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Volumn 338, Issue 25, 1998, Pages 1813-1821

Thr role of T-cell costimulatory activation pathways in transplant rejection

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOPROTEIN GP 39; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; OKT 3; RAPAMYCIN; TACROLIMUS; B7 ANTIGEN; CD40 ANTIGEN;

EID: 0032543306     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199806183382506     Document Type: Review
Times cited : (502)

References (55)
  • 1
    • 0027305120 scopus 로고
    • Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients
    • Port FK, Wolfe RA, Mauger EA, Berling DP, Jiang K. Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. JAMA 1993;270:1339-43.
    • (1993) JAMA , vol.270 , pp. 1339-1343
    • Port, F.K.1    Wolfe, R.A.2    Mauger, E.A.3    Berling, D.P.4    Jiang, K.5
  • 2
    • 0030358295 scopus 로고    scopus 로고
    • The UNOS scientific renal transplant registry
    • Cecka JM, Terasaki PI, eds. Los Angeles: UCLA Tissue Typing Laboratory
    • Cecka JM. The UNOS scientific renal transplant registry. In: Cecka JM, Terasaki PI, eds. Clinical transplants. Los Angeles: UCLA Tissue Typing Laboratory, 1996:1-14.
    • (1996) Clinical Transplants , pp. 1-14
    • Cecka, J.M.1
  • 3
    • 0009736430 scopus 로고    scopus 로고
    • Alloantigen-dependent events in chronic rejection
    • Tilney NL, Strom TB, Paul LC, eds. Philadelphia: Lippincott-Raven
    • Paul LC, Tilney NL. Alloantigen-dependent events in chronic rejection. In: Tilney NL, Strom TB, Paul LC, eds. Transplantation biology: cellular and molecular aspects. Philadelphia: Lippincott-Raven, 1996:567-75.
    • (1996) Transplantation Biology: Cellular and Molecular Aspects , pp. 567-575
    • Paul, L.C.1    Tilney, N.L.2
  • 4
    • 0002634532 scopus 로고    scopus 로고
    • Antigen-independent events leading to chronic graft dysfunction
    • Tilney NL, Strom TB, Paul LC, eds. Philadelphia: Lippincott-Raven
    • Tilnev NL, Paul LC. Antigen-independent events leading to chronic graft dysfunction. In: Tilney NL, Strom TB, Paul LC, eds. Transplantation biology: cellular and molecular aspects. Philadelphia: Lippincott-Raven, 1996:629-37.
    • (1996) Transplantation Biology: Cellular and Molecular Aspects , pp. 629-637
    • Tilnev, N.L.1    Paul, L.C.2
  • 6
    • 0028178873 scopus 로고
    • Signals and signs for lymphocyte responses
    • Janeway CA Jr, Bottomly K. Signals and signs for lymphocyte responses. Cell 1994;76:275-85.
    • (1994) Cell , vol.76 , pp. 275-285
    • Janeway Jr., C.A.1    Bottomly, K.2
  • 7
    • 0029851224 scopus 로고    scopus 로고
    • Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
    • Reiser H, Stadecker MJ. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases. N Engl J Med 1996;335:1369-77.
    • (1996) N Engl J Med , vol.335 , pp. 1369-1377
    • Reiser, H.1    Stadecker, M.J.2
  • 8
    • 0028197430 scopus 로고
    • Mechanisms of T cell recognition of alloantigen: The role of peptides
    • Savegh MH, Watschinger B, Carpenter CB. Mechanisms of T cell recognition of alloantigen: the role of peptides. Transplantation 1994;57: 1295-302.
    • (1994) Transplantation , vol.57 , pp. 1295-1302
    • Savegh, M.H.1    Watschinger, B.2    Carpenter, C.B.3
  • 10
    • 0032518422 scopus 로고    scopus 로고
    • Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts
    • Ciubotariu R, Liu Z, Colovai AI, et al. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest 1998;101:398-405.
    • (1998) J Clin Invest , vol.101 , pp. 398-405
    • Ciubotariu, R.1    Liu, Z.2    Colovai, A.I.3
  • 11
    • 0030879985 scopus 로고    scopus 로고
    • Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction
    • Vella JP, Spadafora-Ferreira M, Murphy B, et al. Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64:795-800.
