Hepatocyte growth factor, its receptor, and their potential value in cancer therapies

Critical Reviews in Oncology/Hematology

Volumn 53, Issue 1, 2005, Pages 35-69

  Jiang, Wen G ^a   Martin, Tracey A ^a   Parr, Christian ^a   Davies, Gaynor ^a   Matsumoto, Kunio ^b   Nakamura, Toshikazu ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Cancer metastasis; Cancer therapies; cMET; Hepatocyte growth factor; HGF; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 (1 AMINOETHYL) 4 (4 PYRIDYL)BENZAMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYLENYL) 1 PROPENYL]BENZOIC ACID; 5 [(2,6 DICHLOROBENZYL)SULFONYL] 3 [[3,5 DIMETHYL 4 [[(PYRROLIDIN 1 YLMETHYL)PYRROLIDIN 1 YL]CARBONYL] 1H PYRROL 2 YL]METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 6 (2,6 DICHLOROPHENYL) 2 (4 FLUORO 3 METHYLANILINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ACETYLSALICYLIC ACID; ADHESIN; CELECOXIB; EZRIN; GAMMA LINOLENIC ACID; GELDANAMYCIN; ICOSAPENTAENOIC ACID; MARIMASTAT; MOESIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (3 CHLOROPHENYL) 3 [[3,5 DIMETHYL 4 [(4 METHYLPIPERAZIN 1 YL)CARBONYL] 1H PYRROL 2 YL]METHYLENE] N METHYL 2 OXO 2,3 DIHYDRO 1H INDOLE 5 SULFONAMIDE; NK 4; PAXILLIN; PEPTIDE; PHA 665752; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; RAC PROTEIN; RADIXIN; RETINOIC ACID; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SU 11274; UNCLASSIFIED DRUG; UNINDEXED DRUG; WF 536;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; BREAST TUMOR; CANCER CELL; CANCER GROWTH; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; COLORECTAL CANCER; DRUG TARGETING; GLIOMA; HUMAN; LUNG CANCER; METASTASIS; NONHUMAN; OVARY CANCER; PROSTATE CANCER; REVIEW; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; HEPATOCYTE GROWTH FACTOR; HUMANS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MET;

EID: 10644289454     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2004.09.004     Document Type: Review

References (320)

1. T. Nakamura, T. Nishizawa, and M. Hagiya Molecular cloning and expression of human hepatocyte growth factor Nature 342 1989 440 443
2. E. Gerrardi, and M. Stoker Hepatocyte and scatter factor Nature 346 1990 228
3. T. Nakamura, K. Nawa, and A. Ichihara Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats Biochem Biophys Res Commun 122 1984 1450 1459
4. W.G. Jiang, S. Hiscox, K. Matsumoto, and T. Nakamura Hepatocyte growth factor/scatter factor/scatter factor, the molecular, cellular and clinical implications in cancer Crit Rev Oncol/Hematol 29 1999 209 248
5. P.M. Comoglio, and C. Boccaccio Scatter factors and invasive growth Semin Cancer Biol 11 2001 153 165
6. C. Birchmeier, W. Birchmeier, E. Gherardi, and G.F. Vande Woude Met, metastasis, motility and more Nat Rev Mol Cell Biol 4 2003 915 925
7. A. Hall, C.J. Marshall, N.K. Spurr, and R.A. Weiss Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1 Nature (London) 303 1983 396 400
8. A.J. Ridley Rho GTPases and cell migration J Cell Sci 114 2001 2713 2722
9. A.J. Ridley, H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall The small GTP-binding protein rac regulates growth factor-induced membrane ruffling Cell 70 1992 401 410
10. A.J. Ridley Rho-related proteins: actin cytoskeleton and cell cycle Curr Opin Genet Dev 5 1995 24 30
11. K. Yoshioka, S. Nakamori, and K. Itoh Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells Cancer Res 59 1999 2004 2010
12. W.G. Jiang, G. Watkins, and J. Lane Prognostic value of Rho familty and and rho-GDIs in breast cancer Clin Cancer Res 9 2003 6432 6440
13. C.D. Nobles, and A. Hall Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia Cell 81 1995 53 62
14. G. Pelicci, S. Giordano, and Z. Zhen The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein Oncogene 10 1995 1631 1638
15. A.J. Ridley, P.M. Comoglio, and A. Hall Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells Mol Cell Biol. 15 1995 1110 1122
16. K.A. Furge, Y.W. Zhang, and G.F. Vande Woude Met receptor tyrosine kinase: enhanced signaling through adapter proteins Oncogene 19 2000 5582 5589
17. S.M. Riordan, S. Lidder, R. Williams, and G.G. Skouteris The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis Biochem J 350 2000 925 932
18. F. Frasca, P. Vigneri, V. Vella, R. Vigneri, and J.Y.J. Wang Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor Oncogene 20 2001 3845 3856
19. S.J. Fan, Y.X. Ma, and M. Gao The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair Mol Vrll Biol 21 2001 4968 4984
20. G. Maulik, P. Madhiwala, and S. Brooks Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer J Cell Mol Med 6 2002 539 553
21. L. Lamorte, I. Royal, M. Naujokas, and M. Park Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions Mol Biol Cell 13 2002 1449 1461
22. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655
23. S. Potempa, and A.J. Ridley Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly Mol Biol Cell 9 1998 2185 2200
24. C.M. Wells, A. Abo, and A.J. Ridley PAK4 is activated via PI3K in HGF-stimulated epithelial cells J Cell Sci 115 2002 3947 3956
25. K. Matsumoto, K. Matsumoto, T. Nakamura, and R.H. Kramer Hepatocyte growth-factor scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125(FAK)) and promotes migration and invasion by oral squamous-cell carcinoma-cells J Biol Chem 269 1994 31807 31813
26. N. Wernert The multiple roles of tumour stroma Virchows Arch 430 1997 433 443
27. P.C. Chan, C.C. Liang, and K.C. Yu Synergistic effect of focal adhesion kinase overexpression and hepatocyte growth factor stimulation on cell transformation J Biol Chem 277 2002 50373 50379
28. W.G. Jiang, S. Hiscox, and S.K. Singhrao Induction of tyrosine phosphorylation and translocation of ezrin by hepatocyte growth factor (HGF/SF) Biochem Biophys Res Commun 217 1995 1062 1069
29. T. Crepaldi, A. Gautreau, P.M. Comoglio, D. Louvard, and M. Arpin Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells J Cell Biol 138 1997 423 434
30. S. Hiscox, and W.G. Jiang Ezrin regulates cell-cell and cell-matrix adhesion and serves as a tumour suppressor J Cell Sci 112 1999 3081 3090
31. V. Orian-Rousseau, L.F. Chen, J.P. Sleeman, P. Herrlich, and H. Ponta CD44 is required for two consecutive steps in HGF/c-Met signalling Gene Dev 116 2002 3074 3086
32. G. Harrison, G. Davies, T.A. Martin, W.G. Jiang, and M.D. Mason Distribution and expression of CD44 isoforms and ezrin during prostate cancer-endothelium interaction Int J Oncol 21 2002 935 940
33. T.E. Taher, R. van der Voort, and L. Smit Cross-talk between CD44 and c-Met in B cells Curr Top Microbiol Immunol 246 1999 31 37
34. M. Suzuki, H. Kobayashi, N. Kanayama, T. Nishida, M. Takigawa, and T. Terao CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells Biochim Biophys Acta 1591 2002 37 44
