Chromosome instability in neoplasia: Chaotic roots to continuous growth

International Journal of Biochemistry and Cell Biology

Volumn 37, Issue 5 SPEC. ISS., 2005, Pages 1014-1033

  Gagos, Sarantis ^a   Irminger Finger, Irmgard ^b  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

ALT; Aneuploidy; Cancer; Chromosome instability; Telomeres

Indexed keywords

ANEUPLOIDY; CHROMOSOMAL INSTABILITY; CHROMOSOME ANALYSIS; CHROMOSOME CONDENSATION; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; DNA REPAIR; GENE EXPRESSION; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; KARYOTYPE; NEOPLASM; NONHUMAN; REVIEW; RNA INTERFERENCE; TELOMERE;

EID: 14644398628     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2005.01.003     Document Type: Review

References (153)

1. A. Ahmed, and T. Tollefsbol Telomeres and telomerase: basic science implications for aging Journal of the American Geriatric Society 49 2001 1105 1109
2. D.G. Albertson, and D. Pinkel Genomic micro arrays in human genetic disease and cancer Human Molecular Genetics 12 Suppl. 2 2003 145 152
3. S.E. Artandi, S. Chang, S.L. Lee, S. Alson, G.J. Gottlieb, and L. Chin Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice Nature 406 2000 641 644
4. S.M. Bailey, M.A. Brenneman, and E.H. Goodwin Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells Nucleic Acids Research 32 2004 3743 3751
5. S.M. Bailey, E.H. Goodwin, and M.N. Cornforth Strand-specific fluorescence in situ hybridization: the CO-FISH family Cytogenetis and Genome Research 107 2004 14 17
6. P. Baumann, and T.R. Cech Pot1, the putative telomere end-binding protein in fission yeast and humans Science 292 2001 1171 1175
7. O.E. Bechter, Y. Zou, J.W. Shay, and W.E. Wright Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency EMBO Reports 12 2003 1138 1143
8. O.E. Bechter, Y. Zou, W. Walker, W.E. Wright, and J.W. Shay Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition Cancer Research 64 2004 3444 3451
9. C.D. Belair, T.R. Yeager, P.M. Lopez, and C.A. Reznikoff Telomerase activity: a biomarker of cell proliferation, not malignant transformation Proceedings of the National Academy of Sciences of USA 94 1997 13677 13682
10. H. Biessmann, and J.M. Mason Telomere maintenance without telomerase Chromosoma 106 1997 63 69
11. A.J.R. Bishop, and R.H. Schiestl Homologous recombination as a mechanism of carcinogenesis Biochimical and Biophysical Acta 1471 2001 109 121
12. M.A. Blasco, H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, and R.A. DePinho Telomere shortening and tumor formation by mouse cells lacking telomerase RNA Cell 91 1997 25 34
13. T. Boveri Zur Frage der Enstehung Maligner Tumoren 1914 Gustav Fischer Verlag Jena
14. T.M. Bryan, A. Englezou, L. Dalla-Pozza, M.A. Dunham, and R.R. Reddel Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines Nature Medicine 3 1997 1271 1274
15. T.M. Bryan, A. Englezou, J. Gupta, S. Bacchetti, and R.R. Reddel Telomere elongation in immortal human cells without detectable telomerase activity EMBO Journal 14 1995 4240 4248
16. D.P. Cahill, K.W. Kinzler, B. Vogelstein, and C. Lengauer Genetic instability and Darwinian selection in tumors Trends in Cell Biology 9 1999 57 60
17. T.R. Cech Beginning to understand the end of the chromosome Cell 116 2004 273 279
18. A. Celeste, S. Petersen, P.J. Romanienko, O. Fernandez-Capetillo, H.T. Chen, and O.A. Sedelnikova Genomic instability in mice lacking histone H2AX Science 296 2002 922 927
19. M.A. Cerone, J.A. Londono-Vallejo, and S. Bacchetti Telomere maintenance by telomerase and by recombination can coexist in human cells Human Molecular Genetics 10 2001 1945 1952
20. W. Chang, J.N. Dynek, and S. Smith TRF1 is degraded by ubiquitin mediated proteolysis after release from telomeres Genes and Development 17 2003 1328 1333
