., Karsenty, G., Vexiau, P., Du Rostu, H., Rodier, M., Sirmai, J. and Lallemand, A. (1986) Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial. Lancet, 2: 119-124.
-
(1986)
Lancet
, vol.2
, pp. 119-124
-
-
Feutren, G.1
Papoz, L.2
Assan, R.3
Vialettes, B.4
Karsenty, G.5
Vexiau, P.6
Du Rostu, H.7
Rodier, M.8
Sirmai, J.9
Lallemand, A.10
-
50
-
-
0028987251
-
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
-
Finegood, D.T., Scaglia, L. and Bonner-Weir, S. (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes, 44: 249-256.
-
(1995)
Diabetes
, vol.44
, pp. 249-256
-
-
Finegood, D.T.1
Scaglia, L.2
Bonner-Weir, S.3
-
51
-
-
0031659962
-
Functional analysis of a conditionally transformed pancreatic beta-cell line
-
Fleischer, N., Chen, C., Surana, M., Leiser, M., Rossetti, L., Pralong, W. and Efrat, S. (1998) Functional analysis of a conditionally transformed pancreatic beta-cell line. Diabetes, 47: 1419-1425.
-
(1998)
Diabetes
, vol.47
, pp. 1419-1425
-
-
Fleischer, N.1
Chen, C.2
Surana, M.3
Leiser, M.4
Rossetti, L.5
Pralong, W.6
Efrat, S.7
-
52
-
-
0030935124
-
Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival
-
Gainer, A.L., Korbutt, G.S., Rajorte, R.V., Warnock, G.L. and Elliott, J.F. (1997) Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival. Transplantation, 63: 1017-1021.
-
(1997)
Transplantation
, vol.63
, pp. 1017-1021
-
-
Gainer, A.L.1
Korbutt, G.S.2
Rajorte, R.V.3
Warnock, G.L.4
Elliott, J.F.5
-
53
-
-
0032558090
-
Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand
-
Gainer, A.L., Suarez-Pinzon, W.L., Min, W.P., Swiston, J.R., Hancock-Friesen, C., Korbutt, G.S., Rajotte, R.V., Warnock, G.L. and Elliott, J.F. (1998) Improved survival of biolistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand. Transplantation, 66: 194-199.
-
(1998)
Transplantation
, vol.66
, pp. 194-199
-
-
Gainer, A.L.1
Suarez-Pinzon, W.L.2
Min, W.P.3
Swiston, J.R.4
Hancock-Friesen, C.5
Korbutt, G.S.6
Rajotte, R.V.7
Warnock, G.L.8
Elliott, J.F.9
-
54
-
-
0032506750
-
Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis
-
Gallichan, W.S., Kafri, T., Krahl, T., Verma, I.M. and Sarvetnick, N. (1998) Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum. Gene Ther., 9: 2717-2726.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 2717-2726
-
-
Gallichan, W.S.1
Kafri, T.2
Krahl, T.3
Verma, I.M.4
Sarvetnick, N.5
-
55
-
-
0037414812
-
Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death
-
Garcia-Ocana, A., Takane, K.K., Reddy, V.T., Lopez-Talavera, J.C., Vasavada, R.C. and Stewart, A.F. (2003) Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J. Biol. Chem., 278: 343-351.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 343-351
-
-
Garcia-Ocana, A.1
Takane, K.K.2
Reddy, V.T.3
Lopez-Talavera, J.C.4
Vasavada, R.C.5
Stewart, A.F.6
-
56
-
-
0032830997
-
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro
-
Giannoukakis, N., Rudert, W.A., Ghivizzani, S.C., Gambotto, A., Ricordi, C., Trucco, M. and Robbins, P.D. (1999) Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes, 48: 1730-1736.
-
(1999)
Diabetes
, vol.48
, pp. 1730-1736
-
-
Giannoukakis, N.1
Rudert, W.A.2
Ghivizzani, S.C.3
Gambotto, A.4
Ricordi, C.5
Trucco, M.6
Robbins, P.D.7
-
57
-
-
0036022663
-
Gene and cell therapies for diabetes mellitus: Strategies and clinical potential
-
Giannoukakis, N. and Robbins, P.D. (2002) Gene and cell therapies for diabetes mellitus: strategies and clinical potential. Bio. Drugs, 16: 149-173.
-
(2002)
Bio. Drugs
, vol.16
, pp. 149-173
-
-
Giannoukakis, N.1
Robbins, P.D.2
-
58
-
-
0035752674
-
The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats
-
Girman, P., Kriz, J., Dovolilova, E., Cihalova, E. and Saudek, F. (2001) The effect of bone marrow transplantation on survival of allogeneic pancreatic islets with short-term tacrolimus conditioning in rats. Ann. Transplant., 6: 43-45.
-
(2001)
Ann. Transplant.
, vol.6
, pp. 43-45
-
-
Girman, P.1
Kriz, J.2
Dovolilova, E.3
Cihalova, E.4
Saudek, F.5
-
59
-
-
0027420730
-
The glucose transporter family: Structure, function and tissue-specific expression
-
Gould, G.W. and Holman, G.D. (1993) The glucose transporter family: structure, function and tissue-specific expression. Biochem. J., 295 ( Pt 2): 329-341.
-
(1993)
Biochem. J.
, vol.295
, Issue.PART 2
, pp. 329-341
-
-
Gould, G.W.1
Holman, G.D.2
-
60
-
-
0035082335
-
Adenovirus-mediated gene transfer of A20 in murine islets inhibits Fas-induced apoptosis
-
Grey, S.T., Lock, J., Bach, F.H. and Ferran, C. (2001) Adenovirus-mediated gene transfer of A20 in murine islets inhibits Fas-induced apoptosis. Transplant. Proc., 33: 577-578.
-
(2001)
Transplant. Proc.
, vol.33
, pp. 577-578
-
-
Grey, S.T.1
Lock, J.2
Bach, F.H.3
Ferran, C.4
-
61
-
-
0037942826
-
Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function
-
Grey, ST., Longo, C., Shukri, T., Patel, V.I., Csizmadia, E., Daniel, S., Arvelo, M.B., Tchipashvili, V. and Ferran, C. (2003) Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. J. Immunol., 170: 6250-6256.
-
(2003)
J. Immunol.
, vol.170
, pp. 6250-6256
-
-
Grey, S.T.1
Longo, C.2
Shukri, T.3
Patel, V.I.4
Csizmadia, E.5
Daniel, S.6
Arvelo, M.B.7
Tchipashvili, V.8
Ferran, C.9
-
62
-
-
13144279283
-
Effect of gene gun-mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection
-
Guo, Z., Mital, D., Mo, Y.Y., Tian, Y., Shen, J., Chong, A.S., Foster, P., Sankary, H., McChesney, L., Jensik, S.C. and Williams, J.W. (1998) Effect of gene gun-mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection. Transplant. Proc., 30: 589.
-
(1998)
Transplant. Proc.
, vol.30
, pp. 589
-
-
Guo, Z.1
Mital, D.2
Mo, Y.Y.3
Tian, Y.4
Shen, J.5
Chong, A.S.6
Foster, P.7
Sankary, H.8
McChesney, L.9
Jensik, S.C.10
Williams, J.W.11
-
63
-
-
0034748027
-
Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes
-
Guz, Y., Nasir, I. and Teitelman, G. (2001) Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology, 142: 4956-4968.
-
(2001)
Endocrinology
, vol.142
, pp. 4956-4968
-
-
Guz, Y.1
Nasir, I.2
Teitelman, G.3
-
64
-
-
0035491791
-
Gene and cell-replacement therapy in the treatment of type 1 diabetes: How high must the standards be set?
-
Halban, P.A., Kahn, S.E., Lernmark, A. and Rhodes, C.J. (2001) Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes, 50: 2181-2191.
