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1
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0032574750
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Homology-directed repair is a major double-strand break repair pathway in mammalian cells
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This paper demonstrates that a double-strand break made on a mouse chromosome by the site-specific I-SceI endonuclease is frequently repaired by homologous recombination, similar to the way breaks are repaired in budding yeast. In contrast, transfected, linearized DNA only rarely integrates at its homologous target.
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Liang F., Han M., Romanienko P.J., Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc Natl Acad Sci USA. 95:1998;5172-5177. This paper demonstrates that a double-strand break made on a mouse chromosome by the site-specific I-SceI endonuclease is frequently repaired by homologous recombination, similar to the way breaks are repaired in budding yeast. In contrast, transfected, linearized DNA only rarely integrates at its homologous target.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5172-5177
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Liang, F.1
Han, M.2
Romanienko, P.J.3
Jasin, M.4
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2
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0033565609
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Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
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The authors show that when DSBs on a yeast chromosome are created by the site-specific HO endonuclease, NHEJ proves to be competitive with HR in its repair.
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Lee S.E., Paques F., Sylvan J., Haber J.E. Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths. Curr Biol. 9:1999;767-770. The authors show that when DSBs on a yeast chromosome are created by the site-specific HO endonuclease, NHEJ proves to be competitive with HR in its repair.
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(1999)
Curr Biol
, vol.9
, pp. 767-770
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Lee, S.E.1
Paques, F.2
Sylvan, J.3
Haber, J.E.4
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3
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0032859119
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Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis
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Studies in yeast have shown that both Ku proteins and the Mre11p-Rad50p-Xrs2p complex participate in NHEJ (although evidence reviewed here suggests that the Mre11 complex may not have such a strong role in vertebrate cells). In this paper, Ku70p is shown to physically interact with Mre11p in somatic mouse cells, an association not yet seen in yeast. Importantly, the formation of the Mre11p complex at DNA-damage-induced foci within the nucleus depends on the presence of Ku. A second major finding is that the abundance of Ku70p, as monitored by immunocytology, decreases dramatically in meiotic cells (although it could be masked). This suggests an attractive way for the cell to discourage Ku-dependent NHEJ in meiosis and thus to promote HR, which is the desired outcome of meiosis.
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Goedecke W., Eijpe M., Offenberg H.H., van Aalderen M., Heyting C. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat Genet. 23:1999;194-198. Studies in yeast have shown that both Ku proteins and the Mre11p-Rad50p-Xrs2p complex participate in NHEJ (although evidence reviewed here suggests that the Mre11 complex may not have such a strong role in vertebrate cells). In this paper, Ku70p is shown to physically interact with Mre11p in somatic mouse cells, an association not yet seen in yeast. Importantly, the formation of the Mre11p complex at DNA-damage-induced foci within the nucleus depends on the presence of Ku. A second major finding is that the abundance of Ku70p, as monitored by immunocytology, decreases dramatically in meiotic cells (although it could be masked). This suggests an attractive way for the cell to discourage Ku-dependent NHEJ in meiosis and thus to promote HR, which is the desired outcome of meiosis.
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(1999)
Nat Genet
, vol.23
, pp. 194-198
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Goedecke, W.1
Eijpe, M.2
Offenberg, H.H.3
Van Aalderen, M.4
Heyting, C.5
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4
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0032844787
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Rad51/RecA protein families and the associated proteins in eukaryotes
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Shinohara A., Ogawa T. Rad51/RecA protein families and the associated proteins in eukaryotes. Mutat Res. 435:1999;13-21.
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Mutat Res
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Shinohara, A.1
Ogawa, T.2
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5
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0038799991
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Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
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Pâques F., Haber J.E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 63:1999;349-404.
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Microbiol Mol Biol Rev
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Pâques, F.1
Haber, J.E.2
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6
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0032850744
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The essential functions of human Rad51 are independent of ATP hydrolysis
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Using a chicken DT40 cell line in which Rad51 activity is depleted by turning off a conditional promoter, the authors show that sister chromatid repair is greatly reduced, thus confirming that the high incidence of sister-chromatid exchanges arise by HR and not by NHEJ.
