Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells

Clinical Cancer Research

Volumn 5, Issue 11, 1999, Pages 3695-3703

  Jiang, Wen G ^a   Hiscox, Steve E ^a   Parr, Christian ^a   Martin, Tracey A ^a   Matsumoto, Kunio ^b   Nakamura, Toshikazu ^b   Mansel, Robert E ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NK 4; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER INHIBITION; CELL MIGRATION; DRUG ANTAGONISM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HEPATOCYTE GROWTH FACTOR; HUMANS; INTERLEUKIN-8; KINETICS; LYMPHOKINES; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RECOMBINANT PROTEINS; UMBILICAL VEINS; VARIATION (GENETICS); VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032713122     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Stoker, M., and Perryman, M. An epithelial scatter factor released by embryo fibroblasts. J. Cell Sci., 77: 209-223, 1985.
2. Nakamura, T., Nishizawa, T., Hagiya, M., Seki, T., Shimoniski, M., Sugimata, A., Tashiro, K., and Shimizu, S. Molecular cloning and expression of human hepatocyte growth factor. Nature (Lond.), 342: 440-443, 1989.
3. Rosen, E. M., Goldberg, I. D., Jaken, S., and Grant, D. S. Regulation of endothelial cell migration and capillary like tube formation by scatter factor. Circulation, 82: 699, 1990.
4. Bussolino, F., DiRenzo, M. F., Ziehe, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., and Comoglio, P. M. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol., 119: 629-641, 1992.
5. Grant, D. S., Kleinman, H. K., Goldberg, I. D., Bhargava, M. M., Nickoloff, B. J., Kinsella, J. L., Polverini, P., and Rosen, E. M. Scatter factor induces blood-vessel formation in vivo. PTOC. Natl. Acad. Sci. USA, 90: 1937-1941, 1993.
6. Lamszus, K., Jin, L., Fuchs, A., Shi, E., Chowdhury, S., Yao, Y., Polverini, P. J., Laterra, J., Goldberg, I. D., and Rosen, E. M. Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice. Lab. Investig., 76: 339-353, 1997.
7. Jiang, W. G., Hiscox, S., Matsumoto, K., and Nakamura, T. Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer. Crit. Rev. Oncol. Hematol., 29: 209-248, 1999.
8. Beviglia, L., Matsumoto, K., Lin, C. S., Ziober, B. L., and Kramer, R. H. Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression. Int. J. Cancer, 74: 301-309, 1997.
9. Jin, L., Fuchs, A., Schnitt, S. J., Yao, Y., Joseph, A., Lamszus, K., Park, M., Goldberg, I. D., and Rosen, E. M. Expression of scatter factor and c-met receptor in benign and malignant breast tissue. Cancer (Phila.), 79: 749-760, 1997.
10. Taniguchi, T., Kitamura, M., Arai, K., Iwasaki, Y., Yamamoto, Y., Igari, A., and Toi, M. Increase in the circulating level of hepatocyte growth factor in gastric cancer patients. Br. J. Cancer, 75: 673-677, 1998.
11. Ghoussoub, R. A. D., Dillon, D. A., Daquila, T., Rimm, E. B., Fearon, E. R., and Rimm, D. L. Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer (Phila.), 82: 1513-1520, 1998.
12. Hendrix, M. J., Wood, W. R., and Sefter, E. A. Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor. Cancer Res., 50: 4121-4130, 1990.
13. Isoai, A., Gototsukamoto, H., Yamori, T., Ohhara, T., Tsuruo, T., Silletti, S., Raz, A., Watanabe, H., Akedo, H., and Kumagai, H. Inhibitory effects of tumor invasion-inhibiting factor-2 and its conjugate on disseminating tumor cells. Cancer Res., 54: 1264-1270, 1994.
14. Jiang, W. G., Hiscox, S., Hallett, M. B., Horrobin, D. F., Mansel, R. E., and Puntis, M. C. A. Regulation of the expression of E-cadherin on human cancer cells by γ linolenic acid. Cancer Res., 55: 5043-5048, 1995.
15. Jiang, W. G., Hiscox, S., Hallett, M. B., Horrobin, D. F., Scott, C., Puntis, M. C. A., and Mansel, R. E. Inhibition of invasion and motility human colon cancer cells by γ linolenic acid. Br. J. Cancer, 71: 744-752, 1995.
16. Koj, A., Guzdek, A., Nakamura, T., and Kordula, T. Hepatocyte growth-factor and retinoic acid exert opposite effects on synthesis of type-1 and type-2 acute-phase proteins in rat hepatoma-cells. Int. J. Biochem. Cell Biol., 27: 39-46, 1995.
17. Uchiyama, A., Essner, R., Doi, F., Nguyen, T., Ramming, K. P., Nakamura, T., Morton, D. L., and Hoon, D. S. B. Interleukin-4 inhibits hepatocyte growth factor-induced invasion and migration of colon carcinomas. J. Cell. Biochem., 62: 443-453, 1996.