-
(2001)
Diabetes
, vol.50
, pp. 2181-2191
-
-
Halban, P.A.1
Kahn, S.E.2
Lernmark, A.3
Rhodes, C.J.4
-
65
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold, K.C., Hagopian, W., Auger, J.A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S.E., Harlan, D.M., Xu, D., Zivin, R.A. and Bluestone, J.A. (2002) Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med., 346: 1692-1698.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
Poumian-Ruiz, E.4
Taylor, L.5
Donaldson, D.6
Gitelman, S.E.7
Harlan, D.M.8
Xu, D.9
Zivin, R.A.10
Bluestone, J.A.11
-
66
-
-
0037820427
-
Bone marrow-derived stem cells initiate pancreatic regeneration
-
Hess, D., Li, L., Martin, M., Sakano, S., Hill, D., Strutt, B., Thyssen, S., Gray, D.A. and Bhatia, M. (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotechnol., 21: 763-770.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 763-770
-
-
Hess, D.1
Li, L.2
Martin, M.3
Sakano, S.4
Hill, D.5
Strutt, B.6
Thyssen, S.7
Gray, D.A.8
Bhatia, M.9
-
67
-
-
0032080663
-
Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production
-
Hohmeier, H.E., Thigpen, A., Tran, V.V., Davis, R. and Newgard, C.B. (1998) Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. J. Clin. Invest., 101: 1811-1820.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1811-1820
-
-
Hohmeier, H.E.1
Thigpen, A.2
Tran, V.V.3
Davis, R.4
Newgard, C.B.5
-
68
-
-
0037058934
-
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
-
Hori, Y., Rulifson, I.C., Tsai, B.C., Heit, J.J., Cahoy, J.D. and Kim, S.K. (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A., 99: 16105-16110.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 16105-16110
-
-
Hori, Y.1
Rulifson, I.C.2
Tsai, B.C.3
Heit, J.J.4
Cahoy, J.D.5
Kim, S.K.6
-
69
-
-
0026569634
-
Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells
-
Hughes, S.D., Johnson, J.H., Quaade, C. and Newgard, C.B. (1992) Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc. Natl. Acad. Sci. U. S. A., 89: 688-692.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 688-692
-
-
Hughes, S.D.1
Johnson, J.H.2
Quaade, C.3
Newgard, C.B.4
-
70
-
-
0027337362
-
Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism
-
Hughes, S.D., Quaade, C., Johnson, J.H., Ferber, S. and Newgard, C.B. (1993) Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. J. Biol. Chem., 268: 15205-15212.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15205-15212
-
-
Hughes, S.D.1
Quaade, C.2
Johnson, J.H.3
Ferber, S.4
Newgard, C.B.5
-
71
-
-
0035084164
-
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
-
Hui, H., Wright, C. and Perfetti, R. (2001) Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes, 50: 785-796.
-
(2001)
Diabetes
, vol.50
, pp. 785-796
-
-
Hui, H.1
Wright, C.2
Perfetti, R.3
-
72
-
-
0031763478
-
Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: Identification of betacellulin as a novel beta-cell mitogen
-
Huotari, M.A., Palgi, J. and Otonkoski, T. (1998) Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Endocrinology, 139: 1494-1499.
-
(1998)
Endocrinology
, vol.139
, pp. 1494-1499
-
-
Huotari, M.A.1
Palgi, J.2
Otonkoski, T.3
-
73
-
-
3042758642
-
Stem-cell therapy for diabetes mellitus
-
Hussain, M.A. and Theise, N.D. (2004) Stem-cell therapy for diabetes mellitus. Lancet, 364: 203-205.
-
(2004)
Lancet
, vol.364
, pp. 203-205
-
-
Hussain, M.A.1
Theise, N.D.2
-
74
-
-
0025647147
-
Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages
-
Hutchings, P., Rosen, H., O'Reilly, L., Simpson, E., Gordon, S. and Cooke, A. (1990) Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages. Nature, 348: 639-642.
-
(1990)
Nature
, vol.348
, pp. 639-642
-
-
Hutchings, P.1
Rosen, H.2
O'Reilly, L.3
Simpson, E.4
Gordon, S.5
Cooke, A.6
-
75
-
-
0027941216
-
Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases
-
Hutton, J.C. (1994) Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases. Diabetologia, 37 Suppl 2: S48-56.
-
(1994)
Diabetologia
, vol.37
, Issue.SUPPL. 2
-
-
Hutton, J.C.1
-
76
-
-
0037364517
-
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
-
Ianus, A., Holz, G.G., Theise, N.D. and Hussain, M.A. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest., 111: 843-850.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 843-850
-
-
Ianus, A.1
Holz, G.G.2
Theise, N.D.3
Hussain, M.A.4
-
77
-
-
0000314396
-
Preparation of insulin-releasing Chinese hamster ovary cell transfection of human insulin gene: Its implantation into diabetic mice
-
Eds. Shalaby, S.W., Ikada, Y., Langer, R. & Williams, J. Oxford University Press, New York
-
Iwata, H., Ogawa, N. Tkagi, T. and Mizoguchi, J. (1994) Preparation of insulin-releasing Chinese hamster ovary cell transfection of human insulin gene: its implantation into diabetic mice. In: Polymers of Biological and Biomedical Significance, Eds. Shalaby, S.W., Ikada, Y., Langer, R. & Williams, J. Oxford University Press, New York, pp306-313.
-
(1994)
Polymers of Biological and Biomedical Significance
, pp. 306-313
-
-
Iwata, H.1
Ogawa, N.2
Tkagi, T.3
Mizoguchi, J.4
-
78
-
-
0027186032
-
Mammalian glucokinase and its gene
-
Iynedjian, P.B. (1993) Mammalian glucokinase and its gene. Biochem. J., 293 ( Pt 1): 1-13.
-
(1993)
Biochem. J.
, vol.293
, Issue.PART 1
, pp. 1-13
-
-
Iynedjian, P.B.1
-
79
-
-
0141615656
-
Insulin-positive cells in vitro generated from rat bone marrow stromal cells
-
Jahr, H. and Bretzel, R.G. (2003) Insulin-positive cells in vitro generated from rat bone marrow stromal cells. Transplant. Proc.,, 35: 2140-2141.
-
(2003)
Transplant. Proc.
, vol.35
, pp. 2140-2141
-
-
Jahr, H.1
Bretzel, R.G.2
-
80
-
-
0345870063
-
Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft
-
Jin, Y.Z. and Xie, S.S. (2003) Bicistronic adenovirus-mediated gene transfer of CTLA4Ig gene and CD40Ig gene result in indefinite survival of islet xenograft. Transplant. Proc., 35: 3165-3166.
-
(2003)
Transplant. Proc.
, vol.35
, pp. 3165-3166
-
-
Jin, Y.Z.1
Xie, S.S.2
-
81
-
-
0032969537
-
Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) - Genetic predisposition and metabolic abnormalities
-
Jun, H., Bae, H.Y., Lee, B.R., Koll, K.S., Kim, Y.S., Lee, K.W., Kim, H. and Yoon, J. (1999) Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) - genetic predisposition and metabolic abnormalities. Adv. Drug Deliv. Rev., 35: 157-177.
-
(1999)
Adv. Drug Deliv. Rev.
, vol.35
, pp. 157-177
-
-
Jun, H.1
Bae, H.Y.2
Lee, B.R.3
Koll, K.S.4
Kim, Y.S.5
Lee, K.W.6
Kim, H.7
Yoon, J.8
-
82
-
-
0042767581
-
Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: An in vitro model to study islet differentiation
-
Kahan, B.W., Jacobson, L.M., Hullett, D.A., Ochoada, J.M., Oberley, T.D., Lang, K.M. and Odorico, J.S. (2003) Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes, 52: 2016-2024.
-
(2003)
Diabetes
, vol.52
, pp. 2016-2024
-
-
Kahan, B.W.1
Jacobson, L.M.2
Hullett, D.A.3
Ochoada, J.M.4
Oberley, T.D.5
Lang, K.M.6
Odorico, J.S.7
-
83
-
-
0034897889
-
Long-term islet allograft function in the absence of chronic immunosuppression: A case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor
-
Kawai, T., Sogawa, H., Koulmanda, M., Smith, R.N., O'Neil, J.J., Wee, S.L., Boskovic, S., Sykes, M., Colvin, R.B., Sachs, D.H., Auchincloss, H., Jr., Cosimi, A.B. and DS, C.K. (2001) Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation, 72: 351-354.
-
(2001)
Transplantation
, vol.72
, pp. 351-354
-
-
Kawai, T.1
Sogawa, H.2
Koulmanda, M.3
Smith, R.N.4
O'Neil, J.J.5
Wee, S.L.6
Boskovic, S.7
Sykes, M.8
Colvin, R.B.9
Sachs, D.H.10
Auchincloss Jr., H.11
Cosimi, A.B.12
Cosimi, D.S.13
Cosimi, C.K.14
-
84
-
-
0015804157
-
Transplantation of isolated pancreatic islets into the portal vein of diabetic rats
-
Kemp, C.B., Knight, M.J., Scharp, D.W., Lacy, P.E. and Ballinger, W.F. (1973) Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Nature, 244: 447.
-
(1973)
Nature
, vol.244
, pp. 447
-
-
Kemp, C.B.1
Knight, M.J.2
Scharp, D.W.3
Lacy, P.E.4
Ballinger, W.F.5
-
85
-
-
0033529235
-
Long-term survival and function of intrahepatic islet allografts; in rhesus monkeys treated with humanized anti-CD154
-
Kenyon, N.S., Chatzipetrou, M., Masetti, M., Ranuncoli, A., Oliveira, M., Wagner, J.L., Kirk, A.D., Harlan, D.M., Burkly, L.C. and Ricordi, C. (1999) Long-term survival and function of intrahepatic islet allografts; in rhesus monkeys treated with humanized anti-CD154. Proc. Natl. Acad. Sci. U. S. A., 96: 8132-8137.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 8132-8137
-
-
Kenyon, N.S.1
Chatzipetrou, M.2
Masetti, M.3
Ranuncoli, A.4
Oliveira, M.5
Wagner, J.L.6
Kirk, A.D.7
Harlan, D.M.8
Burkly, L.C.9
Ricordi, C.10
-
86
-
-
0002298062
-
Islet cell transplantation
-
2nd edition, Eds. LeRoith, D., Taylor, S.I. & Olefsky, J.M. Williams & Wilkins, Philadelphia
-
Kenyon, N.S., Harlan, D.M., Alejando, R., Ricordi, C. and Minps, D.H. (2000) Islet cell transplantation. In: Diabetes Mellitus: A Fundamental and Clinical Text, 2nd edition, Eds. LeRoith, D., Taylor, S.I. & Olefsky, J.M. Williams & Wilkins, Philadelphia, pp. 507-517.