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Morrison C., Shinohara A., Sonoda E., Yamaguchi-Iwai Y., Takata M., Weichselbaum R.R., Takeda S. The essential functions of human Rad51 are independent of ATP hydrolysis. Mol Cell Biol. 19:1999;6891-6897. Using a chicken DT40 cell line in which Rad51 activity is depleted by turning off a conditional promoter, the authors show that sister chromatid repair is greatly reduced, thus confirming that the high incidence of sister-chromatid exchanges arise by HR and not by NHEJ.
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(1999)
Mol Cell Biol
, vol.19
, pp. 6891-6897
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Morrison, C.1
Shinohara, A.2
Sonoda, E.3
Yamaguchi-Iwai, Y.4
Takata, M.5
Weichselbaum, R.R.6
Takeda, S.7
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7
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0032999346
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Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
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Sonoda E., Sasaki M.S., Morrison C., Yamaguchi-Iwai Y., Takata M., Takeda S. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol. 19:1999;5166-5169.
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(1999)
Mol Cell Biol
, vol.19
, pp. 5166-5169
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Sonoda, E.1
Sasaki, M.S.2
Morrison, C.3
Yamaguchi-Iwai, Y.4
Takata, M.5
Takeda, S.6
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8
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0033569684
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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
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Pierce A.J., Johnson R.D., Thompson L.H., Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 13:1999;2633-2638.
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(1999)
Genes Dev
, vol.13
, pp. 2633-2638
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Pierce, A.J.1
Johnson, R.D.2
Thompson, L.H.3
Jasin, M.4
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9
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0033598437
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Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
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Johnson R.D., Liu N., Jasin M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature. 401:1999;397-399.
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(1999)
Nature
, vol.401
, pp. 397-399
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Johnson, R.D.1
Liu, N.2
Jasin, M.3
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10
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0032832810
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Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation
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Petukhova G., Van Komen S., Vergano S., Klein H., Sung P. Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation. J Biol Chem. 274:1999;29453-29462.
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J Biol Chem
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Petukhova, G.1
Van Komen, S.2
Vergano, S.3
Klein, H.4
Sung, P.5
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11
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0032803238
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The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage
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Kooistra R., Pastink A., Zonneveld J.B., Lohman P.H., Eeken J.C. The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage. Mol Cell Biol. 19:1999;6269-6275.
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Mol Cell Biol
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, pp. 6269-6275
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Kooistra, R.1
Pastink, A.2
Zonneveld, J.B.3
Lohman, P.H.4
Eeken, J.C.5
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12
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0033602450
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Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation
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Tan T.L., Essers J., Citterio E., Swagemakers S.M., de Wit J., Benson F.E., Hoeijmakers J.H., Kanaar R. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation. Curr Biol. 9:1999;325-328.
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Curr Biol
, vol.9
, pp. 325-328
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Tan, T.L.1
Essers, J.2
Citterio, E.3
Swagemakers, S.M.4
De Wit, J.5
Benson, F.E.6
Hoeijmakers, J.H.7
Kanaar, R.8
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13
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0032904714
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The Saccharomyces cerevisiae RAD54 gene is important but not essential for natural homothallic mating-type switching
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Schmuckli-Maurer J., Heyer W.D. The Saccharomyces cerevisiae RAD54 gene is important but not essential for natural homothallic mating-type switching. Mol Gen Genet. 260:1999;551-558.
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Mol Gen Genet
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Schmuckli-Maurer, J.1
Heyer, W.D.2
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14
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0033522410
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Sister chromatid-based DNA repair is mediated by RAD54, not by DMC1 or TID1
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Arbel A., Zenvirth D., Simchen G. Sister chromatid-based DNA repair is mediated by RAD54, not by DMC1 or TID1. EMBO J. 18:1999;2648-2658.
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EMBO J
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Arbel, A.1
Zenvirth, D.2
Simchen, G.3
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15
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0033519702
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Mutations in the RAD54 recombination gene in primary cancers
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Matsuda M., Miyagawa K., Takahashi M., Fukuda T., Kataoka T., Asahara T., Inui H., Watatani M., Yasutomi M., Kamada N. et al. Mutations in the RAD54 recombination gene in primary cancers. Oncogene. 18:1999;3427-3430.
