Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing

Digestion

Volumn 67, Issue 3, 2003, Pages 118-128

  Netzer, Peter ^a,b,d   Halter, Fred ^a   Ma, Thomas Y ^a   Hoa, Neil ^a   Nguyen, Nathan ^a   Nakamura, Toshikazu ^c   Tarnawski, Andrzej S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cyclooxygenase 2; Gastric epithelium; Hepatocyte growth factor; Non steroidal anti inflammatory drug; Wound healing

Indexed keywords

ACTIN; CYCLOOXYGENASE 2 INHIBITOR; FLUORESCEIN; INDOMETACIN; MITOMYCIN C; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PHALLOIDIN; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CELL LABELING; CELL MIGRATION; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; EPIFLUORESCENCE MICROSCOPE; EPITHELIZATION; IN VITRO STUDY; MEASUREMENT; MICROFILAMENT; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STANDARDIZATION; STOMACH EPITHELIUM; WOUND; WOUND HEALING;

ACTINS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL SURVIVAL; GASTRIC MUCOSA; GROWTH SUBSTANCES; HEPATOCYTE GROWTH FACTOR; INDOMETHACIN; MODELS, ANIMAL; NITROBENZENES; RATS; STOMACH ULCER; SULFONAMIDES; WOUND HEALING;

EID: 0037634338     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071291     Document Type: Article

References (55)