-
(2000)
Diabetes Mellitus: A Fundamental and Clinical Text
, pp. 507-517
-
-
Kenyon, N.S.1
Harlan, D.M.2
Alejando, R.3
Ricordi, C.4
Minps, D.H.5
-
87
-
-
17644444812
-
In vivo functioning and transplantable mature pancreatic islet-like cell clusters differentiated from embryonic stem cell
-
Kim, D., Gu, Y., Ishii, M., Fujimiya, M., Qi, M., Nakamura, N., Yoshikawa, T., Sumi, S. and Inoue, K. (2003) In vivo functioning and transplantable mature pancreatic islet-like cell clusters differentiated from embryonic stem cell. Pancreas, 27: e34-41.
-
(2003)
Pancreas
, vol.27
-
-
Kim, D.1
Gu, Y.2
Ishii, M.3
Fujimiya, M.4
Qi, M.5
Nakamura, N.6
Yoshikawa, T.7
Sumi, S.8
Inoue, K.9
-
88
-
-
0033917737
-
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
-
Kishimoto, K., Dong, V.M., Issazadeh, S., Fedoseyeva, E.V., Waaga, A.M., Yamada, A., Sho, M., Benichou, G., Auchincloss, H., Jr., Grusby, M.J., Khoury, S.J. and Sayegh, M.H. (2000) The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J. Clin. Invest., 106: 63-72.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 63-72
-
-
Kishimoto, K.1
Dong, V.M.2
Issazadeh, S.3
Fedoseyeva, E.V.4
Waaga, A.M.5
Yamada, A.6
Sho, M.7
Benichou, G.8
Auchincloss Jr., H.9
Grusby, M.J.10
Khoury, S.J.11
Sayegh, M.H.12
-
89
-
-
0242582180
-
Islet regeneration during the reversal of autoimmune diabetes in NOD mice
-
Kodama, S., Kuhtreiber, W., Fujimura, S., Dale, E.A. and Faustman, D.L. (2003) Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science, 302: 1223-1227.
-
(2003)
Science
, vol.302
, pp. 1223-1227
-
-
Kodama, S.1
Kuhtreiber, W.2
Fujimura, S.3
Dale, E.A.4
Faustman, D.L.5
-
90
-
-
0036312398
-
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin
-
Kojima, H., Nakamura, T., Fujita, Y., Kishi, A., Fujimiya, M., Yamada, S., Kudo, M., Nishio, Y., Maegawa, H., Haneda, M., Yasuda, H., Kojima, I., Seno, M., Wong, N.C., Kikkawa, R. and Kashiwagi, A. (2002) Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes, 51: 1398-1408.
-
(2002)
Diabetes
, vol.51
, pp. 1398-1408
-
-
Kojima, H.1
Nakamura, T.2
Fujita, Y.3
Kishi, A.4
Fujimiya, M.5
Yamada, S.6
Kudo, M.7
Nishio, Y.8
Maegawa, H.9
Haneda, M.10
Yasuda, H.11
Kojima, I.12
Seno, M.13
Wong, N.C.14
Kikkawa, R.15
Kashiwagi, A.16
-
91
-
-
0038413922
-
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
-
Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M. and Chan, L. (2003) NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat. Med., 9: 596-603.
-
(2003)
Nat. Med.
, vol.9
, pp. 596-603
-
-
Kojima, H.1
Fujimiya, M.2
Matsumura, K.3
Younan, P.4
Imaeda, H.5
Maeda, M.6
Chan, L.7
-
92
-
-
0029990981
-
Large scale isolation, growth, and function of porcine neonatal islet cells
-
Korbutt, G.S., Elliott, J.F., Ao, Z., Smith, D.K., Warnock, G.L. and Rajotte, R.V. (1996) Large scale isolation, growth, and function of porcine neonatal islet cells. J. Clin. Invest., 97: 2119-2129.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2119-2129
-
-
Korbutt, G.S.1
Elliott, J.F.2
Ao, Z.3
Smith, D.K.4
Warnock, G.L.5
Rajotte, R.V.6
-
93
-
-
0042868826
-
Toward clinical trials of islet xenotransplantation
-
Korsgren, O., Buhler, L.H. and Groth, C.G. (2003) Toward clinical trials of islet xenotransplantation. Xenotransplantation, 10: 289-292.
-
(2003)
Xenotransplantation
, vol.10
, pp. 289-292
-
-
Korsgren, O.1
Buhler, L.H.2
Groth, C.G.3
-
94
-
-
0020633329
-
Expression of the human insulin gene and cDNA in a heterologous mammalian system
-
Laub, O. and Rutter, W.J. (1983) Expression of the human insulin gene and cDNA in a heterologous mammalian system. J. Biol. Chem., 258: 6043-6050.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 6043-6050
-
-
Laub, O.1
Rutter, W.J.2
-
95
-
-
0037431319
-
CTLA4Ig adenoviral gene transfer induces long-term islet rat allograft survival, without tolerance, after systemic but not local intragraft expression
-
Laumonier, T., Potiron, N., Boeffard, F., Chagneau, C., Brouard, S., Guillot, C., Soulillou, J.P., Anegon, I. and Le Mauff, B. (2003) CTLA4Ig adenoviral gene transfer induces long-term islet rat allograft survival, without tolerance, after systemic but not local intragraft expression. Hum. Gene Ther., 14: 561-575.
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 561-575
-
-
Laumonier, T.1
Potiron, N.2
Boeffard, F.3
Chagneau, C.4
Brouard, S.5
Guillot, C.6
Soulillou, J.P.7
Anegon, I.8
Le Mauff, B.9
-
96
-
-
1442326000
-
No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo
-
Lechner, A., Yang, Y.G., Blacken, R.A., Wang, L., Nolan, A.L. and Habener, J.F. (2004) No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes, 53: 616-623.
-
(2004)
Diabetes
, vol.53
, pp. 616-623
-
-
Lechner, A.1
Yang, Y.G.2
Blacken, R.A.3
Wang, L.4
Nolan, A.L.5
Habener, J.F.6
-
97
-
-
0034707028
-
Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
-
Lee, H.C., Kim, S.J., Kim, K.S., Shin, H.C. and Yoon, J.W. (2000) Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature, 408: 483-488.
-
(2000)
Nature
, vol.408
, pp. 483-488
-
-
Lee, H.C.1
Kim, S.J.2
Kim, K.S.3
Shin, H.C.4
Yoon, J.W.5
-
98
-
-
0026738641
-
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig
-
Lenschow, D.J., Zeng, Y., Thistlethwaite, J.R., Montag, A., Brady, W., Gibson, M.G., Linsley, P.S. and Bluestone, JA. (1992) Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science, 257: 789-792.
-
(1992)
Science
, vol.257
, pp. 789-792
-
-
Lenschow, D.J.1
Zeng, Y.2
Thistlethwaite, J.R.3
Montag, A.4
Brady, W.5
Gibson, M.G.6
Linsley, P.S.7
Bluestone, J.A.8
-
99
-
-
0037191135
-
Beta-cell dysfunction and insulin resistance in type 2 diabetes: Role of metabolic and genetic abnormalities
-
LeRoith, D. (2002) Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am. J. Med., 113 Suppl 6A: 3S-11S.
-
(2002)
Am. J. Med.
, vol.113
, Issue.SUPPL. 6A
-
-
LeRoith, D.1
-
100
-
-
0033120723
-
Towards gene therapy of diabetes mellitus
-
Levine, F. and Leibowitz, G. (1999) Towards gene therapy of diabetes mellitus. Mol. Med. Today, 5: 165-171.
-
(1999)
Mol. Med. Today
, vol.5
, pp. 165-171
-
-
Levine, F.1
Leibowitz, G.2
-
101
-
-
0029092748
-
Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts
-
Li, H., Colson, Y.L. and Ildstad, S.T. (1995) Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts. Transplantation, 60: 523-529.
-
(1995)
Transplantation
, vol.60
, pp. 523-529
-
-
Li, H.1
Colson, Y.L.2
Ildstad, S.T.3
-
102
-
-
0037446810
-
Non-lethal conditioning for the induction of allogeneic chimerism and tolerance to islet allografts
-
Li, H., Inverardi, L., Molano, R.D., Pileggi, A. and Ricordi, C. (2003) Non-lethal conditioning for the induction of allogeneic chimerism and tolerance to islet allografts. Transplantation, 75: 966-970.
-
(2003)
Transplantation
, vol.75
, pp. 966-970
-
-
Li, H.1
Inverardi, L.2
Molano, R.D.3
Pileggi, A.4
Ricordi, C.5
-
103
-
-
0035206953
-
Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats
-
Li, L., Seno, M., Yamada, H. and Kojima, I. (2001) Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats. Endocrinology, 142: 5379-5385.