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Oncogene
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Matsuda, M.1
Miyagawa, K.2
Takahashi, M.3
Fukuda, T.4
Kataoka, T.5
Asahara, T.6
Inui, H.7
Watatani, M.8
Yasutomi, M.9
Kamada, N.10
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16
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0033519693
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Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer
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Hiramoto T., Nakanishi T., Sumiyoshi T., Fukuda T., Matsuura S., Tauchi H., Komatsu K., Shibasaki Y., Inui H., Watatani M. et al. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. Oncogene. 18:1999;3422-3426.
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Oncogene
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Hiramoto, T.1
Nakanishi, T.2
Sumiyoshi, T.3
Fukuda, T.4
Matsuura, S.5
Tauchi, H.6
Komatsu, K.7
Shibasaki, Y.8
Inui, H.9
Watatani, M.10
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17
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0032837270
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Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: Pathological correlations
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Gonzalez R., Silva J.M., Dominguez G., Garcia J.M., Martinez G., Vargas J., Provencio M., Espana P., Bonilla F. Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations. Br J Cancer. 81:1999;503-509.
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Br J Cancer
, vol.81
, pp. 503-509
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Gonzalez, R.1
Silva, J.M.2
Dominguez, G.3
Garcia, J.M.4
Martinez, G.5
Vargas, J.6
Provencio, M.7
Espana, P.8
Bonilla, F.9
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18
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0033213392
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Brca1 controls homology-directed DNA repair
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The association of BRCA1p with Rad51p had previously been shown by physical and cytological approaches, but this paper provides direct evidence that BRCA1 (which has also been reported to interact with other proteins involved in other central cell processes, such as transcription) plays a role in HR. Recombination workers rejoice!
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Moynahan M.E., Chiu J.W., Koller B.H., Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell. 4:1999;511-518. The association of BRCA1p with Rad51p had previously been shown by physical and cytological approaches, but this paper provides direct evidence that BRCA1 (which has also been reported to interact with other proteins involved in other central cell processes, such as transcription) plays a role in HR. Recombination workers rejoice!
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(1999)
Mol Cell
, vol.4
, pp. 511-518
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Moynahan, M.E.1
Chiu, J.W.2
Koller, B.H.3
Jasin, M.4
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19
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0033618621
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Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
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Zhong Q., Chen C.F., Li S., Chen Y., Wang C.C., Xiao J., Chen P.L., Sharp Z.D., Lee W.H. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science. 285:1999;747-750.
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(1999)
Science
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, pp. 747-750
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Zhong, Q.1
Chen, C.F.2
Li, S.3
Chen, Y.4
Wang, C.C.5
Xiao, J.6
Chen, P.L.7
Sharp, Z.D.8
Lee, W.H.9
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20
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0032959506
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RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
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Some cancers have immortalized cells in the absence of reactivating telomerase. Genetic analysis in yeast suggests there could be more than one recombination-dependent alternative pathway for telomere maintenance.
-
Le S., Moore J.K., Haber J.E., Greider C.W. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics. 152:1999;143-152. Some cancers have immortalized cells in the absence of reactivating telomerase. Genetic analysis in yeast suggests there could be more than one recombination-dependent alternative pathway for telomere maintenance.
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(1999)
Genetics
, vol.152
, pp. 143-152
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Le, S.1
Moore, J.K.2
Haber, J.E.3
Greider, C.W.4
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21
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0032712707
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A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59
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Bai Y., Davis A.P., Symington L.S. A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59. Genetics. 153:1999;1117-1130.
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Genetics
, vol.153
, pp. 1117-1130
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Bai, Y.1
Davis, A.P.2
Symington, L.S.3
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22
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0032832286
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A double-strand break repair component is essential for S phase completion in fission yeast cell cycling
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Suto K., Nagata A., Murakami H., Okayama H. A double-strand break repair component is essential for S phase completion in fission yeast cell cycling. Mol Biol Cell. 10:1999;3331-3343.
