Telomeres and telomerase: Basic science implications for aging

Journal of the American Geriatrics Society

Volumn 49, Issue 8, 2001, Pages 1105-1109

  Ahmed, Ali ^a,b   Tollefsbol, Trygve ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Aging; Life expectancy; Lifespan; Telomerase; Telomeres

Indexed keywords

TELOMERASE;

AGING; ARTICLE; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; LIFE EXPECTANCY; LIFESPAN; MEDICAL RESEARCH; TELOMERE;

AGED; AGING; AGING, PREMATURE; CELL AGING; DNA DAMAGE; HUMANS; TELOMERASE; TELOMERE; WERNER SYNDROME;

EID: 0034875078     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2001.49217.x     Document Type: Article

References (90)

1. The aging process. Physiologic changes and pharmacologic implications
2. Aging is a specific biological function rather than the result of a disorder in complex living systems: Biochemical evidence in support of Weismann's hypothesis
3. Developmental regulation of telomerase activity in human fetal tissues during gestation
4. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
5. The demography of aging
6. Genetics of human disease, longevity, and aging
7. United States life tables 1997
8. Decennial life tables for 1989-91
9. Longevity is moderately heritable in a sample of Danish twins born 1870-1880
10. The limited in-vitro lifetime of human diploid cell strains
11. The cell biology of aging
12. Why are transformed cells immortal? Is the process reversible?
13. Evidence for two senescence loci on human chromosome 1
14. Molecular genetic approaches to the study of cellular senescence
15. Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1
16. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
17. Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents
18. Caloric intake and aging: Mechanisms in rodents and a study in nonhuman primates
19. Calorie restriction in nonhuman primates: Mechanisms of reduced morbidity and mortality
20. Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)
21. Caloric restriction and aging
22. Calorie restriction in primates: Will it work and how will we know?
23. Calorie restriction and age-related oxidative stress
24. Caloric restriction and genomic stability
25. Mechanisms of caloric restriction affecting aging and disease
26. Physiological benefits from low levels of ionizing radiation
27. Effects of a very low dose rate of chronic ionizing radiation on the division potential of human embryonic lung fibroblasts in vitro
28. A re-examination of the effects of ionizing radiation on lifespan and transformation of human diploid fibroblasts
29. Review of genetic investigations into the aging processes of Drosophila
30. Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain of Drosophila
31. A C. elegans mutant that lives twice as long as wild type
32. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
33. Determination of life-span in Caenorhabditis elegans by four clock genes
34. The genetics of caloric restriction in Caenorhabditis elegans
35. Molecular genetics of life span in C. elegans: How much does it teach us?
36. Werner's syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations
37. Werner's syndrome
38. Telomeres, cancer, and aging. Altering the human life span
39. The Werner syndrome. A model for the study of human aging
40. Excess of rare cancers in Werner syndrome (adult progeria)
41. A genetic analysis of the Werner syndrome region on human chromosome 8p
42. Mutation-causing mutations
43. Progeroid syndromes: Probing the molecular basis of aging?
44. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
45. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
46. Progeria
47. Progeria and Werner's syndrome as models for the study of normal human aging
48. Cardiovascular abnormalities in progeria. Case report and review of the literature
49. Histological and ultrastructural features of atherosclerosis in progeria
50. A case of progeria syndrome with cerebral infarction
51. Patient with unusual Hutchinson-Gilford syndrome (progeria)
52. Telomere length predicts replicative capacity of human fibroblasts
53. Precocious aging and dementia in patients with Down's syndrome
54. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
55. Reverse transcriptase motifs in the catalytic subunit of telomerase
56. Human telomeres are attached to the nuclear matrix
57. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
58. Telomeres, telomerase, and immortality
59. Telomeres shorten during ageing of human fibroblasts
60. Experimental elongation of telomeres extends the lifespan of immortal X normal cell hybrids
61. Extension of life-span by introduction of telomerase into normal human cells
62. Telomeres and senescence: Ending the debate
63. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
64. A survey of telomerase activity in human cancer
65. Telomerase and the aging cell: Implications for human health
66. The biology of replicative senescence
67. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
68. Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model
69. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
70. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
71. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
72. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
73. Telomerase activity in human cancer
74. Telomerase in human development and cancer
75. Telomerase: A promising marker of biological immortality of germ, stem, and cancer cells. A review
76. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
77. Telomerase in the early detection of cancer
78. Telomere elongation in immortal human cells without detectable telomerase activity
79. How might replicative senescence contribute to human ageing?
80. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
81. What does cell death have to do with aging?
82. Cancer, aging and cellular senescence
83. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
84. Cell senescence in human aging: A review of the theory
85. Telomere length inversely correlates with pulse pressure and is highly familial
86. The role of telomerase expression and telomere length maintenance in human and mouse
87. Replicative senescence: The human fibroblast comes of age
88. In vivo loss of telomeric repeats with age in humans
89. Telomere shortening is an in vivo marker of myocyte replication and aging