-
(2001)
Endocrinology
, vol.142
, pp. 5379-5385
-
-
Li, L.1
Seno, M.2
Yamada, H.3
Kojima, I.4
-
104
-
-
1442276960
-
Activin A and betacellulin: Effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats
-
Li, L., Yi, Z., Seno, M. and Kojima, I. (2004) Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Diabetes, 53: 608-615.
-
(2004)
Diabetes
, vol.53
, pp. 608-615
-
-
Li, L.1
Yi, Z.2
Seno, M.3
Kojima, I.4
-
105
-
-
0029738626
-
Insulin-secreting non-islet cells are resistant to autoimmune destruction
-
Lipes, M.A., Cooper, E.M., Skelly, R., Rhodes, C.J., Boschetti, E., Weir, G.C. and Davalli, A.M. (1996) Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. U. S. A., 93: 8595-8600.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 8595-8600
-
-
Lipes, M.A.1
Cooper, E.M.2
Skelly, R.3
Rhodes, C.J.4
Boschetti, E.5
Weir, G.C.6
Davalli, A.M.7
-
106
-
-
0030959913
-
Genetic engineering of insulin expression in nonislet cells: Implications for beta-cell replacement therapy for insulin-dependent diabetes mellitus
-
Lipes, M.A., Davalli, A.M. and Cooper, E.M. (1997) Genetic engineering of insulin expression in nonislet cells: implications for beta-cell replacement therapy for insulin-dependent diabetes mellitus. Acta Diabetol., 34: 2-5.
-
(1997)
Acta Diabetol.
, vol.34
, pp. 2-5
-
-
Lipes, M.A.1
Davalli, A.M.2
Cooper, E.M.3
-
107
-
-
0029801229
-
Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis
-
Liu, Y., Rabinovitch, A., Suarez-Pinzon, W., Muhkerjee, B., Brownlee, M., Edelstein, D. and Federoff, H.J. (1996) Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum. Gene Ther., 7: 1719-1726.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1719-1726
-
-
Liu, Y.1
Rabinovitch, A.2
Suarez-Pinzon, W.3
Muhkerjee, B.4
Brownlee, M.5
Edelstein, D.6
Federoff, H.J.7
-
108
-
-
0020359344
-
Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: A rapid expression assay for cloned genes
-
Lomedico, P.T. (1982) Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: a rapid expression assay for cloned genes. Proc. Natl. Acad. Sci. U. S. A., 79: 5798-5802.
-
(1982)
Proc. Natl. Acad. Sci. U. S. A.
, vol.79
, pp. 5798-5802
-
-
Lomedico, P.T.1
-
109
-
-
0031828799
-
Regulatable production of insulin from primary-cultured hepatocytes: Insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin
-
Lu, D., Tamemoto, H., Shibata, H., Saito, I. and Takeuchi, T. (1998) Regulatable production of insulin from primary-cultured hepatocytes: insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin. Gene Ther., 5: 888-895.
-
(1998)
Gene Ther.
, vol.5
, pp. 888-895
-
-
Lu, D.1
Tamemoto, H.2
Shibata, H.3
Saito, I.4
Takeuchi, T.5
-
110
-
-
0035906902
-
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
-
Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science, 292: 1389-1394.
-
(2001)
Science
, vol.292
, pp. 1389-1394
-
-
Lumelsky, N.1
Blondel, O.2
Laeng, P.3
Velasco, I.4
Ravin, R.5
McKay, R.6
-
111
-
-
0032499917
-
Pancreas transplantation and diabetic complications
-
Luzi, L. (1998) Pancreas transplantation and diabetic complications. N. Engl. J. Med., 339: 115-117.
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 115-117
-
-
Luzi, L.1
-
112
-
-
5444226677
-
Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy
-
Machen, J., Bertera, S., Chang, Y., Bottino, R., Balamurugan, A.N., Robbins, P.D., Trucco, M. and Giannoukakis, N. (2004) Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy. Gene Ther., 11: 1506-1514.
-
(2004)
Gene Ther.
, vol.11
, pp. 1506-1514
-
-
Machen, J.1
Bertera, S.2
Chang, Y.3
Bottino, R.4
Balamurugan, A.N.5
Robbins, P.D.6
Trucco, M.7
Giannoukakis, N.8
-
113
-
-
1942451803
-
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice
-
Makhlouf, L., Grey, S.T., Dong, V., Csizmadia, E., Arvelo, M.B., Auchincloss, H., Jr., Ferran, C. and Sayegh, M.H. (2004) Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice. Transplantation, 77: 990-997.
-
(2004)
Transplantation
, vol.77
, pp. 990-997
-
-
Makhlouf, L.1
Grey, S.T.2
Dong, V.3
Csizmadia, E.4
Arvelo, M.B.5
Auchincloss Jr., H.6
Ferran, C.7
Sayegh, M.H.8
-
114
-
-
0032578311
-
Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells
-
Martin, U., Kiessig, V., Blusch, J.H., Haverich, A., von der Heim, K., Herden, T. and Steinhoff, G. (1998) Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet, 352: 692-694.
-
(1998)
Lancet
, vol.352
, pp. 692-694
-
-
Martin, U.1
Kiessig, V.2
Blusch, J.H.3
Haverich, A.4
von der Heim, K.5
Herden, T.6
Steinhoff, G.7
-
115
-
-
0036845732
-
Human insulin production and amelioration of diabetes in mice by electrotransfer-enhanced plasmid DNA gene transfer to the skeletal muscle
-
Martinenghi, S., Cusella De Angelis, G., Biressi, S., Amadio, S., Bifari, F., Roncarolo, M.G., Bordignon, C. and Falqui, L. (2002) Human insulin production and amelioration of diabetes in mice by electrotransfer-enhanced plasmid DNA gene transfer to the skeletal muscle. Gene Ther., 9: 1429-1437.
-
(2002)
Gene Ther.
, vol.9
, pp. 1429-1437
-
-
Martinenghi, S.1
Cusella De Angelis, G.2
Biressi, S.3
Amadio, S.4
Bifari, F.5
Roncarolo, M.G.6
Bordignon, C.7
Falqui, L.8
-
116
-
-
0029864906
-
Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells
-
Mashima, H., Ohnishi, H., Wakabayashi, K., Mine, T., Miyagawa, J., Hanafusa, T., Seno, M., Yamada, H. and Kojima, I. (1996a) Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J. Clin. Invest. 97: 1647-1654.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 1647-1654
-
-
Mashima, H.1
Ohnishi, H.2
Wakabayashi, K.3
Mine, T.4
Miyagawa, J.5
Hanafusa, T.6
Seno, M.7
Yamada, H.8
Kojima, I.9
-
117
-
-
0029815929
-
Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor
-
Mashima, H., Shibata, H., Mine, T. and Kojima, I. (1996b) Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology, 137: 3969-3976.
-
(1996)
Endocrinology
, vol.137
, pp. 3969-3976
-
-
Mashima, H.1
Shibata, H.2
Mine, T.3
Kojima, I.4
-
118
-
-
0034775035
-
Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function
-
McKinnon, C.M. and Docherty, K. (2001) Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function. Diabetologia, 44: 1203-1214.
-
(2001)
Diabetologia
, vol.44
, pp. 1203-1214
-
-
McKinnon, C.M.1
Docherty, K.2
-
119
-
-
0035574854
-
Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system
-
Milo-Landesman, D., Surana, M., Berkovich, I., Compagni, A., Christofori, G., Fleischer, N. and Efrat, S. (2001) Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant., 10: 645-650.
-
(2001)
Cell Transplant.
, vol.10
, pp. 645-650
-
-
Milo-Landesman, D.1
Surana, M.2
Berkovich, I.3
Compagni, A.4
Christofori, G.5
Fleischer, N.6
Efrat, S.7
-
120
-
-
1842527497
-
Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
-
Miyazaki, S., Yamato, E. and Miyazaki, J. (2004) Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes, 53: 1030-1037.
-
(2004)
Diabetes
, vol.53
, pp. 1030-1037
-
-
Miyazaki, S.1
Yamato, E.2
Miyazaki, J.3
-
121
-
-
0035145720
-
Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation
-
Molano, R.D., Berney, T., Li, H., Cattan, P., Pileggi, A., Vizzardelli, C., Kenyon, N.S., Ricordi, C., Burkly, L.C. and Inverardi, L. (2001) Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation. Diabetes, 50: 270-276.
-
(2001)
Diabetes
, vol.50
, pp. 270-276
-
-
Molano, R.D.1
Berney, T.2
Li, H.3
Cattan, P.4
Pileggi, A.5
Vizzardelli, C.6
Kenyon, N.S.7
Ricordi, C.8
Burkly, L.C.9
Inverardi, L.10
-
122
-
-
0021024216
-
Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation
-
Moore, H.P., Walker, M.D., Lee, F. and Kelly, R.B. (1983) Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell, 35: 531-538.