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Mol Biol Cell
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Suto, K.1
Nagata, A.2
Murakami, H.3
Okayama, H.4
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23
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0033588386
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Human Rad51 amino acid residues required for Rad52 binding
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Kurumizaka H., Aihara H., Kagawa W., Shibata T., Yokoyama S. Human Rad51 amino acid residues required for Rad52 binding. J Mol Biol. 291:1999;537-548.
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J Mol Biol
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Kurumizaka, H.1
Aihara, H.2
Kagawa, W.3
Shibata, T.4
Yokoyama, S.5
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24
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0033594407
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Binding of double-strand breaks in DNA by human Rad52 protein
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Van Dyck E., Stasiak A.Z., Stasiak A., West S.C. Binding of double-strand breaks in DNA by human Rad52 protein. Nature. 398:1999;728-731.
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Nature
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Stasiak, A.Z.2
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West, S.C.4
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25
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0032721091
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The Mre11-Rad50-xrs2 protein complex facilitates homologous recombination-based double-strand break repair in saccharomyces cerevisiae
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Bressan D.A., Baxter B.K., Petrini J.H. The Mre11-Rad50-xrs2 protein complex facilitates homologous recombination-based double-strand break repair in saccharomyces cerevisiae. Mol Cell Biol. 19:1999;7681-7687.
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Bressan, D.A.1
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Petrini, J.H.3
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26
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0032775025
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SbcB sbcC null mutations allow RecF-mediated repair of arrested replication forks in rep recBC mutants
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Bidnenko V., Seigneur M., Penel-Colin M., Bouton M.F., Dusko Ehrlich S., Michel B. sbcB sbcC null mutations allow RecF-mediated repair of arrested replication forks in rep recBC mutants. Mol Microbiol. 33:1999;846-857.
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Mol Microbiol
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Bidnenko, V.1
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Michel, B.6
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27
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0033525095
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Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases
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Gene conversion induced by a DSB in budding yeast requires Polα and primase to complete recombination. This observation suggests that DNA replication during repair is closely related to DNA recombination and also supports certain SDSA models of recombination.
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Holmes A.M., Haber J.E. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell. 96:1999;415-424. Gene conversion induced by a DSB in budding yeast requires Polα and primase to complete recombination. This observation suggests that DNA replication during repair is closely related to DNA recombination and also supports certain SDSA models of recombination.
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Cell
, vol.96
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Holmes, A.M.1
Haber, J.E.2
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Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair
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RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes
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Tarsounas M., Morita T., Pearlman R.E., Moens P.B. RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes. J Cell Biol. 147:1999;207-220.
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Interhomolog bias during meiotic recombination: Meiotic functions promote a highly differentiated interhomolog-only pathway
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Human Dmc1 protein binds DNA as an octameric ring
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Passy S.I., Yu X., Li Z., Radding C.M., Masson J.Y., West S.C., Egelman E.H. Human Dmc1 protein binds DNA as an octameric ring. Proc Natl Acad Sci USA. 96:1999;10684-10688.
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Egelman, E.H.7
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0030882664
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DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway
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Dresser M.E., Ewing D.J., Conrad M.N., Dominguez A.M., Barstead R., Jiang H., Kodadek T. DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway. Genetics. 147:1997;533-544.
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Genetics
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Dresser, M.E.1
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Dominguez, A.M.4
Barstead, R.5
Jiang, H.6
Kodadek, T.7
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37
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0033569601
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A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p
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The finding that mice have a Spo11p homologue makes it much more likely that the mechanism of meiotic recombination described in Saccharomyces, beginning with a DSB created by Spo11p, is very likely to occur in mammals.
-
Keeney S., Baudat F., Angeles M., Zhou Z.H., Copeland N.G., Jenkins N.A., Manova K., Jasin M. A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics. 61:1999;170-182. The finding that mice have a Spo11p homologue makes it much more likely that the mechanism of meiotic recombination described in Saccharomyces, beginning with a DSB created by Spo11p, is very likely to occur in mammals.
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Genomics
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Keeney, S.1
Baudat, F.2
Angeles, M.3
Zhou, Z.H.4
Copeland, N.G.5
Jenkins, N.A.6
Manova, K.7
Jasin, M.8
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38
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0033569602
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Cloning, characterization, and localization of mouse and human SPO11
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Along with [37•], this paper identifies the mouse gene encoding Spo11p. They also report the isolation of the homologous genes from humans and its chromosomal localization.
