Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion

Journal of Cell Science

Volumn 115, Issue 3, 2002, Pages 517-529

  Wiggan, O'Neil ^a   Fadel, Marc P ^a   Hamel, Paul A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

C met; Cell adhesion; Cell aggregation; Mesenchymal epithelial transition; Pax3

Indexed keywords

SCATTER FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX3; UNCLASSIFIED DRUG;

ARTICLE; CELL AGGREGATION; CELL MEMBRANE; CELL SHAPE; CELL SIZE; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOARCHITECTURE; DROSOPHILA; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MAMMAL; MESENCHYME CELL; MORPHOGENESIS; MOUSE; MULTIGENE FAMILY; NEURAL TUBE DEFECT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; TISSUE SPECIFICITY;

ACTINS; ADENOVIRIDAE; ANIMALS; CADHERINS; CELL AGGREGATION; CELL POLARITY; CELL SIZE; COS CELLS; CULTURE MEDIA, CONDITIONED; CYTOSKELETAL PROTEINS; CYTOSKELETON; DNA-BINDING PROTEINS; EPITHELIUM; GENES, REPORTER; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MESODERM; MICROTUBULES; OSTEOSARCOMA; PAIRED BOX TRANSCRIPTION FACTORS; PHENOTYPE; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS C-MET; RHABDOMYOSARCOMA; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0036472493     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3
2. A model for development and evolution of complex morphological structures
3. Analysis of the developmental effects of a lethal mutation in the house mouse
4. The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium
5. An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome
6. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
7. Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion
8. Scatter factor/hepatocyte growth factor (SF/HGF) induces emigration of myogenic cells at interlimb level in vivo
9. The formation of somite compartments in the avian embryo
10. Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation
11. Early stages of chick somite development
12. How is myogenesis initiated in the embryo?
13. Pax genes and organogenesis
14. Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse
15. Mesenchyme to epithelium transition during development of the mammalian kidney tubule
16. Molecular aspects of the epithelial phenotype
17. The role of SF/HGF and c-Met in the development of skeletal muscle
18. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
19. Pax3 modulates expression of the c-Met receptor during limb muscle development
20. Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor
21. A role for N-cadherin in the development of the differentiated osteoblastic phenotype
22. Persistent truncus arteriosus in the Splotch mutant mouse
23. The Splotch mutation interferes with muscle development in the limbs
24. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
25. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
26. Apiconuclear organization of microtubules does not specify protein delivery from the trans-Golgi network to different membrane domains in polarized epithelial cells
27. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex
28. An overview of epithelio-mesenchymal transformation
29. A simplified system for generating recombinant adenoviruses
30. Regulation and function of SF/HGF during migration of limb muscle precursor cells in chicken
31. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin
32. Cloning and expression analysis of a novel mesodermally expressed cadherin
33. Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS
34. Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos
35. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
36. Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
37. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue
38. Anomalies of neuroepithelial cell associations in the Splotch mutant embryo
39. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite
40. Evolution and role of Pax genes
41. Calreticulin modulates cell adhesiveness via regulation of vinculin expression
42. Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation
43. Scatter factor/hepatocyte growth factor is essential for liver development
44. Cadherin 11 expression marks the mesenchymal phenotype: Towards new functions for cadherins?
45. A role for wnts in morpho-genesis and tissue polarity
46. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
47. Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD
48. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene
49. Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs
50. Pax-2 controls multiple steps of urogenital development
51. A 135-kd membrane protein of intercellular adherens junctions
52. Pax: A murine multigene family of paired box-containing genes
53. 2-terminal truncated nitric-oxide synthase
54. Interaction of the pRB-family proteins with factors containing paired-like homeodomains
55. Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade
56. Abnormalities of neural tube formation in pre-spina bifida splotch-delayed mouse embryos
57. Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice
58. Cell-to-cell adherens junction formation and actin filament organization: Similarities and differences between non-polarized fibroblasts and polarized epithelial cells