-
(1983)
Cell
, vol.35
, pp. 531-538
-
-
Moore, H.P.1
Walker, M.D.2
Lee, F.3
Kelly, R.B.4
-
123
-
-
0030587792
-
Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway
-
Moriyama, H., Yokono, K., Amano, K., Nagata, M., Hasegawa, Y., Okamoto, N., Tsukamoto, K., Miki, M., Yoneda, R., Yagi, N., Tommaga, Y., Kikutani, H., Hioki, K., Okumura, K., Yagita, H. and Kasuga, M. (1996) Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway. J. Immunol., 157: 3737-3743.
-
(1996)
J. Immunol.
, vol.157
, pp. 3737-3743
-
-
Moriyama, H.1
Yokono, K.2
Amano, K.3
Nagata, M.4
Hasegawa, Y.5
Okamoto, N.6
Tsukamoto, K.7
Miki, M.8
Yoneda, R.9
Yagi, N.10
Tommaga, Y.11
Kikutani, H.12
Hioki, K.13
Okumura, K.14
Yagita, H.15
Kasuga, M.16
-
124
-
-
0036023129
-
Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies
-
Mottram, P.L., Murray-Segal, L.J., Han, W., Maguire, J. and Stein-Oakley, A.N. (2002) Remission and pancreas isograft survival in recent onset diabetic NOD mice after treatment with low-dose anti-CD3 monoclonal antibodies. Transpl. Immunol., 10: 63-72.
-
(2002)
Transpl. Immunol.
, vol.10
, pp. 63-72
-
-
Mottram, P.L.1
Murray-Segal, L.J.2
Han, W.3
Maguire, J.4
Stein-Oakley, A.N.5
-
125
-
-
0036839226
-
CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways
-
Nicolls, M.R., Coulombe, M., Beilke, J., Gelhaus, H.C. and Gill, R.G. (2002) CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. J. Immunol., 169: 4831-4839.
-
(2002)
J. Immunol.
, vol.169
, pp. 4831-4839
-
-
Nicolls, M.R.1
Coulombe, M.2
Beilke, J.3
Gelhaus, H.C.4
Gill, R.G.5
-
126
-
-
0037113979
-
Immunologic and genetic factors in type 1 diabetes
-
Notkins, A.L. (2002) Immunologic and genetic factors in type 1 diabetes. J. Biol. Chem., 277: 43545-43548.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43545-43548
-
-
Notkins, A.L.1
-
127
-
-
9144237453
-
Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs
-
Okitsu, T., Kobayashi, N., Jun, H.S., Shin, S., Kim, S.J., Han, J., Kwon, H., Sakaguchi, M., Totsugawa, T., Kohara, M., Westerman, K.A., Tanaka, N., Leboulch, P. and Yoon, J.W. (2004) Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes, 53: 105-112.
-
(2004)
Diabetes
, vol.53
, pp. 105-112
-
-
Okitsu, T.1
Kobayashi, N.2
Jun, H.S.3
Shin, S.4
Kim, S.J.5
Han, J.6
Kwon, H.7
Sakaguchi, M.8
Totsugawa, T.9
Kohara, M.10
Westerman, K.A.11
Tanaka, N.12
Leboulch, P.13
Yoon, J.W.14
-
128
-
-
0142010650
-
Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats
-
Olson, D.E., Paveglio, S.A., Huey, P.U., Porter, M.H. and Thule, P.M. (2003) Glucose-responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum. Gene Ther., 14: 1401-1413.
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 1401-1413
-
-
Olson, D.E.1
Paveglio, S.A.2
Huey, P.U.3
Porter, M.H.4
Thule, P.M.5
-
129
-
-
0037222059
-
Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice
-
Omer, A., Duvivier-Kali, V.F., Trivedi, N., Wilmot, K., Bonner-Weir, S. and Weir, G.C. (2003) Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes, 52: 69-75.
-
(2003)
Diabetes
, vol.52
, pp. 69-75
-
-
Omer, A.1
Duvivier-Kali, V.F.2
Trivedi, N.3
Wilmot, K.4
Bonner-Weir, S.5
Weir, G.C.6
-
130
-
-
0347367029
-
Production of alpha 1,3-galactosyltransferase-deficient pigs
-
Phelps, C.J., Koike, C., Vaught, T.D., Boone, J., Wells, K.D., Chen, S.H., Ball, S., Specht, S.M., Polejaeva, I.A., Monahan, J.A., Jobst, P.M., Sharma, S.B., Lamborn, A.E., Garst, A.S., Moore, M., Demetris, A.J., Rudert, W.A., Bottino, R., Bertera, S., Trucco, M., Starzi, T.E., Dai, Y. and Ayares, D.L. (2003) Production of alpha 1,3-galactosyltransferase-deficient pigs. Science, 299: 411-414.
-
(2003)
Science
, vol.299
, pp. 411-414
-
-
Phelps, C.J.1
Koike, C.2
Vaught, T.D.3
Boone, J.4
Wells, K.D.5
Chen, S.H.6
Ball, S.7
Specht, S.M.8
Polejaeva, I.A.9
Monahan, J.A.10
Jobst, P.M.11
Sharma, S.B.12
Lamborn, A.E.13
Garst, A.S.14
Moore, M.15
Demetris, A.J.16
Rudert, W.A.17
Bottino, R.18
Bertera, S.19
Trucco, M.20
Starzi, T.E.21
Dai, Y.22
Ayares, D.L.23
more..
-
131
-
-
0345161818
-
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction
-
Rabinovitch, A., Suarez-Pinzen, W., Strynadka, K., Ju, Q., Edelstein, D., Brownlee, M., Korbutt, G.S. and Rajotte, R.V. (1999) Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction. Diabetes, 48: 1223-1229.
-
(1999)
Diabetes
, vol.48
, pp. 1223-1229
-
-
Rabinovitch, A.1
Suarez-Pinzen, W.2
Strynadka, K.3
Ju, Q.4
Edelstein, D.5
Brownlee, M.6
Korbutt, G.S.7
Rajotte, R.V.8
-
132
-
-
0030912531
-
Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
-
Rafaeloff, R., Pittenger, G.L., Barlow, S.W., Qin, X.F., Yan, B., Rosenberg, L., Duguid, W.P. and Vinik, A.I. (1997) Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J. Clin. Invest., 99: 2100-2109.
-
(1997)
J. Clin. Invest.
, vol.99
, pp. 2100-2109
-
-
Rafaeloff, R.1
Pittenger, G.L.2
Barlow, S.W.3
Qin, X.F.4
Yan, B.5
Rosenberg, L.6
Duguid, W.P.7
Vinik, A.I.8
-
133
-
-
0037449573
-
Insulin staining of ES cell progeny from insulin uptake
-
Rajagopal, J., Anderson, W.J., Kume, S., Martinez, O.I. and Melton, D.A. (2003) Insulin staining of ES cell progeny from insulin uptake. Science, 299: 363.
-
(2003)
Science
, vol.299
, pp. 363
-
-
Rajagopal, J.1
Anderson, W.J.2
Kume, S.3
Martinez, O.I.4
Melton, D.A.5
-
134
-
-
0034100823
-
Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
-
Ramiya, V.K., Maraist, M., Arfors, K.E., Schatz, D.A., Peck, A.B. and Cornelius, J.G. (2000) Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat. Med., 6: 278-282.
-
(2000)
Nat. Med.
, vol.6
, pp. 278-282
-
-
Ramiya, V.K.1
Maraist, M.2
Arfors, K.E.3
Schatz, D.A.4
Peck, A.B.5
Cornelius, J.G.6
-
135
-
-
0037984344
-
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide
-
Rehman, K.K., Bertera, S., Bottino, R., Balamurugan, A.N., Mai, J.C., Mi, Z., Trucco, M. and Robbins, P D. (2003) Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J. Biol. Chem., 278: 9862-9868.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9862-9868
-
-
Rehman, K.K.1
Bertera, S.2
Bottino, R.3
Balamurugan, A.N.4
Mai, J.C.5
Mi, Z.6
Trucco, M.7
Robbins, P.D.8
-
136
-
-
0038353787
-
Islet transplantation: A brave new world
-
Ricordi, C. (2003) Islet transplantation: a brave new world. Diabetes, 52: 1595-1603.
-
(2003)
Diabetes
, vol.52
, pp. 1595-1603
-
-
Ricordi, C.1
-
137
-
-
1842731851
-
Clinical islet transplantation: Advances and immunological challenges
-
Ricordi, C. and Strom, T.B. (2004) Clinical islet transplantation: advances and immunological challenges. Nat. Rev. Immunol., 4: 259-268.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 259-268
-
-
Ricordi, C.1
Strom, T.B.2
-
138
-
-
0034603114
-
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
-
Rivera, V.M., Wang, X., Wardwell, S., Courage, N.L., Volchuk, A., Keenan, T., Holt, D.A., Gilman, M., Orci, L., Cerasoli, F., Jr., Rothman, J.E. and Clackson, T. (2000) Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287: 826-830.
-
(2000)
Science
, vol.287
, pp. 826-830
-
-
Rivera, V.M.1
Wang, X.2
Wardwell, S.3
Courage, N.L.4
Volchuk, A.5
Keenan, T.6
Holt, D.A.7
Gilman, M.8
Orci, L.9
Cerasoli Jr., F.10
Rothman, J.E.11
Clackson, T.12
-
139
-
-
0028265612
-
Long-term metabolic control with pancreatic transplantation
-
Robertson, R.P., Kendall, D., Teuscher, A. and Sutherland, D. (1994) Long-term metabolic control with pancreatic transplantation. Transplant. Proc., 26: 386-387.
