Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

Cancer Research

Volumn 64, Issue 10, 2004, Pages 3444-3451

  Bechter, Oliver E ^a   Zou, Ying ^b   Walker, William ^b   Wright, Woodring E ^b   Shay, Jerry W ^b,c  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; COLON CANCER; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MISMATCH REPAIR; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SISTER CHROMATID; TELOMERE; TELOMERE ELONGATION; TELOMERE LENGTH; TELOMERIC RECOMBINATION;

ANIMALS; BASE PAIR MISMATCH; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, NUDE; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE; TELOMERASE; TELOMERE;

EID: 2442659384     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0323     Document Type: Article

References (31)

1. Watson JD. Origin of concatemeric T7 DNA. Nat New Biol 1972;239:197-201.
2. Olovnikov AM. Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol 1996;31:443-8.
3. Jacob NK, Kirk KE, Price CM. Generation of telomeric G strand overhangs involves both G and C strand cleavage. Mol Cell 2003;11:1021-32.
4. Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J 2002;21:4338-48.
5. Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol 1989;9:3088-92.
6. Greider CW, Blackburn EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987;51:887-98.
7. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
8. Henson JD, Neumann AA, Yeager TR, Reddel RR. Alternative lengthening of telomeres in mammalian cells. Oncogene 2002;21:598-610.
9. Dunham MA, Neumann AA, Fasching CL, Reddel RR. Telomere maintenance by recombination in human cells. Nat Genet 2000;26:447-50.
10. Bechter OE, Zou Y, Shay JW, Wright WE. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. EMBO Rep 2003;4:1138-43.
11. Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell 2002;2:257-65.
12. Rayssiguier C, Thaler DS, Radman M. The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature (Lond) 1989;342:396-401.
13. Elliott B, Jasin M. Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells. Mol Cell Biol 2001;21:2671-82.
14. Rizki A, Lundblad V. Defects in mismatch repair promote telomerase-independent proliferation. Nature (Lond) 2001;411:713-6.
15. Stewart SA, Hahn WC, O'Connor BF, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 2002;99:12606-11.
16. Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW. Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun 1999;254:795-803.
17. Herbert BS, Wright AC, Passons CM, et al. Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. J Natl Cancer Inst (Bethesda) 2001;93:39-45.
18. Lettieri T, Marra G, Aquilina G, et al. Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15. Carcinogenesis 1999;20:373-82.
19. Wright WE, Tesmer VM, Liao ML, Shay JW. Normal human telomeres are not late replicating. Exp Cell Res 1999;251:492-9.
20. Chai W, Ford LP, Lenertz L, Wright WE, Shay JW. Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem 2002;277:47242-7.
21. Goodwin E, Meyne J. Strand-specific FISH reveals orientation of chromosome 18 alphoid DNA. Cytogenet Cell Genet 1993;63:126-7.
22. Bailey SM, Goodwin EH, Meyne J, Cornforth MN. CO-FISH reveals inversions associated with isochromosome formation. Mutagenesis 1996;11:139-44.
23. Ford LP, Zou Y, Pongracz K, Gryaznov SM, Shay JW, Wright WE. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. J Biol Chem 2001;276:32198-203.
24. Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 1999;96:14276-81.
25. Delhommeau F, Thierry A, Feneux D, et al. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene 2002;21:8262-71.
26. Teng SC, Zakian VA. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol 1999;19:8083-93.
27. Lundblad V, Blackburn EH. An alternative pathway for yeast telomere maintenance rescues estl-senescence. Cell 1993;73:347-60.
28. McEachern MJ, Iyer S. Short telomeres in yeast are highly recombinogenic. Mol Cell 2001;7:695-704.
29. Teng SC, Chang J, McCowan B, Zakian VA. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol Cell 2000;6:947-52.
30. Murnane JP, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell line. EMBO J 1994;13:4953-62.
31. Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 2003;17:88-100.