21. S. Chang, C.M. Khoo, M.L. Naylor, R.S. Maser, and R.A. DePinho Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression Genes and Development 17 2003 88 100
22. J.-L. Chen, M.A. Blasco, and C.W. Greider Secondary structure of vertebrate telomerase RNA Cell 100 2000 503 514
23. K. Chin, C.O. de Solorzano, D. Knowles, A. Jones, W. Chou, and E.G. Rodriguez In situ analyses of genome instability in breast cancer Nature Genetics 36 2004 984 988
24. K. Collins, and J.R. Mitchell Telomerase in the human organism Oncogene 21 2002 564 579
25. M.W. Deininger, J.M. Goldman, and J.V. Melo The molecular biology of chronic myeloid leukemia Blood 96 2000 3343 3356
26. T. de Lange Activation of telomerase in a human tumor Proceedings of the National Academy of Sciences of USA 91 1994 2882 2885
27. T. de Lange Protection of mammalian telomeres Oncogene 21 2002 532 540
28. E.T. Dermitzakis, A. Reymond, R. Lyle, N. Scamuffa, C. Ucla, and S. Deutsch Numerous potentially functional but non-genic conserved sequences on human chromosome 21 Nature 420 6915 2002 578 582
29. H. der-Sarkissian, S. Bacchetti, L. Cazes, and J.A. Londono-Vallejo The shortest telomeres drive karyotype evolution in transformed cells Oncogene 23 2004 1221 1228
30. M.J. Difilippantonio, J. Zhu, H.T. Chen, E. Meffre, M.C. Nussenzweig, and E.E. Max DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation Nature 404 6777 2000 510 514
31. H. Ding, M. Schertzer, X. Wu, M. Gertsenstein, S. Selig, and M. Kammori Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein Cells 117 2004 873 886
32. M.A. Dunham, A.A. Neumann, C.L. Fasching, and R.R. Reddel Telomere maintenance by recombination in human cells Nature Genetics 26 2000 447 450
33. A. Eden, F. Gaudet, A. Waghmare, and R. Jaenisch Chromosomal instability and tumors promoted by DNA hypomethylation Science 300 5618 2003 455
34. B. Elliott, and M. Jasin Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells Molecular Cell Biology 21 2001 2671 2682
35. J.R. Eshleman, G. Casey, M.E. Kochera, W.D. Sedwick, S.E. Swinler, and M.L. Veigl Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53 Oncogene 17 1998 719 725
36. A. Fabarius, R. Hehlmann, and P.H. Duesberg Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy Cancer Genetis and Cytogenetics 143 2003 59 72
37. E.R. Fearon Human cancer syndromes: clues to the origin and nature of cancer Science 278 5340 1997 1043 1050
38. D.O. Ferguson, and F.W. Alt DNA double strand break repair and chromosomal translocation: Lessons from animal models Oncogene 20 2001 5572 5579
39. R. Fodde, J. Kuipers, C. Rosenberg, R. Smits, M. Kielman, and C. Gaspar Mutations in the APC tumour suppressor gene cause chromosomal instability Nature Cell Biology 3 2001 433 438
40. M. Fran Lynch, C.J. Fernandes, L.G. Shaffer, and L. Potocki Trisomy 14 mosaicism: A case report and review of the literature Journal of Perinatology 24 2004 121 123
41. S. Gagos, D. Iliopoulos, S. Tseleni-Balafouta, M. Agapitos, C. Antachopoulos, and A. Kostakis Cell senescence and a mechanism of clonal evolution leading to continuous cell proliferation, loss of heterozygosity, and tumor heterogeneity: studies on two immortal colon cancer cell lines Cancer Genetis and Cytogenetics 90 1996 157 165
42. D. Gisselsson, T. Jonson, A. Petersen, B. Strombeck, P. Dal Cin, and M. Hoglund Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors Proceedings of the National Academy of Sciences of USA 98 2001 12683 81268
43. G.R. Gorla, H. Malhi, and S. Gupta Polyploidy associated with oxidative injury attenuates proliferative potential of cells Journal of Cell Science 114 2001 2943 2951
44. J. Graakjaer, L. Pascoe, H. Der-Sarkissian, G. Thomas, S. Kolvraa, and K. Christensen The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life Aging Cell 3 2004 97 102