-
(1994)
Transplant. Proc.
, vol.26
, pp. 386-387
-
-
Robertson, R.P.1
Kendall, D.2
Teuscher, A.3
Sutherland, D.4
-
140
-
-
0032088910
-
Therapeutic controversy: Pancreas transplantation for type I diabetes
-
Robertson, R.P., Holohan, T.V. and Genuth, S. (1998) Therapeutic controversy: Pancreas transplantation for type I diabetes. J. Clin. Endocrinol. Metab., 83: 1868-1874.
-
(1998)
J. Clin. Endocrinol. Metab.
, vol.83
, pp. 1868-1874
-
-
Robertson, R.P.1
Holohan, T.V.2
Genuth, S.3
-
141
-
-
0033970352
-
Pancreas and islet transplantation for patients with diabetes
-
Robertson, R.P., Davis, C., Larsen, J., Stratta, R. and Sutherland, D.E. (2000) Pancreas and islet transplantation for patients with diabetes. Diabetes Care, 23: 112-116.
-
(2000)
Diabetes Care
, vol.23
, pp. 112-116
-
-
Robertson, R.P.1
Davis, C.2
Larsen, J.3
Stratta, R.4
Sutherland, D.E.5
-
142
-
-
1442265579
-
Islet transplantation as a treatment for diabetes - A work in progress
-
Robertson, R.P. (2004) Islet transplantation as a treatment for diabetes - a work in progress. N. Engl. J. Med., 350: 694-705.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 694-705
-
-
Robertson, R.P.1
-
143
-
-
0029919866
-
Induction of immunological tolerance to islet allografts
-
Rossini, A.A., Parker, D.C., Phillips, N.E., Durie, F.H., Noelle, R.J., Mordes, J.P. and Greiner, D.L. (1996) Induction of immunological tolerance to islet allografts. Cell Transplant., 5: 49-52.
-
(1996)
Cell Transplant
, vol.5
, pp. 49-52
-
-
Rossini, A.A.1
Parker, D.C.2
Phillips, N.E.3
Durie, F.H.4
Noelle, R.J.5
Mordes, J.P.6
Greiner, D.L.7
-
144
-
-
0036303015
-
Successful islet transplantation: Continued insulin reserve provides long-term glycemic control
-
Ryan, E.A., Lakey, J.R., Paty, B.W., Imes, S., Korbutt, G.S., Kneteman, N.M., Bigam, D., Rajotte, R.V. and Shapiro, A.M. (2002) Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes, 51: 2148-2157.
-
(2002)
Diabetes
, vol.51
, pp. 2148-2157
-
-
Ryan, E.A.1
Lakey, J.R.2
Paty, B.W.3
Imes, S.4
Korbutt, G.S.5
Kneteman, N.M.6
Bigam, D.7
Rajotte, R.V.8
Shapiro, A.M.9
-
145
-
-
4444367086
-
Risks and side effects of islet transplantation
-
Ryan, E.A., Paty, B.W., Senior, P.A. and Shapiro, A.M. (2004) Risks and side effects of islet transplantation. Curr. Diab. Rep., 4: 304-309.
-
(2004)
Curr. Diab. Rep.
, vol.4
, pp. 304-309
-
-
Ryan, E.A.1
Paty, B.W.2
Senior, P.A.3
Shapiro, A.M.4
-
146
-
-
0034939166
-
Reversal of established autoimmune diabetes by restoration of endogenous beta cell function
-
Ryu, S., Kodama, S., Ryu, K., Schoenfeld, D.A. and Faustman, D.L. (2001) Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. J. Clin. Invest., 108: 63-72.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 63-72
-
-
Ryu, S.1
Kodama, S.2
Ryu, K.3
Schoenfeld, D.A.4
Faustman, D.L.5
-
147
-
-
0034524101
-
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
-
Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Dela Cruz, F., Schwitzgebel, V., Hayes-Jordan, A. and German, M. (2000) Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development, 127: 5533-5540.
-
(2000)
Development
, vol.127
, pp. 5533-5540
-
-
Sander, M.1
Sussel, L.2
Conners, J.3
Scheel, D.4
Kalamaras, J.5
Dela Cruz, F.6
Schwitzgebel, V.7
Hayes-Jordan, A.8
German, M.9
-
148
-
-
0032543306
-
The role of T-cell costimulatory activation pathways in transplant rejection
-
Sayegh, M.H. and Turka, L.A. (1998) The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med., 338: 1813-1821.
-
(1998)
N. Engl. J. Med.
, vol.338
, pp. 1813-1821
-
-
Sayegh, M.H.1
Turka, L.A.2
-
149
-
-
0025269474
-
Insulin independence after islet transplantation into type I diabetic patient
-
Scharp, D.W., Lacy, P.E., Santiago, J.V., McCullough, C.S., Weide, L.G., Falqui, L., Marchetti, P., Gingerich, R.L., Jaffe, A.S., Cryer, P.E., Anderson, C.B. and Flye, M.W. (1990) Insulin independence after islet transplantation into type I diabetic patient. Diabetes, 39: 515-518.
-
(1990)
Diabetes
, vol.39
, pp. 515-518
-
-
Scharp, D.W.1
Lacy, P.E.2
Santiago, J.V.3
McCullough, C.S.4
Weide, L.G.5
Falqui, L.6
Marchetti, P.7
Gingerich, R.L.8
Jaffe, A.S.9
Cryer, P.E.10
Anderson, C.B.11
Flye, M.W.12
-
150
-
-
0012617553
-
Adult porcine islets transduced with human complement regulatory proteins CD55 (DAF) or CD59 are partially protected from lysis in complement active human serum
-
Schmidt, P., Goto, M., Wennberg, L., Groth, C.G., Le Mauff, B., Anegoll, I. and Korsgren, O. (2001) Adult porcine islets transduced with human complement regulatory proteins CD55 (DAF) or CD59 are partially protected from lysis in complement active human serum. Xenotransplantation, 8 (Suppl. 1): 3.
-
(2001)
Xenotransplantation
, vol.8
, Issue.SUPPL. 1
, pp. 3
-
-
Schmidt, P.1
Goto, M.2
Wennberg, L.3
Groth, C.G.4
Le Mauff, B.5
Anegoll, I.6
Korsgren, O.7
-
152
-
-
0033825383
-
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
-
Schwitzgebel, V.M., Scheel, D.W., Conners, J.R., Kalamaras, J., Lee, J.E., Anderson, D.J., Sussel, L., Johnson, J.D. and German, M.S. (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development, 127: 3533-3542.
-
(2000)
Development
, vol.127
, pp. 3533-3542
-
-
Schwitzgebel, V.M.1
Scheel, D.W.2
Conners, J.R.3
Kalamaras, J.4
Lee, J.E.5
Anderson, D.J.6
Sussel, L.7
Johnson, J.D.8
German, M.S.9
-
153
-
-
4444320484
-
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
-
Seaberg, R.M., Smukler, S.R., Kieffer, T.J., Enikolopov, G., Asghar, Z., Wheeler, M.B., Korbutt, G. and Van Der Kooy, D. (2004) Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat. Biotechnol., 22: 1115-1124.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1115-1124
-
-
Seaberg, R.M.1
Smukler, S.R.2
Kieffer, T.J.3
Enikolopov, G.4
Asghar, Z.5
Wheeler, M.B.6
Korbutt, G.7
Van Der Kooy, D.8
-
154
-
-
0023641198
-
Regulation of insulin-gene expression. Implications for gene therapy
-
Selden, R.F., Skoskiewicz, M.J., Russell, P.S. and Goodman, H.M. (1987) Regulation of insulin-gene expression. Implications for gene therapy. N. Engl. J. Med., 317: 1067-1076.
-
(1987)
N. Engl. J. Med.
, vol.317
, pp. 1067-1076
-
-
Selden, R.F.1
Skoskiewicz, M.J.2
Russell, P.S.3
Goodman, H.M.4
-
155
-
-
0029915504
-
Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form
-
Seno, M., Tada, H., Kosaka, M., Sasada, R., Igarashi, K., Shing, Y., Folkman, J., Ueda, M. and Yamada, H. (1996) Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. Growth Factors, 13: 181-191.
-
(1996)
Growth Factors
, vol.13
, pp. 181-191
-
-
Seno, M.1
Tada, H.2
Kosaka, M.3
Sasada, R.4
Igarashi, K.5
Shing, Y.6
Folkman, J.7
Ueda, M.8
Yamada, H.9
-
156
-
-
0036910731
-
Apoptosis in the beta cells: Cause or consequence of insulin secretion defect in diabetes?
-
Sesti, G. (2002) Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? Ann. Med., 34: 444-450.
-
(2002)
Ann. Med.