35. L. Schmidt, F. Duh, and F. Chan Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas Nat Genet 16 1997 68 73
36. M. Jeffers, L. Schmidt, and N. Nakagawa Activating mutations for the Met tyrosine kinase receptor in human cancer Proc Natl Acad Sci USA 94 1997 11445 11450
37. G. Davies, W.G. Jiang, and M.D. Mason Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in HGF/SF induced cell-cell dissociation and in vitro invasion Clin Cancer Res 7 2001 3289 3297
38. G. Li, H. Schaider, K. Satyamoorthy, Y. Hanakawa, K. Hashimoto, and M. Herlyn Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development Oncogene 20 2001 8125 8135
39. S. Hiscox, and W.G. Jiang Association of the HGF/SF receptor, c-MET, with the cell-surface adhesion molecule, E-cadherin and catenins in human tumour cells Biochem Biophys Res Commun 261 1999 406 411
40. D.K. Wang, Z.B. Li, E.M. Messing, and G. Wu Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM J Biol Chem 277 2002 36216 36222
41. A. Danilkovitch-Miagkova, A. Miagkov, A. Skeel, N. Nakaigawa, B. Zbar, and E.J. Leonard Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway Mol Cell Biol 21 2001 5857 5868
42. M.I. Gallego, B. Bierie, and L. Hennighausen Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways Oncogene 22 2003 8498 8508
43. K.A. Walter, M.A. Hossain, C. Luddy, N. Goel, T.E. Reznik, and J. Laterra Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, cdk2 activation, or E2F1-dependent transcription Mol Cell Biol 22 2002 2703 2715
44. X. Wang, M.C. DeFrances, and Y. Dai A mechanism of cell survival: sequestration of Fas by the HGF factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells J Biol Chem 278 2003 4705 4712
45. Y.W. Zhang, L.M. Wang, R. Jove, and G.F. Vande Woude Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis Oncogene 21 2002 217 226
46. K. Kitta, R.M. Day, Y. Kim, I. Torregroza, T. Evans, and Y.J. Suzuki Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells J Biol Chem 278 2003 4705 4712
47. R. Sharp, J.A. Recio, and C. Jhappan Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis Nat Med 8 2002 1276 1280
48. J.A. Recio, and G. Merlino Hepatocyte growth factor/scatter factor induces feedback up-regulation of CD44v6 in melanoma cells through Egr-1 Cancer Res 63 2003 1576 1582
49. G.M. Yerushalmi, R. Leibowitz-Amit, M. Shaharabany, and I. Tsarfaty Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarisation Neoplasia 4 2002 510 522
50. M.K. Cho, and S.G. Kim Hepatocyte growth factor activates CCAAT enhancer binding protein and cell replication via P13-kinase pathway Hepatology 37 2003 686 695
51. Q.H. Zeng, L.K. McCauley, and C.Y. Wang Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2 - implication in head and neck squamous cell carcinoma progression J Biol Chem 277 2002 50137 50142
52. T. Shimada, H. Hiraishi, and A. Terano Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2 Life Sci 68 2000 539 546
53. H. Tajima, K. Matsumoto, and T. Nakamura Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines FEBS Lett 291 1991 229 232
54. W.G. Jiang, D. Lloyd, Puntis MCA, T. Nakamura, and M.B. Hallett Regulation of spreading and growth of human colon cancer cells by hepatocyte growth factor Clin Exp Metastasis 11 1993 235 242
55. S.S. McAllister, M. Becker-Hapak, G. Pintucci, M. Pagano, and S.F. Dowdy Novel p27 (kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions Mol Biol Cells 23 2003 216 228
56. Y. Leshem, and O. Halevy Phosphorylation of pRb is required for HGF-induced muscle cell proliferation and is p27kip1-dependent J Cell Physiol 191 2002 173 182
57. T. Nakamura, K. Nawa, and A. Ichihara Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats Biochem Biophys Res Commun 122 1984 1450 1459
58. Y. Okano, K. Mizuno, S. Osada, T. Nakamura, and Y. Nozawa Tyrosine phosphorylation of phospholipase C gamma in c-met/HGF receptor-stimulated hepatocytes: comparison with HepG2 hepatocarcinoma cells Biochem Biophys Res Commun 190 1993 842 848
59. E. Matteucci, S. Modora, M. Simone, and M.A. Desiderio Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: favouring role of hypoxia-inducible factor-1 deficiency Oncogene 22 2003 4062 4073
60. K. Nakanishi, J. Fujimoto, and T. Ueki Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase Clin Exp Metastasis 17 1999 507 514
61. P. Gual, S. Giordano, T.A. Williams, S. Rocchi, E. Van Obberghen, and P.M. Comoglio Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis Oncogene 19 2000 1509 1518
62. H. Ogasawara, J. Hiramoto, and M. Takahashi Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells Gastroenterology 114 1998 775 781
63. S. Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, and P.M. Comoglio Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene Cancer Cell 3 2003 347 361
64. D.P. Bottaro, and L.A. Liotta Out of air is not out of action Nature 423 2003 593 595
65. J. Wojta, T. Nakamura, and A. Fabry Hepatocyte growth-factor stimulates expression of plasminogen-activator inhibitor type-1 and tissue factor in HEPG2 cells Blood 84 1994 151 157
66. S.E. Dunsmore, J.S. Rubin, and Kovacs So Mechanisms of hepatocyte growth-factor stimulation of keratinocyte metalloproteinase production J Biol Chem 271 1996 24567 24582
67. E.L. Rosenthal, T.M. Johnson, E.D. Allen, I.J. Apel, A. Punturieri, and S.J. Weiss Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells Cancer Res 58 1998 5221 5230
68. L. Trusolino, A. Bertotti, and P.M. Comoglio A signaling adapter function for alpha 6 beta 4 integrin in the control of HGF-dependent invasive growth Cell 107 2001 643 654
69. S. Giordano, S. Corso, and P. Conrotto The Semaphorin 4D receptor controls invasive growth by coupling with Met Nat Cell Biol 4 2002 720 724
70. Y.W. Zhang, Y.L. Su, O.V. Volpert, and G.F. Van de Woude Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation PNAS 100 2003 12718 12723
71. K.J. Purdie, G.S. Whitley, A.P. Johnstone, and J.E. Cartwright Hepatocyte growth factor-induced endothelial cell motility is mediated by the upregulation of inducible nitric oxide synthase expression Circ Res 54 2002 659 668
72. N. Tomita, R. Morishita, and Y. Taniyama Angiogenic property of hepatocyte growth factor is dependent on Upregulation of essential transcription factor for angiogenesis, ets-1 Circulation 107 2003 1411 1417
73. K. Reisinger, R. Kaufmann, and J. Gille Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor (HGF/SF)-induced vascular endothelial growth factor (VEGF/VPF) transcription J Cell Sci 116 2003 225 238
74. L. Tacchini, P. Dansi, E. Matteucci, and M.A. Desiderio Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells Carcinogenesis 22 2001 1363 1371
75. M. Nakabayashi, R. Morishita, and H. Nakagami HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model Diabetologia 46 2003 115 123