45. R.A. Green, and K.B. Kaplan Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC Cell Biology 163 2003 949 961
46. C.W. Greider, and E.H. Blackburn Identification of a specific telomere terminal transferase activity in Tetrahymena extracts Cell 43 1985 405 413
47. S. Gruber, C.H. Haering, and K. Nasmyth Chromosomal cohesin forms a ring Cell 112 2003 765 777
48. S. Gupta Hepatic polyploidy and liver growth control Seminars in Cancer Biology 10 2000 161 171
49. J.E. Haber Recombination: A frank view of exchanges and vice versa Current Opinion in Cell Biology 12 2002 286 292
50. J.A. Hackett, and C.W. Greider Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis Oncogene 21 2002 619 626
51. W.C. Hahn, S.A. Stewart, M.W. Brooks, S.G. York, E. Eaton, and A. Kurachi Inhibition of telomerase limits the growth of human cancer cells Nature Medicine 5 1999 1164 1170
52. I.M. Hall, K. Noma, and S.I.S. Grewal RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast Proceedings of the National Academy of Sciences of USA 100 2003 193 198
53. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
54. M.P. Hande, E. Samper, P. Lansdorp, and M.A. Blasco Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice Journal of Cell Biology 144 1999 589 601
55. R.S. Hansen, C. Wijmenga, P. Luo, A.M. Stanek, T.K. Canfield, and C.M. Weemaes The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome Proceedings of the National Academy of Sciences of USA 96 1999 14412 14417
56. C.B. Harley Telomere loss: Mitotic clock or genetic time bomb? Mutation Research 256 1991 271 282
57. C.B. Harley, A.B. Futcher, and C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
58. L. Harrington Those dam-aged telomeres! Current Opinion in Genetics and Development 14 2004 22 28
59. L. Hayflick The limited in vitro lifetime of human diploid strains Experimental Cell Research 37 1965 614 636
60. L. Hayflick Mortality and immortality at the cellular level: A review Biochemistry 62 1997 1180 1190
61. S. Heim, and F. Mitelman Cancer Cytogenetics 1994 Alan R. Liss, Inc. New York pp. 23-37
62. M.T. Hemann, M.A. Strong, L.Y. Hao, and C.W. Greider The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability Cell 107 2001 67 77
63. J.D. Henson, A.A. Neumann, T.R. Yeager, and R.R. Reddel Alternative lengthening of telomeres in mammalian cells Oncogene 21 2002 598 610
64. T. Hirano SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes and Development 13 1999 11 19
65. I. Irminger-Finger, J.V. Soriano, G. Vaudan, R. Montesano, and A.P. Sappino In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells Journal of Cell Biology 143 1998 1329 1339
66. ISCN (1995). In F. Mitelman (Ed.), An International System for Human Cytogenetic Nomenclature. Basel: S. Karger.
67. H. Izumi, T. Haray, A. Oga, K. Matsuday, Y. Satoz, and K. Naitoy High telomerase activity correlates with the stabilities of genome and dna ploidy in renal cell carcinoma Neoplasia 4 2002 103 111
68. P.V. Jallepalli, and C. Lengauer Chromosome segregation and cancer: Cutting through the mystery Nature Reviews 1 2001 109 117
69. P.V. Jallepalli, I.C. Waizenegger, F. Bunz, S. Langer, M.R. Speicher, and J.M. Peters Securin is required for chromosomal stability in human cells Cell 105 2001 445 457
70. M. Jasin Chromosome breaks and genomic instability Cancer Investigation 18 2000 73, 78-86
71. P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nature Reviews Genetics 3 2002 415 428
72. R.R. Khakhar, J.A. Cobb, L. Bjergbaek, I.D. Hickson, and S.M. Gasser RecQ helicases: Multiple roles in genome maintenance Trends in Cell Biology 9 2003 493 501
73. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, and P.L.C. Ho Specific association of human telomerase activity with immortal cells and cancer Science 266 1994 2011 2015