-
Romanienko P.J., Camerini-Otero R.D. Cloning, characterization, and localization of mouse and human SPO11. Genomics. 61:1999;156-169. Along with [37•], this paper identifies the mouse gene encoding Spo11p. They also report the isolation of the homologous genes from humans and its chromosomal localization.
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Genomics
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Romanienko, P.J.1
Camerini-Otero, R.D.2
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39
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0033548443
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Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes
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Marsischky G.T., Lee S., Griffith J., Kolodner R.D. Saccharomyces cerevisiae MSH2/6 complex interacts with Holliday junctions and facilitates their cleavage by phage resolution enzymes. J Biol Chem. 274:1999;7200-7206.
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J Biol Chem
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Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast
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The authors report that the deletion of msh4 in budding yeast reduces crossing-over by a factor of two, whereas the analogous mutation in worms abolishes crossing-over.
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Zalevsky, J.1
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Mammalian MutS homologue 5 is required for chromosome pairing in meiosis
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In mice, the absence of Msh5p not only apparently abolishes crossing-over, but prevents the intimate synapsis of homologous chromosomes that is the hallmark of successful recombination.
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Edelmann W., Cohen P.E., Kneitz B., Winand N., Lia M., Heyer J., Kolodner R., Pollard J.W., Kucherlapati R. Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 21:1999;123-127. In mice, the absence of Msh5p not only apparently abolishes crossing-over, but prevents the intimate synapsis of homologous chromosomes that is the hallmark of successful recombination.
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Nat Genet
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Edelmann, W.1
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Kolodner, R.7
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43
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0033105760
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Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
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As with [42•], the authors find that the absence of mouse Msh5 not only causes both the absence of meiotic chromosome synapsis but also apoptosis of meiotic cells.
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de Vries S.S., Baart E.B., Dekker M., Siezen A., de Rooij D.G., de Boer P., te Riele H. Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev. 13:1999;523-531. As with [42•], the authors find that the absence of mouse Msh5 not only causes both the absence of meiotic chromosome synapsis but also apoptosis of meiotic cells.
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Te Riele, H.7
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44
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0032910958
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Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans
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Parisi S., McKay M.J., Molnar M., Thompson M.A., van der Spek P.J., van Drunen-Schoenmaker E., Kanaar R., Lehmann E., Hoeijmakers J.H., Kohli J. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. Mol Cell Biol. 19:1999;3515-3528.
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Parisi, S.1
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Cohesin Rec8 is required for reductional chromosome segregation at meiosis
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Nature
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46
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Krawchuk M.D., DeVeaux L.C., Wahls W.P. Meiotic chromosome dynamics dependent upon the rec8(+), rec10(+) and rec11(+) genes of the fission yeast Schizosaccharomyces pombe. Genetics. 153:1999;57-68.
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Krawchuk, M.D.1
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47
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0033538518
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A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis
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The authors demonstrate that a meiosis-specific cohesin subunit, Rec8p, is necessary not only for normal axial element and synaptonemal complex formation, but also for the completion of recombination in budding yeast.
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Klein F., Mahr P., Galova M., Buonomo S.B., Michaelis C., Nairz K., Nasmyth K. A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell. 98:1999;91-103. The authors demonstrate that a meiosis-specific cohesin subunit, Rec8p, is necessary not only for normal axial element and synaptonemal complex formation, but also for the completion of recombination in budding yeast.
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Cell
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Klein, F.1
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Nasmyth, K.7
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0033304088
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49
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0032417640
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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
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This paper addresses the issue of whether brain cells undergo programmed chromosomal rearrangements similar to the immune system genes. The absence of DNA ligase IV not only eliminates V(D)J recombination, but also is embryonic lethal, which may be attributable to the death of post-replicational neuronal cells.
