Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer

Journal of Cellular and Molecular Medicine

Volumn 6, Issue 4, 2002, Pages 539-553

  Maulik, G ^a   Madhiwala, P ^a   Brooks, S ^a   Ma, P C ^a,b   Kijima, T ^a   Tibaldi, E V ^a   Schaefer, E ^c   Parmar, K ^a,d   Salgia, Ravi ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c Biosource International   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

c Met HGF; Cell motility; Geldanamycin; PI3 K; Signal transduction in lung cancer

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; BENZOQUINONE DERIVATIVE; CENP META PROTEIN, DROSOPHILA; CENP-META PROTEIN, DROSOPHILA; CHROMONE DERIVATIVE; DROSOPHILA PROTEIN; ENZYME INHIBITOR; GAB2 PROTEIN, HUMAN; GELDANAMYCIN; GROWTH PROMOTOR; MACROCYCLIC LACTAM; MICROTUBULE ASSOCIATED PROTEIN; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; QUINONE DERIVATIVE; SERINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROSINE;

ARTICLE; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CYTOSKELETON; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; LUNG TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMALL CELL CARCINOMA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BENZOQUINONES; CARCINOMA, SMALL CELL; CELL MOVEMENT; CELL SURVIVAL; CHROMONES; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; ENZYME INHIBITORS; GROWTH SUBSTANCES; HUMANS; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; MORPHOLINES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; QUINONES; SERINE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0037686249     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2002.tb00453.x     Document Type: Article

References (42)