74. K.E. Kirk, B.P. Harmon, I.K. Reichardt, J.W. Sedat, and E.H. Blackburn Block in anaphase chromosome separation caused by a telomerase template mutation Science 275 5305 1997 1478 1481
75. S. Kishi, X.Z. Zhou, Y. Ziv, C. Khoo, D.E. Hill, and Y. Shiloh Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks Journal of Biological Chemistry 276 2001 29282 29291
76. T.S. Kitajima, S.A. Kawashima, and Y. Watanabe The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis Nature 427 2004 510 517
77. T.S. Kitajima, S. Yokobayashi, M. Yamamoto, and Y. Watanabe Distinct cohesin complexes organize meiotic chromosome domains Science 300 2003 1152 1155
78. E. Kolomietz, M.S. Meyn, A. Pandita, and J.A. Squire The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors Genes Chromosomes Cancer 35 2002 97 112
79. B.N. Kudryavtsev, M.V. Kudryavtseva, G.A. Sakuta, and G.I. Stein Human hepatocyte polyploidization kinetics in the course of life cycle Virchows Achieves B. Cell Pathology Including Molecular Pathology 64 1993 387 393
80. C. Lengauer, K.W. Kinzler, and B. Vogelstein Genetic instabilities in human cancers Nature 396 1998 643 649
81. S.-Y. Lin, and S.J. Elledge Multiple tumor suppressor pathways negatively regulate telomerase Cell 113 2003 881 889
82. G. Liu, J.M. Parant, G. Lang, P. Chau, A. Chavez-Reyes, and A.K. El-Naggar Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice Nature Genetics 36 2004 63 68
83. J.A. Londono-Vallejo, H. Der-Sarkissian, L. Cazes, S. Bacchetti, and R.R. Reddel Alternative lengthening of telomeres is characterized by high rates of telomeric exchange Cancer Research 64 2004 2324 2327
84. T. Lukusa, M. Holvoet, J.R. Vermeesch, K. Devriendt, and J.P. Fryns Partial monosomy 11q and trisomy 12q: Variable expression in two siblings Genetic Counseling 14 2003 155 164
85. V. Lundblad, and J.W. Szostak A mutant with a defect in telomere elongation leads to senescence in yeast Cell 57 1989 633 664
86. J.R. Lupski, J.R. Roth, and G.M. Weinstock Chromosomal duplications in bacteria, fruit flies, and humans American Journal of Human Genetics 58 1996 21 27
87. R. Lyle, C. Gehrig, C. Neergaard-Henrichsen, S. Deutsch, and S.E. Antonarakis Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome Genome Research 14 2004 1268 1274
88. P. Maraschio, O. Zuffardi, T. Dalla Fior, and L. Tiepolo Immunodeficiency, centromeric heterochromatin instability of chromosomes 1, 9 and 16, and facial anomalies: The ICF syndrome Journal of Medical Genetics 25 3 1988 173 180
89. R.S. Maser, and R.A. DePinho Connecting chromosomes, crisis, and cancer Science 297 2002 565 569
90. J.M. Mason, and H. Biessmann The unusual telomeres of Drosophila Trends in Genetics 11 1995 58 62
91. K. Masutomi, E.Y. Yu, S. Khurts, I. Ben-Porath, J.L. Currier, and G.B. Metz Telomerase maintains telomere structure in normal human cells Cell 114 2003 241 253
92. E.E. McCarthy, J.T. Celebi, R. Baer, and T. Ludwig Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability Molecular Cell Biology 23 14 2003 5056 5063
93. B. McClintock The behavior in successive nuclear divisions of a chromosome broken at meiosis Genetics 25 1939 405 416
94. B. McClintock The stability of broken ends of chromosomes in Zea mays Genetics 26 1941 234 282
95. L.D. McDaniel, and R.A. Schultz Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15 Proceedings of the National Academy of Sciences of USA 89 1992 7968 7972
96. A.K. Meeker, J.L. Hicks, C.A. Iacobuzio-Donahue, E.A. Montgomery, W.H. Westra, and T.Y. Chan Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis Clinical Cancer Research 10 2004 3317 3326
97. L.S. Michel, V. Liberal, A. Chatterjee, R. Kirchwegger, B. Pasche, and W. Gerald MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells Nature 409 2001 355 359
98. Mitelman, F., Johansson, B., & Mertens, F. (Eds.) (2005). Mitelman Data Base of Chromosome Aberrations http://cgap.nci.gov/Chromosomes/Mitelman.