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Gao Y., Sun Y., Frank K.M., Dikkes P., Fujiwara Y., Seidl K.J., Sekiguchi J.M., Rathbun G.A., Swat W., Wang J. et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95:1998;891-902. This paper addresses the issue of whether brain cells undergo programmed chromosomal rearrangements similar to the immune system genes. The absence of DNA ligase IV not only eliminates V(D)J recombination, but also is embryonic lethal, which may be attributable to the death of post-replicational neuronal cells.
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Cell
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Gao, Y.1
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Sekiguchi, J.M.7
Rathbun, G.A.8
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Wang, J.10
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50
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0032585526
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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
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See annotation [49••].
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Barnes D.E., Stamp G., Rosewell I., Denzel A., Lindahl T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr Biol. 8:1998;1395-1398. See annotation [49••].
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Barnes, D.E.1
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Lindahl, T.5
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51
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0033544724
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The DNA double strand break repair gene hMre11, is mutated in individuals with a new ataxia telangiectasia like disorder (ATLD)
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In human cells, Mre11 and Rad50 proteins co-purify with NBS1, a protein associated with Nijmegan breakage syndrome, a disease resembling ataxia telangiectasia. Patients with this syndrome are cancer-prone, immune deficient, and radiosensitive. Last year's excitement over NBS should be equaled by the finding of patients who have mutations in Mre11 and have a clinically similar disease. It still remains to be seen whether the defect in these people stems from deficiencies in recombination or in DNA damage signaling, as with ATM-related diseases.
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Stewart G., Maser R.S., Stankovic T., Bressan D.A., Kaplan M.I., Jaspers N.G.J., Petrini J.H.J., Taylor A.M.R. The DNA double strand break repair gene hMre11, is mutated in individuals with a new ataxia telangiectasia like disorder (ATLD). Cell. 99:1999;577-587. In human cells, Mre11 and Rad50 proteins co-purify with NBS1, a protein associated with Nijmegan breakage syndrome, a disease resembling ataxia telangiectasia. Patients with this syndrome are cancer-prone, immune deficient, and radiosensitive. Last year's excitement over NBS should be equaled by the finding of patients who have mutations in Mre11 and have a clinically similar disease. It still remains to be seen whether the defect in these people stems from deficiencies in recombination or in DNA damage signaling, as with ATM-related diseases.
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(1999)
Cell
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Stewart, G.1
Maser, R.S.2
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Jaspers, N.G.J.6
Petrini, J.H.J.7
Taylor, A.M.R.8
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52
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0033168094
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The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance
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Wilson S., Warr N., Taylor D.L., Watts F.Z. The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance. Nucleic Acids Res. 27:1999;2655-2661.
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Nucleic Acids Res
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Wilson, S.1
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Watts, F.Z.4
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53
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0033485758
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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
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Yamaguchi-Iwai Y., Sonoda E., Sasaki M.S., Morrison C., Haraguchi T., Hiraoka Y., Yamashita Y.M., Yagi T., Takata M., Price C. et al. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J. 18:1999;6619-6629.
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EMBO J
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Yamaguchi-Iwai, Y.1
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Morrison, C.4
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Yamashita, Y.M.7
Yagi, T.8
Takata, M.9
Price, C.10
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54
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0032860479
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Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
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Mammalian cancer cells show many types of chromosomal rearrangements that are associated both with the creation of fusion genes associated with cancer and with loss of heterozygosity. The Kolodner laboratory continues its study of the way defects in many DNA repair and replication proteins affects this process in the model system, S. cerevisiae. The most striking aspect of the present study is that cells lacking Mre11p implicated in both HR and NHEJ exhibit a high level of chromosomal rearrangements (i.e. deletions, translocations) whose junction points lack the microhomology seen for most NHEJ events.
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Chen C., Kolodner R.D. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat Genet. 23:1999;81-85. Mammalian cancer cells show many types of chromosomal rearrangements that are associated both with the creation of fusion genes associated with cancer and with loss of heterozygosity. The Kolodner laboratory continues its study of the way defects in many DNA repair and replication proteins affects this process in the model system, S. cerevisiae. The most striking aspect of the present study is that cells lacking Mre11p implicated in both HR and NHEJ exhibit a high level of chromosomal rearrangements (i.e. deletions, translocations) whose junction points lack the microhomology seen for most NHEJ events.