    • (1997) Transplantation , vol.64 , pp. 795-800
    • Vella, J.P.1    Spadafora-Ferreira, M.2    Murphy, B.3
  • 12
    • 0029661947 scopus 로고    scopus 로고
    • CD4+ but not CD8+ cells are essential for allorejection
    • Krieger NR, Yin DP, Garrison Fathman C. CD4+ but not CD8+ cells are essential for allorejection. J Exp Med 1996;184:2013-8.
    • (1996) J Exp Med , vol.184 , pp. 2013-2018
    • Krieger, N.R.1    Yin, D.P.2    Garrison Fathman, C.3
  • 14
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporine A and FK506
    • Schreiber SL, Crabtree GR. The mechanism of action of cyclosporine A and FK506. Immunol Today 1992;13:136-42.
    • (1992) Immunol Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 15
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kd S6 protein kinases
    • Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kd S6 protein kinases. Cell 1992;69:1227-36.
    • (1992) Cell , vol.69 , pp. 1227-1236
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3    Blenis, J.4
  • 16
    • 0030272487 scopus 로고    scopus 로고
    • Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: Tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
    • Brazelton TR, Morris RE. Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr Opin Immunol 1996;8:710-20.
    • (1996) Curr Opin Immunol , vol.8 , pp. 710-720
    • Brazelton, T.R.1    Morris, R.E.2
  • 17
    • 0028812791 scopus 로고
    • Mechanisms of action and overview of OKT3
    • Norman DJ. Mechanisms of action and overview of OKT3. Ther Drug Monit 1995;17:615-20.
    • (1995) Ther Drug Monit , vol.17 , pp. 615-620
    • Norman, D.J.1
  • 18
    • 0027479685 scopus 로고
    • "Infectious" transplantation tolerance
    • Qin S, Cobbold SP, Pope H, et al. "Infectious" transplantation tolerance. Science 1993;259:974-7.
    • (1993) Science , vol.259 , pp. 974-977
    • Qin, S.1    Cobbold, S.P.2    Pope, H.3
  • 19
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993;11:191-212.
    • (1993) Annu Rev Immunol , vol.11 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 22
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas TL, Bakker CY, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 1996;183:2541-50.
    • (1996) J Exp Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 23
    • 0027284230 scopus 로고
    • Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation
    • Gimmi CD, Freeman GJ, Gribben JG, Gray G, Nadler LM. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A 1993;90:6586-90.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6586-6590
    • Gimmi, C.D.1    Freeman, G.J.2    Gribben, J.G.3    Gray, G.4    Nadler, L.M.5
  • 24
    • 0030006733 scopus 로고    scopus 로고
    • CD28 costimulation prevents cell death during primary T cell activation
    • Noel PJ, Boise LH, Green JM, Thompson CB. CD28 costimulation prevents cell death during primary T cell activation. J Immunol 1996;157: 636-42.
    • (1996) J Immunol , vol.157 , pp. 636-642
    • Noel, P.J.1    Boise, L.H.2    Green, J.M.3    Thompson, C.B.4
  • 25
    • 0027397169 scopus 로고
    • Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
    • Tan P, Anasetti C, Hansen JA, et al. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med 1993;177:165-73.
    • (1993) J Exp Med , vol.177 , pp. 165-173
    • Tan, P.1    Anasetti, C.2    Hansen, J.A.3
  • 26
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80 and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80 and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A 1996;93:13967-72.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13967-13972
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3    Peach, R.4    Linsley, P.S.5    Turka, L.A.6
  • 28
    • 0031463831 scopus 로고    scopus 로고
    • CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection
    • Reul RM, Fang JC, Denton MD, et al. CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection. Transplantation 1997;64:1765-74.
    • (1997) Transplantation , vol.64 , pp. 1765-1774
    • Reul, R.M.1    Fang, J.C.2    Denton, M.D.3
  • 29
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim EA, Kipps TJ. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993;177:925-35.
