Understanding autoimmune diabetes: Insights from mouse models

Trends in Molecular Medicine

Volumn 8, Issue 1, 2002, Pages 31-38

  Adorini, Luciano ^a   Gregori, Silvia ^a   Harrison, Leonard C ^b  

^a ROCHE MILANO RICERCHE   (Italy)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; GENE MAPPING; GENETIC SUSCEPTIBILITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; REVIEW;

ALLELES; ANIMALS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; INTERLEUKIN-12; LYMPHOCYTES; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; MODELS, BIOLOGICAL;

ANIMALIA; RODENTIA;

EID: 0036137987     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)02193-1     Document Type: Review

References (93)

1. Insulin-dependent diabetes mellitus as an autoimmune disease
2. The NOD mouse model of type 1 diabetes: As good as it gets?
3. Genetic control of autoimmune diabetes in the NOD mouse
4. Cytokines that regulate autoimmune responses
5. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes
6. Suppression of Th1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10
7. Local expression of TNFα in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
8. Local expression of transgene encoded TNFα in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells
9. Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
10. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse
11. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
12. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+immunoregulatory T cells that control autoimmune diabetes
13. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
14. β2-microglobulin-deficient NOD mice do not develop insulitis or diabetes
15. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: Studies using NOD/CIITA-deficient mice
16. RIP-β2-microglobulin transgene expression restores insulitis, but not diabetes, in β2-microglobulin null nonobese diabetic mice
17. The role of IL-12 in the induction of organ-specific autoimmune diseases
18. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse
19. Interleukin-4 deficiency does not exacerbate disease in NOD mice
20. IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic islets
21. HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved?
22. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice
23. Development of autoimmune insulitis is prevented in E α d but not in A beta k NOD transgenic mice
24. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain
25. MHC-linked protection from diabetes dissociated from clonal deletion of T cells
26. + thymocytes by protective MHC class II molecules
27. g7 molecule
28. Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
29. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
30. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders
31. MHC structure and autoimmune T cell repertoire development
32. g7, the class II MHC molecule of NOD and Biozzi AB/H mice
33. g7 and autoimmune diabetes
34. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
35. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library
36. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells
37. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease
38. Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes
39. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop
40. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation
41. Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays
42. Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
43. Neural network-based prediction of candidate T-cell epitopes
44. T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes
45. T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin
46. Determination of glutamic acid decarboxylase 65 peptides presented by the type 1 diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif
47. Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4
48. Antigen-based immunotherapy for autoimmune disease: From animal models to humans?
49. Antigen-specific therapy for autoimmune disease
50. IL-12 administration induces Th1 cells and accelerates autoimmune diabetes in NOD mice
51. Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation
52. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
53. Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse
54. Mechanism underlying counterregulation of autoimmune diabetes by IL-4
55. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
56. Regulatory T cells in autoimmmunity
57. Characterization of peripheral regulatory CD4+T cells that prevent diabetes onset in nonobese diabetic mice
58. Gamma delta T cells as mediators of mucosal tolerance: The autoimmune diabetes model
59. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
60. NKT cell-induced protection against diabetes in V α 14-J alpha 281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen
61. NKT cells: Facts, functions and fallacies
62. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
63. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes
64. IL-12 plays a pathologic role at the inflammatory loci in the development of diabetes in NOD mice
65. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
66. Increased in vitro interleukin-12 production by peripheral blood in high-risk IDDM first degree relatives
67. Interleukin 12 and autoimmune diabetes
68. Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene
69. Tolerance to islet autoantigens in type 1 diabetes
70. The natural killer T-cell ligand a-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
71. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes
72. g7 β-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus
73. An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells
74. k transgenic mice
75. NOD to the development of insulitis in non-obese diabetic mice
76. Transgenic HLA-DRα faithfully reconstitutes I-E-controlled immune functions and induces cross-tolerance to Eα in Eα° mutant mice
77. Glycosuria and insulitis in NOD mice expressing the HLA-DQw6 molecule
78. Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1z.ast;0302 transgenic IA(null) NOD mice
79. Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules
80. Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet β-cells
81. Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice
82. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice
83. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice
84. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
85. A role of Hsp60 in autoimmune diabetes: Analysis in a transgenic model
86. Following a diabetogenic T cell from genesis through pathogenesis
87. Acceleration of spontaneous diabetes in TCR-β-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+T cells expressing identical endogenous TCR-α chains
88. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
89. Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci
90. Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice
91. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes
92. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells