Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange

Cancer Research

Volumn 64, Issue 7, 2004, Pages 2324-2327

  Londoño Vallejo, J Arturo ^a   Der Sarkissian, Héra ^b   Cazes, Lucien ^b   Bacchetti, Silvia ^c   Reddel, Roger R ^d  

^a INSERM   (France)

^b FONDATION JEAN DAUSSET CEPH   (France)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TELOMERASE;

ALTERNATIVE LENGTHENING OF TELOMERE; ARTICLE; BLOOM SYNDROME; CANCER; CELL LINE; CONTROLLED STUDY; DNA DAMAGE; DNA RECOMBINATION; DNA REPLICATION; DNA TEMPLATE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; TELOMERE; TELOMERE EXCHANGE;

ANIMALS; CELL LINE, TUMOR; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; NEOPLASMS; NIH 3T3 CELLS; SISTER CHROMATID EXCHANGE; TELOMERE;

EID: 1942538563     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-4035     Document Type: Article

References (19)

1. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
2. Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997;3:1271-4.
3. Ulaner GA, Huang HY, Otero J, et al. Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcoma. Cancer Res 2003;63:1759-63.
4. Hakin-Smith V, Jellinek DA, Levy D, et al. Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. Lancet 2003;361:836-8.
5. Murnane JP, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell line. EMBO J 1994;13:4953-62.
6. Dunham MA, Neumann AA, Fasching CL, Reddel RR. Telomere maintenance by recombination in human cells. Nat Genet 2000;26:447-50.
7. Varley H, Pickett HA, Foxon JL, Reddel RR, Royle NJ. Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nat Genet 2002;30:301-5.
8. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:4240-8.
9. Neumann AA, Reddel RR. Telomere maintenance and cancer-look, no telomerase. Nat Rev Cancer 2002;2:879-84.
10. Bryan TM, Marusic L, Bacchetti S, Namba M, Reddel RR. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet 1997;6:921-6.
11. Perrem K, Colgin LM, Neumann AA, Yeager TR, Reddel RR. Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol 2001;21:3862-75.
12. Cerone MA, Londono-Vallejo JA, Bacchetti S. Telomere maintenance by telomerase and by recombination can coexist in human cells. Hum Mol Genet 2001;10:1945-52.
13. Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Curr Biol 2003;13:942-6.
14. Bianchi MS, Larramendy ML, Bianchi NO. Mitomycin C-induced damage and repair in human and pig lymphocytes. Mutat Res 1986;160:27-32.
15. Cornforth MN, Eberle RL. Termini of human chromosomes display elevated rates of mitotic recombination. Mutagenesis 2001;16:85-9.
16. Meyne J, Goodwin EH, Moyzis RK. Chromosome localization and orientation of the simple sequence repeat of human satellite I DNA. Chromosoma 1994;103:99-103.
17. Henson JD, Neumann AA, Yeager TR, Reddel RR. Alternative lengthening of telomeres in mammalian cells. Oncogene 2002;21:598-610.
18. 3 repeats. Proc Natl Acad Sci USA 1997;94:7423-8.
19. Bechter OE, Zou Y, Shay JW, Wright WE. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. EMBO Rep 2003;4:1138-43.