, vol.34
, pp. 444-450
-
-
Sesti, G.1
-
157
-
-
0034654374
-
Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
-
Seung, E., Iwakoshi, N., Woda, B.A., Markees, T.G., Mordes, J.P., Rossini, A.A. and Greiner, D.L. (2000) Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood, 95: 2175-2182.
-
(2000)
Blood
, vol.95
, pp. 2175-2182
-
-
Seung, E.1
Iwakoshi, N.2
Woda, B.A.3
Markees, T.G.4
Mordes, J.P.5
Rossini, A.A.6
Greiner, D.L.7
-
158
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro, A.M., Lakey, J.R., Ryan, E.A., Korbutt, G.S., Toth, E., Warnock, G.L., Kneteman, N.M. and Rajotte, R.V. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med., 343: 230-238.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
Korbutt, G.S.4
Toth, E.5
Warnock, G.L.6
Kneteman, N.M.7
Rajotte, R.V.8
-
159
-
-
0033009460
-
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
-
Sharma, A., Zangen, D.H., Reitz, P., Taneja, M., Lissauer, M,E., Miller, C.P., Weir, G.C., Habener, J.F. and Bonner-Weir, S. (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes, 48: 507-513.
-
(1999)
Diabetes
, vol.48
, pp. 507-513
-
-
Sharma, A.1
Zangen, D.H.2
Reitz, P.3
Taneja, M.4
Lissauer, M.E.5
Miller, C.P.6
Weir, G.C.7
Habener, J.F.8
Bonner-Weir, S.9
-
160
-
-
4344672423
-
Long-term islet graft survival in NOD mice by abrogation of recurrent autoimmunity
-
Shi, Q., Wang, D., Hadley, G.A., Bingaman, A.W., Bartlett, S.T. and Farber, D.L. (2004) Long-term islet graft survival in NOD mice by abrogation of recurrent autoimmunity. Diabetes, 53: 2338-2345.
-
(2004)
Diabetes
, vol.53
, pp. 2338-2345
-
-
Shi, Q.1
Wang, D.2
Hadley, G.A.3
Bingaman, A.W.4
Bartlett, S.T.5
Farber, D.L.6
-
161
-
-
0029094172
-
Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription
-
Shih, H.M., Liu, Z. and Towle, H.C. (1995) Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. J. Biol. Chem., 270: 21991-21997.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21991-21997
-
-
Shih, H.M.1
Liu, Z.2
Towle, H.C.3
-
162
-
-
0023735943
-
Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus
-
Silverstein, J., Maclaren, N., Riley, W., Spillar, R., Radjenovic, D. and Johnson, S. (1988) Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N. Engl. J. Med., 319: 599-604.
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 599-604
-
-
Silverstein, J.1
Maclaren, N.2
Riley, W.3
Spillar, R.4
Radjenovic, D.5
Johnson, S.6
-
163
-
-
0029027780
-
Developmental biology of the pancreas
-
Slack, J.M. (1995) Developmental biology of the pancreas. Development, 121: 1569-1580.
-
(1995)
Development
, vol.121
, pp. 1569-1580
-
-
Slack, J.M.1
-
164
-
-
0033979603
-
Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
-
Soria, B., Roche, E., Berna, G., Leon-Quinto, T., Reig, J.A. and Martin, F. (2000) Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes, 49: 157-162.
-
(2000)
Diabetes
, vol.49
, pp. 157-162
-
-
Soria, B.1
Roche, E.2
Berna, G.3
Leon-Quinto, T.4
Reig, J.A.5
Martin, F.6
-
165
-
-
0030897629
-
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
-
Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G. and Gruss, P. (1997) The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature, 386: 399-402.
-
(1997)
Nature
, vol.386
, pp. 399-402
-
-
Sosa-Pineda, B.1
Chowdhury, K.2
Torres, M.3
Oliver, G.4
Gruss, P.5
-
166
-
-
0027963253
-
Insulin-releasing pituitary cells as a model for somatic cell gene therapy in diabetes mellitus
-
Stewart, C., Taylor, N.A., Green, I.C., Docherty, K. and Bailey, C.J. (1994) Insulin-releasing pituitary cells as a model for somatic cell gene therapy in diabetes mellitus. J. Endocrinol., 142: 339-343.
-
(1994)
J. Endocrinol.
, vol.142
, pp. 339-343
-
-
Stewart, C.1
Taylor, N.A.2
Green, I.C.3
Docherty, K.4
Bailey, C.J.5
-
167
-
-
1542328921
-
Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes
-
Street, C.N., Sipione, S., Helms, L., Binette, T., Rajotte, R.V., Bleackley, R.C. and Korbutt, G.S. (2004) Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes. Int. J. Biochem. Cell Biol., 36: 667-683.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 667-683
-
-
Street, C.N.1
Sipione, S.2
Helms, L.3
Binette, T.4
Rajotte, R.V.5
Bleackley, R.C.6
Korbutt, G.S.7
-
168
-
-
0031843386
-
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
-
Sussel, L., Kalamaras, J., Hartigan-O'Connor, D.J., Meneses, J.J., Pedersen, R.A., Rubenstein, J.L. and German, M.S. (1998) Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development, 125: 2213-2221.
-
(1998)
Development
, vol.125
, pp. 2213-2221
-
-
Sussel, L.1
Kalamaras, J.2
Hartigan-O'Connor, D.J.3
Meneses, J.J.4
Pedersen, R.A.5
Rubenstein, J.L.6
German, M.S.7
-
169
-
-
0035076928
-
Lessons learned from more than 1,000 pancreas transplants at a single institution
-
Sutherland, D.E., Gruessner, R.W., Dunn, D.L., Matas, A.J., Humar, A., Kandaswamy, R., Mauer, S.M., Kennedy, W.R., Goetz, F.C., Robertson, R.P., Gruessner, A.C. and Najarian, J.S. (2001) Lessons learned from more than 1,000 pancreas transplants at a single institution. Ann. Surg., 233: 463-501.
-
(2001)
Ann. Surg.
, vol.233
, pp. 463-501
-
-
Sutherland, D.E.1
Gruessner, R.W.2
Dunn, D.L.3
Matas, A.J.4
Humar, A.5
Kandaswamy, R.6
Mauer, S.M.7
Kennedy, W.R.8
Goetz, F.C.9
Robertson, R.P.10
Gruessner, A.C.11
Najarian, J.S.12
-
170
-
-
0037628628
-
Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
-
Suzuki, A., Nakauchi, H. and Taniguchi, H. (2003) Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc. Natl. Acad. Sci. U. S. A., 100: 5034-5039.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 5034-5039
-
-
Suzuki, A.1
Nakauchi, H.2
Taniguchi, H.3
-
171
-
-
10744223119
-
Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons
-
Teranishi, K., Alwayn, I.P., Buhler, L., Gollackner, B., Knosalla, C., Huck, J., Duthaler, R., Katopodis, A., Sachs, D.H., Schuurman, H.J., Awwad, M. and Cooper, D.K. (2003) Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons. Xenotransplantation, 10: 357-367.
-
(2003)
Xenotransplantation
, vol.10
, pp. 357-367
-
-
Teranishi, K.1
Alwayn, I.P.2
Buhler, L.3
Gollackner, B.4
Knosalla, C.5
Huck, J.6
Duthaler, R.7
Katopodis, A.8
Sachs, D.H.9
Schuurman, H.J.10
Awwad, M.11
Cooper, D.K.12
-
172
-
-
0034004456
-
Glucose regulated production of human insulin in rat hepatocytes
-
Thule, P.M., Liu, J. and Phillips, L.S. (2000) Glucose regulated production of human insulin in rat hepatocytes. Gene Ther. 7: 205-214.
-
(2000)
Gene Ther.
, vol.7
, pp. 205-214
-
-
Thule, P.M.1
Liu, J.2
Phillips, L.S.3
-
173
-
-
0033765795
-
Regulated hepatic insulin gene therapy of STZ-diabetic rats
-
Thule, P.M. and Liu, J.M. (2000) Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther., 7: 1744-1752.
-
(2000)
Gene Ther.
, vol.7
, pp. 1744-1752
-
-
Thule, P.M.1
Liu, J.M.2
-
174
-
-
0032791152
-
Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells
-
Tiedge, M., Lortz, S., Munday, R. and Lenzen, S. (1999) Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia, 42: 849-855.
-
(1999)
Diabetologia
, vol.42
, pp. 849-855
-
-
Tiedge, M.1
Lortz, S.2
Munday, R.3
Lenzen, S.4
-
175
-
-
0035405821
-
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age
-
Tourrel, C., Bailbe, D., Meile, M.J., Kergoat, M. and Portha, B. (2001) Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes, 50: 1562-1570.
-
(2001)
Diabetes
, vol.50
, pp. 1562-1570
-
-
Tourrel, C.1
Bailbe, D.2
Meile, M.J.3
Kergoat, M.4
Portha, B.5
-
176
-
-
0035046940
-
Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells
-
Trivedi, N., Hollister-Lock, J., Lopez-Avalos, M.D., O'Neil, J.J., Keegan, M., Bonner-Weir, S. and Weir, G.C. (2001) Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology, 142: 2115-2122.