76. E. Gherardi, M. Sharpe, K. Lane, A. Sirulnik, and M. Stoker Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behaviour of epithelial cells Symp Soc Exp Biol 47 1993 163 181
77. K. Matsumoto, and T. Nakamura Emerging multipotent aspects of hepatocyte growth factor J Biochem (Tokyo) 119 1996 591 600
78. R. Montesano, K. Matsumoto, T. Nakamura, and L. Orci Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor Cell 67 1991 901 908
79. O. Wiggan, M.P. Fadel, and P.A. Hamel Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion J Cell Sci 115 2002 517 529
80. C. Boccaccio, M. Ando, and L. Tamagnone Induction of epithelial tubules by growth factor HGF depends on the STAT pathway Nature 391 1998 285 288
81. H. Yamaguchi, H. Miki, and T. Takenawa Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells Cancer Res 62 2002 2503 2509
82. S.L. Kominsky, P. Argani, and D. Korz Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast Oncogene 22 2003 2021 2033
83. T.A. Martin, R.E. Mansel, and W.G. Jiang Regulation of tight junction function by Hepatocyte growth factor in human breast cancer cells Cell Biol Int. 28 2004 361 371
84. W.G. Jiang, T.A. Martin, T. Nakamura, and R.E. Mansel Hepatocyte growth factor/scatter decreases the expression of occludin and paracellular permeability and increases the transendothelial resistence of human vascular endothelial cells J Cell Physiol 181 1999 319 329
85. F. Hollande, E.M. Blanc, and J.P. Bali HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line Am J Physiol Gastrointest Liver Physiol 280 2001 G910 G921
86. T. Inoue, H. Okada, and T. Kobayashi Hepatocyte growth factor counteracts transforming growth factor-beta(1), through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice FASEB J 16 2002 U205 U222
87. S. Grisendi, B. Chambraud, I. Gout, P.M. Comoglio, and T. Crepaldi Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor J Biol Chem 276 2001 46632 46638
88. C. Seidel, M. Borset, and O. Hjertner High levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activity Blood 96 2000 3139 3146
89. L.J. Lai, and I. Goldschneider Identification of a hybrid cytokine consisting of IL-7 and the beta-chain of the hepatocyte growth factor/scatter factor J Immunol 167 2001 3550 3554
90. A. Grenier, S. Chollet-Martin, and B. Crestani Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils Blood 99 2002 2997 3004
91. M. Wislez, N. Rabbe, and J. Marchal Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death Cancer Res 63 2003 1405 1412
92. B. Crestani, M. Dehoux, and G. Hayem Differential role of neutrophils and alveolar macrophages in hepatocyte growth factor production in pulmonary fibrosis Lab Invest 82 2002 1015 1022
93. M. Kinoshita, T. Miyamoto, N. Ohashi, S. Sasayama, and A. Matsumori Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells Circulation 106 2002 3133 3138
94. J.S. Rubin, R.M. Day, and D. Breckenridge Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate-c-Met interaction facilitates signaling J Biol Chem 276 2001 32977 32983
95. J.G. Jiang, C. Johnson, and R. Zarnegar Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element J Biol Chem 276 2001 25049 25056
96. K. Matsumoto, H. Tajima, M. Hamanoue, S. Kohno, T. Kinoshita, and T. Nakamura Identification and characterization of "injurin", an inducer of expression of the gene for hepatocyte growth factor Proc Natl Acad Sci USA 89 1992 3800 3804
97. H. Okazaki, K. Matsumoto, and T. Nakamura Partial purification and characterization of 'injurin-like' factor which stimulates production of hepatocyte growth factor Biochim Biophys Acta 1220 3 1994 291 298
98. T. Shimomura, K. Miyazawa, and Y. Komiyama Activation of hepatocyte growth-factor by 2 homologous proteases, blood-coagulation factor-xiia and hepatocyte growth-factor activator Eur J Biochem 229 1995 257 261
99. K. Miyazawa, T. Shimomura, and N. Kitamura Activation of hepatocyte growth-factor in the injured tissues is mediated by hepatocyte growth-factor activator J Biol Chem 271 1996 3615 3618
100. C. Parr, G. Cunnnick, R.E. Mansel, and W.G. Jiang Expression on HGF, its activator and inhibitors in human breast cancer Clin Cancer Res 10 2004 202 211
101. H. Kataoka, R. Hamasuna, H. Itoh, N. Kitamura, and M. Koono Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma Cancer Res 60 2000 6148 6159
102. C. Parr, and W.G. Jiang Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells Int J Oncol 19 2001 857 863
103. A. Okajima, K. Miyazawa, Y. Naitoh, K. Inoue, and N. Kitamura Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation Hepatology 25 1997 97 102
104. H. Kataoka, H. Itoh, R. Hamasuna, J.Y. Meng, and M. Koono Pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF) in colorectal carcinomas: roles of HGF activator (HGFA) and HGFA inhibitor type 1 (HAI-1) Hum Cell 14 2001 83 93
105. H. Kataoka, S. Miyata, S. Uchinokura, and H. Itoh Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor Cancer Metastasis Rev 22 2003 223 236
106. M. Peek, P. Moran, N. Mendoza, D. Wickramasinghe, and D. Kirchhofer Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor Xia J Biol Chem 277 2002 47804 47809
107. A. Petrelli, G.F. Gilestro, S. Lanzardo, P.M. Comoglio, N. Migone, and S. Giordano The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met Nature 416 2002 187 190
108. J. Copp, M. Marino, M. Banerjee, P. Ghosh, and P. van der Geer Multiple regions of internalin B contribute to its ability to turn on the Ras-mitogen-activated protein kinase pathway J Biol Chem 278 2003 7783 7789
109. C.Y. Lin, J.K. Wang, J. Torri, L. Dou, A. Sang, and R.M. Dickson Characcterization of a novel membranme bound 80 kDa matrix degrading protease from human breast cancer cells J Biol Chem 272 1997 9147 9152
110. C.Y. Lin, J. Anders, M. Johnson, and R.M. Dickson Purification and characterization of a complex containing matriptase and a Kunitz-type serine serine protease inhibitor from human milk J Biol Chem 274 1999 18237 18242
111. C.Y. Lin, J. Anders, M. Johnson, Q.A. Sang, and R.B. Dickson Molecular cloning of cDNA for matriptase, a matriz-degrading serine protease with trypson-like activity J Biol Chem 274 1999 18231 18236
112. S.L. Lee, R.B. Dickson, and C.Y. Lin Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease J Biol Chem 275 2000 36720 36725
113. Y. Zhang, X. Cai, B. Schlegelberger, and S. Zheng Assignment of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24 to q25 by in situ hydridization Cytogenet Cell Genet 83 1998 56 57
114. H. Tanimoto, L.J. Underwood, Y. Wang, K. Shigemasa, T.H. Parmley, and T.J. O'Brien Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention Tumour Biol 22 2001 104 114
115. E.G. Cho, M.G. Kim, and S.R. Kim N-terminal processing is essential for release of epithin, a mouse type-II membrane serine protease J Biol Chem 276 2001 44581 44589
