메뉴 건너뛰기




Volumn 144, Issue 4, 1999, Pages 589-601

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

Author keywords

Cancer; Chromosome fusions; Q FISH; Telomerase deficient mice; Telomeres

Indexed keywords

TELOMERASE;

EID: 0033593814     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.144.4.589     Document Type: Article
Times cited : (286)

References (62)
  • 1
    • 0030943322 scopus 로고    scopus 로고
    • Telomeres cluster de novo before the initiation of synapsis: A three-dimensional spatial analysis of telomere positions before and during meiotic prophase
    • Bass, H.W., W.F. Marshall, J.W. Sedat, D.A. Agard, and W.Z. Cande. 1997. Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J. Cell Biol. 137:5-18.
    • (1997) J. Cell Biol. , vol.137 , pp. 5-18
    • Bass, H.W.1    Marshall, W.F.2    Sedat, J.W.3    Agard, D.A.4    Cande, W.Z.5
  • 2
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn, E.H. 1991. Structure and function of telomeres. Nature. 350:569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 3
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M.A., W.D. Funk, B. Villeponteau, and C.W. Greider. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science. 269:1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.D.2    Villeponteau, B.3    Greider, C.W.4
  • 6
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
    • Boulton, S.J., and S.P. Jackson. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 8
    • 0030916582 scopus 로고    scopus 로고
    • The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
    • Bryan, T.M., L. Marusic, S. Bacchetti, M. Namba, and R.R. Reddel. 1997. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum. Mol. Genet. 6:921-926.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 921-926
    • Bryan, T.M.1    Marusic, L.2    Bacchetti, S.3    Namba, M.4    Reddel, R.R.5
  • 9
    • 0031025531 scopus 로고    scopus 로고
    • Meiotic nuclear reorganization: Switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe
    • Chikashige, Y., D.Q. Ding, Y. Imai, M. Yamamoto, T. Haraguchi, and Y. Hiraoka. 1997. Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO (Eur. Mol. Biol. Organ.) J. 16:193-202.
    • (1997) EMBO (Eur. Mol. Biol. Organ.) J. , vol.16 , pp. 193-202
    • Chikashige, Y.1    Ding, D.Q.2    Imai, Y.3    Yamamoto, M.4    Haraguchi, T.5    Hiraoka, Y.6
  • 11
    • 0030746030 scopus 로고    scopus 로고
    • Tam1, a telomere-associaled meiotic protein, functions in chromosome synapsis and crossover interference
    • Chua, P.R., and G.S. Roeder. 1997. Tam1, a telomere-associaled meiotic protein, functions in chromosome synapsis and crossover interference. Genes Dev. 11:1786-1800.
    • (1997) Genes Dev. , vol.11 , pp. 1786-1800
    • Chua, P.R.1    Roeder, G.S.2
  • 12
    • 0028990123 scopus 로고
    • Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
    • Collins, K., R. Kobayashi, and C.W. Greider. 1995. Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell. 81:677-686.
    • (1995) Cell , vol.81 , pp. 677-686
    • Collins, K.1    Kobayashi, R.2    Greider, C.W.3
  • 13
    • 0030915814 scopus 로고    scopus 로고
    • Ndj1p, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast
    • Conrad, M.N., A.M. Dominguez, and M.W. Dresser. 1997. Ndj1p, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast. Science. 276:1252-1255.
    • (1997) Science , vol.276 , pp. 1252-1255
    • Conrad, M.N.1    Dominguez, A.M.2    Dresser, M.W.3
  • 14
    • 0032560121 scopus 로고    scopus 로고
    • Fission yeast tazl protein is required for meiotic telomere clustering and recombination
    • Cooper, J.P., Y. Watanabe, and P. Nurse. 1998. Fission yeast tazl protein is required for meiotic telomere clustering and recombination. Nature. 392:828-831.
    • (1998) Nature , vol.392 , pp. 828-831
    • Cooper, J.P.1    Watanabe, Y.2    Nurse, P.3
  • 16
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter, C.M., F.M. Botelho, P. Wang, C.B. Harley, and S. Bacchetti. 1994. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68:3410-3414.
    • (1994) J. Virol. , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Wang, P.3    Harley, C.B.4    Bacchetti, S.5
  • 17
    • 0002309826 scopus 로고
    • Telomere dynamics and genome instability in human cancer
    • Cold Spring Harbor Press. Cold Spring Harbor, NY
    • de Lange, T. 1995. Telomere dynamics and genome instability in human cancer. In Telomeres. Cold Spring Harbor Press. Cold Spring Harbor, NY. 265-293.
    • (1995) Telomeres , pp. 265-293
    • Lange, T.1