-
(2001)
Endocrinology
, vol.142
, pp. 2115-2122
-
-
Trivedi, N.1
Hollister-Lock, J.2
Lopez-Avalos, M.D.3
O'Neil, J.J.4
Keegan, M.5
Bonner-Weir, S.6
Weir, G.C.7
-
178
-
-
0030695820
-
Specific problems facing gene therapy for insulin-dependent diabetes mellitus: Glucose-regulated insulin secretion from hepatocytes
-
Wanke, I.E. and Wong, N.C. (1997) Specific problems facing gene therapy for insulin-dependent diabetes mellitus: glucose-regulated insulin secretion from hepatocytes. Proc. West. Pharmacol. Soc., 40: 131-133.
-
(1997)
Proc. West. Pharmacol. Soc.
, vol.40
, pp. 131-133
-
-
Wanke, I.E.1
Wong, N.C.2
-
179
-
-
0028331909
-
Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein
-
Watanabe, T., Yonemura, Y., Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama, K., Moriizumi, S., Unno, M., Tanaka, O., Kondo, H., Bone, A.J., Takasawa, S. and Okamoto, H. (1994) Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc. Natl. Acad. Sci. U. S. A., 91: 3589-3592.
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 3589-3592
-
-
Watanabe, T.1
Yonemura, Y.2
Yonekura, H.3
Suzuki, Y.4
Miyashita, H.5
Sugiyama, K.6
Moriizumi, S.7
Unno, M.8
Tanaka, O.9
Kondo, H.10
Bone, A.J.11
Takasawa, S.12
Okamoto, H.13
-
180
-
-
0037272161
-
Prevention strategies for type 1 diabetes mellitus: Current status and future directions
-
Winter, W.E. and Schatz, D. (2003) Prevention strategies for type 1 diabetes mellitus: current status and future directions. BioDrugs, 17: 39-64.
-
(2003)
BioDrugs
, vol.17
, pp. 39-64
-
-
Winter, W.E.1
Schatz, D.2
-
181
-
-
4143146428
-
Dipeptide boronic acid, a novel proteasome inhibitor, prevents islet-allograft rejection
-
Wu, Y., Han, B., Luo, H., Shi, G. and Wu, J. (2004) Dipeptide boronic acid, a novel proteasome inhibitor, prevents islet-allograft rejection. Transplantation, 78: 360-366.
-
(2004)
Transplantation
, vol.78
, pp. 360-366
-
-
Wu, Y.1
Han, B.2
Luo, H.3
Shi, G.4
Wu, J.5
-
182
-
-
0033668752
-
Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion
-
Yamamoto, K., Miyagawa, J., Waguri, M., Sasada, R., Igarashi, K., Li, M., Nammo, T., Moriwaki, M., Imagawa, A., Yamagata, K., Nakajima, H., Namba, M., Tochino, Y., Hanafusa, T. and Matsuzawa, Y. (2000) Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. Diabetes, 49: 2021-2027.
-
(2000)
Diabetes
, vol.49
, pp. 2021-2027
-
-
Yamamoto, K.1
Miyagawa, J.2
Waguri, M.3
Sasada, R.4
Igarashi, K.5
Li, M.6
Nammo, T.7
Moriwaki, M.8
Imagawa, A.9
Yamagata, K.10
Nakajima, H.11
Namba, M.12
Tochino, Y.13
Hanafusa, T.14
Matsuzawa, Y.15
-
183
-
-
0037062515
-
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
-
Yang, L., Li, S., Hatch, H., Ahrens, K., Cornelius, J.G., Petersen, B.E. and Peck, A.B. (2002) In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc. Natl. Acad. Sci. U. S. A., 99: 8078-8083.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 8078-8083
-
-
Yang, L.1
Li, S.2
Hatch, H.3
Ahrens, K.4
Cornelius, J.G.5
Petersen, B.E.6
Peck, A.B.7
-
184
-
-
7844230594
-
Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice
-
Yasuda, H., Nagata, M., Arisawa, K., Yoshida, R., Fujihira, K., Okamoto, N., Moriyama, H., Miki, M., Saito, I., Hamada, H., Yokono, K. and Kasuga, M. (1998) Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice. J. Clin. Invest., 102: 1807-1814.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1807-1814
-
-
Yasuda, H.1
Nagata, M.2
Arisawa, K.3
Yoshida, R.4
Fujihira, K.5
Okamoto, N.6
Moriyama, H.7
Miki, M.8
Saito, I.9
Hamada, H.10
Yokono, K.11
Kasuga, M.12
-
185
-
-
0002798851
-
Insulin-dependent diabetes mellitus
-
Eds. Roitt, I.M. & Delves, P.J. Academic Press, London
-
Yoon, J.W. and Jun, H.S. (1998) Insulin-dependent diabetes mellitus. In: Encyclopedia of Immunology, Eds. Roitt, I.M. & Delves, P.J. Academic Press, London, pp1390-1398.
-
(1998)
Encyclopedia of Immunology
, pp. 1390-1398
-
-
Yoon, J.W.1
Jun, H.S.2
-
186
-
-
0036156567
-
Recent advances in insulin gene therapy for type 1 diabetes
-
Yoon, J.W. and Jun, H.S. (2002) Recent advances in insulin gene therapy for type 1 diabetes. Trends Mol. Med., 8: 62-68.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 62-68
-
-
Yoon, J.W.1
Jun, H.S.2
-
187
-
-
0038472015
-
Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells
-
Zalzman, M., Gupta, S., Giri, R.K., Berkovich, I., Sappal, B.S., Karnieli, O., Zern, M.A., Fleischer, N. and Efrat, S. (2003) Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc. Natl. Acad. Sci. U. S. A., 100: 7253-7258.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 7253-7258
-
-
Zalzman, M.1
Gupta, S.2
Giri, R.K.3
Berkovich, I.4
Sappal, B.S.5
Karnieli, O.6
Zern, M.A.7
Fleischer, N.8
Efrat, S.9
-
188
-
-
0344642932
-
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice
-
Zhang, Y.C., Pileggi, A., Agarwal, A., Molano, R.D., Powers, M., Brusko, T., Wasserfall, C., Goudy, K., Zahr, E., Poggioli, R., Scott-Jorgensen, M., Campbell-Thompson, M., Crawford, J.M., Nick, H., Flotte, T., Ellis, T.M., Ricordi, C., Inverardi, L. and Atkinson, M.A. (2003) Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes, 52: 708-716.
-
(2003)
Diabetes
, vol.52
, pp. 708-716
-
-
Zhang, Y.C.1
Pileggi, A.2
Agarwal, A.3
Molano, R.D.4
Powers, M.5
Brusko, T.6
Wasserfall, C.7
Goudy, K.8
Zahr, E.9
Poggioli, R.10
Scott-Jorgensen, M.11
Campbell-Thompson, M.12
Crawford, J.M.13
Nick, H.14
Flotte, T.15
Ellis, T.M.16
Ricordi, C.17
Inverardi, L.18
Atkinson, M.A.19
-
189
-
-
16744368499
-
Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion
-
Zhou, Y.P., Pena, J.C., Roe, M.W., Mittal, A., Levisetti, M., Baldwin, A.C., Pugh, W., Ostrega, D., Ahmed, N., Bindokas, V.P., Philipson, L.H., Hanahan, D., Thompson, C.B. and Polonsky, K.S. (2000) Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am. J. Physiol. Endocrinol. Metab., 278: E340-351.
-
(2000)
Am. J. Physiol. Endocrinol. Metab.
, vol.278
-
-
Zhou, Y.P.1
Pena, J.C.2
Roe, M.W.3
Mittal, A.4
Levisetti, M.5
Baldwin, A.C.6
Pugh, W.7
Ostrega, D.8
Ahmed, N.9
Bindokas, V.P.10
Philipson, L.H.11
Hanahan, D.12
Thompson, C.B.13
Polonsky, K.S.14
-
190
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet, P., Alberti, K.G. and Shaw, J, (2001) Global and societal implications of the diabetes epidemic. Nature, 414: 782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
191
-
-
0038110577
-
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes
-
Zorina, T.D., Subbotin, V.M., Bertera, S., Alexander, A.M., Haluszczak, C., Gambrell, B., Bottino, R., Styche, A.J. and Trucco, M. (2003) Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells, 21: 377-388.
-
(2003)
Stem Cells
, vol.21
, pp. 377-388
-
-
Zorina, T.D.1
Subbotin, V.M.2
Bertera, S.3
Alexander, A.M.4
Haluszczak, C.5
Gambrell, B.6
Bottino, R.7
Styche, A.J.8
Trucco, M.9
-
192
-
-
0035119871
-
Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
-
Zulewski, H., Abraham, E.J., Gerlach, M.J., Daniel, P.B., Moritz, W., Muller, B., Vallejo, M., Thomas, M.K. and Habener, J.F. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes, 50: 521-533.
-
(2001)
Diabetes
, vol.50
, pp. 521-533
-
-
Zulewski, H.1
Abraham, E.J.2
Gerlach, M.J.3
Daniel, P.B.4
Moritz, W.5
Muller, B.6
Vallejo, M.7
Thomas, M.K.8
Habener, J.F.9
|