116. N. Yamaguchi, A. Okui, T. Yamada, H. Kakazato, and S. Mitsui Spinesin/TMPRSS5, a novel transmembrane serine protease cloned from human spnal cord J Biol Chem 277 2002 6806 6812
117. T. Tacheuchi, J.L. Harris, W. Huang, K.W. Yan, S.R. Coughlin, and C.S. Craik Cellular localization of membrane type serine protease-1 and identification of protease activated receptor-2 and single chain urokinase type plasminogen activator as substrate J Biol Chem 275 2000 26333 26342
118. G. Velasco, S. Cal, V. Quesada, L.M. Sanchez, and C. Lopez-Otin Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins J Biol Chem 277 2002 37637 37646
119. J.D. Hooper, L. Camagnolo, G. Goodarzi, T.N. Truong, H. Stuhlmann, and J.P. Wuigley Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues Biochemistry 373 42 2003 689 702
120. W.G. Jiang, M.B. Hallett, and M.C.A. Puntis Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastases Br J Surg 80 1993 1368 1373
121. K. List, C.C. Haudenschild, and R. Szabo Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier functioin, hair follicle development and thymic homeostasis Oncogene 21 2002 3765 3779
122. C. Benaud, R.B. Dickson, and C.Y. Lin Regulation of the activity of matriptase to epitheial cell surfaces by a blood derived factor Eur J Biochem 268 2001 1439 1447
123. C. Benaud, M. Oberst, J.P. Hobson, S. Spegel, R.B. Dickson, and C.Y. Lin Sphinegosine-1-phosphate, present in serum-derived lipoproteins, activates matriptase J Biol Chem 277 2002 10539 10546
124. C. Parr, and W.G. Jiang Hepatocyte growth factor/scatter factor, its activators, inhibitors and antagonists Histol Histopathol 16 2001 251 268
125. J.K. Kang, M. Dollard-Filhart, and I.T. Ocal Tissue microarray analysis of hepatocyte growth factor/met pathway components reveals a role for MET, matriptase, and hepatocyte growth factor activator inhbitor-1 in the progressin of node-negative breast cancer Cancer Res 63 2003 1101 1105
126. J. Sun, J. Pons, and C.S. Craik Potent and selective inhibition of membrane-type serine protease-1 by human single-chain antibodies Biochemistry 42 2003 892 900
127. H. Itoh, and H. Kataoka Roles of hepatocyte growth factor activator (HGFA) and its inhibitor HAI-1 in the regeneration of injured gastrointestinal mucosa J Gasteroenterol 37 2002 15 21
128. J. Cruz, J.S. Reis-Filho, P. Silva, and J.M. Lopes Expression of c-met tyrosine kinase receptor is biologically and prognostically relevant for primary cutaneous malignant melanomas Oncology 65 2003 72 82
129. O. Kollet, S. Shivtiel, and Y.Q. Chen HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34(+) stem cell recruitment to the liver J Clin Invest 112 2003 160 169
130. G. Giannini, and J. Noel Constitutive hepatocyte growth factor-receptor (HGF R)/Met tyrosine kinase activation is associated with cellular transformation independently of mutations within its tyrosine kinase and C-terminal domains Mol Biol Cell 13 2002 875
131. T. Nakatsuji A type of rat hepatosplenic gamma-delta (gamma delta) T-cell lymphoma developed after injections with hepatocyte growth factor (HGF) oligonucleotides, which was rejected by surviving syngeneic spleen graft Leuk Lymphoma 44 2003 175 181
132. H. Takayama, W.J. LaRochelle, and R. Sharp Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor Proc Natl Acad Sci USA 94 1997 701 706
133. N. Horiguchi, H. Takayama, and M. Toyoda Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine Oncogene 21 2002 1791 1799
134. T.J. Liang, A.E. Reid, R. Xavier, R.D. Cardiff, and T.C. Wang Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors J Clin Invest 97 1996 2872 2877
135. G. Shiota, H. Kawasaki, T. Nakamura, and E.V. Schmidt Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha Res Commun Mol Pathol Pharmacol 90 1995 17 24
136. K.A. Furge, D. Kiewlich, and P. Le Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase Proc Natl Acad Sci USA 98 2001 10722 10727
137. A. Lorenzato, M. Olivero, and S. Patane Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion Cancer Res 62 2002 7025 7030
138. M.M. Mueller, and N.E. Fusenig Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells Differentiation 70 2002 486 497
139. S. Verstovsek, H. Kantarjian, and E. Estey Plasma hepatocyte growth factor is a prognostic factor in patients with acute myeloid leukemia but not in patients with myelodysplastic syndrome Leukemia 15 2001 1165 1170
140. T. Nakamura, K. Matsumoto, A. Kiritoshi, Y. Tano, and T. Nakamura Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions Cancer Res 57 1997 3305 3313
141. T. Iwasaki, T. Hamano, A. Ogata, N. Hashimoto, M. Kitano, and E. Kakishita Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma Br J Haematol 116 2002 796 802
142. M.G. Alexandrakis, F.H. Passam, A. Sfiridaki, E. Kandidaki, P. Roussou, and D.S. Kyriakou Elevated serum concentration of hepatocyte growth factor in patients with multiple myeloma: correlation with markers of disease activity Am J Hematol 72 2003 229 233
143. F. Nayeri, L. Brudin, I. Nilsson, and P. Forsberg Sample handling and stability of hepatocyte growth factor in blood samples Cytokine 19 2002 201 205
144. H. Yamagamim, M. Moriyama, and H. Matsumura Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases Cancer 95 2002 824 834
145. R.L. Woodbury, S.M. Varnum, and R.C. Zanegar Elevated HGF levels in sera from breast cancer patients detected using a protein microarray ELISA J Proteome Res 1 2002 233 237
146. R. Greenberg, I. Schwartz, Y. Skornick, and O. Kaplan Detection of hepatocyte growth factor/scatter factor receptor (c-Met) in axillary drainage after operations for breast cancer using reverse transcriptase-polymerase chain reaction Breast Cancer Res 5 2003 R71 R76
147. K. Takeuchi, and F. Ito Protective action of HGF/SF against adriamycin-induced apoptosis Mol Biol Cell 13 2002 2422
148. K. Date, K. Matsumoto, and H. Shimura HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocye growth factor FEBS Lett 420 1997 1 6
149. K. Matsumoto, H. Kataoka, K. Date, and T. Nakamura Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses J Biol Chem 273 1998 21920 22913
150. S. Hiscox, C. Parr, K. Matsumot, T. Nakamura, R.E. Mansel, and W.G. Jiang NK4, a HGF/SF variant, inhibits in vitro invasiveness of breast cancer cells Breast Cancer Res Treat 59 2000 245 254
151. K. Date, K. Matsumoto, K. Kuba, H. Shimura, M. Tanaka, and T. Nakamura Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor Oncogene 17 1998 3045 3054
152. C. Parr, S. Hiscox, J. Cai, K. Matsumoto, T. Nakamura, and W.G. Jiang Inhibition of HGF/SF and fibroblasts induced motility and invasion of colorectal cancer cells by NK4, a new HGF antagonist Int J Cancer 85 2000 563 570