  • 19
    • 0032030840 scopus 로고    scopus 로고
    • Interaction of recombinant tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
    • Gandhi, L., and K. Collins. 1998. Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates. Genes Dev. 12:721-733.
    • (1998) Genes Dev. , vol.12 , pp. 721-733
    • Gandhi, L.1    Collins, K.2
  • 20
    • 0029088371 scopus 로고
    • TEL1, a gene involved in controlling telomere length in S. Cerevisiae, is homologous to the human Ataxia Telangiectasia gene
    • Greenwell, P.W., S.L. Kronmal, S.E. Porter, J. Gassenhuber, B. Obermaier, and T.D. Petes. 1995. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human Ataxia Telangiectasia gene. Cell. 82:823-829.
    • (1995) Cell , vol.82 , pp. 823-829
    • Greenwell, P.W.1    Kronmal, S.L.2    Porter, S.E.3    Gassenhuber, J.4    Obermaier, B.5    Petes, T.D.6
  • 21
    • 0029894237 scopus 로고    scopus 로고
    • Telomere length regulation
    • Greider, C.W. 1996. Telomere length regulation. Annu. Rev. Biochem. 65:337-365.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 337-365
    • Greider, C.W.1
  • 22
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C.W., and E.H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43:405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 23
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider, C.W., and E.H. Blackburn. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 24
    • 0029938929 scopus 로고    scopus 로고
    • Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridisation
    • Hande, M.P., J.J.W.A. Boei, and A.T. Natarajan. 1996. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridisation. Int. J. Radiat. Biol. 69:437-446.
    • (1996) Int. J. Radiat. Biol. , vol.69 , pp. 437-446
    • Hande, M.P.1    Boei, J.J.W.A.2    Natarajan, A.T.3
  • 25
    • 0025279931 scopus 로고
    • Telomeres shorten during aging of human fibroblasts
    • Harley, C.B., A.B. Futcher, and C.W. Greider. 1990. Telomeres shorten during aging of human fibroblasts. Nature. 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 28
    • 85030358366 scopus 로고    scopus 로고
    • Telomerase deficiency and telomere loss in mTR embryos is associated with failure to close the neural lube
    • Herrera, E., E. Samper, and M.A. Blasco. 1999. Telomerase deficiency and telomere loss in mTR embryos is associated with failure to close the neural lube. EMBO (Eur. Mol. Biol. Organ.) J. 18:5.
    • (1999) EMBO (Eur. Mol. Biol. Organ.) J. , vol.18 , pp. 5
    • Herrera, E.1    Samper, E.2    Blasco, M.A.3
  • 30
    • 0031047642 scopus 로고    scopus 로고
    • Block in anaphase chromosome separation caused by a telomerase template mutation
    • Kirk, K.E. B.P. Harmon, I.K. Reichardt, J.W. Sedat, and E.H. Blackburn. 1997. Block in anaphase chromosome separation caused by a telomerase template mutation. Science. 275:1478-1481.
    • (1997) Science , vol.275 , pp. 1478-1481
    • Kirk, K.E.1    Harmon, B.P.2    Reichardt, I.K.3    Sedat, J.W.4    Blackburn, E.H.5
  • 32
    • 0030671192 scopus 로고    scopus 로고
    • Lessons from mice without telomerase
    • Lansdorp, P.M. 1997. Lessons from mice without telomerase. J. Cell Biol. 139: 309-312.
    • (1997) J. Cell Biol. , vol.139 , pp. 309-312
    • Lansdorp, P.M.1
  • 35
  • 36
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est 1-senescence
    • Lundblad, V., and E.H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est 1-senescence. Cell. 73:347-360.
    • (1993) Cell , vol.73 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 38
    • 0032168370 scopus 로고    scopus 로고
    • Expression of mouse telomerase catalytic subunit in embryos and adult tissues
    • Martín-Rivera, L., E. Herrera, J.P. Albar, and M.A. Blasco. 1998. Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl. Acad. Sci. USA. 95:10471-10476.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10471-10476
    • Martín-Rivera, L.1    E Herrera, J.P.A.2    Blasco, M.A.3
  • 39
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in Zea mays
    • McClintock, B. 1941. The stability of broken ends of chromosomes in Zea mays. Genitics. 26:234-282.
    • (1941) Genitics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 40
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachern, M.J., and E.H. Blackburn. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature. 376:403-409.
    • (1995) Nature , vol.376 , pp. 403-409
    • McEachern, M.J.1    Blackburn, E.H.2
  • 41
    • 0029746495 scopus 로고    scopus 로고
