Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells

Cancer Research

Volumn 63, Issue 11, 2003, Pages 2990-2996

  Herynk, Matthew H ^a,b   Stoeltzing, Oliver ^a   Reinmuth, Niels ^a   Parikh, Nila U ^a   Abounader, Roger ^c   Laterra, John ^c   Radinsky, Robert ^a,b   Ellis, Lee M ^a,b   Gallick, Gary E ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; RIBOZYME; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL; CANCER GROWTH; CASE REPORT; CELL GROWTH; CELL SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GROWTH INHIBITION; GROWTH RATE; HUMAN; HUMAN CELL; LIVER METASTASIS; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REDUCTION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL DIVISION; CELL MOVEMENT; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOWN-REGULATION; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RNA, CATALYTIC; TRANSFECTION; TYROSINE;

EID: 0037905558     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Jemal, A., Thomas, A., Murray, T., and Thun, M. Cancer statistics, 2002. CA Cancer J. Clin., 52: 23-47, 2002.
2. Arteaga, C. L., Khuri, F., Krystal, G., and Sebti, S. Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer. Semin. Oncol., 29: 15-26, 2002.
3. Michalopoulos, G. K., and DeFrances, M. C. Liver regeneration. Science (Wash. DC), 276: 60-66, 1997.
4. Noji, S., Tashiro, K., Koyama, E., Nohno, T., Ohyama, K., Taniguchi, S., and Nakamura, T. Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization. Biochem. Biophys. Res. Commun., 173: 42-47, 1990.
5. Vigna, E., Naldini, L., Tamagnone, L., Longati, P., Bardelli, A., Maina, F., Ponzetto, C., and Comoglio, P. M. Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol. Biol., 40: 597-604, 1994.
6. Di Renzo, M. F., Olivero, M., Giacomini, A., Porte, H., Chastre, E., Mirossay, L., Nordlinger, B., Bretti, S., Bottardi, S., and Giordano, S. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin. Cancer Res., 1: 147-154, 1995.
7. Hasegawa, Y., Yamamoto, M., Maeda, S., and Salomon, D. Hepatocyte growth factor and its receptor/c-Met regulate both cell growth and invasion of human pancreatic cancer. Int. J. Oncol., 7: 877-881, 1995.
8. Rusciano, D., Lorenzoni, P., and Burger, M. M. Expression of constitutively activated hepatocyte growth factor/scatter factor receptor (c-met) in B16 melanoma cells selected for enhanced liver colonization. Oncogene, 11: 1979-1987, 1995.
9. Ferracini, R., Di Renzo, M. F., Scotlandi, K., Baldini, N., Olivero, M., Lollini, P., Cremona, O., Campanacci, M., and Comoglio, P. M. The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene, 10: 739-749, 1995.
10. Singh, R. K., Tsan, R., and Radinsky, R. Influence of the host microenvironment on the clonal selection of human colon carcinoma cells during primary tumor growth and metastasis. Clin. Exp. Metastasis, 15: 140-150, 1997.
11. Abounader, R., Ranganathan, S., Lal, B., Fielding, K., Book, A., Dietz, H., Burger, P., and Laterra, J. Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression. J. Natl. Cancer Inst., 91: 1548-1556, 1999.
12. Jiang, W. G., Grimshaw, D., Lane, J., Martin, T. A., Abounder, R., Laterra, J., and Mansel, R. E. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clin. Cancer Res., 7: 2555-2562, 2001.
13. Abounader, R., Lal, B., Luddy, C., Koe, G., Davidson, B., Rosen, E. M., and Laterra, J. In vivo targeting of SF/HGF and c-met expression via UlsnRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J., 16: 108-110, 2002.
14. Morikawa, K., Walker, S. M., Jessup, J. M., and Fidler, I. J. In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res., 48: 1943-1948, 1988.
15. Morikawa, K., Walker, S. M., Nakajima, M., Pathak, S., Jessup, J. M., and Fidler, I. J. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res., 48: 6863-6871, 1988.
16. Montgomery, R. A., and Dietz, H. C. Inhibition of fibrillin 1 expression using U1 snRNA as a vehicle for the presentation of antisense targeting sequence. Hum. Mol. Genet., 6: 519-525, 1997.
17. Talamonti, M. S., Roh, M. S., Curley, S. A., and Gallick, G. E. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J. Clin. Investig., 91: 53-60, 1993.