153. C. Parr, G. Davies, T. Nakamura, K. Matsumoto, M.D. Mason, and W.G. Jiang A HGF/SF antagonist, NK4, regulates matrix-adhesion and paxillin phosphorylation in prostate cancer cells Biochem Biophys Res Commun 285 2001 1330 1337
154. M.A. Brockmann, A. Papadimitriou, M. Brandt, R. Fillbrandt, M. Westphal, and K. Lamszus Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4 Clin Cancer Res 9 2003 4578 4585
155. N. Maehara, K. Matsumoto, K. Kuba, K. Mizumoto, M. Tanaka, and T. Nakamura NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells Br J Cancer 84 2001 864 873
156. S. Hirao, Y. Yamada, and F. Koyama Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas Cancer Gene Ther 9 2002 700 707
157. K. Kuba, K. Matsumoto, K. Date, H. Shimura, M. Tanaka, and T. Nakamura HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice Cancer Res 60 2000 6737 6743
158. K. Kuba, K. Matsumoto, K. Ohnishi, T. Shiratsuchi, M. Tanaka, and T. Nakamura Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells Biochem Biophys Res Commun 279 2000 846 852
159. W.G. Jiang, S. Hiscox, and J. Cai Antagonistic effects of NK4, an novel HGF variant, on the in vitro angiogenesis of human vascular endothelial cells Clin Cancer Res 5 1999 3695 3703
160. T.A. Martin, R.E. Mansel, and W.G. Jiang Antagonistic effect of NK4 on HGF/SF induced changes in the transendothelial resistance (TER) and paracellular permeability of human vascular endothelial cells J Cell Physiol 192 2002 268 275
161. M. Maemondo, K. Narumi, and Y. Saijo Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy Mol Ther 5 2002 177 185
162. D.A. Heideman, V.W. Van Beusechem, and E. Bloemena Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4 J Gene Med 6 2004 317 327
163. T. Kikuchi, M. Maemondo, K. Narumi, K. Matsumoto, T. Nakamura, and T. Nukiwa Tumor suppression induced by intratumor administration ofadenovirus vector expressing NK4, a 4-kringle antagonist ofhepatocyte growth factor, and naive dendritic cells Blood 100 2002 3950 3959
164. N. Maehara, E. Nagai, and K. Mizumoto Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer Clin Exp Metastasis 19 2002 417 426
165. D. Tomioka, N. Maehara, and K. Kuba Inhibition of growth, invasion, and
166. M. Saimura, E. Nagai, and K. Mizumoto Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice Cancer Gene Ther 9 2002 799 806
167. K. Matsumoto, and T. Nakamura NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics Cancer Sci 94 2003 321 327
168. T. Manabe, K. Mizumoto, and E. Nagai Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet Clin Cancer Res 9 2003 3158 3166
169. T.A. Martin, C. Parr, and G. Davies Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist Carcinogenesis 24 2003 1317 1323
170. N. Murakami, K. Koufuji, and K. Shirouzu Influence of hepatocyte growth factor secreted from fibroblasts on the growth and invasion of scirrhous gastric cancer Int Surg 86 2001 151 157
171. J. Wen, K. Matsumoto, N. Taniura, D. Tomioka, and T. Nakamura Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice Cancer Gene Ther 11 2004 419 430
172. G. Davies, M.D. Mason, T.A. Martin, C. Parr, G. Watkins, and J. Lane NK4, an HGF/SF antagonist, inhibit HGF/SF and HGF/SF-producing fibroblasts induced prostate cancer growth in vivo Int J Cancer 106 2003 348 354
173. E.B. Carson-Walter, D.N. Watkins, A. Nanda, B. Vogelstein, K.W. Kinzler, and B. St. Croix Cell surface tumor endothelial markers are conserved in mice and humans Cancer Res 61 2001 6649 6655
174. G. Davies, M.D. Mason, R.E. Mansel, and W.G. Jiang Expression of tumour-endothelial markers in human breast cancer Clin Exp Metastasis 21 2004 31 37
175. K. Matsumoto, H. Yoshitomi, J. Rossant, and K.S. Zaret Liver organogenesis promoted by endothelial cells prior to vascular function Science 294 2001 559 563
176. C. Saucier, H. Khoury, and K.M. Lai The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis Proc Natl Acad Sci USA 101 8 2004 2345 2350
177. M. Nakabayashi, R. Morishita, and H. Nakagami HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model Diabetology 46 2003 115 123
178. Y. Saga, H. Mizukami, and M. Suzuki Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival Gene Ther 8 2001 1450 1455
179. T.A. Martin, K.G. Harding, and W.G. Jiang Regulation of angiogenesis and endothelial cell motility by matrix-bound fibroblasts Angiogenesis 3 1999 69 76
180. J.G. Christensen, R. Schreck, and J. Burrows A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo Cancer Res 63 2003 7345 7355
181. M. Sattler, Y.B. Pride, and P. Ma A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase Cancer Res 63 2003 5462 5469
182. A. Morotti, S. Mila, P. Accornero, E. Tagliabue, and C. Ponzetto K252a inhibits the oncogenic properties of Met, the HGF receptor Oncogene 21 2002 4885 4893
183. C.P. Webb, C.D. Hose, and S. Koochekpour The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-Met-urokinase plasminogen activator-plasmin proteolytic network Cancer Res 60 2000 342 349
184. Y. Uehara, Y. Murakami, S. Muzuno, and S. Kawai Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A Virology 164 1988 294 298
185. K. Ohashi, K. Nagata, M. Maekawa, T. Ishizaki, S. Narumiya, and K. Mizuno Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop J Biol Chem 275 2000 3577 3582
186. L. Whitesell, E.G. Mimnaugh, B. De Costa, M.P. Myers, and L.M. Neckers Inhibition of heat shock protein Hsp90-pp60-v-src heteroprotein complex formation by benzoquinone anisamycins: essesntial role for stress proteins in oncogenic transformation Proc Natl Acad Sci USA 91 1994 8324 8328
187. P.C. Ma, G. Maulik, J. Christensen, and R. Salgia c-Met: structure, functions and potential for therapeutic inhibition Cancer Metastasis Rev 22 2003 309 325
188. W.G. Jiang, M.C.A. Puntis, and M.B. Hallett Monocyte conditioned media possess a novel factor which increases motility of cancer cells Int J Cancer 53 1993 426 431
189. O. Nakagawa, K. Fujisawa, T. Ishizaki, Y. Saito, K. Nakao, and S. Narumiya ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice FEBS Lett 392 1996 189 193
190. K. Fujisawa, A. Fujita, T. Ishizaki, Y. Saito, and S. Narumiya Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase J Biol Chem 271 1996 23022 23028
191. E. Sahai, and C.J. Marshall Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis Nat Cell Biol 5 2003 711 719
192. R. Dvorsky, L. Blumenstein, I.R. Vetter, and M.R. Ahmadian Structural insights into the interaction of ROCKI with the switch regions of RhoA J Biol Chem 279 2004 7098 7104
193. C. Tran Quang, A. Gautreau, M. Arpin, and R. Treisman Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes EMBO J 19 2000 4565 4576
194. G. Pawlak, and D.M. Helfman MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway J Biol Chem 277 2002 26927 26933