99. M.M. Mogensen, J.B. Tucker, J.B. Mackie, A.R. Prescott, and I.S. Nathke The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells Journal of Cell Biology 157 2002 1041 1048
100. P. Mohaghegh, and I.D. Hickson Premature aging in RecQ helicase-deficient human syndromes International Journal of Biochemistry and Cell Biology 34 2002 1496 1501
101. C.P. Morales, S.E. Holt, M. Ouellette, K.J. Kaur, Y. Yan, and K.S. Wilson Absence of cancer-associated changes in human fibroblasts immortalized with telomerase Nature Genetics 21 1999 115 118
102. G.B. Morin, and T.R. Cech The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats Cell 46 1986 873 883
103. J.P. Murnane, L. Sabatier, B.A. Marder, and W.F. Morgan Telomere dynamics in an immortal human cell line The EMBO Journal 13 1994 4953 4962
104. S.A. Narod, and W.D. Foulkes BRCA1 and BRCA2: 1994 and beyond Nature Reviews Cancer 4 2004 665 676
105. K. Nasmyth Disseminating the genome: joining, resolving and separating sister chromatids during mitosis and meiosis Annual Reviews in Genetics 35 2001 673 745
106. P.C. Nowell The clonal evolution of tumor cell populations Science 194 1976 23 28
107. M. Oberringer, D. Lothschutz, M. Jennewein, M. Koschnick, W. Mutschler, and R.G. Hanselmann Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair Molecular and Cell Biology Research Communication 2 1999 190 196
108. T.K. Pandita, S. Pathak, and C.R. Geard Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells Cytogenetics and Cell Genetics 71 1995 86 93
109. P. Pfeiffer, W. Goedecke, and G. Obe Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations Mutagenesis 15 2000 289 302
110. D. Pinkel, R. Segraves, D. Sudar, S. Clark, I. Poole, and D. Kowbel High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nature Genetics 20 1998 207 211
111. S.S. Poon, and P.M. Lansdorp Measurements of telomere length on individual chromosomes by image cytometry Methods in Cell Biology 64 2001 69 96
112. V. Prasad, P.V. Jallepalli, I.C. Waizenegger, F. Bunz, S. Langer, and M.R. Speicher Securin is required for chromosomal stability in human cells Cell 105 2001 445 457
113. H. Rajagopalan, P.V. Jallepalli, C. Rago, V.E. Velculescu, K.W. Kinzler, and B. Vogelstein Inactivation of hCDC4 can cause chromosomal instability Nature 428 6978 2004 77 81
114. P. Reichenbach, M. Hoss, C.M. Azzalin, M. Nabholz, P. Bucher, and J. Lingner A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed Current Biology 13 2003 568 574
115. A. Rizki, and V. Lundblad Defects in mismatch repair promote telomerase-independent proliferation Nature 411 2001 713 716
116. A.V. Roschke, K. Stover, G. Tonon, A.A. Schaffer, and I.R. Kirsch Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability Neoplasia 4 2002 19 31
117. C.W. Roth, F. Kobeski, M.F. Walter, and H. Biessmann Chromosome end elongation by recombination in the mosquito Anopheles gambiae Molecular Cell Biology 17 1997 5176 5183
118. H.W. Rudiger, C.R. Bartram, W. Harder, and E. Passarge Rate of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by co-cultivation with normal fibroblasts American Journal of Human Genetics 32 1980 150 157
119. K.L. Rudolph, S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, and C. Greider Longevity, stress response, and cancer in aging telomerase deficient mice Cell 96 1999 701 712
120. L.L. Sandell, and V.A. Zakian Loss of a yeast telomere: arrest, recovery, and chromosome loss Cell 75 1993 729 739
121. N.G. Saran, M.T. Pletcher, J.E. Natale, Y. Cheng, and R.H. Reeves Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Human Molecular Genetics 16 2003 2013 2019
122. K. Savitsky, S. Sfez, D.A. Tagle, Y. Ziv, A. Sartiel, and F.S. Collins The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species Human Molecular Genetics 4 1995 2025 2032
123. C. Scheel, K.L. Schaefer, A. Jauch, M. Keller, D. Wai, and C. Brinkschmidt Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas Oncogene 20 2001 3835 3844
124. J.W. Shay, O.M. Pereira-Smith, and W.E. Wright A role for both RB and p53 in the regulation of human cellular senescence Experimental Cell Research 196 1991 33 39
125. O.M. Sieber, K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, and C.A. Simpson Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC Proceedings of the National Academy of Sciences of USA 99 2002 16910 16915