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(1999)
Nat Genet
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Chen, C.1
Kolodner, R.D.2
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55
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0033611465
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Yeast cell-type regulation of DNA repair
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Åström S.U., Okamura S.M., Rine J. Yeast cell-type regulation of DNA repair. Nature. 397:1999;310.
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Nature
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Åström, S.U.1
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Rine, J.3
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56
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0033612189
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MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
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In Saccharomyces, DNA damage inflicted by restriction enzymes or bleomycin causes the delocalization of the Sir3 protein that is needed to maintain telomere silencing. The loss of Sir3p from telomeres appears to occur predominantly during S phase and requires the DNA damage-sensing checkpoint gene MEC1 to be functional. Sir3p is also found at DSB sites created by expression of the EcoRI enzyme.
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Mills K.D., Sinclair D.A., Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 97:1999;609-620. In Saccharomyces, DNA damage inflicted by restriction enzymes or bleomycin causes the delocalization of the Sir3 protein that is needed to maintain telomere silencing. The loss of Sir3p from telomeres appears to occur predominantly during S phase and requires the DNA damage-sensing checkpoint gene MEC1 to be functional. Sir3p is also found at DSB sites created by expression of the EcoRI enzyme.
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(1999)
Cell
, vol.97
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Mills, K.D.1
Sinclair, D.A.2
Guarente, L.3
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57
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0033612287
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Relocalization of telomeric Ku and SIR proteins in response to double strand breaks in yeast
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Even a single DSB, created by the HO endonuclease, is sufficient to delocalize both Sir3p and Ku proteins from telomeres, though not sufficient to cause a delocalization of telomeres themselves. As with DNA damage caused by chemical agents, the response depends on the RAD9-mediated checkpoint gene. Chromatin immunoprecipitation shows that first Ku proteins and then Sir proteins arrive at these sites of DNA damage. This paper also demonstrates that tethering Ku protein adjacent to a reporter gene is sufficient to cause gene silencing in the absence of normal silencer sequences.
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Martin S., Laroche T., Suka N., Grunstein M., Gasser S.M. Relocalization of telomeric Ku and SIR proteins in response to double strand breaks in yeast. Cell. 97:1999;621-633. Even a single DSB, created by the HO endonuclease, is sufficient to delocalize both Sir3p and Ku proteins from telomeres, though not sufficient to cause a delocalization of telomeres themselves. As with DNA damage caused by chemical agents, the response depends on the RAD9-mediated checkpoint gene. Chromatin immunoprecipitation shows that first Ku proteins and then Sir proteins arrive at these sites of DNA damage. This paper also demonstrates that tethering Ku protein adjacent to a reporter gene is sufficient to cause gene silencing in the absence of normal silencer sequences.
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(1999)
Cell
, vol.97
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Martin, S.1
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58
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0033539095
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DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p
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See annotation [56•].
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McAinsh A.D., Scott-Drew S., Murray J.A., Jackson S.P. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr Biol. 9:1999;963-966. See annotation [56•].
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Curr Biol
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McAinsh, A.D.1
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Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination
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Thompson D.A., Stahl F.W. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics. 153:1999;621-641.
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Thompson, D.A.1
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60
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0032822543
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Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice
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Grushcow J.M., Holzen T.M., Park K.J., Weinert T., Lichten M., Bishop D.K. Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics. 153:1999;607-620.
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Grushcow, J.M.1
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The Saccharomyces cerevisiae RAD9 checkpoint reduces the DNA damage-associated stimulation of directed translocations
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Fasullo M., Bennett T., AhChing P., Koudelik J. The Saccharomyces cerevisiae RAD9 checkpoint reduces the DNA damage-associated stimulation of directed translocations. Mol Cell Biol. 18:1998;1190-1200.
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The controlling role of ATM in homologous recombinational repair of DNA damage
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The role of ATM checkpoint protein has been more directly implicated in the control of DNA damage repair, by experiments in chicken DT40 cells. Deletion of the ATM gene leads to severely reduced recombination and repair.
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Morrison C., Sonoda E., Takao N., Shinohara A., Yamamoto K., Takeda S. The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J. 19:1999;463-471. The role of ATM checkpoint protein has been more directly implicated in the control of DNA damage repair, by experiments in chicken DT40 cells. Deletion of the ATM gene leads to severely reduced recombination and repair.