195. E. Sahai, and C.J. Marshall ROCK and Dia have opposing effects on adherens junctions downstream of Rho Nat Cell Biol 4 2002 408 415
196. T. Kamai, T. Tsujii, and K. Arai Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer Clin Cancer Res 9 2003 2632 2641
197. M. Nakajima, K. Hayashi, and Y. Egi Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma Cancer Chemother Pharmacol 52 2003 319 324
198. M. Nakajima, K. Hayashi, and K. Katayama Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions Eur J Pharmacol 459 2003 113 120
199. A.V. Somlyo, C. Phelps, and C. Dipierro Rho kinase and matrix metalloproteinase inhibitors cooperate toinhibit angiogenesis and growth of human prostate cancer xenotransplants FASEB J 17 2003 223 243
200. M. Nakajima, K. Katayama, and I. Tamechika Wf-536 inhibits metastatic invasion by enhancing the host cell barrier and inhibiting tumour cell motility Clin Exp Pharmacol Physiol 30 2003 457 463
201. F. Imamura, M. Mukai, M. Ayaki, and H. Akedo Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal adhesion and focal adhesion kinase Jpn J Cancer Res 91 2000 811 816
202. R. McMullan, S. Lax, and V.H. Robertson Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway Curr Biol 13 2003 2185 2189
203. H. Honing, T.K. Van Den Berg, and S.M. Van Der Pol RhoA activation promotes transendothelial migration of monocytes via ROCK J Leukoc Biol 75 2004 523 528
204. G. Totsukawa, Y. Wu, and Y. Sasaki Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts J Cell Biol 164 2004 427 439
205. K.K. Svoboda, P. Moessner, T. Field, and J. Acevedo ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium Dev Dyn 229 2004 579 590
206. S. Abiru, K. Nakao, and T. Ichikawa Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells Hepatology 35 2002 1117 1124
207. K. Takami, N. Takuwa, and H. Okazaki Interferon-gamma inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells upregulation of p27(kip1) cyclin-dependent kinase inhibitor Am J Resp Cell Mol Biol 26 2002 231 238
208. S. Sengupta, L.A. Sellers, and R.C. Li Fan TPD Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growthfactor/scatter factor-induced angiogenesis Circulation 107 2003 2955 2961
209. M. Ozaki, S. Haga, H.Q. Zhang, K. Irani, and S. Suzuki Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic siqnaling: role of P13-K and Akt kinase upon rac1 Cell Death Different 10 2003 508 515
210. L.X. Song, J. Turkson, J.G. Karras, R. Jove, and E.B. Haura Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells Oncogene 22 2003 4150 4165
211. Y. Ueoka, K. Kato, and N. Wake Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via ras mediated pathway Mol Cell Endocrinol 202 2003 81 88
212. F. Liu, Y.A. Su, B.L. Li, and B.H. Ni Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP(751) Exp Cell Res 287 2003 387 396
213. R.V. Hay, B. Cao, and R.S. Skinner Radioimmunoscintigraphy of tumors autocrine for human met and hepatocyte growth factor/scatter factor Mol Imaging 1 2002 56 62
214. R.V. Hay, B. Cao, and R.S. Skinner Radioimmunoscintigraphy of human Met-expressing tumor xenografts using Met3, a new monoclonal antibody Clin Cancer Res 9 2003 3839S 3844S
215. B. Cao, Y.L. Su, and M. Oskarsson Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models Proc Natl Acad Sci USA 98 2001 7443 7448
216. S. Yoshida, Y. Yamaguchi, and S. Itami Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation J Invest Dermatol 120 2003 335 345
217. W.G. Jiang, S. Hiscox, M.B. Hallett, D.F. Horrobin, R.E. Mansel, and M.C.A. Puntis Regulation of the expression of E-cadherin on human cancer cells by gamma linolenic acid Cancer Res 55 1995 5043 5048
218. N.D. Kim, B. Kaplan, and M. Gupta Chemopreventive and adhuvent therapeutic potential of pomegranate (Punica granatum) for human breast cancer Breast Cancer Res Treat 71 2002 203 217
219. S.B. Shappell, W.E. Boeglin, S.J. Olson, S. Kasper, and A.R. Brash 15-Lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma Am J Pathol 155 1999 235 245
220. X. Gao, A.T. Porter, and K.V. Honn Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer Therapeutic implications Adv Exp Med Biol 407 1997 41 53
221. D. Baatar, M.K. Jones, and R. Pai Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation Am J Pathol 160 2002 963 972
222. M. Takahashi, Y. Katayama, H. Takada, H. Kuwayama, and A. Terano The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts Aliment Pharmacol Ther 14 Suppl 1 2000 44 49
223. S. Sengupta, L.A. Sellers, and T. Cindrova ATCyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis Cancer Res 63 2003 8351 8359
224. R. Pai, T. Nakamura, W.S. Moon, and A.S. Tarnawski Prostaglandins promote colon cancer cell invasion, signaling by cross-talk between two distinct growth factor receptors FASEB J 17 2003 1640 1647
225. P. Netzer, F. Halter, and T.Y. Ma Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing Digestion 67 2003 118 128
226. S.L. Ding, T. Merkulova-Rainon, Z.C. Han, and G. Tobelem HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis Blood 101 2003 4816 4822
227. X.H. Xin, S.Y. Yang, and G. Ingle Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo Am J Pathol 158 2001 1111 1120
228. N. Wajih, and D.C. Sane Angiostatin selectively inhibits signaling by hepatocyte growth factor in endothelial and smooth muscle cells Blood 101 2003 1857 1863
229. K. Neben, T. Moehler, and A. Kraemer Response to thalidomide in progressive multiple myeloma is not mediated by inhibition of angiogenic cytokine secretion Br J Haematol 115 2001 605 608
230. I.J. Fidler, and L.M. Ellis The implications of angiogenesis for the biology and therapy of cancer metastasis Cell 79 1994 185 188
231. H.P. Gerber Anti-angiogenesis: biology is the foundation for therapy Drug Discov Today 8 2003 344 346
232. J. Folkman Angiogenesis inhibitors: a new class of drugs Cancer Biol Ther 2 2003 S127 S133
233. I.J. Fidler Critical determinants of cancer metastasis: rationale for therapy Cancer Chemother Pharmacol 43 Suppl 1999 3 10
234. J. Folkman Role of angiogenesis in tumor growth and metastasis Semin Oncol 29 2002 15 18
235. R.S. Muraoka, S.E. Waltz, and S.J. Degen Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3′,5′-monophosphate response element-binding protein (CREB)-binding protein (CBP) Endocrinology 140 1999 187 196
236. N. Chattopadhyay, R.R. Butters, and E.M. Brown Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells Brain Res Mol Brain Res 87 2001 100 108
237. E. Bertrand, R. Pictet, and T. Grange Can hammerhead ribozymes be efficient tools to inactivate gene function? Nucl Acid Res 22 1994 292 300
238. R.A. Montgomery, and H.C. Dietz Inhibition of fibrillin expression using U1 snRNA as a vehicle for the presentation of antisense targeting sequence Hum Mol Genet 6 1997 519 525