1. Eberhart CE, DuBois RN: Eicosanoids and the gastrointestinal tract. Gastroenterology 1995;109:285-301.
2. Tarnawski A, Halter F: Cellular mechanisms, interactions, and dynamics of gastric ulcer healing. J Clin Gastroenterol 1995;21(suppl 1):S93-S97.
3. Schmassmann A, Peskar BM, Stettler C, Netzer P, Stroff T, Flogerzi B, Halter F: Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol 1998;123:795-804.
4. Tsuji S, Kawano S, Tsujii M, Fusamoto H, Kamada T: Roles of hepatocyte growth factor and its receptor in gastric mucosa. Dig Dis Sci 1995;40:1132-1139.
5. Schmassmann A, Hirschi C, Stettler C, Poulsom R, Halter F: Recent work with hepatocyte growth/scatter factor; in Halter F, Winton D, Wright NA (eds): The Gut as a Model in Cell and Molecular Biology. Dordrecht, Kluwer Academic Press, 1997, pp 180-193.
6. Matsumoto K, Nakamura T: Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun 1997;239:639-644.
7. Kinoshita Y, Nakata H, Hassan S, Asahara M, Kawanami C, Matsushima Y, Naribayashi-Inomoto Y, Ping CY, Min D, Nakamura A, Chiba T: Gene expression of keratinocyte and hepatocyte growth factors during the healing of rat gastric mucosal lesions. Gastroenterology 1995;109:1068-1077.
8. Schmassmann A, Stettler C, Poulsom R, Tarasova N, Hirschi C, Flogerzi B, Matsumoto K, Nakamura T, Halter F: Roles of hepatocyte growth factor and its receptor met during gastric ulcer healing in rats. Gastroenterology 1997;113:1858-1872.
9. Hori K, Shiota G, Kawasaki H: Expression of hepatocyte growth factor and c-met receptor in gastric mucosa during gastric ulcer healing. Scand J Gastroenterol 2000;35:23-31.
10. Halter F, Tarnawski AS, Schmassmann A, Peskar BM: Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives. Gut 2001;49:443-453.
11. 2 treatment on the rat gastrointestinal mucosa. Gastroenterology 1983;85:1003-1010.
12. 2 on human gastric mucosa. A light microscopic, cell kinetic, and ultrastructural study. Gastroenterology 1986;90:1111-1120.
13. Banan A, Smith GS, Rieckenberg CL, Kokoska ER, Miller TA: Protection against ethanol injury by prostaglandin in a human intestinal cell line: Role of microtubules. Am J Physiol 1998;274:G111-G121.
14. Banan A, Smith GS, Kokoska ER, Miller TA: Role of actin cytoskeleton in prostaglandin-induced protection against ethanol in an intestinal epithelial cell line. J Surg Res 2000;88:104-113.
15. Matsumoto K, Okazaki H, Nakamura T: Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. J Biochem 1995;117:458-464.
16. Takahashi M, Ota S, Hata Y, Mikami Y, Azuma N, Nakamura T, Terano A, Omata M: Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach. J Clin Invest 1996;98:2604-2611.
17. Horie-Sakata K, Shimada T, Hiraishi H, Terano A: Role of cyclooxygenase 2 in hepatocyte growth factor-mediated gastric epithelial restitution. J Clin Gastroenterol 1998;27(suppl 1):S40-S46.
18. Jones MK, Sasaki E, Halter F, Pai R, Nakamura T, Arakawa T, Kuroki T, Tarnawski AS: HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: Action mediated through the ERK2 signaling pathway. FASEB J 1999;13:2186-2194.
19. Cooper JA: The role of actin polymerization in cell motility. Annu Rev Physiol 1991;53:585-605.
20. Kobayashi I, Kawano S, Tsuji S, Matsui H, Nakama A, Sawaoka H, Masuda E, Takei Y, Nagano K, Fusamoto H, Ohno T, Fukutomi H, Kamada T: RGM1, a cell line derived from normal gastric mucosa of rat. In Vitro Cell Dev Biol Anim 1996;32:259-261.
21. McCormack SA, Viar MJ, Johnson LR: Migration of IEC-6 cells: A model for mucosal healing. Am J Physiol 1992;263:426-435.
22. Dignass AU, Tsunekawa S, Podolsky DK: Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 1994;106:1254-1262.
23. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S: NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55-59.
24. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Seibert K: Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 1994;91:3228-3232.
25. Gratzner HG: Monoclonal antibody to 5-bromo- and 5-iododeoxy-uridine: A new reagent for detection of DNA replication. Science 1982;214:474-475.
26. Watanabe S, Hirose M, Wang XE, Maehiro K, Murai T, Kobayashi O, Mikami H, Otaka K, Miyazaki A, Sato N: A new model to study repair of gastric mucosa using primary cultured rabbit gastric epithelial cells. J Clin Gastroenterol 1995;21(suppl 1):40-44.
27. Minami T, Tojo H, Zushi S, Shinomura Y, Matsuzawa Y: Phospholipase A2 stimulates rat gastric epithelial cell line (RGM-1) migration. Inflamm Res 1997;46:103-107.
28. Nakamura E, Takahashi S, Matsui H, Okabe S: Interleukin-1beta inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers. Dig Dis Sci 1998;43:476-484.
29. Liu W: A simplified cytologic staining technique. Am J Clin Pathol 1970;54:767-768.
30. DeRenzis FA, Schechtman A: Staining by neutral red and trypan blue in sequence for assaying vital and nonvital cultured cells. Stain Technol 1973;48:135-136.
31. Domek MJ, Netzer P, Prins B, Nguyen T, Liang D, Wyle FA, Warner A: Helicobacter pylori induces apoptosis in human epithelial gastric cells by stress activated protein kinase pathway. Helicobacter 2001;6:110-115.
32. 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury. Toxicol Appl Pharmacol 1998;150:98-105.
33. Netzer P, Domek M, Pai R, Halter F, Tarnawski A: Inhibition of human colon cancer cell growth by antisense oligodeoxynucleotides targeted at basic fibroblast growth factor. Aliment Pharmacol Ther 2001;15:1673-1679.
34. Mitchison T, Klymkowsky M, Kellogg D, Moritz M, Raff J, Stewart M: The cytoskeleton; in Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (eds): Molecular Biology of the Cell, ed3. New York, Gerland, 1994, pp 788-861.
35. Ma TY, Hollander D, Tran LT, Nguyen D, Hoa N, Bhalla D: Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability. J Cell Physiol 1995;164:533-545.
36. Giap AQ, Tarnawski A, Hoa NT, Akotia V, Ma TY: NSAID inhibition of RGM1 gastric monolayer wound re-epithelialization: Comparison of selective COX-2 versus non-selective COX inhibitors. Life Sci 2002;70:3029-3037.
37. Pai R, Szabo IL, Giap AQ, Kawanaka H, Tarnawski AS: Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signaling. Life Sci 2001;69:3055-3071.
38. Nusrat A, Parkos CA, Bacarra AE, Godowski PJ, Delp-Archer C, Rosen EM, Madara JL: Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J Clin Invest 1994;93:2056-2065.
39. Takahashi M, Ota S, Shimada T, Hamada E, Kawabe T, Okudaira T, Matsumura M, Kaneko N, Terano A, Nakamura T, Omata M: Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture. J Clin Invest 1995;95:1994-2003.
40. Watanabe S, Hirose M, Wang XE, Maehiro K, Murai T, Kobayashi O, Nagahara A, Sato N: Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem Biophys Res Commun 1994;199:1453-1460.
41. Dignass AU, Lynch-Devaney K, Podolsky DK: Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration. Biochem Biophys Res Commun 1994;202:701-709.
42. Szabo IL, Pai R, Jones MK, Ehring GR, Kawanaka H, Tarnawski AS: Indomethacin delays gastric restitution: Association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers. Exp Biol Med (Maywood) 2002;227:412-424.
43. Wallace JL, Granger DN: The cellular and molecular basis of gastric mucosal defense. FASEB J 1996;10:731-740.
44. Lacy ER, Ito S: Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 1984;51:573-583.
45. Kaur P, Potten CS: Cell migration velocities in the crypts of the small intestine after cytotoxic insult are not dependent on mitotic activity. Cell Tissue Kinet 1986;19:601-610.
46. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, Kasuga M: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 1997;112:387-397.
47. Kishimoto Y, Wada K, Nakamoto K, Kawasaki H, Hasegawa J: Levels of cyclooxygenase-1 and -2 mRNA expression at various stages of acute gastric injury induced by ischemia-reperfusion in rats. Arch Biochem Biophys 1998;352:153-157.
48. DuBois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LBA, Lipsky PE: Cyclooxygenase in biology and disease. FASEB J 1998;12:1063-1073.
49. Ukawa H, Yamakuni H, Kato S, Takeuchi K: Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach. Dig Dis Sci 1998;43:2003-2011.
50. Bamba H, Ota S, Kato A, Matsuzaki F: Nonsteroidal anti-inflammatory drugs may delay the repair of gastric mucosa by suppressing prostaglandin-mediated increase of hepatocyte growth factor production. Biochem Biophys Res Commun 1998;245:567-571.
51. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Schuppan D, Drozdowicz D, Ptak A, Pawlik M, Nakamura T, Hahn EG: Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor. J Physiol Pharmacol 2000;51:751-773.
52. 2 and HGF in human gastric fibroblasts. Aliment Pharmacol Ther 2000;14(suppl 1):44-49.
53. Spenney JG, Bhown M: Effect of acetylsalicylic acid on gastric mucosa. II. Mucosal ATP and phosphocreatine content, and salicylate effects on mitochondrial metabolism. Gastroenterology 1977;73:995-999.
54. Mahmud T, Scott DL, Bjarnason I: A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity. Ann Rheum Dis 1996;55:211-213.
55. Somasundaram S, Hayllar H, Rafi S, Wrigglesworth JM, Macpherson AJ, Bjarnason I: The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: A review and a hypothesis. Scand J Gastroenterol 1995;30:289-299.