    • (1993) J Exp Med , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 30
    • 0029787322 scopus 로고    scopus 로고
    • Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
    • Guo Y, Wu Y, Shinde S, Sy MS, Aruffo A, Liu Y. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J Exp Med 1996;184:955-61.
    • (1996) J Exp Med , vol.184 , pp. 955-961
    • Guo, Y.1    Wu, Y.2    Shinde, S.3    Sy, M.S.4    Aruffo, A.5    Liu, Y.6
  • 31
    • 0026738641 scopus 로고
    • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig
    • Lenschow DJ, Zeng Y, Thistlethwaite JR, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 1992;257: 789-92.
    • (1992) Science , vol.257 , pp. 789-792
    • Lenschow, D.J.1    Zeng, Y.2    Thistlethwaite, J.R.3
  • 32
    • 0026459468 scopus 로고
    • T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
    • Turka LA, Linsley PS, Lin H, et al. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl Acad Sci U S A 1992;89:11102-5.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11102-11105
    • Turka, L.A.1    Linsley, P.S.2    Lin, H.3
  • 33
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
    • Lin H, Bolling SF, Linsley PS, et al. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med 1993;178:1801-6.
    • (1993) J Exp Med , vol.178 , pp. 1801-1806
    • Lin, H.1    Bolling, S.F.2    Linsley, P.S.3
  • 34
    • 0031464292 scopus 로고    scopus 로고
    • Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treafed murine cardiac allograft recipients
    • Savegh MH, Zheng X-G, Magee C, Hancock WW, Turka LA. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treafed murine cardiac allograft recipients. Transplantation 1997;64:1646-50.
    • (1997) Transplantation , vol.64 , pp. 1646-1650
    • Savegh, M.H.1    Zheng, X.-G.2    Magee, C.3    Hancock, W.W.4    Turka, L.A.5
  • 35
    • 0029944669 scopus 로고    scopus 로고
    • CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model: Evidence for hematopoietic chimerism
    • Pearson TC, Alexander DZ, Hendrix R, et al. CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model: evidence for hematopoietic chimerism. Transplantation 1996;61:997-1004.
    • (1996) Transplantation , vol.61 , pp. 997-1004
    • Pearson, T.C.1    Alexander, D.Z.2    Hendrix, R.3
  • 36
    • 0028903939 scopus 로고
    • CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
    • Savegh MH, Alcalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995;181:1869-74.
    • (1995) J Exp Med , vol.181 , pp. 1869-1874
    • Savegh, M.H.1    Alcalin, E.2    Hancock, W.W.3
  • 38
    • 0029937962 scopus 로고    scopus 로고
    • CTLA4Ig alone or in combination with low-dose cyclosporine fails to reverse acute rejection of renal allograft in the rat
    • Perico N, Amuchastegui S, Bontempelli M, Remuzzi G. CTLA4Ig alone or in combination with low-dose cyclosporine fails to reverse acute rejection of renal allograft in the rat. Transplantation 1996;61:1320-2.
    • (1996) Transplantation , vol.61 , pp. 1320-1322
    • Perico, N.1    Amuchastegui, S.2    Bontempelli, M.3    Remuzzi, G.4
  • 39
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • Lenschow DJ, Ho SC, Sattar H, et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995;181:1145-55.
    • (1995) J Exp Med , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1    Ho, S.C.2    Sattar, H.3
  • 40
    • 0031203940 scopus 로고    scopus 로고
    • The role of donor and recipient B7-1 (CD80) in allograft rejection
    • Zheng XX, Sayegh MH, Zheng X-G, et al. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol 1997;159:1169-73.
    • (1997) J Immunol , vol.159 , pp. 1169-1173
    • Zheng, X.X.1    Sayegh, M.H.2    Zheng, X.-G.3
  • 41
  • 42
    • 0030051268 scopus 로고    scopus 로고
    • Chronic cardiac reaction in the LEW to F344 rat model: Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis
    • Russell ME, Hancock WW, Akalin E, et al. Chronic cardiac reaction in the LEW to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. J Clin Invest 1996;97:833-8.