239. R. Abounader, B. Lal, and C. Luddy In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis FASEB J 15 2001 U22 U37
240. W.G. Jiang, D. Grimshaw, J. Leterra, R. Abounader, J. Lane, and R.E. Mansel Supression of invasiveness and cellular motility of breast cancer cells by a hammerhead ribozyme encoding cMET antisense Clin Cancer Res 7 2001 2555 2562
241. G. Davies, M.D. Mason, and W.G. Jiang Targeting HGF receptor, cMET, using hammerhead ribozyme transgenes in human prostate cancer Prostate 60 2004 317 324
242. M.H. Herynk, O. Stoeltzing, and N. Reinmuth Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells Cancer Res 63 2003 2990 2996
243. R. Abounader, B. Lal, and C. Luddy In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis FASEB J 16 2002 108 110
244. S.J. Kim, M. Johnson, K. Koterba, M.H. Herynk, H. Uehara, and G.E. Gallick Reduced c-Met expression by an adenovirus expressing a c-Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model Clin Cancer Res 9 2003 5161 5170
245. W.G. Jiang, D. Grimshaw, and T.A. Martin Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET Clin Cancer Res 9 2003 4274 4281
246. L.P. Stabile, J.S. Lyker, L. Huang, and J.M. Siegfried Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy Gene Ther 11 2004 324 335
247. S.C. Presnell, M.J. Hooth, K.M. Borchert, W.B. Coleman, J.W. Grisham, and G.J. Smith Establishment of a functional HGF/C-MET autocrine loop in spontaneous transformants of WB-F344 rat liver stem-like cells Hepatology 28 1998 1253 1259
248. S. Kitamura, S. Kondo, and Y. Shinomura Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers Br J Cancer 83 2000 668 673
249. M. Kaji, Y. Yonemura, S. Harada, X. Liu, I. Terada, and H. Yamamoto Participation of c-met in the progression of human gastric cancers: anti-c-met oligonucleotides inhibit proliferation or invasiveness of gastric cancer cells Cancer Gene Ther 3 1996 393 404
250. N.M. Dean, and C.F. Bennett Antisense oligonucleotide-based therapeutics for cancer Oncogene 22 2003 9087 9096
251. F. Pastorino, D. Stuart, M. Ponzoni, and T.M. Allen Targeted delivery of antisense oligonucleotides in cancer J Control Release 74 2001 69 75
252. T. Shimomura, K. Denda, and A. Kitamura Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor J Biol Chem 272 1997 6370 6376
253. T. Kawaguchi, L. Qin, and T. Shimomura Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor J Biol Chem 272 1997 27558 27564
254. L. Qin, K. Denda, T. Shimomura, T. Kawaguchi, and N. Kitamura Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2 FEBS Lett 436 1998 111 114
255. K. Nagata, S. Hirono, and A. Ido Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma Biochem Biophys Res Commun 289 2001 205 211
256. D. Kirchhofer, M. Peek, and W. Li Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator Inhibitor-1B (HAI-1B), a new splice variant of HAI-1 J Biol Chem 278 2003 36341 36349
257. R. Hamasuna, H. Kataoka, and J.Y. Meng Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI-21PB in glioblastoma cells In J Cancer 93 2001 339 345
258. M. Suzuki, H. Kobayashi, and N. Kanayama Inhibition of tumor invasion by genomic downregulation of matriptase through suppression of activation of receptor-bound pro-urokinase J Biol Chem. 279 2004 14899 148908
259. S. Radaeva, B. Jaruga, and F. Hong Interferon-alpha activates multiple STAT signals and downregulates c-Met in primary human hepatocytes Gastroenterology 122 2002 1020 1034
260. A. Uchiyama, R. Essner, and F. Doi Interleukin 4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinomas J Cell Biochem 62 1996 443 453
261. S. Hiscox, M.C.A. Puntis, M.B. Hallett, and W.G. Jiang Inhibition of motility and invasion of human colon cancer cells by interleukin-12 Clin Expl Metastasis 13 1995 396 404
262. R.R. Oh, J.Y. Park, and J.H. Lee Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas APMIS 110 2002 229 238
263. S.C. Clifford, K. Czapla, F.M. Richards, D.J. O'Donoghue, and E.R. Maher Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of c-myc, c-fos, c-met, VEGF and the VHL tumour-suppressor and related genes Br J Cancer 77 1998 1420 1428
264. S. Koochekpour, M. Jeffers, and P.H. Wang The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells Mol Cell Biol 1999 5902 5912
265. T.E.I. Taher, E.P.M. Tjin, E.A. Beuling, J. Borst, M. Spaargaren, and S.T. Pals c-Cbl is involved in met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination J Immunol 169 2002 3793 3800
266. J. Lai, J. Chien, and J. Staub Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer J Biol Chem 278 2003 23107 23117
267. J.P. Lai, J. Chien, and S.E. Strome HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma Oncogene 23 2004 1439 1447
268. G. Shiota, H. Kawasaki, T. Nakamura, and E.V. Schmidt Inhibitory effect of hepatocyte growth factor on metastasis of hepatocellular carcinoma in transgenic mice Res Commun Mol Pathol Pharmacol 91 1996 33 39
269. S. Crouch, C.S. Spidel, and J.S. Lindsey HGF and ligation of alphavbeta5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering Exp Cell Res 292 2004 274 287
270. I. Hardan, L. Weiss, and R. Hershkoviz Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics Int J Cancer 55 1993 123 128
271. T.N. Yoganathan, P. Costello, and X. Chen Integrin-linked kinase (ILK): a "hot" therapeutic target Biochem Pharmacol 60 2000 1115 1119
272. E. Ruoslahti Integrins as signaling molecules and targets for tumor therapy Kidney Int 51 1997 1413 1417
273. W. Su, D.H. Gutmann, A. Perry, R. Abounader, J. Laterra, and L.S. Sherman CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro Glia 45 2004 297 306
274. Y. Guo, J. Ma, and J. Wang Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody Cancer Res 54 1994 1561 1565
275. S. Goodison, V. Urquidi, and D. Tarin CD44 cell adhesion molecules Mol Pathol 52 1999 189 196
276. W.G. Jiang, R.P. Bryce, D.F. Horrobin, and R.E. Mansel Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids Biochem Biophys Res Commun 244 1998 414 420
277. A. Isoai, Y. Giga-Hama, K. Shinkai, M. Mukai, H. Akedo, and H. Kumagai Tumor invasion-inhibiting factor 2: primary structure and inhibitory effect on invasion in vitro and pulmonary metastasis of tumor cells Cancer Res 52 1992 1422 1426
278. V.J. Uitto, J.D. Firth, L. Nip, and L.M. Golub Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes Ann N Y Acad Sci 732 1994 140 151
279. R. Greenwald, and L. Golub Biologic properties of non-antibiotic, chemically modified tetracyclines (CMTs): a structured, annotated bibliography Curr Med Chem 8 3 2001 237 242
280. R.E. Seftor, E.A. Seftor, and J.E. De Larco Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis Clin Exp Metastasis 16 1998 217 225
281. R.S. Fife, G.W. Sledge Jr., S. Sissons, and B. Zerler Effects of tetracyclines on angiogenesis in vitro Cancer Lett 153 2000 75 78