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EMBO J
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Morrison, C.1
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63
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Regulation of Rad51 function by c-Abl in response to DNA damage
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Yuan Z.M., Huang Y., Ishiko T., Nakada S., Utsugisawa T., Kharbanda S., Wang R., Sung P., Shinohara A., Weichselbaum R., Kufe D. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem. 273:1998;3799-3802.
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Yuan, Z.M.1
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Kharbanda, S.6
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Sung, P.8
Shinohara, A.9
Weichselbaum, R.10
Kufe, D.11
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64
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Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
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Chen G., Yuan S.S., Liu W., Xu Y., Trujillo K., Song B., Cong F., Goff S.P., Wu Y., Arlinghaus K. et al. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. J Biol Chem. 274:1999;12748-12752.
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J Biol Chem
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Chen, G.1
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Cong, F.7
Goff, S.P.8
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Arlinghaus, K.10
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65
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Molecular characterisation of two paralogous SPO11 homologues in Arabidopsis thaliana
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The universality of Spo11 control of meiosis is suggested by the finding of two homologues in Arabidopsis, which are expressed not only in reproductive cells but to a lesser extent in somatic tissue.
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Hartung F., Puchta H. Molecular characterisation of two paralogous SPO11 homologues in Arabidopsis thaliana. Nucleic Acids Res. 28:2000;1548-1554. The universality of Spo11 control of meiosis is suggested by the finding of two homologues in Arabidopsis, which are expressed not only in reproductive cells but to a lesser extent in somatic tissue.
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Nucleic Acids Res
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Hartung, F.1
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0032700170
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Differential genes expression of mammalian SPO11/TOP6A homologs during meiosis
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This paper reports that Spo11 is found in mice and humans.
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Shannon M., Richardson L., Christian A., Handel M.A., Thelen M.P. Differential genes expression of mammalian SPO11/TOP6A homologs during meiosis. FEBS Lett. 462:1999;329-334. This paper reports that Spo11 is found in mice and humans.
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FEBS Lett
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Shannon, M.1
Richardson, L.2
Christian, A.3
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Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein
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Li W., Hesabi B., Babbo A., Pacione C., Liu J., Chen D.J., Nickoloff J.A., Shen Z. Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein. Nucleic Acids Res. 28:2000;1145-1153.
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Nucleic Acids Res
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Li, W.1
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Chen, D.J.6
Nickoloff, J.A.7
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0342546023
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RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates
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Bartsch S., Kang L.E., Symington L.S. RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates. Mol Cell Biol. 20:2000;1194-1205.
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Mol Cell Biol
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Bartsch, S.1
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Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis
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Cohen H., Sears D.D., Zenvirth D., Hieter P., Simchen G. Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis. Mol Cell Biol. 19:1999;4153-4158.
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Mol Cell Biol
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Cohen, H.1
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70
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0034102420
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Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast
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The authors make the important observation that the CAG region becomes a prominent site for Spo11p-mediated DSBs and that both large expansions and contractions are frequently found during recombination between two different-sized CAG-containing regions at the same site on homologous chromosomes.
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Jankowski C., Nasar F., Nag D.K. Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast. Proc Natl Acad Sci USA. 97:2000;2134-2139. The authors make the important observation that the CAG region becomes a prominent site for Spo11p-mediated DSBs and that both large expansions and contractions are frequently found during recombination between two different-sized CAG-containing regions at the same site on homologous chromosomes.
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Proc Natl Acad Sci USA
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Jankowski, C.1
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Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11/RAD50/XRS2 complex
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in press
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Richard G-F, Goellner GM, McMurray CT, Haber JE: Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11/RAD50/XRS2 complex. EMBO J 2000, in press.
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EMBO J
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Richard, G.-F.1
Goellner, G.M.2
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Lif1p targets the DNA ligase lig4p to sites of DNA double-strand breaks
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Teo S.H., Jackson S.P. Lif1p targets the DNA ligase lig4p to sites of DNA double-strand breaks. Curr Biol. 10:2000;165-168.
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