Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis

Clinical Cancer Research

Volumn 10, Issue 10, 2004, Pages 3317-3326

  Meeker, Alan K ^a   Hicks, Jessica L ^a   Iacobuzio Donahue, Christine A ^a   Montgomery, Elizabeth A ^a   Westra, William H ^a   Chan, Theresa Y ^a   Ronnett, Brigitte M ^a   De Marzo, Angelo M ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Genitourinary Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; BLADDER CARCINOGENESIS; CANCER INCIDENCE; CANCER INVASION; CARCINOGENESIS; CELL SIZE; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; GENETIC STABILITY; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LARGE INTESTINE CANCER; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; MOUTH CARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROSTATE CARCINOMA; TELOMERE; UTERINE CERVIX CARCINOMA;

ADULT; AGED; ANIMALS; BREAST NEOPLASMS; CHROMOSOME ABERRATIONS; CHROMOSOMES; COLONIC NEOPLASMS; EPITHELIAL CELLS; ESOPHAGEAL NEOPLASMS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASMS; NEOPLASMS, GLANDULAR AND EPITHELIAL; NUCLEIC ACID HYBRIDIZATION; PROSTATIC NEOPLASMS; TELOMERE; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

EID: 2542461165     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-0984-03     Document Type: Article

References (59)