282. M.A. Rudek, J. Venitz, Y. Ando, E. Reed, J.M. Pluda, and W.D. Figg Factors involved in the pharmacokinetics of COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer: clinical and experimental studies J Clin Pharmacol 43 2003 1124 1135
283. B.L. Lokeshwar, H.L. Houston-Clark, M.G. Selzer, N.L. Block, and L.M. Golub Potential application of a chemically modified non-antimicrobial tetracycline (CMT-3) against metastatic prostate cancer Adv Dent Res 12 1998 97 102
284. M.G. Selzer, B. Zhu, N.L. Block, and B.L. Lokeshwar CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer Ann N Y Acad Sci 878 1999 678 682
285. B.L. Lokeshwar, M.G. Selzer, B.Q. Zhu, N.L. Block, and L.M. Golub Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model Int J Cancer 98 2002 297 309
286. B.L. Lokeshwar, E. Escatel, and B. Zhu Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3) Curr Med Chem 8 2001 271 279
287. Q.H. Meng, J.W. Xu, I.D. Goldberg, E.M. Rosen, R.A. Greenwald, and S.J. Fan Influence of chemically modified tetracyclines on proliferation, invasion and migration properties of MDA-MB-468 human breast cancer cells Clin Exp Metastasis 18 2000 139 146
288. S. Spiegel, and R. Kolesnick Sphingosine 1-phosphate as a therapeutic agent Leukemia 16 2002 1596 1602
289. C.M. Benaud, M. Oberst, R.B. Dickson, and C.Y. Lin Deregulated activation of matriptase in breast cancer cells Clin Exp Metastasis 19 2002 639 649
290. H. Ikeda, H. Satoh, and M. Yanase Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5 Gastroenterology 124 2003 459 469
291. Y. Sadahira, F. Ruan, S. Hakomori, and Y. Igarashi Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness Proc Natl Acad Sci USA 89 1992 9686 9690
292. S. Hyuga, N. Kawasaki, and M. Hyuga Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met Int J Cancer 94 2001 328 334
293. S. Yamamura, S. Hakomori, A. Wada, and Y. Igarashi Sphingosine-1- phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho Ann N Y Acad Sci 905 2000 301 307
294. Y. Sadahira, M. Zheng, F. Ruan, S. Hakomori, and Y. Igarashi Sphingosine-1-phosphate inhibits extracellular matrix protein-induced haptotactic motility but not adhesion of B16 mouse melanoma cells FEBS Lett 340 1994 99 103
295. V. De Ledinghen, A. Monvoisin, and V. Neaud Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells Int J Oncol 19 2001 83 88
296. S.G. Hillier, and F. Miro Inhibin, activin, and follistatin Potential roles in ovarian physiology Ann N Y Acad Sci 687 1993 29 38
297. C. Gonzalez-Manchon, and W. Vale Activin-A, inhibin and transforming growth factor-beta modulate growth of two gonadal cell lines Endocrinology 125 1989 1666 1672
298. J.S. Jeruss, C.D. Sturgis, A.W. Rademaker, and T.K. Woodruff Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer Cancer Res 63 2003 3783 3790
299. S. Niimi, M. Hyuga, and H. Kazama TI Activins A, AB, and B inhibit hepatocyte growth factor synthesis by MRC-5 human lung fibroblasts Biol Pham Bull 25 2002 1405 1408
300. M. Furue, and S. Saito Hepatocyte growth factor regulates activin betaA mRNA in submandibular gland In Vitro Cell Dev Biol Anim 34 1998 520 523
301. K. Tamama, H. Sumino, and S. Ichikawa Hormone replacement therapy causes a decrease in hepatocyte growth factor in hypertensive women J Hypertens 21 2003 1151 1156
302. Y. Liu, L. Lin, and R. Zarnegar Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary Mol Cell Endocrinol 104 1994 173 181
303. J.G. Jiang, A. Bell, Y. Liu, and R. Zarnegar Transcriptional regulation of the hepatocyte growth factor gene by the nuclear receptors chicken ovalbumin upstream promoter transcription factor and estrogen receptor J Biol Chem 272 1997 3928 3934
304. J.A. Parrott, and M.K. Skinner Developmental and hormonal regulation of hepatocyte growth factor expression and action in the bovine ovarian follicle Biol Reprod 59 1998 553 560
305. M. Jeffers, G.A. Taylor, K.M. Weidner, S. Omura, and G.F. Vande Woude Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway Mol Cell Biol 17 1997 799 808
306. D.E. Hammond, S. Urbe, G.F. Vande Woude, and M.J. Clague Down-regulation of MET, the receptor for hepatocyte growth factor Oncogene 20 2001 2761 2770
307. C. Seidel, S. Lenhoff, and S. Brabrand Hepatocyte growth factor in myeloma patients treated with high-dose chemotherapy Br J Haematol 119 2002 672 676
308. T. Iwasaki, and H. Sano Predicting treatment responses and disease progression in myeloma using serum vascular endothelial growth factor and hepatocyte growth factor levels Leuk Lymphoma 44 2003 1347 1351
309. C. Jakob, C. Fleissner, I. Zavrski, U. Heider, K. Possinger, and O. Sezer Circulating hepatocyte growth factor levels in multiple myeloma Br J Haematol 121 2003 532
310. L.T. Hsiao, J.T. Lin, and I.T. Yu High serum hepatocyte growth factor level in patients with non-Hodgkin's lymphoma Eur J Haematol 70 2003 282 289
311. J. Dluzniewska, D. Zolich, J. Polanski, L. Zajac, D. Sitkiewicz, and B. Lukomska Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy Med Sci Monit 8 2002 CR690 CR696
312. K.P. de Jong, B.A. von Geusau, and C.A. Rottier Serum response of hepatocyte growth factor, insulin-like growth factor-I, interleukin-6, and acute phase proteins in patients with colorectal liver metastases treated with partial hepatectomy or cryosurgery J Hepatol 34 2001 422 427
313. K. Beppu, A. Uchiyama, and T. Morisaki Elevation of serum hepatocyte growth factor concentration in patients with gastric cancer is mediated by production from tumor tissue Anticancer Res 20 2B 2000 1263 1267
314. D. von Schweinitz, A. Faundez, and B. Teichmann Hepatocyte growth-factor-scatter factor can stimulate post-operative tumor-cell proliferation in childhood hepatoblastoma Int J Cancer 85 2000 151 159
315. R.H. Hu, P.H. Lee, S.C. Yu, J.C. Sheu, and M.Y. Lai Serum hepatocyte growth factor before and after resection for hepatocellular carcinoma Hepatogastroenterology 46 1999 1842 1847
316. M. Mabed, S. Aref, and D.A. Aladle Hepatocellular carcinoma of a short malignant transformation time in a patient with acute myeloblastic leukemia Ann Hematol 82 2003 318 320
317. K. Jankowski, M. Kucia, and M. Wysoczynski Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy Cancer Res 63 2003 7926 7935
318. A. Rasola, S. Anguissola, and N. Ferrero Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin Cancer Res 64 2004 1744 1750
319. A. Matsuki, S. Yamamoto, and H. Nakagami No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice Biochem Biophys Res Commun 315 2004 59 65
320. T. Nakatsuji A type of rat hepatosplenic gamma-delta (gammadalta) T-cell lymphoma developed after injections with hepatocyte growth factor (HGF) oligonucleotides, which was rejected by surviving syngeneic spleen graft Leuk Lymphoma 44 2003 175 181