    • (1996) J Clin Invest , vol.97 , pp. 833-838
    • Russell, M.E.1    Hancock, W.W.2    Akalin, E.3
  • 43
    • 0029864501 scopus 로고    scopus 로고
    • Blockade of T-cell costimulation prevents development of experimental chronic allograft rejection
    • Azuma H, Chandraker A, Nadeau K, et al. Blockade of T-cell costimulation prevents development of experimental chronic allograft rejection. Proc Natl Acad Sci U S A 1996;93:12439-44.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12439-12444
    • Azuma, H.1    Chandraker, A.2    Nadeau, K.3
  • 44
    • 0030890270 scopus 로고    scopus 로고
    • T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: Effects of cyclosporine and donor antigen
    • Chandraker A, Russell ME, Glysing-Jensen T, Willett TA, Sayegh MH. T-cell costimulatory blockade in experimental chronic cardiac allograft rejection: effects of cyclosporine and donor antigen. Transplantation 1997;63:1053-8.
    • (1997) Transplantation , vol.63 , pp. 1053-1058
    • Chandraker, A.1    Russell, M.E.2    Glysing-Jensen, T.3    Willett, T.A.4    Sayegh, M.H.5
  • 45
    • 0030931388 scopus 로고    scopus 로고
    • The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury
    • Takada M, Chandraker A, Nadeau KC, Sayegh MH, Tilney NL. The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. J Clin Invest 1997;100:1199-203.
    • (1997) J Clin Invest , vol.100 , pp. 1199-1203
    • Takada, M.1    Chandraker, A.2    Nadeau, K.C.3    Sayegh, M.H.4    Tilney, N.L.5
  • 46
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection: Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection: suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61:4-9.
    • (1996) Transplantation , vol.61 , pp. 4-9
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 47
    • 0028882526 scopus 로고
    • Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
    • Parker DC, Greiner DL, Phillips NE, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci U S A 1995;92:9560-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9560-9564
    • Parker, D.C.1    Greiner, D.L.2    Phillips, N.E.3
  • 49
    • 0031307384 scopus 로고    scopus 로고
    • Immunosuppressive effects of hCTLA4Ig in a nonhuman primate model of allogeneic pancreatic islet transplantation
    • Levisetti M, Padrid P, Szot G, et al. Immunosuppressive effects of hCTLA4Ig in a nonhuman primate model of allogeneic pancreatic islet transplantation. J Immunol 1997;159:5187-91.
    • (1997) J Immunol , vol.159 , pp. 5187-5191
    • Levisetti, M.1    Padrid, P.2    Szot, G.3
  • 51
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997;94:8789-94.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 52
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996;381:343-8.
    • (1996) Nature , vol.381 , pp. 343-348
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 53
    • 0013600514 scopus 로고    scopus 로고
    • CTLA4Ig (BMS-188667)-mediated blockade of T cell costimulation in patients with psoriasis vulgaris
    • abstract
    • Lebwohl M, Kang S, Guzzo C, et al. CTLA4Ig (BMS-188667)-mediated blockade of T cell costimulation in patients with psoriasis vulgaris. J Invest Dermatol 1997;108:570. abstract.
    • (1997) J Invest Dermatol , vol.108 , pp. 570
    • Lebwohl, M.1    Kang, S.2    Guzzo, C.3
  • 54
    • 0029851220 scopus 로고    scopus 로고
    • Blockade of multiple costimulatory receptors induces hyporesponsiveness: Inhibition of CD2 plus CD28 pathways
    • Woodward JE, Qin L, Chavin KD, et al. Blockade of multiple costimulatory receptors induces hyporesponsiveness: inhibition of CD2 plus CD28 pathways. Transplantation 1996;62:1011-8.
    • (1996) Transplantation , vol.62 , pp. 1011-1018
    • Woodward, J.E.1    Qin, L.2    Chavin, K.D.3
  • 55
    • 0029090104 scopus 로고
    • Induction of tolerance to heart allografts in high responder rats by combining anti-CD4 with CTLA4Ig
    • Yin D, Fathman CG. Induction of tolerance to heart allografts in high responder rats by combining anti-CD4 with CTLA4Ig. J Immunol 1995; 155:1655-9.
    • (1995) J Immunol , vol.155 , pp. 1655-1659
    • Yin, D.1    Fathman, C.G.2


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