1. Sandberg AA, Wake N. Chromosomal changes in primary and metastatic tumors and in lymphoma: their nonrandomness and significance. In: Arrighi FE, Rao PN, Stubblefield E, editors, Genes, chromosomes, and neoplasia. New York: Raven Press; 1981. p. 104-33.
2. Mittelamn F. Catalog of chromosome aberrations in cancer, 6th ed. New York: Alan R. Liss, 1998,
3. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature (Lond.) 1998;396:643-9.
4. Loeb LA, A mutator phenotype in cancer. Cancer Res 2001;61:3230-9.
5. Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 2001;61:818-22.
6. Qian J, Jenkins RB, Bostwick DG. Genetic and chromosomal alterations in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization. Eur Urol 1999;35:479-83.
7. Hartwell L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 1992;71:543-6.
8. Myung K, Chen C, Kolodner RD. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature (Lond.) 2001;411:1073-6.
9. Jallepalli PV, Lengauer C. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 2001;1:109-17.
10. Nowak MA, Komarova NL, Sengupta A, et al. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci USA 2002;99:16226-31.
11. Blackburn EH. Structure and function of telomeres. Nature (Lond.) 1991;350:569-72.
12. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB. Telomere end-replication problem and cell aging. J Mol Biol 1992;225:951-60.
13. von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995;220:186-93.
14. Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 1985;43:405-13.
15. Lundblad V, Blackburn EH. An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell 1993;73:347-60.
16. Henson JD, Neumann AA, Yeager TR, Reddel RR, Alternative lengthening of telomeres in mammalian cells. Oncogene 2002;21:598-610.
17. McClintock B. The stability of broken ends of chromosomes in Zea mays. Genetics 1941;26:234-82.
18. Hackett JA, Feldser DM, Greider CW. Telomere dysfunction increases mutation rate and genomic instability. Cell 2001;106:275-86.
19. Shay JW, Wright WE, Werbin H, Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1991;1072:1-7.
20. Harley CB, Kim NW, Prowse KR, et al. Telomerase, cell immortality, and cancer. Cold Spring Harb Symp Quant Biol 1994;59:307-15.
21. Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000;6:849-51.
22. O'Hagan RC, Chang S, Maser RS, et al. Telomere dysfunction provokes regional amplification and deletion in cancer genome. Cancer Cell 2002;2:149-55.
23. Hastie N, Dempster M, Dunlop M, Thompson A, Green D, Alshire R. Telomere reduction in human colorectal carcinoma and with ageing. Nature (Lond.) 1990;346:866-8.
24. de Lange, T. Telomere dynamics and genome instability in human cancer. In: Blackburn EAG, editor. Telomeres, Plainview, NY: Cold Spring Harbor Press; 1995. p. 265-293.
25. von Zglinicki T. Are the ends of chromosomes the beginning of tumor genesis? On the role of telomeres in cancer development [in German]. Fortschr Med 1996;114:12-4.
26. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991;256:271-82.
27. Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997;91:25-34.
28. Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-12.
29. Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (Lond.) 2000;406:641-5.
30. O'Shaughnessy JA, Kelloff GJ, Gordon GB, et al. Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development. Clin Cancer Res 2002;8:314-46.
31. Galipeau PC, Prevo LJ, Sanchez CA, Longton GM, Reid BJ. Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue. J Natl Cancer Inst (Bethesda) 1999;91:2087-95.
32. Buerger H, Otterbach F, Simon R, et al. Comparative genomic hybridization of ductal carcinoma in situ of the breast evidence of multiple genetic pathways. J Pathol 1999;187:396-402.
33. Meeker AK, Gage WR, Hicks JL, et al. Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am J Pathol 2002;160:1259-68.
34. Meeker AK, Hicks JL, Platz EA, et al. Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis. Cancer Res 2002;62:6405-9.
35. Vukovic B, Park PC, Al-Maghrabi J, et al. Evidence of multifocality of telomere erosion in high-grade prostatic intraepithelial neoplasia (HP1N) and concurrent carcinoma. Oncogene 2003;22:1978-87.
36. van Heek NT, Meeker AK, Kern SE, et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 2002;161:1541-7.
37. Chen C, Hong YK, Ontiveros SD, Egholm M, Strauss WM. Single base discrimination of CENP-B repeats on mouse and human Chromosomes with PNA-FISH. Mamm Genome 1999;10:13-18.
38. Harley CB. Telomeres and aging: fact, fancy, and the future. J NIH Res 1995;7:64-8.
39. Henderson S, Allsopp R, Spector D, Wang SS, Harley C. In situ analysis of changes in telomere size during replicative aging and cell transformation. J Cell Biol 1996;134:1-12.
40. Lansdorp PM, Verwoerd NP, van de Rijke FM, et al. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 1996;5:685-91.
41. O'Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet 2002;32:280-4.
42. Nowell PC. The clonal evolution of tumor cell populations. Science (Wash. DC) 1976;194:23-8.
43. Fialkow PJ. The origin and development of human tumors studied with cell markers. N Engl J Med 1974;291:26-35.
44. Cairns J. Mutation selection and the natural history of cancer. Nature (Lond.) 1975;255:197-200.
45. van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1 [see comments]. Nature (Lond.) 1997;385:740-3.
46. Baumann P, Cech TR. Potl, the putative telomere end-binding protein in fission yeast and humans. Science (Wash. DC) 2001;292:1171-5.
47. Coussens LM, Werb Z. Inflammation and cancer. Nature (Lond.) 2002;420:860-7.
48. Koeneman KS, Pan CX, Jin JK, et al. Telomerase activity, telomere length, and DNA ploidy in prostatic intraepithelial neoplasia (PIN). J Urol 1998;160:1533-9.
49. Meeker AK, Coffey DS. Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review. Biochemistry (Mosc.) 1997;62:1323-31.
50. Kanamaru T, Tanaka K, Kotani J, et al. Telomerase activity and hTERT mRNA in development and progression of adenoma to colorectal cancer. Int J Mol Med 2002;10:205-10.
51. Kim HR, Christensen R, Park NH, Sapp P, Kang MK. Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ. Clin Cancer Res 2001;7:3079-86.
52. Frost M, Bobak JB, Gianani R, et al. Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix. Am J Clin Pathol 2000;114:726-34.
53. Kolquist KA, Ellisen LW, Counter CM, et al. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet 1998;19:182-6.
54. Mueller C, Riese U, Kosmehl H, Dahse R, Claussen U, Ernst G. Telomerase activity in microdissected human breast cancer tissues: association with p53, p21 and outcome. Int J Oncol 2002;20:385-90.
55. Wisman GB, De Jong S, Meersma GJ, et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol 2000;31:1304-12.
56. Tsao JI, Zhao YL, Lukas J, et al. Telomerase activity in normal and neoplastic breast. Clin Cancer Res 1997;3:627-31.
57. Kleinschmidt-Demasters BK, Evans LC, Bobak JB, et al. Quantitative telomerase expression in glioblastomas shows regional variation and down-regulation with therapy but no correlation with patient outcome. Hum Pathol 2000;31:905-13.
58. Yeager TR, Neumann AA, Englezou A, Huschtscha LI, Noble JR, Reddel RR. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res 1999;59:4175-9.
59. Meeker AK, Hicks J, Argani P, Gabrielson E, Strauss WM, DeMarzo A. Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma. Am J Pathol 2004;164:925-35.