    • Cap-prevented recombination between terminal telomeric repeats arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
    • McEachern, M.J., and E.H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeats arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822-1834.
    • (1996) Genes Dev. , vol.10 , pp. 1822-1834
    • McEachern, M.J.1    Blackburn, E.H.2
  • 44
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin, G.B. 1989. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 45
    • 0031686574 scopus 로고    scopus 로고
    • Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
    • Naito, T., A. Matsuura, and F. Ishikawa. 1998. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat. Genet. 20: 203-206.
    • (1998) Nat. Genet. , vol.20 , pp. 203-206
    • Naito, T.1    Matsuura, A.2    Ishikawa, F.3
  • 47
    • 3543142313 scopus 로고    scopus 로고
    • Two modes of survival of fission yeast without telomerase
    • Nakamura, T.M., J.P. Cooper, and T. Cech. 1998. Two modes of survival of fission yeast without telomerase. Science. 282:493-496.
    • (1998) Science , vol.282 , pp. 493-496
    • Nakamura, T.M.1    Cooper, J.P.2    Cech, T.3
  • 48
    • 0030898989 scopus 로고    scopus 로고
    • TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeat family
    • Nakayama, J., M. Saito, H. Nakamura, A. Matsura, and F. Ishikawa. 1997. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeat family. Cell. 88:875-884.
    • (1997) Cell , vol.88 , pp. 875-884
    • Nakayama, J.1    Saito, M.2    Nakamura, H.3    Matsura, A.4    Ishikawa, F.5
  • 51
    • 0345691187 scopus 로고    scopus 로고
    • Progressive organ dysfunction and increased cancer incidence with age in telomerase deficient mice
    • In press
    • Rudolph, K.L., S. Chang, H.W. Lee, M.A. Blasco, G. Gottlieb, C.W. Greider, and R.A. dePinho. 1999. Progressive organ dysfunction and increased cancer incidence with age in telomerase deficient mice. Cell. In press.
    • (1999) Cell
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3    Blasco, M.A.4    Gottlieb, G.5    Greider, C.W.6    DePinho, R.A.7
  • 52
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery and chromosome loss
    • Sandell, L.L., and V.A. Zakian. 1993. Loss of a yeast telomere: arrest, recovery and chromosome loss. Cell. 75:729-739.
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 53
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay, J.W., and S. Bacchetti. 1997. A survey of telomerase activity in human cancer. Eur. J. Cancer. 33:787-791.
    • (1997) Eur. J. Cancer. , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 54
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of the saccharomyces cerevisiae telomerase
    • Singer, M.S., and D.E. Gottschling. 1994. TLC1: template RNA component of the Saccharomyces cerevisiae telomerase. Science. 266:387-388.
    • (1994) Science , vol.266 , pp. 387-388
    • Singer, M.S.1    Gottschling, D.E.2
  • 55
    • 84883840386 scopus 로고
    • Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
    • Todaro, G.J., and H. Green. 1963. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17:299-313.
    • (1963) J. Cell Biol. , vol.17 , pp. 299-313
    • Todaro, G.J.1    Green, H.2
  • 56
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • Van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 59
    • 0024253390 scopus 로고
    • Sequence organisation and cytological localization of the minor satellite of mouse
    • Wong, A.K.C., and J.B. Rattner. 1988. Sequence organisation and cytological localization of the minor satellite of mouse. Nucleic Acad Res. 16:11645-11661.
    • (1988) Nucleic Acad Res. , vol.16 , pp. 11645-11661
    • Wong, A.K.C.1    Rattner, J.B.2
  • 60
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated tetrahymena telomerase RNAs
    • Yu, G.-L., J.D. Bradley, L.D. Attardi, and E.H. Blackburn. 1990. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature. 344:126-132.
    • (1990) Nature , vol.344 , pp. 126-132
    • Yu, G.-L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 62
    • 0030612349 scopus 로고    scopus 로고
    • Expression of the p16INK4a tumor suppressor versus other 1NK4 family members during mouse development and aging
    • Zindy, F., D.E. Quelle, M.F. Roussel, and C.J. Sherr. 1997. Expression of the p16INK4a tumor suppressor versus other 1NK4 family members during mouse development and aging. Oncogene. 15:203-211.
    • (1997) Oncogene , vol.15 , pp. 203-211
    • Zindy, F.1    Quelle, D.E.2    Roussel, M.F.3    Sherr, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.