18. Chan, A. M. L., Rubin, J. S., Bottaro, D. P., Hirschfield, D. W., Chedid, M., and Aaronson, S. A. Identification of a competitive HGF antagonist encoded by an alternative transcript. Science (Washington DC), 254: 1382-1385, 1991.
19. Hartmann, G., Naldini, L., Weidner, M., Sachs, M., Vigna, E., Comoglio, P. M., and Birchmeier, W. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci. USA, 89: 11574-11578, 1992.
20. Lokker, N. A., and Godowski, P. W. Generation and charaterization of a competitive agonist of human hepatocyte growth factor, HGF/NK1. J. Biol. Chem., 268: 17145-17150, 1993.
21. Cioce, V., Csaky, K. G., Chan, A. M. L., Bottaro, D. P., Taylor, W. G., Jensen, R., Aaronson, S. A., and Rubin, J. S. Hepatocyte growth-factor (HGF)/NK1 is a naturally-occurring HGF scatter factor variant with partial agonist-antagonist activity. J. Biol. Chem., 271: 13110-13115, 1996.
22. Schwall, R. H., Chang, L. Y., Godowski, P. J., Kahn, D. W., Hillan, K. J., Bauer, K. D., and Zioncheck, T. F. Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth-factor antagonists NK1 and NK2. J. Cell Biol., 133: 709-718, 1996.
23. Jakubczak, J. L., LaRochelle, W. J., and Merlino, G. NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. Mol. Cell. Biol., 18: 1275-1283, 1998.
24. Date, K., Matsumoto, K., Shimura, H., Tanaka, M., and Nakamura, T. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett., 420: 1-6, 1997.
25. Matsumoto, K., Kataoka, H., Date, K., and Nakamura, T. Cooperative interaction between α-and β-chains of hepatocyte growth factor on c-met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. J. Biol. Chem., 273: 22913-22920, 1998.
26. Gimbrone, M., Catran, R., and Folkman, J. Human vascular endothelial cells in culture. J. Cell Biol., 60: 673-684, 1974.
27. Kanayasu, T., Morita, I., Nakaohayashi, J., Asuwa, N., Fujisawa, C., Ishii, T., Ito, H., and Murota, S. Eicosapentaenoic acid inhibits tube formation of vascular endothelial-cells in vitro. Lipids, 26: 271-276, 1991.
28. Bach, T., Bargisian, C., Chalupowicz, D. G., Busier, D., Yaen, C. H., Grant, D. S., and Martinez, V. E-cadherin mediates endothelial cell capillary tube formation in fibrin and collagen gels. Exp. Cell Res., 238: 324-334, 1998.
29. Jiang, W. G., Hiscox, S., Hallett, M. B., Mansel, R. E., and Puntis, M. C. A. Regulation of motility and invasion of cancer cells by human monocytes. Anticancer Res., 15: 1303-1310, 1995.
30. Jiang, W. G., and Harding, K. G. Enhancement of wound tissue expansion and angiogenesis by matrix-embedded fibroblasts: a role of hepatocyte growth factor/scatter factor. Int. J. Mol. Med., 2: 203-210, 1998.
31. Jiang, W. G., Puntis, M. C. A., and Hallett, M. B. Monocyte conditioned media possess a novel factor which increases motility of cancer cells. Int. J. Cancer, 53: 426-431, 1993.
32. 2+. Exp. Cell Res., 220: 424-433, 1995.
33. Hiscox, S., and Jiang, W. G. Hepatocyte growth factor/scatter factor disrupts epithelial tumour cell-cell adhesion: involvement of β-catenin. Anticancer Res., 19: 509-519, 1999.
34. Herynk, M. H., Tsan, R., and Radinsky, R. cMET differentially interacts with β-catenin in high versus low metastatic human colon carcinoma (HCC) cells. Proc. Am. Assoc. Cancer Res., 40: 105, 1999.
35. Comoglio, P. M., DiRenzo, M. F., Ziehe, M., Naldini, L., Olivero, M., Gaudino, G., Tamagrone, L., and Busselino, F. Hepatocyte growth factor is a potent angiogenic facto which stimulates endothelial cell motility and growth. J. Cell. Biochem., S174: 232, 1993.
36. Moriraoto, A., Okamura, K., Hamanaka, R., Sato, Y., Shima, K., Higashio, K., and Kuwano, M. Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture. Biochem. Biophys. Res. Commun., 179: 1042-1049, 1991.
37. Folkman, J. Anti-angiogenesis: new concept for therapy of solid tumours. Ann. Surg., 175: 409-416, 1972.
38. Folkman, J., Weisz, P. B., Jouille, M. M., Li, W. W., and Ewing, W. R. Control of angiogenesis with sythemic heparin substitute. Science (Washington DC), 243: 1490-1493, 1989.
39. Rak, J., and Kerbel, R. S. Treating cancer by inhibiting angiogenesis. Cancer Metastasis Rev., 15: 231-236, 1996.