126. A. Smogorzewska, and T. de Lange Different telomere damage signaling pathways in human and mouse cells The EMBO Journal 21 2002 4338 4348
127. A. Smogorzewska, B. van Steensel, A. Bianchi, S. Oelmann, M.R. Schaefer, and G. Schnapp Control of human telomere length by TRF1 and TRF2 Molecular Cell Biology 20 2000 1659 1668
128. B.E. Snow, N. Erdmann, J. Cruickshank, H. Goldman, R.M. Gill, and M.O. Robinson Functional conservation of the telomerase protein est1p in humans Current Biology 13 2003 698 704
129. P. Stankiewicz, and J.R. Lupski Molecular-evolutionary mechanisms for genomic disorders Current Opinion in Genetics and Development 12 2002 312 319
130. A.E. Stellwagen, Z.W. Haimberger, J.R. Veatch, and D.E. Gottschling Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends Genes and Development 17 2003 1 11
131. Z. Storchova, and D. Pellman From polyploidy to aneuploidy, genome instability and cancer Nature Reviews, Cancer 5 2004 45 54
132. M. Tarsounas, P. Munoz, A. Claas, P.G. Smiraldo, D.L. Pittman, and M.A. Blasco Telomere maintenance requires the RAD51D recombination/repair protein Cell 117 2004 337 347
133. M.R. Teixeira, H. Tsarouha, S.M. Kraggerud, N. Pandis, E. Dimitriadis, and J.A. Andersen Evaluation of breast cancer polyclonality by combined chromosome banding and comparative genomic hybridization analysis Neoplasia 3 2001 204 214
134. M.T. Teixeira, M. Arneric, P. Sperisen, and J. Lingner Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states Cell 117 2004 323 335
135. S. Thiagalingam, S. Laken, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein Mechanisms underlying losses of heterozygosity in human colorectal cancers Proceedings of the National Academy of Sciences of USA 98 2001 2698 2702
136. S.N. Thibodeau, G. Bren, and D. Schaid Microsatellite instability in cancer of the proximal colon Science 260 1993 816 819
137. M.W. Thompson, R.R. McInnes, and H.F. Willard Thompson and Thompson: Genetics in Medicine 5th ed. 1996 W.B. Saunders Philadelphia Chapters 9, 10
138. L. Tomaska, M.J. McEachern, and J. Nosek Alternatives to telomerase: Keeping linear chromosomes via telomeric circles FEBS Letters 567 2004 142 146
139. B.J. Trask Human cytogenetics: 46 chromosomes 46 years and counting Nature Reviews 3 2002 769 778
140. H. Varley, H.A. Pickett, J.L. Foxon, R.R. Reddel, and N.J. Royle Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells Nature Genetics 30 2002 301 305
141. M. Vasa, K. Breitschopf, A.M. Zeiher, and S. Dimmeler Nitric oxide activates telomerase and delays endothelial cell senescence Circulation Research 87 2000 540 542
142. A.R. Venkitaraman Cancer susceptibility and the functions of BRCA1 and BRCA2 Cell 108 2002 171 182
143. B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nature Medicine 10 8 2004 789 799
144. T. Vulliamy, A. Marrone, F. Goldman, A. Dearlove, M. Bessler, and P.J. Mason The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita Nature 413 2001 432 435
145. Y. Watanabe, and P. Nurse Cohesin Rec8 is required for reductional chromosome segregation at meiosis Nature 400 1999 461 464
146. Y. Wei, L. Yu, J. Bowen, M.A. Gorovsky, and C.D. Allis Phosphorylation of histone H3 is required for proper chromosome condensation and segregation Cell 97 1999 99 109
147. Z. Xin, and D. Broccoli Manipulating mouse telomeres: Models of tumorigenesis and aging Cytogenetics and Genome Research 105 2004 471 478
148. T.R. Yeager, A.A. Neumann, A. Englezou, L.I. Huschtscha, J.R. Noble, and R.R. Reddel Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body Cancer Research 59 1999 4175 4179
149. V.P.C.C. Yu, M. Koehler, C. Steinlein, M. Schmid, L. Hanakahi, and A. van Gool Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation Genes and Development 14 2000 1400 1406
150. X. Zhang, V. Mar, W. Zhou, L. Harrington, and M.O. Robinson Telomere shortening and apoptosis in telomere-inhibited human tumor cells Genes and Development 13 1999 2388 2399
151. Y. Zhang, N. Zeleznik-Le, N. Emmanuel, N. Jayathilaka, J. Chen, and P. Strissel Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16) Genes Chromosomes Cancer 41 2004 257 265
152. Y. Zou, S.M. Gryaznov, J.W. Shay, W.E. Wright, and M.N. Cornforth Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes Proceedings of the National Academy of Sciences of USA 101 2004 12928 12933
153. Y. Zou, X. Yi, W.E. Wright, and J.W. Shay Human telomerase can immortalize Indian muntjac cells Experimental Cell Research 281 2002 63 76