1. Maulik G., Kijima T., Ma P.C., Ghosh S.K., Lin J., Shapiro G.I., Schaefer E., Tibaldi E., Johnson B.E., and Salgia R., Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer, Clin. Cancer Res., 8: 620-627, 2002
2. Salgia R., Skarin, A.T., Molecular abnormalities in lung cancer, J. Clin. Oncol., 16: 1207-1217, 1998.
3. Wang W.L., Healy M.E., Sattler M., Verma S., Lin J., Maulik G., Stiles C.D., Griffin J.D., Johnson B.E., Salgia R., Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571, Oncogene, 19: 3521-3528, 2000
4. B.E. J., Phase II study of ST571 (Gleevec) for patients with small cell lung cancer, Thirty Eight Annual Meeting of American Society of Clinical Oncology, Orlando, Florida, May 20, 2002, pp. 293a
5. To C.T. Tsao M.S., The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review), Oncol. Rep., 5: 1013-1024, 1998
6. Faletto D.L., Tsarfaty I., Kmiecik T.E., Gonzatti M., Suzuki T., Vande Woude G.F., Evidence for non-covalent clusters of the c-met proto-oncogene product, Oncogene, 7: 1149-1157, 1992
7. Schmidt L., Junker K., Weirich G., Glenn G., Choyke P., Lubensky I., Zhuang Z., Jeffers M., Vande Woude G., Neumann H., Walther M., Linehan W.M., Zbar B., Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene, Cancer Res., 58: 1719-1722, 1998
8. Stella M.C. Comoglio P.M., HGF: a multifunctional growth factor controlling cell scattering, Int. J. Biochem. Cell. Biol., 31: 1357-1362, 1999.
9. Ueno H., Honda H., Nakamoto T., Yamagata T., Sasaki K., Miyagawa K., Mitani K., Yazaki Y., Hirai H., The phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase, Oncogene, 14: 3067-3072, 1997
10. Kubota Y., Angelotti T., Niederfellner G., Herbst R., Ullrich A., Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases, Cell. Growth Differ., 9: 247-256, 1998
11. Kennedy S.G., Wagner A.J., Conzen S.D., Jordan J., Bellacosa A., Tsichlis P.N., Hay N., The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal, Genes Dev., 11: 701-713, 1997
12. Moore S.M., Rintoul R.C., Walker T.R., Chilvers E.R., Haslett C., Sethi T., The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway, Cancer Res., 58: 5239-5247, 1998
13. Rameh L.E., Cantley L.C., The role of phosphoinositide 3-kinase lipid products in cell function, J. Biol. Chem., 274: 8347-8350, 1999
14. Berrie C.P., Phosphoinositide 3-kinase inhibition in cancer treatment, Expert Opin. Investig. Drugs, 10: 1085-1098, 2001
15. Guo M., Joiakim A., Reiners, J.J. Jr., Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), Biochem. Pharmacol., 60: 635-642, 2000
16. Maulik G., Shrikhande A., Kijima T., Ma P.C., Morrison P.T., Salgia R., Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition, Cytokine Growth Factor Rev., 13: 41-59, 2002
17. Olivero M., Rizzo M., Madeddu R., Casadio C., Pennacchietti S., Nicotra M.R., Prat M., Maggi G., Arena N., Natali P.G., Comoglio P.M., Di Renzo M.F., Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas, Br. J. Cancer, 74: 1862-1868, 1996
18. Ichimura E., Maeshima A., Nakajima T., Nakamura T., Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance, Jpn. J. Cancer Res., 87: 1063-1069, 1996
19. Rygaard K., Nakamura T., Spang-Thomsen M., Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts, Br. J. Cancer, 67: 37-46, 1993
20. Wybenga-Groot L.E., Baskin B., Ong S.H., Tong J., Pawson T., Sicheri F., Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region, Cell, 106: 745-757, 2001
21. Baxter R.M., Secrist J.P., Vaillancourt R.R., Kazlauskas A., Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events, J. Biol. Chem., 273: 17050-17055, 1998
22. Irusta P.M., DiMaio D., A single amino acid substitution in a WW-like domain of diverse tyrosine kinases causes constitutive receptor activation, Embo. J., 17: 6912-6923, 1998
23. Nakao M., Yokota S., Iwai T., Kaneko H., Horiike S., Kashima K., Sonoda Y., Fujimoto T., Misawa S., Internal tandem duplication of the flt3 gene found in acute myeloid leukemia, Leukemia, 10: 1911-1918, 1996
24. Yokota S., Kiyoi H., Nakao M., Iwai T., Misawa S., Okuda T., Sonoda Y., Abe T., Kahsima K., Matsuo Y., Naoe T., Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines, Leukemia, 11: 1605-1609, 1997
25. Hayakawa F., Towatari M., Kiyoi H., Tanimoto M., Kitamura T., Saito H., Naoe, T., Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines, Oncogene, 19: 624-631, 2000
26. Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C., Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments], Nature, 376: 768-771, 1995.
27. Nobes C.D., Hall A., Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility, Biochem. Soc. Trans., 23: 456-459, 1995
28. Nobes C.D., Hall A., Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81: 53-62, 1995
29. Derman M.P., Cunha M.J., Barros E.J., Nigam S.K., Cantley L.G., HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase, Am. J. Physiol., 268: F1211-1217, 1995
30. Derman M.P., Chen J.Y., Spokes K.C., Songyang Z., Cantley L.G., An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase C, J. Biol. Chem., 271: 4251-4255, 1996
31. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., Hall A., The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, 70: 401-410, 1992
32. Ridley A.J., Hall A., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70: 389-399, 1992
33. Ridley A.J., Comoglio P.M., Hall A., Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells, Mol. Cell. Biol., 15: 1110-1122, 1995
34. Graziani A., Gramaglia D., dalla Zonca P., Comoglio P.M., Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger, J. Biol. Chem., 268: 9165-9168, 1993
35. Itoh M., Yoshida Y., Nishida K., Narimatsu M., Hibi M., Hirano T., Role of Gab1 in heart, placenta, and skin development and growth factor and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation, Mol. Cell. Biol., 20: 3695-3704, 2000
36. Gu H., Saito K., Klaman L.D., Shen J., Fleming T., Wang Y., Pratt J.C., Lin G., Lim B., Kinet J.P., Neel B.C., Essential role for Gab2 in the allergic response, Nature, 412: 186-190, 2001
37. Zhang S., Broxmeyer H.E., Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase, Biochem. Biophys. Res. Commun., 277: 195-199, 2000
38. Yamasaki S., Nishida K., Hibi M., Sakuma M., Shiina R., Takeuchi A., Ohnishi H., Hirano T., Saito T., Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules, J. Biol. Chem., 276: 45175-45183, 2001
39. Neckers L., Schulte T., Mimnaugh E., Geldanamycin as a potential anti-cancer agent: Its molecular target and biochemical activity, Invest. New Drugs, 17: 361-373, 1999
40. An W.G., Schulte T.W., Neckers L.M., The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome [In Process Citation], Cell Growth Differ., 11: 355-360, 2000
41. Tamura Y., Peng P., Liu K., Daou M., Srivastava P., Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations, Science, 278: 117-120, 1997
42. Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., Stevenson M.A., Calderwood S.K., Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4, J. Biol. Chem., 277: 15028-15034, 2002