Recovery of the endogenous β cell function in the NOD model of autoimmune diabetes

Stem Cells

Volumn 21, Issue 4, 2003, Pages 377-388

  Zorina, Tatiana D ^a   Subbotin, Vladimir M ^b   Bertera, Suzanne ^a   Alexander, Angela M ^a   Haluszczak, Catherine ^a   Gambrell, Beverley ^a   Bottino, Rita ^a   Styche, Alexis J ^a   Trucco, Massimo ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Mirus Bio Corporation   (United States)

Author keywords

Allogeneic chimerism; Autoimmune diabetes; NOD mouse

Indexed keywords

GLUCOSE; INSULIN;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL REGENERATION; CHIMERA; CONTROLLED STUDY; DIABETOGENESIS; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; IRRADIATION; KIDNEY CAPSULE; MOUSE; MOUSE STRAIN; NEPHRECTOMY; NONHUMAN; PANCREAS ISLET BETA CELL; SHORT SURVEY;

ANIMALIA;

EID: 0038110577     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.21-4-377     Document Type: Short Survey

References (41)

1. Beattie GM, Lopez AD, Otonkoski T et al. Transplantation of human fetal pancreas: fresh vs. cultured fetal islets or ICCS. J Mol Med 1999;77:70-73.
2. Oberholzer J, Toso C, Ris F et al. Beta cell replacement for the treatment of diabetes. Ann NY Acad Sci 2001;944:373-387.
3. Ryan EA, Lakey JR, Rajotte RV et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001;50:710-719.
4. Shapiro AM, Ryan EA, Lakey JR. Diabetes. Islet cell transplantation. Lancet 2001;358(suppl 1):21.
5. Piemonti L, Leone BE, Nano R et al. Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes 2002;51:55-65.
6. Montana E, Bonner-Weir S, Weir GC. Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass. J Clin Invest 1994;93:1577-1582.
7. Warnock GL. Frontiers in transplantation of insulin-secreting tissue for diabetes mellitus. Can J Surg 1999;42:421-426.
8. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
9. Drachenberg CB, Klassen DK, Weir MR et al. Islet cell damage associated with tacrolimus and cyclosporin: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 1999;68:396-402.
10. Shapiro AM, Gallant H, Hao E et al. Portal vein immunosuppressant levels and islet graft toxicity. Transplant Proc 1998;30:641.
11. Li H, Ricordi C, Demetris AJ et al. Mixed xenogeneic chimerism (mouse+rat→mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts. Transplantation 1994;57:592-598.
12. Seung E, Iwakoshi N, Woda BA et al. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 2000;95:2175-2182.
13. Carroll PB, Fontes P, Rao AS et al. Simultaneous solid organ, bone marrow, and islet allotransplantation in type 1 diabetic patients. Transplant Proc 1994;26:3523-3524.
14. Corry RJ, Chakrabarti PK, Shapiro R et al. Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients. Ann Surg 1999;230:372-381.
15. Serreze DV, Leiter EH. Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium. J Immunol 1991;147:1222-1229.
16. Serreze DV, Gaedeke JW, Leiter EH. Hematopoietic stemcell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C. Proc Natl Acad Sci USA 1993;90:9625-9629.
17. Zorina TD, Kaufman CL, Ildstad ST. Mixed allogeneic chimerism for the prevention of autoimmune diabetes and the reversal of insulitis in the non-obese diabetic (NOD) mouse. J Immunol 1993;150.
18. Li H, Kaufman CL, Boggs SS et al. Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 1996;156:380-388.
19. Li H, Inverardi L, Ricordi C. Chimerism-induced remission of overt diabetes in nonobese diabetic mice. Transplant Proc 1999;31:640.
20. Zorina T, Subbotin V, Bertera S et al. Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes. Cell Transplant 2002;11:113-123.
21. Kritzik MR, Jones E, Chen Z et al. PDX-1 and Msx-2 expression in the regenerating and developing pancreas. J Endocrinol 1999;163:523-530.
22. Sachs DH, Bonner-Weir S. New islets from old. Nat Med 2000;6:250-251.
23. Ramiya VK, Maraist M, Arfors KE et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000;6:278-282.
24. Jorns A, Klempnauer J, Tiedge M et al. Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats. Pancreas 2001;23:186-196.
25. Bonner-Weir S. Beta-cell turnover: its assessment and implications. Diabetes 2001;50(suppl 1):20-24.
26. Trivedi N, Hollister-Lock J, Lopez-Avalos MD et al. Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology 2001;142:2115-2122.
27. Guz Y, Nasir I, Teitelman G. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 2001;142:4956-4968.
28. Zulewski H, Abraham EJ, Gerlach MJ et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001;50:521-533.
29. Ildstad ST, Wren SM, Bluestone JA et al. Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med 1985;162:231-244.
30. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967;16:35-39.
31. Liu M, Shapiro ME. A new method for isolation of murine islets with markedly improved yields. Transplant Proc 1995;27:3208-3210.
32. Kaufman CL, Li H, Ildstad ST. Patterns of hemopoietic reconstitution in nonobese diabetic mice: dichotomy of allogeneic resistance versus competitive advantage of disease-resistant marrow. J Immunol 1997;158:2435-2442.
33. Montana ES, Bonner-Weir S, Weir GC. Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozotocin diabetic C57BL/6 mice. J Clin Invest 1993; 91:780-787.
34. Ferrand N, Astesano A, Phan HH et al. Dynamics of pancreatic cell growth and differentiation during diabetes reversion in STZ-treated newborn rats. Am J Physiol 1995;269:C1250-C1264.
35. Zenilman ME, Chen J, Magnuson TH. Effect of reg protein on rat pancreatic ductal cells. Pancreas 1998;17:256-261.
36. Ianus A, Holz GG, Theise ND et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-850.
37. Yamamoto AM, Chernajovsky Y, Lepault F et al. The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy. J Immunol 2001;166:4973-4980.
38. Ryu S, Kodama S, Ryu K et al. Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. J Clin Invest 2001;108:63-72.
39. Chatenoud L. Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation. Diabetologia 2001;44:521-536.
40. + T cells requires stimulation by MHCpeptide complexes and can be induced in the presence of costimulation. Transplantation 2001;72:369-376.
41. Hara M, Kingsley CI, Niimi M et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001;166:3789-3796.