18. Herynk, M. H., Tsan, R., Radinsky, R., and Gallick, G. E. Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated β-catenin. Clin. Exp. Metastasis, 2003.
19. Kim, S. J., Johnson, M., Koterba, K., Herynk, M. H., Vehara, H., and Gallick, G. E. Reduced c-met expression by an adenovirus expressing a c-met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model. Clin. Cancer Res., in press, 2003.
20. Di Renzo, M. F., Olivero, M., Martone, T., Maffe, A., Maggiora, P., Stefani, A. D., Valente, G., Giordano, S., Cortesina, G., and Comoglio, P. M. Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene, 19: 1547-1555, 2000.
21. Ebert, M., Yokoyama, M., Friess, H., Buchler, M. W., and Korc. M. Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res., 54: 5775-5778, 1994.
22. Mondino, A., Giordano, S., and Comoglio, P. M. Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto-oncogene (hepatocyte growth factor receptor). Mol. Cell Biol., 11: 6084-6092, 1991.
23. Olivero, M., Valente, G., Bardelli, A., Longati, P., Ferrero, N., Cracco, C., Terrone, C., Rocca-Rossetti, S., Comoglio, P. M., and Di Renzo, M. F. Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family. Int. J. Cancer, 82: 640-643, 1999.
24. Park, M., Dean, M., Cooper, C. S., Schmidt, M., O'Brien, S. J., Blair, D. G., and Vande, W. G. Mechanism of met oncogene activation. Cell, 45: 895-904, 1986.
25. Park, W. S., Dong, S. M., Kim, S. Y., Na, E. Y., Shin, M. S., Pi, J. H., Kim, B. J., Bae, J. H., Hong, Y. K., Lee, K. S., Lee, S. H., Yoo, N. J., Jang, J. J., Pack, S., Zhuang, Z., Schmidt, L., Zbar, B., and Lee, J. Y. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res., 59: 307-310, 1999.
26. Rahimi, N., Tremblay, E., McAdam, L., Park, M., Schwall, R., and Elliott, B. Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma. Cell Growth Differ., 7: 263-270, 1996.
27. Schmidt, L., Duh, F. M., Chen, F., Kishida, T., Glenn, G., Choyke, P., Scherer, S. W., Zhuang, Z., Lubensky, I., Dean, M., Allikmets, R., Chidambaram, A., Bergerheim, U. R., Feltis, J. T., Casadevall, C., Zamarron, A., Bernues, M., Richard, S., Lips, C. J., Walther, M. M., Tsui, L. C., Geil, L., Orcutt, M. L., Stackhouse, T., and Zbar, B. Germline and somatic mutations in the tyrosine kinase domain of the MET protooncogene in papillary renal carcinomas. Nat. Genet., 16: 68-73, 1997.
28. Schmidt, L., Junker, K., Weirich, G., Glenn, G., Choyke, P., Lubensky, I., Zhuang, Z., Jeffers, M., Vande, W. G., Neumann, H., Walther, M., Linehan, W. M., and Zbar, B. Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene. Cancer Res., 58: 1719-1722, 1998.
29. Rusciano, D., Lorenzoni, P., and Burger, M. M. Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by a cytosolic tyrosine phosphatase activity. J. Biol. Chem., 271: 20763-20769, 1996.
30. Wang, R., Kobayashi, R., and Bishop, J. M. Cellular adherence elicits ligandindependent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. USA, 93: 8425-8430, 1996.
31. Mao, W., Irby, R., Coppola, D., Fu, L., Wloch, M., Turner, J., Yu, H., Garcia, R., Jove, R., and Yeatman, T. J. Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene, 15: 3083-3090, 1997.
32. Thomas, S. M., and Brugge, J. S. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol., 13: 513-609, 1997.
33. Schlessinger, J. New roles for Src kinases in control of cell survival and angiogenesis. Cell, 100: 293-296, 2000.
34. Windham, T. C., Parikh, N. U., Siwak, D. R., Summy, J. M., McConkey, D. J., Kraker, A. J., and Gallick, G. E. Src activation regulates anoikis in human colon tumor cell lines. Oncogene, 21: 7797-7807, 2002.
35. Staley, C. A., Parikh, N. U., and Gallick, G. E. Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth Differ., 8: 269-274, 1997.
36. Hiscox, S., and Jiang, W. G. Hepatocyte growth factor/scatter factor disrupts epithelial tumour cell-cell adhesion: involvement of β-catenin. Anticancer Res., 19: 509-517, 1999.
37. Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., Oku, N., Miyazawa, K., Kitamura, N., Takeichi, M., and Ito, F. Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes. Commun., 1: 295-305, 1994.